NUAK2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NUAK2
Entrez Gene ID	81788
Full Name	NUAK family kinase 2
Synonyms	SNARK
General protein information	Preferred Names NUAK family kinase 2 Names NUAK family SNF1-like kinase 2 NUAK family, SNF1-like kinase, 2 SNF1/AMP activated protein kinase SNF1/AMP kinase-related kinase omphalocele kinase 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q32.1
Disorder MIM:	608131

mRNA and Protein(s)

mRNA	Protein	Name
XM_005245515.4	XP_005245572.1	NUAK family SNF1-like kinase 2 isoform X1
NM_030952.2	NP_112214.2	NUAK family SNF1-like kinase 2
NM_030952.3	NP_112214.3	NUAK family SNF1-like kinase 2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	NUAK2	XP_004934986.1
Xenopus tropicalis (tropical clawed frog)	nuak2	NP_001121499.1
Homo sapiens (human)	NUAK2	NP_112214.1
Rattus norvegicus (Norway rat)	Nuak2	NP_001007618.1
Canis lupus familiaris (dog)	NUAK2	XP_545687.2
Mus musculus (house mouse)	Nuak2	NP_001181954.1
Danio rerio (zebrafish)	nuak2	XP_688764.3
Pan troglodytes (chimpanzee)	NUAK2	XP_003308757.1
	NUAK2	XP_001088883.2

Gene Ontology
Bibliography

Related articles in PubMed

Sucrose Non-Fermenting Related Kinase Regulates Both Adipose Inflammation and Energy Homeostasis in Mice and Humans.
Li J, Feng B, Nie Y, Jiao P, Lin X, Huang M, An R, He Q, Zhou HE, Salomon A, Sigrist KS, Wu Z, Liu S, Xu H
Diabetes(2018 Jan)

miR-143 inhibits oncogenic traits by degrading NUAK2 in glioblastoma.
Fu TG, Wang L, Li W, Li JZ, Li J
International journal of molecular medicine37(6)1627-35(2016 Jun)

Sucrose non-fermenting AMPK related kinase/Pentraxin 3 and DNA damage axis: a gateway to cardiovascular disease in systemic lupus erythematosus among Egyptian patients.
Zineldeen DH, Keshk WA, Ghazy AH, El-Barbary AM
Annals of clinical biochemistry53(Pt 2)240-51(2016 Mar)

NUAK2 Amplification Coupled with PTEN Deficiency Promotes Melanoma Development via CDK Activation.
Namiki T, Yaguchi T, Nakamura K, Valencia JC, Coelho SG, Yin L, Kawaguchi M, Vieira WD, Kaneko Y, Tanemura A, Katayama I, Yokozeki H, Kawakami Y, Hearing VJ
Cancer research75(13)2708-15(2015 Jul)

The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-? signaling.
Goto K, Lin W, Zhang L, Jilg N, Shao RX, Schaefer EA, Zhao H, Fusco DN, Peng LF, Kato N, Chung RT
Journal of hepatology59(5)942-8(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

miR143 inhibited the proliferation, migration and invasion of the glioblastoma cells by degrading NUAK2 in glioblastoma.
Title: miR-143 inhibits oncogenic traits by degrading NUAK2 in glioblastoma.

Sucrose non-fermenting AMPK related kinase/Pentraxin 3 combined role in immunometabolic signaling and DNA damage response is proposed to accelerate cardiovascular complications in systemic lupus erythematosus patients
Title: Sucrose non-fermenting AMPK related kinase/Pentraxin 3 and DNA damage axis: a gateway to cardiovascular disease in systemic lupus erythematosus among Egyptian patients.

NUAK2 silencing and inactivation of the PI3K pathway efficiently controlled CDK2 expression, whereas CDK2 inactivation specifically abrogated the growth of NUAK2-amplified and PTEN-deficient melanoma cells.
Title: NUAK2 Amplification Coupled with PTEN Deficiency Promotes Melanoma Development via CDK Activation.

The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-beta signaling.
Title: The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-? signaling.

