HIST1H2AJ cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HIST1H2AJ
Entrez Gene ID	8331
Full Name	histone cluster 1 H2A family member j
Synonyms	H2A/E,H2AFE,dJ160A22.4
General protein information	Preferred Names histone cluster 1 H2A family member j Names histone cluster 1, H2aj H2A histone family, member E histone 1, H2aj
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.1
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015].
Disorder MIM:	602791

mRNA and Protein(s)

mRNA	Protein	Name
NM_021066.3	NP_066544.1	histone cluster 1, H2aj
NM_021066.2	NP_066544.1	histone cluster 1, H2aj

Pathways from BioSystems

Homologies

Homo sapiens (human)	HIST1H2AJ	NP_066544.1
Canis lupus familiaris (dog)	LOC488304	XP_545426.4
Bos taurus (cattle)	HIST1H2AJ	XP_002697519.1
Pan troglodytes (chimpanzee)	LOC737087	XP_001138786.1
	HIST1H2AJ	XP_001095773.1
Mus musculus (house mouse)	Hist1h2af	NP_783592.1

Gene Ontology
Bibliography

Related articles in PubMed

Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter.
Lusic M, Marcello A, Cereseto A, Giacca M
The EMBO journal22(24)6550-61(2003 Dec)

The human and mouse replication-dependent histone genes.
Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ
Genomics80(5)487-98(2002 Nov)

Directed proteomic analysis of the human nucleolus.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI
Current biology : CB12(1)1-11(2002 Jan)

Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA.
Deng L, Wang D, de la Fuente C, Wang L, Li H, Lee CG, Donnelly R, Wade JD, Lambert P, Kashanchi F
Virology289(2)312-26(2001 Oct)

Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones.
Deng L, de la Fuente C, Fu P, Wang L, Donnelly R, Wade JD, Lambert P, Li H, Lee CG, Kashanchi F
Virology277(2)278-95(2000 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following HIST1H2AJ gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HIST1H2AJ cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28978	NM_021066.3 Latest version!	Homo sapiens H2A clustered histone 14 (H2AC14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu28978	NM_021066.2	Homo sapiens histone cluster 1 H2A family member j (HIST1H2AJ), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HIST1H2AJ ( NM_021066.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_066544.1 Homo sapiens H2A clustered histone 14 (H2AC14), mRNA.

Price & Availability↑

CloneID	OHu28978
Clone ID Related Accession (Same CDS sequence)	NM_021066.3 , NM_021066.2
Accession Version	NM_021066.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	histone cluster 1, H2aj
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL049822.30. On Dec 3, 2019 this sequence version replaced NM_021066.2. ##Evidence-Data-START## Transcript is intronless :: BC133048.1, CF272102.2 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGGGC GTGGTAAGCA GGGAGGCAAA GCTCGCGCCA AGGCCAAGAC CCGCTCTTCT 
CGGGCCGGGC TTCAGTTTCC CGTAGGCCGA GTGCATCGCC TGCTCCGCAA AGGCAACTAT 
GCGGAGCGGG TCGGTGCTGG AGCGCCGGTG TACCTGGCGG CGGTGCTGGA GTACCTGACC 
GCCGAGATCC TGGAGCTGGC TGGCAACGCG GCCCGCGACA ACAAGAAGAC TCGCATCATC 
CCGCGTCACC TCCAGCTGGC CATCCGCAAC GATGAGGAGC TCAACAAGCT TCTGGGCAAA 
GTCACCATCG CACAGGGTGG CGTCCTGCCC AACATCCAGG CCGTGCTGCT GCCAAAGAAA 
ACTGAGAGCC ACCACAAGAC TAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066544.1
CDS	38..424
Translation	MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKTK

Target ORF information:

RefSeq Version	NM_021066.3
Organism	Homo sapiens(human)
Definition	Homo sapiens H2A clustered histone 14 (H2AC14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021066.3

ORF Insert Sequence:

