FZD4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FZD4
Entrez Gene ID	8322
Full Name	frizzled class receptor 4
Synonyms	CD344,EVR1,FEVR,FZD4S,Fz-4,Fz4,FzE4,GPCR,hFz4
General protein information	Preferred Names frizzled class receptor 4 Names frizzled-4 WNT receptor frizzled-4 frizzled 4, seven transmembrane spanning receptor frizzled family receptor 4 frizzled homolog 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q14.2
Summary	This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. [provided by RefSeq, Jul 2008].
Disorder MIM:	604579
Disorder Html:	Exudative vitreoretinopathy 1, 133780 (3); Retinopathy of prematurity, 133780 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_012193.3	NP_036325.2	frizzled-4 precursor
NM_012193.4	NP_036325.2	frizzled-4 precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	fzd4	XP_002936589.1
	FZD4	XP_001103927.1
Mus musculus (house mouse)	Fzd4	NP_032081.3
Rattus norvegicus (Norway rat)	Fzd4	NP_072145.1
Canis lupus familiaris (dog)	FZD4	XP_005633439.1
Danio rerio (zebrafish)	fzd4	XP_005173482.1
Pan troglodytes (chimpanzee)	FZD4	XP_001175326.2
Bos taurus (cattle)	FZD4	NP_001193198.1
Gallus gallus (chicken)	FZD4	NP_989430.1
Homo sapiens (human)	FZD4	NP_036325.2

Gene Ontology
Bibliography

Related articles in PubMed

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.
Voloshanenko O, Gmach P, Winter J, Kranz D, Boutros M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(11)4832-4844(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Three affected individuals within a family with FEVR presented with variable disease severity. All three affected family members harboured mutation c.349T>C (p.Cys117Arg) in FZD4.
Title: Variable Familial Exudative Vitreoretinopathy in a family harbouring variants in both FZD4 and TSPAN12.

his study showed that Let7b modulates the proliferation, invasiveness, and migration of liver cancer cell and reduces the proportion of cancer stem cells in liver cancer cell by inhibiting Wnt/beta-catenin signaling pathway via downregulated Frizzled4.
Title: Let7b modulates the Wnt/?-catenin pathway in liver cancer cells via downregulated Frizzled4.

FZD4 down-regulation leads to loss of WNT/beta-catenin signal activity and subsequently to reduced alveolar epithelial cell wound repair capacity and impaired expression of elastogenic components.
Title: Reduced Frizzled Receptor 4 Expression Prevents WNT/?-Catenin-driven Alveolar Lung Repair in Chronic Obstructive Pulmonary Disease.

Among the detected mutations, LRP5 accounted for the largest proportion with a mean mutation rate of 16.1% (5/31, 16.1%), followed by NDP (3/31, 9.7%), FZD4 (2/31, 6.5%), TSPAN12 (1/31, 3.2%), and KIF11 (1/31, 3.2%). All the novel changes were predicted to be pathogenic by a series of bioinformatics analyses.
Title: Mutations in LRP5,FZD4, TSPAN12, NDP, ZNF408, or KIF11 Genes Account for 38.7% of Chinese Patients With Familial Exudative Vitreoretinopathy.

Study shows that WNT5A stimulates dimerization of membrane-anchored FZD4 CRDs and oligomerization of full-length FZD4, which requires the integrity of CRD palmitoleoyl-binding residues. These results suggest that FZD receptors may form signalosomes in response to Wnt binding through the CRDs and that the Wnt palmitoleoyl group is important in promoting these interactions.
Title: Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization.

The following FZD4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FZD4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21807	NM_012193.4 Latest version!	Homo sapiens frizzled class receptor 4 (FZD4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu21807	NM_012193.3	Homo sapiens frizzled class receptor 4 (FZD4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FZD4 ( NM_012193.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036325.2 Homo sapiens frizzled class receptor 4 (FZD4), mRNA.

