CAPZA2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CAPZA2
Entrez Gene ID	830
Full Name	capping actin protein of muscle Z-line alpha subunit 2
Synonyms	CAPPA2,CAPZ
General protein information	Preferred Names capping actin protein of muscle Z-line alpha subunit 2 Names F-actin-capping protein subunit alpha-2 F-actin capping protein alpha-2 subunit capZ alpha-2 capping protein (actin filament) muscle Z-line, alpha 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q31.2
Summary	The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. [provided by RefSeq, Jul 2008].
Disorder MIM:	601571

mRNA and Protein(s)

mRNA	Protein	Name
NM_006136.2	NP_006127.1	F-actin-capping protein subunit alpha-2
NM_006136.3	NP_006127.1	F-actin-capping protein subunit alpha-2

Pathways from BioSystems

Homologies

Homo sapiens (human)	CAPZA2	NP_006127.1
Canis lupus familiaris (dog)	CAPZA2	NP_001013013.1
Bos taurus (cattle)	CAPZA2	NP_001013016.1
Saccharomyces cerevisiae (baker's yeast)	CAP1	NP_012918.1
Kluyveromyces lactis	KLLA0B13453g	XP_452130.1
Mus musculus (house mouse)	Capza2	NP_031630.1
Gallus gallus (chicken)	CAPZA2	NP_001004380.1
Neurospora crassa	NCU03911	XP_957550.1
	CAPZA2	NP_001162080.1
Magnaporthe oryzae (rice blast fungus)	MGG_12818	XP_003717048.1
Xenopus tropicalis (tropical clawed frog)	capza2	NP_001017254.1
Pan troglodytes (chimpanzee)	CAPZA2	NP_001129289.1
Rattus norvegicus (Norway rat)	Capza2	NP_001009180.1
Eremothecium gossypii	AGOS_ABR007C	NP_982953.1

Gene Ontology
Bibliography

Related articles in PubMed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CAPZA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CAPZA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02089	NM_006136.3 Latest version!	Homo sapiens capping actin protein of muscle Z-line subunit alpha 2 (CAPZA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu02089	NM_006136.2	Homo sapiens capping actin protein of muscle Z-line alpha subunit 2 (CAPZA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CAPZA2 ( NM_006136.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006127.1 Homo sapiens capping actin protein of muscle Z-line alpha subunit 2 (CAPZA2), mRNA.

Price & Availability↑

CloneID	OHu02089
Clone ID Related Accession (Same CDS sequence)	NM_006136.2 , NM_006136.3
Accession Version	NM_006136.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	F-actin-capping protein subunit alpha-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI553815.1, BC005338.1, U03851.1 and BX386541.2. On Jan 26, 2004 this sequence version replaced NM_006136.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.49544.1, SRR1803614.150644.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGATC TGGAGGAGCA GTTGTCTGAT GAAGAGAAGG TGCGTATAGC AGCAAAATTC 
ATCATTCATG CCCCTCCTGG AGAATTTAAT GAGGTTTTCA ATGATGTTCG GTTACTGCTT 
AATAATGACA ATCTTCTCAG GGAAGGAGCA GCCCATGCAT TTGCACAGTA TAACTTGGAC 
CAGTTTACTC CAGTAAAAAT TGAAGGTTAT GAAGATCAGG TATTGATAAC AGAACATGGC 
GACTTGGGAA ATGGAAAGTT TTTGGATCCA AAGAACAGAA TCTGTTTTAA ATTTGATCAC 
TTAAGGAAGG AGGCAACTGA TCCAAGACCC TGTGAAGTAG AAAATGCAGT TGAATCATGG 
AGAACTTCAG TAGAAACTGC TCTGAGAGCT TACGTAAAAG AACATTACCC GAATGGAGTC 
TGCACTGTGT ATGGCAAAAA AATAGATGGA CAGCAAACCA TTATTGCATG CATAGAAAGC 
CATCAGTTCC AAGCAAAAAA TTTTTGGAAT GGTCGTTGGA GGTCAGAATG GAAGTTTACA 
ATCACTCCTT CAACCACTCA AGTGGTTGGC ATCTTGAAAA TTCAGGTTCA TTATTATGAA 
GATGGTAATG TTCAGCTAGT GAGTCATAAA GATATACAAG ATTCCCTAAC AGTGTCTAAT 
GAAGTGCAAA CAGCAAAAGA ATTTATAAAG ATTGTAGAAG CTGCAGAAAA TGAATACCAG 
ACTGCCATCA GTGAGAATTA TCAGACAATG TCGGACACTA CTTTCAAAGC CTTACGTCGA 
CAGTTGCCAG TTACACGCAC TAAGATTGAT TGGAACAAGA TCCTTAGCTA CAAGATTGGC 
AAAGAGATGC AGAATGCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006127.1
CDS	104..964
Translation	MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPCEVENAVESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA

Target ORF information:

RefSeq Version	NM_006136.2
Organism	Homo sapiens(human)
Definition	Homo sapiens capping actin protein of muscle Z-line alpha subunit 2 (CAPZA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006136.2

ORF Insert Sequence:

ATGGCGGATC TGGAGGAGCA GTTGTCTGAT GAAGAGAAGG TGCGTATAGC AGCAAAATTC 
ATCATTCATG CCCCTCCTGG AGAATTTAAT GAGGTTTTCA ATGATGTTCG GTTACTGCTT 
AATAATGACA ATCTTCTCAG GGAAGGAGCA GCCCATGCAT TTGCACAGTA TAACTTGGAC 
CAGTTTACTC CAGTAAAAAT TGAAGGTTAT GAAGATCAGG TATTGATAAC AGAACATGGC 
GACTTGGGAA ATGGAAAGTT TTTGGATCCA AAGAACAGAA TCTGTTTTAA ATTTGATCAC 
TTAAGGAAGG AGGCAACTGA TCCAAGACCC TGTGAAGTAG AAAATGCAGT TGAATCATGG 
AGAACTTCAG TAGAAACTGC TCTGAGAGCT TACGTAAAAG AACATTACCC GAATGGAGTC 
TGCACTGTGT ATGGCAAAAA AATAGATGGA CAGCAAACCA TTATTGCATG CATAGAAAGC 
CATCAGTTCC AAGCAAAAAA TTTTTGGAAT GGTCGTTGGA GGTCAGAATG GAAGTTTACA 
ATCACTCCTT CAACCACTCA AGTGGTTGGC ATCTTGAAAA TTCAGGTTCA TTATTATGAA 
GATGGTAATG TTCAGCTAGT GAGTCATAAA GATATACAAG ATTCCCTAAC AGTGTCTAAT 
GAAGTGCAAA CAGCAAAAGA ATTTATAAAG ATTGTAGAAG CTGCAGAAAA TGAATACCAG 
ACTGCCATCA GTGAGAATTA TCAGACAATG TCGGACACTA CTTTCAAAGC CTTACGTCGA 
CAGTTGCCAG TTACACGCAC TAAGATTGAT TGGAACAAGA TCCTTAGCTA CAAGATTGGC 
AAAGAGATGC AGAATGCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CAPZA2 ( NM_006136.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006127.1 Homo sapiens capping actin protein of muscle Z-line subunit alpha 2 (CAPZA2), mRNA.

Price & Availability↑

CloneID	OHu02089
Clone ID Related Accession (Same CDS sequence)	NM_006136.2 , NM_006136.3
Accession Version	NM_006136.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	F-actin-capping protein subunit alpha-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI553815.1, BC005338.1, U03851.1, BX386541.2 and AC002543.1. On Nov 22, 2018 this sequence version replaced NM_006136.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.91645.1, SRR1803616.33636.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000361183.8/ ENSP00000354947.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGATC TGGAGGAGCA GTTGTCTGAT GAAGAGAAGG TGCGTATAGC AGCAAAATTC 
ATCATTCATG CCCCTCCTGG AGAATTTAAT GAGGTTTTCA ATGATGTTCG GTTACTGCTT 
AATAATGACA ATCTTCTCAG GGAAGGAGCA GCCCATGCAT TTGCACAGTA TAACTTGGAC 
CAGTTTACTC CAGTAAAAAT TGAAGGTTAT GAAGATCAGG TATTGATAAC AGAACATGGC 
GACTTGGGAA ATGGAAAGTT TTTGGATCCA AAGAACAGAA TCTGTTTTAA ATTTGATCAC 
TTAAGGAAGG AGGCAACTGA TCCAAGACCC TGTGAAGTAG AAAATGCAGT TGAATCATGG 
AGAACTTCAG TAGAAACTGC TCTGAGAGCT TACGTAAAAG AACATTACCC GAATGGAGTC 
TGCACTGTGT ATGGCAAAAA AATAGATGGA CAGCAAACCA TTATTGCATG CATAGAAAGC 
CATCAGTTCC AAGCAAAAAA TTTTTGGAAT GGTCGTTGGA GGTCAGAATG GAAGTTTACA 
ATCACTCCTT CAACCACTCA AGTGGTTGGC ATCTTGAAAA TTCAGGTTCA TTATTATGAA 
GATGGTAATG TTCAGCTAGT GAGTCATAAA GATATACAAG ATTCCCTAAC AGTGTCTAAT 
GAAGTGCAAA CAGCAAAAGA ATTTATAAAG ATTGTAGAAG CTGCAGAAAA TGAATACCAG 
ACTGCCATCA GTGAGAATTA TCAGACAATG TCGGACACTA CTTTCAAAGC CTTACGTCGA 
CAGTTGCCAG TTACACGCAC TAAGATTGAT TGGAACAAGA TCCTTAGCTA CAAGATTGGC 
AAAGAGATGC AGAATGCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006127.1
CDS	26..886
Translation	MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPCEVENAVESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA

Target ORF information:

RefSeq Version	NM_006136.3
Organism	Homo sapiens(human)
Definition	Homo sapiens capping actin protein of muscle Z-line subunit alpha 2 (CAPZA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006136.3

ORF Insert Sequence:

ATGGCGGATC TGGAGGAGCA GTTGTCTGAT GAAGAGAAGG TGCGTATAGC AGCAAAATTC 
ATCATTCATG CCCCTCCTGG AGAATTTAAT GAGGTTTTCA ATGATGTTCG GTTACTGCTT 
AATAATGACA ATCTTCTCAG GGAAGGAGCA GCCCATGCAT TTGCACAGTA TAACTTGGAC 
CAGTTTACTC CAGTAAAAAT TGAAGGTTAT GAAGATCAGG TATTGATAAC AGAACATGGC 
GACTTGGGAA ATGGAAAGTT TTTGGATCCA AAGAACAGAA TCTGTTTTAA ATTTGATCAC 
TTAAGGAAGG AGGCAACTGA TCCAAGACCC TGTGAAGTAG AAAATGCAGT TGAATCATGG 
AGAACTTCAG TAGAAACTGC TCTGAGAGCT TACGTAAAAG AACATTACCC GAATGGAGTC 
TGCACTGTGT ATGGCAAAAA AATAGATGGA CAGCAAACCA TTATTGCATG CATAGAAAGC 
CATCAGTTCC AAGCAAAAAA TTTTTGGAAT GGTCGTTGGA GGTCAGAATG GAAGTTTACA 
ATCACTCCTT CAACCACTCA AGTGGTTGGC ATCTTGAAAA TTCAGGTTCA TTATTATGAA 
GATGGTAATG TTCAGCTAGT GAGTCATAAA GATATACAAG ATTCCCTAAC AGTGTCTAAT 
GAAGTGCAAA CAGCAAAAGA ATTTATAAAG ATTGTAGAAG CTGCAGAAAA TGAATACCAG 
ACTGCCATCA GTGAGAATTA TCAGACAATG TCGGACACTA CTTTCAAAGC CTTACGTCGA 
CAGTTGCCAG TTACACGCAC TAAGATTGAT TGGAACAAGA TCCTTAGCTA CAAGATTGGC 
AAAGAGATGC AGAATGCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Nature communications711491(2016 May)
Boldt K,van Reeuwijk J,Lu Q,Koutroumpas K,Nguyen TM,Texier Y,van Beersum SE,Horn N,Willer JR,Mans DA,Dougherty G,Lamers IJ,Coene KL,Arts HH,Betts MJ,Beyer T,Bolat E,Gloeckner CJ,Haidari K,Hetterschijt L,Iaconis D,Jenkins D,Klose F,Knapp B,Latour B,Letteboer SJ,Marcelis CL,Mitic D,Morleo M,Oud MM,Riemersma M,Rix S,Terhal PA,Toedt G,van Dam TJ,de Vrieze E,Wissinger Y,Wu KM,Apic G,Beales PL,Blacque OE,Gibson TJ,Huynen MA,Katsanis N,Kremer H,Omran H,van Wijk E,Wolfrum U,Kepes F,Davis EE,Franco B,Giles RH,Ueffing M,Russell RB,Roepman R,

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

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CAPZA2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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