Activation of AMP-activated protein kinase protects the integrity of the blood-brain barrier by suppressing the induction of NADPH oxidase-derived superoxide anions.
Title: Activation of AMP-activated protein kinase alleviates high-glucose-induced dysfunction of brain microvascular endothelial cell tight-junction dynamics.

The following NUAK2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NUAK2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu34729	XM_005245515.4 Latest version!	Homo sapiens NUAK family kinase 2 (NUAK2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OHu72985	NM_030952.2 Latest version!	Homo sapiens NUAK family kinase 2 (NUAK2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
OHu107490	NM_030952.3 Latest version!	Homo sapiens NUAK family kinase 2 (NUAK2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NUAK2 ( XM_005245515.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005245572.1 Homo sapiens NUAK family kinase 2 (NUAK2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu34729
Clone ID Related Accession (Same CDS sequence)	XM_005245515.4
Accession Version	XM_005245515.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1146bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	NUAK family SNF1-like kinase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005245515.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCTTTG ATGGGCATGA CCATAAGATC CTAGTGAAAC AGATCAGCAA CGGGGCCTAC 
CGGGAGCCAC CTAAACCCTC TGATGCCTGT GGCCTGATCC GGTGGCTGTT GATGGTGAAC 
CCCACCCGCC GGGCCACCCT GGAGGATGTG GCCAGTCACT GGTGGGTCAA CTGGGGCTAC 
GCCACCCGAG TGGGAGAGCA GGAGGCTCCG CATGAGGGTG GGCACCCTGG CAGTGACTCT 
GCCCGCGCCT CCATGGCTGA CTGGCTCCGG CGTTCCTCCC GCCCCCTCCT GGAGAATGGG 
GCCAAGGTGT GCAGCTTCTT CAAGCAGCAT GCACCTGGTG GGGGAAGCAC CACCCCTGGC 
CTGGAGCGCC AGCATTCGCT CAAGAAGTCC CGCAAGGAGA ATGACATGGC CCAGTCTCTC 
CACAGTGACA CGGCTGATGA CACTGCCCAT CGCCCTGGCA AGAGCAACCT CAAGCTGCCA 
AAGGGCATTC TCAAGAAGAA GGTGTCAGCC TCTGCAGAAG GGGTACAGGA GGACCCTCCG 
GAGCTCAGCC CAATCCCTGC GAGCCCAGGG CAGGCTGCCC CCCTGCTCCC CAAGAAGGGC 
ATTCTCAAGA AGCCCCGACA GCGCGAGTCT GGCTACTACT CCTCTCCCGA GCCCAGTGAA 
TCTGGGGAGC TCTTGGACGC AGGCGACGTG TTTGTGAGTG GGGATCCCAA GGAGCAGAAG 
CCTCCGCAAG CTTCAGGGCT GCTCCTCCAT CGCAAAGGCA TCCTCAAACT CAATGGCAAG 
TTCTCCCAGA CAGCCTTGGA GCTCGCGGCC CCCACCACCT TCGGCTCCCT GGATGAACTC 
GCCCCACCTC GCCCCCTGGC CCGGGCCAGC CGACCCTCAG GGGCTGTGAG CGAGGACAGC 
ATCCTGTCCT CTGAGTCCTT TGACCAGCTG GACTTGCCTG AACGGCTCCC AGAGCCCCCA 
CTGCGGGGCT GTGTGTCTGT GGACAACCTC ACGGGGCTTG AGGAGCCCCC CTCAGAGGGC 
CCTGGAAGCT GCCTGAGGCG CTGGCGGCAG GATCCTTTGG GGGACAGCTG CTTTTCCCTG 
ACAGACTGCC AGGAGGTGAC AGCGACCTAC CGACAGGCAC TGAGGGTCTG CTCAAAGCTC 
ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005245572.1
CDS	162..1307
Translation	MPFDGHDHKILVKQISNGAYREPPKPSDACGLIRWLLMVNPTRRATLEDVASHWWVNWGYATRVGEQEAPHEGGHPGSDSARASMADWLRRSSRPLLENGAKVCSFFKQHAPGGGSTTPGLERQHSLKKSRKENDMAQSLHSDTADDTAHRPGKSNLKLPKGILKKKVSASAEGVQEDPPELSPIPASPGQAAPLLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVFVSGDPKEQKPPQASGLLLHRKGILKLNGKFSQTALELAAPTTFGSLDELAPPRPLARASRPSGAVSEDSILSSESFDQLDLPERLPEPPLRGCVSVDNLTGLEEPPSEGPGSCLRRWRQDPLGDSCFSLTDCQEVTATYRQALRVCSKLT

