H2AC15 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H2AC15
Entrez Gene ID	8330
Full Name	histone cluster 1 H2A family member k
Synonyms	H2A/d,H2AFD
General protein information	Preferred Names histone cluster 1 H2A family member k Names histone H2A type 1 H2A histone family, member D H2A.1 histone 1, H2ak histone H2A type 1-J histone H2A/ptl histone cluster 1, H2ak
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.1
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015].
Disorder MIM:	602788

mRNA and Protein(s)

mRNA	Protein	Name
NM_003510.2	NP_003501.1	histone H2A type 1
NM_003510.3	NP_003501.1	histone H2A type 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LOC471909	XP_527287.2
	LOC704994	XP_001096671.1
Canis lupus familiaris (dog)	HIST2H2AA4	XP_850808.1
Canis lupus familiaris (dog)	LOC483168	XP_540286.2
Bos taurus (cattle)	HIST2H2AA4	XP_002686100.1
Mus musculus (house mouse)	Hist1h2ac	NP_835496.1
Rattus norvegicus (Norway rat)	Hist1h2af	NP_001019453.1
Homo sapiens (human)	HIST1H2AK	NP_003501.1
Bos taurus (cattle)	LOC541108	XP_002686102.1

Gene Ontology
Bibliography

Related articles in PubMed

De novo dominant ASXL3 mutations alter H2A deubiquitination and transcription in Bainbridge-Ropers syndrome.
Srivastava A, Ritesh KC, Tsan YC, Liao R, Su F, Cao X, Hannibal MC, Keegan CE, Chinnaiyan AM, Martin DM, Bielas SL
Human molecular genetics25(3)597-608(2016 Feb)

Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain.
Lubula MY, Eckenroth BE, Carlson S, Poplawski A, Chruszcz M, Glass KC
FEBS letters588(21)3844-54(2014 Nov)

Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase.
Kim W, Chakraborty G, Kim S, Shin J, Park CH, Jeong MW, Bharatham N, Yoon HS, Kim KT
The Journal of biological chemistry287(8)5278-89(2012 Feb)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

Transcriptional activation of polycomb-repressed genes by ZRF1.
Richly H, Rocha-Viegas L, Ribeiro JD, Demajo S, Gundem G, Lopez-Bigas N, Nakagawa T, Rospert S, Ito T, Di Croce L
Nature468(7327)1124-8(2010 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

De novo dominant ASXL3 mutations alter H2A deubiquitination and transcription in Bainbridge-Ropers syndrome.
Title: De novo dominant ASXL3 mutations alter H2A deubiquitination and transcription in Bainbridge-Ropers syndrome.

The following H2AC15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H2AC15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13117	NM_003510.3 Latest version!	Homo sapiens H2A clustered histone 15 (H2AC15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu13117	NM_003510.2	Homo sapiens histone cluster 1 H2A family member k (HIST1H2AK), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H2AC15 ( NM_003510.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003501.1 Homo sapiens histone cluster 1 H2A family member k (HIST1H2AK), mRNA.

Price & Availability↑

CloneID	OHu13117
Clone ID Related Accession (Same CDS sequence)	NM_003510.2 , NM_003510.3
Accession Version	NM_003510.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Homo sapiens(human)
Product	histone H2A type 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z83739.1. On Sep 21, 2001 this sequence version replaced NM_003510.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCGGGAC GTGGCAAGCA GGGCGGCAAA GCTCGCGCCA AGGCTAAGAC CCGTTCTTCA 
AGGGCGGGTC TTCAGTTCCC AGTGGGCCGA GTGCACCGAC TGCTCCGCAA GGGCAACTAC 
GCTGAGCGGG TCGGTGCCGG AGCGCCGGTG TACCTGGCGG CGGTGTTGGA GTACCTAACC 
GCCGAGATCC TGGAACTGGC TGGCAACGCG GCCCGCGACA ACAAGAAGAC CCGCATCATC 
CCGCGCCACT TGCAGCTGGC CATCCGCAAC GACGAGGAGC TCAACAAGCT GCTTGGTAAA 
GTGACCATCG CCCAGGGTGG TGTCCTGCCC AATATCCAGG CCGTGCTGCT GCCTAAGAAA 
ACTGAGAGCC ACCACAAGGC CAAGGGCAAG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003501.1
CDS	1..393
Translation	MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAKGK

Target ORF information:

RefSeq Version	NM_003510.2
Organism	Homo sapiens(human)
Definition	Homo sapiens histone cluster 1 H2A family member k (HIST1H2AK), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003510.2

ORF Insert Sequence:

ATGTCGGGAC GTGGCAAGCA GGGCGGCAAA GCTCGCGCCA AGGCTAAGAC CCGTTCTTCA 
AGGGCGGGTC TTCAGTTCCC AGTGGGCCGA GTGCACCGAC TGCTCCGCAA GGGCAACTAC 
GCTGAGCGGG TCGGTGCCGG AGCGCCGGTG TACCTGGCGG CGGTGTTGGA GTACCTAACC 
GCCGAGATCC TGGAACTGGC TGGCAACGCG GCCCGCGACA ACAAGAAGAC CCGCATCATC 
CCGCGCCACT TGCAGCTGGC CATCCGCAAC GACGAGGAGC TCAACAAGCT GCTTGGTAAA 
GTGACCATCG CCCAGGGTGG TGTCCTGCCC AATATCCAGG CCGTGCTGCT GCCTAAGAAA 
ACTGAGAGCC ACCACAAGGC CAAGGGCAAG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H2AC15 ( NM_003510.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003501.1 Homo sapiens H2A clustered histone 15 (H2AC15), mRNA.

Price & Availability↑

CloneID	OHu13117
Clone ID Related Accession (Same CDS sequence)	NM_003510.2 , NM_003510.3
Accession Version	NM_003510.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	histone H2A type 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z98744.2. On Dec 3, 2019 this sequence version replaced NM_003510.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC034487.2, DA827858.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCGGGAC GTGGCAAGCA GGGCGGCAAA GCTCGCGCCA AGGCTAAGAC CCGTTCTTCA 
AGGGCGGGTC TTCAGTTCCC AGTGGGCCGA GTGCACCGAC TGCTCCGCAA GGGCAACTAC 
GCTGAGCGGG TCGGTGCCGG AGCGCCGGTG TACCTGGCGG CGGTGTTGGA GTACCTAACC 
GCCGAGATCC TGGAACTGGC TGGCAACGCG GCCCGCGACA ACAAGAAGAC CCGCATCATC 
CCGCGCCACT TGCAGCTGGC CATCCGCAAC GACGAGGAGC TCAACAAGCT GCTTGGTAAA 
GTGACCATCG CCCAGGGTGG TGTCCTGCCC AATATCCAGG CCGTGCTGCT GCCTAAGAAA 
ACTGAGAGCC ACCACAAGGC CAAGGGCAAG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003501.1
CDS	37..429
Translation	MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAKGK

Target ORF information:

RefSeq Version	NM_003510.3
Organism	Homo sapiens(human)
Definition	Homo sapiens H2A clustered histone 15 (H2AC15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003510.3

ORF Insert Sequence:

ATGTCGGGAC GTGGCAAGCA GGGCGGCAAA GCTCGCGCCA AGGCTAAGAC CCGTTCTTCA 
AGGGCGGGTC TTCAGTTCCC AGTGGGCCGA GTGCACCGAC TGCTCCGCAA GGGCAACTAC 
GCTGAGCGGG TCGGTGCCGG AGCGCCGGTG TACCTGGCGG CGGTGTTGGA GTACCTAACC 
GCCGAGATCC TGGAACTGGC TGGCAACGCG GCCCGCGACA ACAAGAAGAC CCGCATCATC 
CCGCGCCACT TGCAGCTGGC CATCCGCAAC GACGAGGAGC TCAACAAGCT GCTTGGTAAA 
GTGACCATCG CCCAGGGTGG TGTCCTGCCC AATATCCAGG CCGTGCTGCT GCCTAAGAAA 
ACTGAGAGCC ACCACAAGGC CAAGGGCAAG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

De novo dominant ASXL3 mutations alter H2A deubiquitination and transcription in Bainbridge-Ropers syndrome.
Human molecular genetics25(3)597-608(2016 Feb)
Srivastava A,Ritesh KC,Tsan YC,Liao R,Su F,Cao X,Hannibal MC,Keegan CE,Chinnaiyan AM,Martin DM,Bielas SL

Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain.
FEBS letters588(21)3844-54(2014 Nov)
Lubula MY,Eckenroth BE,Carlson S,Poplawski A,Chruszcz M,Glass KC

Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase.
The Journal of biological chemistry287(8)5278-89(2012 Feb)
Kim W,Chakraborty G,Kim S,Shin J,Park CH,Jeong MW,Bharatham N,Yoon HS,Kim KT

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

Transcriptional activation of polycomb-repressed genes by ZRF1.
Nature468(7327)1124-8(2010 Dec)
Richly H,Rocha-Viegas L,Ribeiro JD,Demajo S,Gundem G,Lopez-Bigas N,Nakagawa T,Rospert S,Ito T,Di Croce L

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H2AC15 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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