Price & Availability↑

CloneID	OHu21807
Clone ID Related Accession (Same CDS sequence)	NM_012193.3 , NM_012193.4
Accession Version	NM_012193.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1614bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	frizzled-4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK292768.1, AP001528.4 and BC114527.1. This sequence is a reference standard in the RefSeqGene project. On May 21, 2011 this sequence version replaced NM_012193.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292768.1, AB032417.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467148, SAMEA2467150 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: community standard (PMID:10544037) ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCTGGC GGGGCGCAGG GCCGAGCGTC CCGGGGGCGC CCGGGGGCGT CGGTCTCAGT 
CTGGGGTTGC TCCTGCAGTT GCTGCTGCTC CTGGGGCCGG CGCGGGGCTT CGGGGACGAG 
GAAGAGCGGC GCTGCGACCC CATCCGCATC TCCATGTGCC AGAACCTCGG CTACAACGTG 
ACCAAGATGC CCAACCTGGT TGGGCACGAG CTGCAGACGG ACGCCGAGCT GCAGCTGACA 
ACTTTCACAC CGCTCATCCA GTACGGCTGC TCCAGCCAGC TGCAGTTCTT CCTTTGTTCT 
GTTTATGTGC CAATGTGCAC AGAGAAGATC AACATCCCCA TTGGCCCATG CGGCGGCATG 
TGTCTTTCAG TCAAGAGACG CTGTGAACCC GTCCTGAAGG AATTTGGATT TGCCTGGCCA 
GAGAGTCTGA ACTGCAGCAA ATTCCCACCA CAGAACGACC ACAACCACAT GTGCATGGAA 
GGGCCAGGTG ATGAAGAGGT GCCCTTACCT CACAAAACCC CCATCCAGCC TGGGGAAGAG 
TGTCACTCTG TGGGAACCAA TTCTGATCAG TACATCTGGG TGAAAAGGAG CCTGAACTGT 
GTGCTCAAGT GTGGCTATGA TGCTGGCTTA TACAGCCGCT CAGCCAAGGA GTTCACTGAT 
ATCTGGATGG CTGTGTGGGC CAGCCTGTGT TTCATCTCCA CTGCCTTCAC AGTACTGACC 
TTCCTGATCG ATTCTTCTAG GTTTTCCTAC CCTGAGCGCC CCATCATATT TCTCAGTATG 
TGCTATAATA TTTATAGCAT TGCTTATATT GTCAGGCTGA CTGTAGGCCG GGAAAGGATA 
TCCTGTGATT TTGAAGAGGC AGCAGAACCT GTTCTCATCC AAGAAGGACT TAAGAACACA 
GGATGTGCAA TAATTTTCTT GCTGATGTAC TTTTTTGGAA TGGCCAGCTC CATTTGGTGG 
GTTATTCTGA CACTCACTTG GTTTTTGGCA GCAGGACTCA AATGGGGTCA TGAAGCCATT 
GAAATGCACA GCTCTTATTT CCACATTGCA GCCTGGGCCA TCCCCGCAGT GAAAACCATT 
GTCATCTTGA TTATGAGACT GGTGGATGCA GATGAACTGA CTGGCTTGTG CTATGTTGGA 
AACCAAAATC TCGATGCCCT CACCGGGTTC GTGGTGGCTC CCCTCTTTAC TTATTTGGTC 
ATTGGAACTT TGTTCATTGC TGCAGGTTTG GTGGCCTTGT TCAAAATTCG GTCAAATCTT 
CAAAAGGATG GGACAAAGAC AGACAAGTTA GAAAGACTGA TGGTCAAGAT TGGGGTGTTC 
TCAGTACTGT ACACAGTTCC TGCAACGTGT GTGATTGCCT GTTATTTTTA TGAAATCTCC 
AACTGGGCAC TTTTTCGGTA TTCTGCAGAT GATTCCAACA TGGCTGTTGA AATGTTGAAA 
ATTTTTATGT CTTTGTTGGT GGGCATCACT TCAGGCATGT GGATTTGGTC TGCCAAAACT 
CTTCACACGT GGCAGAAGTG TTCCAACAGA TTGGTGAATT CTGGAAAGGT AAAGAGAGAG 
AAGAGAGGAA ATGGTTGGGT GAAGCCTGGA AAAGGCAGTG AGACTGTGGT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036325.2
CDS	314..1927
Translation	MAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGSETVV

Target ORF information:

RefSeq Version	NM_012193.3
Organism	Homo sapiens(human)
Definition	Homo sapiens frizzled class receptor 4 (FZD4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012193.3