Target ORF information:

RefSeq Version	XM_005245515.4
Organism	Homo sapiens(human)
Definition	Homo sapiens NUAK family kinase 2 (NUAK2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005245515.4

ORF Insert Sequence:

ATGCCCTTTG ATGGGCATGA CCATAAGATC CTAGTGAAAC AGATCAGCAA CGGGGCCTAC 
CGGGAGCCAC CTAAACCCTC TGATGCCTGT GGCCTGATCC GGTGGCTGTT GATGGTGAAC 
CCCACCCGCC GGGCCACCCT GGAGGATGTG GCCAGTCACT GGTGGGTCAA CTGGGGCTAC 
GCCACCCGAG TGGGAGAGCA GGAGGCTCCG CATGAGGGTG GGCACCCTGG CAGTGACTCT 
GCCCGCGCCT CCATGGCTGA CTGGCTCCGG CGTTCCTCCC GCCCCCTCCT GGAGAATGGG 
GCCAAGGTGT GCAGCTTCTT CAAGCAGCAT GCACCTGGTG GGGGAAGCAC CACCCCTGGC 
CTGGAGCGCC AGCATTCGCT CAAGAAGTCC CGCAAGGAGA ATGACATGGC CCAGTCTCTC 
CACAGTGACA CGGCTGATGA CACTGCCCAT CGCCCTGGCA AGAGCAACCT CAAGCTGCCA 
AAGGGCATTC TCAAGAAGAA GGTGTCAGCC TCTGCAGAAG GGGTACAGGA GGACCCTCCG 
GAGCTCAGCC CAATCCCTGC GAGCCCAGGG CAGGCTGCCC CCCTGCTCCC CAAGAAGGGC 
ATTCTCAAGA AGCCCCGACA GCGCGAGTCT GGCTACTACT CCTCTCCCGA GCCCAGTGAA 
TCTGGGGAGC TCTTGGACGC AGGCGACGTG TTTGTGAGTG GGGATCCCAA GGAGCAGAAG 
CCTCCGCAAG CTTCAGGGCT GCTCCTCCAT CGCAAAGGCA TCCTCAAACT CAATGGCAAG 
TTCTCCCAGA CAGCCTTGGA GCTCGCGGCC CCCACCACCT TCGGCTCCCT GGATGAACTC 
GCCCCACCTC GCCCCCTGGC CCGGGCCAGC CGACCCTCAG GGGCTGTGAG CGAGGACAGC 
ATCCTGTCCT CTGAGTCCTT TGACCAGCTG GACTTGCCTG AACGGCTCCC AGAGCCCCCA 
CTGCGGGGCT GTGTGTCTGT GGACAACCTC ACGGGGCTTG AGGAGCCCCC CTCAGAGGGC 
CCTGGAAGCT GCCTGAGGCG CTGGCGGCAG GATCCTTTGG GGGACAGCTG CTTTTCCCTG 
ACAGACTGCC AGGAGGTGAC AGCGACCTAC CGACAGGCAC TGAGGGTCTG CTCAAAGCTC 
ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NUAK2 ( NM_030952.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_112214.2 Homo sapiens NUAK family kinase 2 (NUAK2), mRNA.