ATGTCTGGGC GTGGTAAGCA GGGAGGCAAA GCTCGCGCCA AGGCCAAGAC CCGCTCTTCT 
CGGGCCGGGC TTCAGTTTCC CGTAGGCCGA GTGCATCGCC TGCTCCGCAA AGGCAACTAT 
GCGGAGCGGG TCGGTGCTGG AGCGCCGGTG TACCTGGCGG CGGTGCTGGA GTACCTGACC 
GCCGAGATCC TGGAGCTGGC TGGCAACGCG GCCCGCGACA ACAAGAAGAC TCGCATCATC 
CCGCGTCACC TCCAGCTGGC CATCCGCAAC GATGAGGAGC TCAACAAGCT TCTGGGCAAA 
GTCACCATCG CACAGGGTGG CGTCCTGCCC AACATCCAGG CCGTGCTGCT GCCAAAGAAA 
ACTGAGAGCC ACCACAAGAC TAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HIST1H2AJ ( NM_021066.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_066544.1 Homo sapiens histone cluster 1 H2A family member j (HIST1H2AJ), mRNA.

Price & Availability↑

CloneID	OHu28978
Clone ID Related Accession (Same CDS sequence)	NM_021066.3 , NM_021066.2
Accession Version	NM_021066.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	histone cluster 1, H2aj
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z83736.1. On Sep 21, 2001 this sequence version replaced NM_021066.1. ##Evidence-Data-START## Transcript is intronless :: DA559284.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGGGC GTGGTAAGCA GGGAGGCAAA GCTCGCGCCA AGGCCAAGAC CCGCTCTTCT 
CGGGCCGGGC TTCAGTTTCC CGTAGGCCGA GTGCATCGCC TGCTCCGCAA AGGCAACTAT 
GCGGAGCGGG TCGGTGCTGG AGCGCCGGTG TACCTGGCGG CGGTGCTGGA GTACCTGACC 
GCCGAGATCC TGGAGCTGGC TGGCAACGCG GCCCGCGACA ACAAGAAGAC TCGCATCATC 
CCGCGTCACC TCCAGCTGGC CATCCGCAAC GATGAGGAGC TCAACAAGCT TCTGGGCAAA 
GTCACCATCG CACAGGGTGG CGTCCTGCCC AACATCCAGG CCGTGCTGCT GCCAAAGAAA 
ACTGAGAGCC ACCACAAGAC TAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066544.1
CDS	1..387
Translation	MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKTK

Target ORF information:

RefSeq Version	NM_021066.2
Organism	Homo sapiens(human)
Definition	Homo sapiens histone cluster 1 H2A family member j (HIST1H2AJ), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021066.2

ORF Insert Sequence:

ATGTCTGGGC GTGGTAAGCA GGGAGGCAAA GCTCGCGCCA AGGCCAAGAC CCGCTCTTCT 
CGGGCCGGGC TTCAGTTTCC CGTAGGCCGA GTGCATCGCC TGCTCCGCAA AGGCAACTAT 
GCGGAGCGGG TCGGTGCTGG AGCGCCGGTG TACCTGGCGG CGGTGCTGGA GTACCTGACC 
GCCGAGATCC TGGAGCTGGC TGGCAACGCG GCCCGCGACA ACAAGAAGAC TCGCATCATC 
CCGCGTCACC TCCAGCTGGC CATCCGCAAC GATGAGGAGC TCAACAAGCT TCTGGGCAAA 
GTCACCATCG CACAGGGTGG CGTCCTGCCC AACATCCAGG CCGTGCTGCT GCCAAAGAAA 
ACTGAGAGCC ACCACAAGAC TAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter.
The EMBO journal22(24)6550-61(2003 Dec)
Lusic M,Marcello A,Cereseto A,Giacca M

The human and mouse replication-dependent histone genes.
Genomics80(5)487-98(2002 Nov)
Marzluff WF,Gongidi P,Woods KR,Jin J,Maltais LJ

Directed proteomic analysis of the human nucleolus.
Current biology : CB12(1)1-11(2002 Jan)
Andersen JS,Lyon CE,Fox AH,Leung AK,Lam YW,Steen H,Mann M,Lamond AI

Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA.
Virology289(2)312-26(2001 Oct)
Deng L,Wang D,de la Fuente C,Wang L,Li H,Lee CG,Donnelly R,Wade JD,Lambert P,Kashanchi F

Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones.
Virology277(2)278-95(2000 Nov)
Deng L,de la Fuente C,Fu P,Wang L,Donnelly R,Wade JD,Lambert P,Li H,Lee CG,Kashanchi F

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HIST1H2AJ cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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