ORF Insert Sequence:

ATGGCCTGGC GGGGCGCAGG GCCGAGCGTC CCGGGGGCGC CCGGGGGCGT CGGTCTCAGT 
CTGGGGTTGC TCCTGCAGTT GCTGCTGCTC CTGGGGCCGG CGCGGGGCTT CGGGGACGAG 
GAAGAGCGGC GCTGCGACCC CATCCGCATC TCCATGTGCC AGAACCTCGG CTACAACGTG 
ACCAAGATGC CCAACCTGGT TGGGCACGAG CTGCAGACGG ACGCCGAGCT GCAGCTGACA 
ACTTTCACAC CGCTCATCCA GTACGGCTGC TCCAGCCAGC TGCAGTTCTT CCTTTGTTCT 
GTTTATGTGC CAATGTGCAC AGAGAAGATC AACATCCCCA TTGGCCCATG CGGCGGCATG 
TGTCTTTCAG TCAAGAGACG CTGTGAACCC GTCCTGAAGG AATTTGGATT TGCCTGGCCA 
GAGAGTCTGA ACTGCAGCAA ATTCCCACCA CAGAACGACC ACAACCACAT GTGCATGGAA 
GGGCCAGGTG ATGAAGAGGT GCCCTTACCT CACAAAACCC CCATCCAGCC TGGGGAAGAG 
TGTCACTCTG TGGGAACCAA TTCTGATCAG TACATCTGGG TGAAAAGGAG CCTGAACTGT 
GTGCTCAAGT GTGGCTATGA TGCTGGCTTA TACAGCCGCT CAGCCAAGGA GTTCACTGAT 
ATCTGGATGG CTGTGTGGGC CAGCCTGTGT TTCATCTCCA CTGCCTTCAC AGTACTGACC 
TTCCTGATCG ATTCTTCTAG GTTTTCCTAC CCTGAGCGCC CCATCATATT TCTCAGTATG 
TGCTATAATA TTTATAGCAT TGCTTATATT GTCAGGCTGA CTGTAGGCCG GGAAAGGATA 
TCCTGTGATT TTGAAGAGGC AGCAGAACCT GTTCTCATCC AAGAAGGACT TAAGAACACA 
GGATGTGCAA TAATTTTCTT GCTGATGTAC TTTTTTGGAA TGGCCAGCTC CATTTGGTGG 
GTTATTCTGA CACTCACTTG GTTTTTGGCA GCAGGACTCA AATGGGGTCA TGAAGCCATT 
GAAATGCACA GCTCTTATTT CCACATTGCA GCCTGGGCCA TCCCCGCAGT GAAAACCATT 
GTCATCTTGA TTATGAGACT GGTGGATGCA GATGAACTGA CTGGCTTGTG CTATGTTGGA 
AACCAAAATC TCGATGCCCT CACCGGGTTC GTGGTGGCTC CCCTCTTTAC TTATTTGGTC 
ATTGGAACTT TGTTCATTGC TGCAGGTTTG GTGGCCTTGT TCAAAATTCG GTCAAATCTT 
CAAAAGGATG GGACAAAGAC AGACAAGTTA GAAAGACTGA TGGTCAAGAT TGGGGTGTTC 
TCAGTACTGT ACACAGTTCC TGCAACGTGT GTGATTGCCT GTTATTTTTA TGAAATCTCC 
AACTGGGCAC TTTTTCGGTA TTCTGCAGAT GATTCCAACA TGGCTGTTGA AATGTTGAAA 
ATTTTTATGT CTTTGTTGGT GGGCATCACT TCAGGCATGT GGATTTGGTC TGCCAAAACT 
CTTCACACGT GGCAGAAGTG TTCCAACAGA TTGGTGAATT CTGGAAAGGT AAAGAGAGAG 
AAGAGAGGAA ATGGTTGGGT GAAGCCTGGA AAAGGCAGTG AGACTGTGGT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FZD4 ( NM_012193.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036325.2 Homo sapiens frizzled class receptor 4 (FZD4), mRNA.