Price & Availability↑

CloneID	OHu72985
Clone ID Related Accession (Same CDS sequence)	NM_030952.2
Accession Version	NM_030952.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2019bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	NUAK family SNF1-like kinase 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK303577.1 and BC017306.2. On Dec 16, 2014 this sequence version replaced NM_030952.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL136891.1, SRR1660809.55563.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGTGCT TTACTGCGCG CTCTGGTACT GCTGTGGCTC CCCGTCCTGG TGCGGGACCT 
GTGCCCCGCG CTTCAGCCCT CCCCGCACAG CCTACTGATT CCCCTGCCGC CCTTGCTCAC 
CTCCTGCTCG CCATGGAGTC GCTGGTTTTC GCGCGGCGCT CCGGCCCCAC TCCCTCGGCC 
GCAGAGCTAG CCCGGCCGCT GGCGGAAGGG CTGATCAAGT CGCCCAAGCC CCTAATGAAG 
AAGCAGGCGG TGAAGCGGCA CCACCACAAG CACAACCTGC GGCACCGCTA CGAGTTCCTG 
GAGACCCTGG GCAAAGGCAC CTACGGGAAG GTGAAGAAGG CGCGGGAGAG CTCGGGGCGC 
CTGGTGGCCA TCAAGTCAAT CCGGAAGGAC AAAATCAAAG ATGAGCAAGA TCTGATGCAC 
ATACGGAGGG AGATTGAGAT CATGTCATCA CTCAACCACC CTCACATCAT TGCCATCCAT 
GAAGTGTTTG AGAACAGCAG CAAGATCGTG ATCGTCATGG AGTATGCCAG CCGGGGCGAC 
CTTTATGACT ACATCAGCGA GCGGCAGCAG CTCAGTGAGC GCGAAGCTAG GCATTTCTTC 
CGGCAGATCG TCTCTGCCGT GCACTATTGC CATCAGAACA GAGTTGTCCA CCGAGATCTC 
AAGCTGGAGA ACATCCTCTT GGATGCCAAT GGGAATATCA AGATTGCTGA CTTCGGCCTC 
TCCAACCTCT ACCATCAAGG CAAGTTCCTG CAGACATTCT GTGGGAGCCC CCTCTATGCC 
TCGCCAGAGA TTGTCAATGG GAAGCCCTAC ACAGGCCCAG AGGTGGACAG CTGGTCCCTG 
GGTGTTCTCC TCTACATCCT GGTGCATGGC ACCATGCCCT TTGATGGGCA TGACCATAAG 
ATCCTAGTGA AACAGATCAG CAACGGGGCC TACCGGGAGC CACCTAAACC CTCTGATGCC 
TGTGGCCTGA TCCGGTGGCT GTTGATGGTG AACCCCACCC GCCGGGCCAC CCTGGAGGAT 
GTGGCCAGTC ACTGGTGGGT CAACTGGGGC TACGCCACCC GAGTGGGAGA GCAGGAGGCT 
CCGCATGAGG GTGGGCACCC TGGCAGTGAC TCTGCCCGCG CCTCCATGGC TGACTGGCTC 
CGGCGTTCCT CCCGCCCCCT CCTGGAGAAT GGGGCCAAGG TGTGCAGCTT CTTCAAGCAG 
CATGCACCTG GTGGGGGAAG CACCACCCCT GGCCTGGAGC GCCAGCATTC GCTCAAGAAG 
TCCCGCAAGG AGAATGACAT GGCCCAGTCT CTCCACAGTG ACACGGCTGA TGACACTGCC 
CATCGCCCTG GCAAGAGCAA CCTCAAGCTG CCAAAGGGCA TTCTCAAGAA GAAGGTGTCA 
GCCTCTGCAG AAGGGGTACA GGAGGACCCT CCGGAGCTCA GCCCAATCCC TGCGAGCCCA 
GGGCAGGCTG CCCCCCTGCT CCCCAAGAAG GGCATTCTCA AGAAGCCCCG ACAGCGCGAG 
TCTGGCTACT ACTCCTCTCC CGAGCCCAGT GAATCTGGGG AGCTCTTGGA CGCAGGCGAC 
GTGTTTGTGA GTGGGGATCC CAAGGAGCAG AAGCCTCCGC AAGCTTCAGG GCTGCTCCTC 
CATCGCAAAG GCATCCTCAA ACTCAATGGC AAGTTCTCCC AGACAGCCTT GGAGCTCGCG 
GCCCCCACCA CCTTCGGCTC CCTGGATGAA CTCGCCCCAC CTCGCCCCCT GGCCCGGGCC 
AGCCGACCCT CAGGGGCTGT GAGCGAGGAC AGCATCCTGT CCTCTGAGTC CTTTGACCAG 
CTGGACTTGC CTGAACGGCT CCCAGAGCCC CCACTGCGGG GCTGTGTGTC TGTGGACAAC 
CTCACGGGGC TTGAGGAGCC CCCCTCAGAG GGCCCTGGAA GCTGCCTGAG GCGCTGGCGG 
CAGGATCCTT TGGGGGACAG CTGCTTTTCC CTGACAGACT GCCAGGAGGT GACAGCGACC 
TACCGACAGG CACTGAGGGT CTGCTCAAAG CTCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112214.2
CDS	32..2050
Translation	MLCFTARSGTAVAPRPGAGPVPRASALPAQPTDSPAALAHLLLAMESLVFARRSGPTPSAAELARPLAEGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLGKGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDACGLIRWLLMVNPTRRATLEDVASHWWVNWGYATRVGEQEAPHEGGHPGSDSARASMADWLRRSSRPLLENGAKVCSFFKQHAPGGGSTTPGLERQHSLKKSRKENDMAQSLHSDTADDTAHRPGKSNLKLPKGILKKKVSASAEGVQEDPPELSPIPASPGQAAPLLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVFVSGDPKEQKPPQASGLLLHRKGILKLNGKFSQTALELAAPTTFGSLDELAPPRPLARASRPSGAVSEDSILSSESFDQLDLPERLPEPPLRGCVSVDNLTGLEEPPSEGPGSCLRRWRQDPLGDSCFSLTDCQEVTATYRQALRVCSKLT

