H3C6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H3C6
Entrez Gene ID	8353
Full Name	histone cluster 1 H3 family member e
Synonyms	H3.1,H3/d,H3FD
General protein information	Preferred Names histone cluster 1 H3 family member e Names histone H3.1 H3 histone family, member D histone 1, H3e histone H3/d histone cluster 1, H3e
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.2
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015].
Disorder MIM:	602813

mRNA and Protein(s)

mRNA	Protein	Name
NM_003532.2	NP_003523.1	histone H3.1
NM_003532.3	NP_003523.1	histone H3.1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LOC523214	XP_002697557.1
Danio rerio (zebrafish)	hist2h3c	NP_001093643.1
Canis lupus familiaris (dog)	LOC488306	XP_545428.1
Mus musculus (house mouse)	Hist1h3h	NP_835513.1
Drosophila melanogaster (fruit fly)	His3:CG33836	NP_001027338.1
Arabidopsis thaliana (thale cress)	AT1G75600	NP_177690.1
Homo sapiens (human)	HIST1H3E	NP_003523.1
Pan troglodytes (chimpanzee)	LOC463171	XP_518888.1
Rattus norvegicus (Norway rat)	Hist1h2ail	NP_001013074.1
Xenopus tropicalis (tropical clawed frog)	LOC101732670	XP_004913874.1
Oryza sativa (rice)	Os03g0390600	NP_001050276.1
	LOC705220	XP_001096897.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.
Huang H, Str?mme CB, Saredi G, H?dl M, Strandsby A, Gonz?lez-Aguilera C, Chen S, Groth A, Patel DJ
Nature structural & molecular biology22(8)618-26(2015 Aug)

Human tNASP promotes in vitro nucleosome assembly with histone H3.3.
Kato D, Osakabe A, Tachiwana H, Tanaka H, Kurumizaka H
Biochemistry54(5)1171-9(2015 Feb)

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia.
Title: Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis.

there are significant alterations of H3K4me3 in minimal change nephrotic syndrome patients
Title: Genome-wide analysis of histone H3 lysine 4 trimethylation in peripheral blood mononuclear cells of minimal change nephrotic syndrome patients.

analysis of the binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells
Title: Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq.

analysis of histone posttranslational modifications on H3.1 and H3.3
Title: PTMs on H3 variants before chromatin assembly potentiate their final epigenetic state.

The following H3C6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H3C6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13195	NM_003532.3 Latest version!	Homo sapiens H3 clustered histone 6 (H3C6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu13195	NM_003532.2	Homo sapiens histone cluster 1 H3 family member e (HIST1H3E), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H3C6 ( NM_003532.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003523.1 Homo sapiens histone cluster 1 H3 family member e (HIST1H3E), mRNA.

Price & Availability↑

CloneID	OHu13195
Clone ID Related Accession (Same CDS sequence)	NM_003532.2 , NM_003532.3
Accession Version	NM_003532.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Homo sapiens(human)
Product	histone H3.1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M60746.1. On May 30, 2002 this sequence version replaced NM_003532.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGCGTA CTAAGCAGAC GGCTCGTAAA TCCACAGGCG GTAAAGCACC GCGCAAACAG 
CTGGCCACTA AGGCAGCTCG CAAGAGCGCT CCGGCCACGG GCGGCGTGAA GAAGCCCCAT 
CGCTACCGCC CTGGCACCGT GGCTCTGCGC GAGATCCGTC GCTACCAGAA GTCTACCGAG 
CTTCTAATCC GGAAGCTGCC GTTTCAGCGC CTGGTGCGAG AAATAGCTCA GGACTTCAAG 
ACCGACCTGC GCTTCCAGAG TTCCGCGGTG ATGGCGCTGC AGGAGGCCTG CGAGGCCTAC 
TTGGTGGGGC TTTTCGAGGA CACCAACCTG TGCGCTATTC ATGCCAAACG CGTGACCATC 
ATGCCTAAAG ACATCCAGCT TGCCCGCCGC ATTCGTGGGG AGAGGGCGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003523.1
CDS	1..411
Translation	MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Target ORF information:

RefSeq Version	NM_003532.2
Organism	Homo sapiens(human)
Definition	Homo sapiens histone cluster 1 H3 family member e (HIST1H3E), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003532.2