Price & Availability↑

CloneID	OHu21807
Clone ID Related Accession (Same CDS sequence)	NM_012193.3 , NM_012193.4
Accession Version	NM_012193.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1614bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	frizzled-4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP001528.4. On Nov 23, 2018 this sequence version replaced NM_012193.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB032417.1, BC114527.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467148, SAMEA2467150 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: community standard (PMID:10544037) MANE Ensembl match :: ENST00000531380.2/ ENSP00000434034.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCTGGC GGGGCGCAGG GCCGAGCGTC CCGGGGGCGC CCGGGGGCGT CGGTCTCAGT 
CTGGGGTTGC TCCTGCAGTT GCTGCTGCTC CTGGGGCCGG CGCGGGGCTT CGGGGACGAG 
GAAGAGCGGC GCTGCGACCC CATCCGCATC TCCATGTGCC AGAACCTCGG CTACAACGTG 
ACCAAGATGC CCAACCTGGT TGGGCACGAG CTGCAGACGG ACGCCGAGCT GCAGCTGACA 
ACTTTCACAC CGCTCATCCA GTACGGCTGC TCCAGCCAGC TGCAGTTCTT CCTTTGTTCT 
GTTTATGTGC CAATGTGCAC AGAGAAGATC AACATCCCCA TTGGCCCATG CGGCGGCATG 
TGTCTTTCAG TCAAGAGACG CTGTGAACCC GTCCTGAAGG AATTTGGATT TGCCTGGCCA 
GAGAGTCTGA ACTGCAGCAA ATTCCCACCA CAGAACGACC ACAACCACAT GTGCATGGAA 
GGGCCAGGTG ATGAAGAGGT GCCCTTACCT CACAAAACCC CCATCCAGCC TGGGGAAGAG 
TGTCACTCTG TGGGAACCAA TTCTGATCAG TACATCTGGG TGAAAAGGAG CCTGAACTGT 
GTGCTCAAGT GTGGCTATGA TGCTGGCTTA TACAGCCGCT CAGCCAAGGA GTTCACTGAT 
ATCTGGATGG CTGTGTGGGC CAGCCTGTGT TTCATCTCCA CTGCCTTCAC AGTACTGACC 
TTCCTGATCG ATTCTTCTAG GTTTTCCTAC CCTGAGCGCC CCATCATATT TCTCAGTATG 
TGCTATAATA TTTATAGCAT TGCTTATATT GTCAGGCTGA CTGTAGGCCG GGAAAGGATA 
TCCTGTGATT TTGAAGAGGC AGCAGAACCT GTTCTCATCC AAGAAGGACT TAAGAACACA 
GGATGTGCAA TAATTTTCTT GCTGATGTAC TTTTTTGGAA TGGCCAGCTC CATTTGGTGG 
GTTATTCTGA CACTCACTTG GTTTTTGGCA GCAGGACTCA AATGGGGTCA TGAAGCCATT 
GAAATGCACA GCTCTTATTT CCACATTGCA GCCTGGGCCA TCCCCGCAGT GAAAACCATT 
GTCATCTTGA TTATGAGACT GGTGGATGCA GATGAACTGA CTGGCTTGTG CTATGTTGGA 
AACCAAAATC TCGATGCCCT CACCGGGTTC GTGGTGGCTC CCCTCTTTAC TTATTTGGTC 
ATTGGAACTT TGTTCATTGC TGCAGGTTTG GTGGCCTTGT TCAAAATTCG GTCAAATCTT 
CAAAAGGATG GGACAAAGAC AGACAAGTTA GAAAGACTGA TGGTCAAGAT TGGGGTGTTC 
TCAGTACTGT ACACAGTTCC TGCAACGTGT GTGATTGCCT GTTATTTTTA TGAAATCTCC 
AACTGGGCAC TTTTTCGGTA TTCTGCAGAT GATTCCAACA TGGCTGTTGA AATGTTGAAA 
ATTTTTATGT CTTTGTTGGT GGGCATCACT TCAGGCATGT GGATTTGGTC TGCCAAAACT 
CTTCACACGT GGCAGAAGTG TTCCAACAGA TTGGTGAATT CTGGAAAGGT AAAGAGAGAG 
AAGAGAGGAA ATGGTTGGGT GAAGCCTGGA AAAGGCAGTG AGACTGTGGT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036325.2
CDS	311..1924
Translation	MAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGSETVV

Target ORF information:

RefSeq Version	NM_012193.4
Organism	Homo sapiens(human)
Definition	Homo sapiens frizzled class receptor 4 (FZD4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012193.4

ORF Insert Sequence:

ATGGCCTGGC GGGGCGCAGG GCCGAGCGTC CCGGGGGCGC CCGGGGGCGT CGGTCTCAGT 
CTGGGGTTGC TCCTGCAGTT GCTGCTGCTC CTGGGGCCGG CGCGGGGCTT CGGGGACGAG 
GAAGAGCGGC GCTGCGACCC CATCCGCATC TCCATGTGCC AGAACCTCGG CTACAACGTG 
ACCAAGATGC CCAACCTGGT TGGGCACGAG CTGCAGACGG ACGCCGAGCT GCAGCTGACA 
ACTTTCACAC CGCTCATCCA GTACGGCTGC TCCAGCCAGC TGCAGTTCTT CCTTTGTTCT 
GTTTATGTGC CAATGTGCAC AGAGAAGATC AACATCCCCA TTGGCCCATG CGGCGGCATG 
TGTCTTTCAG TCAAGAGACG CTGTGAACCC GTCCTGAAGG AATTTGGATT TGCCTGGCCA 
GAGAGTCTGA ACTGCAGCAA ATTCCCACCA CAGAACGACC ACAACCACAT GTGCATGGAA 
GGGCCAGGTG ATGAAGAGGT GCCCTTACCT CACAAAACCC CCATCCAGCC TGGGGAAGAG 
TGTCACTCTG TGGGAACCAA TTCTGATCAG TACATCTGGG TGAAAAGGAG CCTGAACTGT 
GTGCTCAAGT GTGGCTATGA TGCTGGCTTA TACAGCCGCT CAGCCAAGGA GTTCACTGAT 
ATCTGGATGG CTGTGTGGGC CAGCCTGTGT TTCATCTCCA CTGCCTTCAC AGTACTGACC 
TTCCTGATCG ATTCTTCTAG GTTTTCCTAC CCTGAGCGCC CCATCATATT TCTCAGTATG 
TGCTATAATA TTTATAGCAT TGCTTATATT GTCAGGCTGA CTGTAGGCCG GGAAAGGATA 
TCCTGTGATT TTGAAGAGGC AGCAGAACCT GTTCTCATCC AAGAAGGACT TAAGAACACA 
GGATGTGCAA TAATTTTCTT GCTGATGTAC TTTTTTGGAA TGGCCAGCTC CATTTGGTGG 
GTTATTCTGA CACTCACTTG GTTTTTGGCA GCAGGACTCA AATGGGGTCA TGAAGCCATT 
GAAATGCACA GCTCTTATTT CCACATTGCA GCCTGGGCCA TCCCCGCAGT GAAAACCATT 
GTCATCTTGA TTATGAGACT GGTGGATGCA GATGAACTGA CTGGCTTGTG CTATGTTGGA 
AACCAAAATC TCGATGCCCT CACCGGGTTC GTGGTGGCTC CCCTCTTTAC TTATTTGGTC 
ATTGGAACTT TGTTCATTGC TGCAGGTTTG GTGGCCTTGT TCAAAATTCG GTCAAATCTT 
CAAAAGGATG GGACAAAGAC AGACAAGTTA GAAAGACTGA TGGTCAAGAT TGGGGTGTTC 
TCAGTACTGT ACACAGTTCC TGCAACGTGT GTGATTGCCT GTTATTTTTA TGAAATCTCC 
AACTGGGCAC TTTTTCGGTA TTCTGCAGAT GATTCCAACA TGGCTGTTGA AATGTTGAAA 
ATTTTTATGT CTTTGTTGGT GGGCATCACT TCAGGCATGT GGATTTGGTC TGCCAAAACT 
CTTCACACGT GGCAGAAGTG TTCCAACAGA TTGGTGAATT CTGGAAAGGT AAAGAGAGAG 
AAGAGAGGAA ATGGTTGGGT GAAGCCTGGA AAAGGCAGTG AGACTGTGGT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(11)4832-4844(2017 Nov)
Voloshanenko O,Gmach P,Winter J,Kranz D,Boutros M

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FZD4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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