H2BC4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H2BC4
Entrez Gene ID	8347
Full Name	histone cluster 1 H2B family member c
Synonyms	H2B.1,H2B/l,H2BFL,dJ221C16.3
General protein information	Preferred Names histone cluster 1 H2B family member c Names histone H2B type 1-C/E/F/G/I H2B histone family, member L histone 1, H2bc histone H2B.1 A histone H2B.l histone cluster 1, H2bc
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.2
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015].
Disorder MIM:	602847

mRNA and Protein(s)

mRNA	Protein	Name
NM_003526.2	NP_003517.2	histone H2B type 1-C/E/F/G/I
NM_003526.3	NP_003517.2	histone H2B type 1-C/E/F/G/I

Pathways from BioSystems

Homologies

Homo sapiens (human)	HIST1H2BC	NP_003517.2
Canis lupus familiaris (dog)	LOC488267	XP_005640151.1
Mus musculus (house mouse)	Hist1h2bg	NP_835503.1
Pan troglodytes (chimpanzee)	LOC100609614	XP_003311101.1
	LOC714001	XP_001110898.1
Rattus norvegicus (Norway rat)	LOC100910200	XP_003751757.1
Bos taurus (cattle)	LOC616868	XP_002697517.1

Gene Ontology
Bibliography

Related articles in PubMed

A subset of replication-dependent histone mRNAs are expressed as polyadenylated RNAs in terminally differentiated tissues.
Lyons SM, Cunningham CH, Welch JD, Groh B, Guo AY, Wei B, Whitfield ML, Xiong Y, Marzluff WF
Nucleic acids research44(19)9190-9205(2016 Nov)

Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere.
Falk SJ, Guo LY, Sekulic N, Smoak EM, Mani T, Logsdon GA, Gupta K, Jansen LE, Van Duyne GD, Vinogradov SA, Lampson MA, Black BE
Science (New York, N.Y.)348(6235)699-703(2015 May)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

Antimicrobial peptides in the first line defence of human colon mucosa.
Tollin M, Bergman P, Svenberg T, J?rnvall H, Gudmundsson GH, Agerberth B
Peptides24(4)523-30(2003 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Histone H2B antimicrobial peptides participate in the colonic defense against bacteria and fungi.
Title: Antimicrobial peptides in the first line defence of human colon mucosa.

The following H2BC4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H2BC4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16299	NM_003526.3 Latest version!	Homo sapiens H2B clustered histone 4 (H2BC4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu16299	NM_003526.2	Homo sapiens histone cluster 1 H2B family member c (HIST1H2BC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H2BC4 ( NM_003526.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003517.2 Homo sapiens histone cluster 1 H2B family member c (HIST1H2BC), mRNA.

Price & Availability↑

CloneID	OHu16299
Clone ID Related Accession (Same CDS sequence)	NM_003526.2 , NM_003526.3
Accession Version	NM_003526.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Homo sapiens(human)
Product	histone H2B type 1-C/E/F/G/I
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z80783.1. On May 24, 2002 this sequence version replaced NM_003526.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: DA696398.1, DA769609.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12860195 RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCTGAGC CAGCCAAGTC TGCTCCCGCC CCGAAGAAGG GCTCCAAGAA GGCAGTGACC 
AAAGCGCAGA AGAAAGATGG CAAGAAGCGC AAGCGCAGCC GCAAGGAGAG TTACTCTGTG 
TACGTGTACA AGGTGCTGAA ACAGGTCCAT CCCGACACTG GCATCTCTTC CAAGGCCATG 
GGCATCATGA ATTCTTTCGT TAACGACATA TTTGAGCGCA TCGCGGGCGA GGCTTCCCGC 
CTGGCGCATT ACAACAAGCG CTCGACCATC ACCTCCAGGG AGATCCAGAC GGCCGTGCGC 
CTGCTGCTTC CCGGAGAGCT GGCCAAGCAC GCCGTGTCGG AGGGCACCAA GGCCGTCACC 
AAGTACACCA GCTCCAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003517.2
CDS	1..381
Translation	MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK

Target ORF information:

RefSeq Version	NM_003526.2
Organism	Homo sapiens(human)
Definition	Homo sapiens histone cluster 1 H2B family member c (HIST1H2BC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003526.2

ORF Insert Sequence:

ATGCCTGAGC CAGCCAAGTC TGCTCCCGCC CCGAAGAAGG GCTCCAAGAA GGCAGTGACC 
AAAGCGCAGA AGAAAGATGG CAAGAAGCGC AAGCGCAGCC GCAAGGAGAG TTACTCTGTG 
TACGTGTACA AGGTGCTGAA ACAGGTCCAT CCCGACACTG GCATCTCTTC CAAGGCCATG 
GGCATCATGA ATTCTTTCGT TAACGACATA TTTGAGCGCA TCGCGGGCGA GGCTTCCCGC 
CTGGCGCATT ACAACAAGCG CTCGACCATC ACCTCCAGGG AGATCCAGAC GGCCGTGCGC 
CTGCTGCTTC CCGGAGAGCT GGCCAAGCAC GCCGTGTCGG AGGGCACCAA GGCCGTCACC 
AAGTACACCA GCTCCAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H2BC4 ( NM_003526.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003517.2 Homo sapiens H2B clustered histone 4 (H2BC4), mRNA.

Price & Availability↑

CloneID	OHu16299
Clone ID Related Accession (Same CDS sequence)	NM_003526.2 , NM_003526.3
Accession Version	NM_003526.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	histone H2B type 1-C/E/F/G/I
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U91328.1. On Dec 3, 2019 this sequence version replaced NM_003526.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: DA383555.1, DA696398.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12860195 RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCTGAGC CAGCCAAGTC TGCTCCCGCC CCGAAGAAGG GCTCCAAGAA GGCAGTGACC 
AAAGCGCAGA AGAAAGATGG CAAGAAGCGC AAGCGCAGCC GCAAGGAGAG TTACTCTGTG 
TACGTGTACA AGGTGCTGAA ACAGGTCCAT CCCGACACTG GCATCTCTTC CAAGGCCATG 
GGCATCATGA ATTCTTTCGT TAACGACATA TTTGAGCGCA TCGCGGGCGA GGCTTCCCGC 
CTGGCGCATT ACAACAAGCG CTCGACCATC ACCTCCAGGG AGATCCAGAC GGCCGTGCGC 
CTGCTGCTTC CCGGAGAGCT GGCCAAGCAC GCCGTGTCGG AGGGCACCAA GGCCGTCACC 
AAGTACACCA GCTCCAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003517.2
CDS	23..403
Translation	MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK

Target ORF information:

RefSeq Version	NM_003526.3
Organism	Homo sapiens(human)
Definition	Homo sapiens H2B clustered histone 4 (H2BC4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003526.3

ORF Insert Sequence:

ATGCCTGAGC CAGCCAAGTC TGCTCCCGCC CCGAAGAAGG GCTCCAAGAA GGCAGTGACC 
AAAGCGCAGA AGAAAGATGG CAAGAAGCGC AAGCGCAGCC GCAAGGAGAG TTACTCTGTG 
TACGTGTACA AGGTGCTGAA ACAGGTCCAT CCCGACACTG GCATCTCTTC CAAGGCCATG 
GGCATCATGA ATTCTTTCGT TAACGACATA TTTGAGCGCA TCGCGGGCGA GGCTTCCCGC 
CTGGCGCATT ACAACAAGCG CTCGACCATC ACCTCCAGGG AGATCCAGAC GGCCGTGCGC 
CTGCTGCTTC CCGGAGAGCT GGCCAAGCAC GCCGTGTCGG AGGGCACCAA GGCCGTCACC 
AAGTACACCA GCTCCAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A subset of replication-dependent histone mRNAs are expressed as polyadenylated RNAs in terminally differentiated tissues.
Nucleic acids research44(19)9190-9205(2016 Nov)
Lyons SM,Cunningham CH,Welch JD,Groh B,Guo AY,Wei B,Whitfield ML,Xiong Y,Marzluff WF

Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere.
Science (New York, N.Y.)348(6235)699-703(2015 May)
Falk SJ,Guo LY,Sekulic N,Smoak EM,Mani T,Logsdon GA,Gupta K,Jansen LE,Van Duyne GD,Vinogradov SA,Lampson MA,Black BE

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

Antimicrobial peptides in the first line defence of human colon mucosa.
Peptides24(4)523-30(2003 Apr)
Tollin M,Bergman P,Svenberg T,J?rnvall H,Gudmundsson GH,Agerberth B

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H2BC4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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