ORF Insert Sequence:

ATGGCGCGTA CTAAGCAGAC GGCTCGTAAA TCCACAGGCG GTAAAGCACC GCGCAAACAG 
CTGGCCACTA AGGCAGCTCG CAAGAGCGCT CCGGCCACGG GCGGCGTGAA GAAGCCCCAT 
CGCTACCGCC CTGGCACCGT GGCTCTGCGC GAGATCCGTC GCTACCAGAA GTCTACCGAG 
CTTCTAATCC GGAAGCTGCC GTTTCAGCGC CTGGTGCGAG AAATAGCTCA GGACTTCAAG 
ACCGACCTGC GCTTCCAGAG TTCCGCGGTG ATGGCGCTGC AGGAGGCCTG CGAGGCCTAC 
TTGGTGGGGC TTTTCGAGGA CACCAACCTG TGCGCTATTC ATGCCAAACG CGTGACCATC 
ATGCCTAAAG ACATCCAGCT TGCCCGCCGC ATTCGTGGGG AGAGGGCGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H3C6 ( NM_003532.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003523.1 Homo sapiens H3 clustered histone 6 (H3C6), mRNA.

Price & Availability↑

CloneID	OHu13195
Clone ID Related Accession (Same CDS sequence)	NM_003532.2 , NM_003532.3
Accession Version	NM_003532.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	histone H3.1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031777.5. On Dec 3, 2019 this sequence version replaced NM_003532.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BX098295.1, DA303911.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGCGTA CTAAGCAGAC GGCTCGTAAA TCCACAGGCG GTAAAGCACC GCGCAAACAG 
CTGGCCACTA AGGCAGCTCG CAAGAGCGCT CCGGCCACGG GCGGCGTGAA GAAGCCCCAT 
CGCTACCGCC CTGGCACCGT GGCTCTGCGC GAGATCCGTC GCTACCAGAA GTCTACCGAG 
CTTCTAATCC GGAAGCTGCC GTTTCAGCGC CTGGTGCGAG AAATAGCTCA GGACTTCAAG 
ACCGACCTGC GCTTCCAGAG TTCCGCGGTG ATGGCGCTGC AGGAGGCCTG CGAGGCCTAC 
TTGGTGGGGC TTTTCGAGGA CACCAACCTG TGCGCTATTC ATGCCAAACG CGTGACCATC 
ATGCCTAAAG ACATCCAGCT TGCCCGCCGC ATTCGTGGGG AGAGGGCGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003523.1
CDS	21..431
Translation	MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Target ORF information:

RefSeq Version	NM_003532.3
Organism	Homo sapiens(human)
Definition	Homo sapiens H3 clustered histone 6 (H3C6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003532.3

ORF Insert Sequence:

ATGGCGCGTA CTAAGCAGAC GGCTCGTAAA TCCACAGGCG GTAAAGCACC GCGCAAACAG 
CTGGCCACTA AGGCAGCTCG CAAGAGCGCT CCGGCCACGG GCGGCGTGAA GAAGCCCCAT 
CGCTACCGCC CTGGCACCGT GGCTCTGCGC GAGATCCGTC GCTACCAGAA GTCTACCGAG 
CTTCTAATCC GGAAGCTGCC GTTTCAGCGC CTGGTGCGAG AAATAGCTCA GGACTTCAAG 
ACCGACCTGC GCTTCCAGAG TTCCGCGGTG ATGGCGCTGC AGGAGGCCTG CGAGGCCTAC 
TTGGTGGGGC TTTTCGAGGA CACCAACCTG TGCGCTATTC ATGCCAAACG CGTGACCATC 
ATGCCTAAAG ACATCCAGCT TGCCCGCCGC ATTCGTGGGG AGAGGGCGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.
Nature structural & molecular biology22(8)618-26(2015 Aug)
Huang H,Str?mme CB,Saredi G,H?dl M,Strandsby A,Gonz?lez-Aguilera C,Chen S,Groth A,Patel DJ

Human tNASP promotes in vitro nucleosome assembly with histone H3.3.
Biochemistry54(5)1171-9(2015 Feb)
Kato D,Osakabe A,Tachiwana H,Tanaka H,Kurumizaka H

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

H3C6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報