GPR101 cDNA ORF clone, Homo sapiens(human)

Characterization of GPR101 transcript structure and expression patterns.
Trivellin G, Bjelobaba I, Daly AF, Larco DO, Palmeira L, Faucz FR, Thiry A, Leal LF, Rostomyan L, Quezado M, Schernthaner-Reiter MH, Janjic MM, Villa C, Wu TJ, Stojilkovic SS, Beckers A, Feldman B, Stratakis CA
Journal of molecular endocrinology57(2)97-111(2016 08)

Germline or somatic GPR101 duplication leads to X-linked acrogigantism: a clinico-pathological and genetic study.
Iacovazzo D, Caswell R, Bunce B, Jose S, Yuan B, Hern?ndez-Ram?rez LC, Kapur S, Caimari F, Evanson J, Ferra? F, Dang MN, Gabrovska P, Larkin SJ, Ansorge O, Rodd C, Vance ML, Ram?rez-Renteria C, Mercado M, Goldstone AP, Buchfelder M, Burren CP, Gurlek A, Dutta P, Choong CS, Cheetham T, Trivellin G, Stratakis CA, Lopes MB, Grossman AB, Trouillas J, Lupski JR, Ellard S, Sampson JR, Roncaroli F, Korbonits M
Acta neuropathologica communications4(1)56(2016 Jun)

p.E308D variant not found in acromegaly cases
Title: Analysis of GPR101 and AIP genes mutations in acromegaly: a multicentric study.

This study shows that different GPR101 transcripts exist and that the brain is the major site of GPR101 expression across different species, although divergent species- and temporal-specific expression patterns are evident. These findings suggest an important role for GPR101 in brain and pituitary development and likely reflect the very different growth, development and maturation patterns among species.
Title: Characterization of GPR101 transcript structure and expression patterns.

This study did not identify GPR101 abnormalities as a frequent cause of growth hormone deficiency.
Title: GPR101 Mutations are not a Frequent Cause of Congenital Isolated Growth Hormone Deficiency.

Study showed that X-linked acrogigantism (XLAG) can result from germline or somatic duplication of GPR101. Duplication of GPR101 alone is sufficient for the development of XLAG, implicating it as the causative gene within the Xq26.3 region. The pathological features of XLAG-associated pituitary adenomas are typical and, together with the clinical phenotype, should prompt genetic testing.
Title: Germline or somatic GPR101 duplication leads to X-linked acrogigantism: a clinico-pathological and genetic study.

Germline GPR101 mutations are very rare in patients with sporadic pituitary adenomas of various histotypes.
Title: Very low frequency of germline GPR101 genetic variation and no biallelic defects with AIP in a large cohort of patients with sporadic pituitary adenomas.