Target ORF information:

RefSeq Version	NM_030952.2
Organism	Homo sapiens(human)
Definition	Homo sapiens NUAK family kinase 2 (NUAK2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030952.2

ORF Insert Sequence:

ATGCTGTGCT TTACTGCGCG CTCTGGTACT GCTGTGGCTC CCCGTCCTGG TGCGGGACCT 
GTGCCCCGCG CTTCAGCCCT CCCCGCACAG CCTACTGATT CCCCTGCCGC CCTTGCTCAC 
CTCCTGCTCG CCATGGAGTC GCTGGTTTTC GCGCGGCGCT CCGGCCCCAC TCCCTCGGCC 
GCAGAGCTAG CCCGGCCGCT GGCGGAAGGG CTGATCAAGT CGCCCAAGCC CCTAATGAAG 
AAGCAGGCGG TGAAGCGGCA CCACCACAAG CACAACCTGC GGCACCGCTA CGAGTTCCTG 
GAGACCCTGG GCAAAGGCAC CTACGGGAAG GTGAAGAAGG CGCGGGAGAG CTCGGGGCGC 
CTGGTGGCCA TCAAGTCAAT CCGGAAGGAC AAAATCAAAG ATGAGCAAGA TCTGATGCAC 
ATACGGAGGG AGATTGAGAT CATGTCATCA CTCAACCACC CTCACATCAT TGCCATCCAT 
GAAGTGTTTG AGAACAGCAG CAAGATCGTG ATCGTCATGG AGTATGCCAG CCGGGGCGAC 
CTTTATGACT ACATCAGCGA GCGGCAGCAG CTCAGTGAGC GCGAAGCTAG GCATTTCTTC 
CGGCAGATCG TCTCTGCCGT GCACTATTGC CATCAGAACA GAGTTGTCCA CCGAGATCTC 
AAGCTGGAGA ACATCCTCTT GGATGCCAAT GGGAATATCA AGATTGCTGA CTTCGGCCTC 
TCCAACCTCT ACCATCAAGG CAAGTTCCTG CAGACATTCT GTGGGAGCCC CCTCTATGCC 
TCGCCAGAGA TTGTCAATGG GAAGCCCTAC ACAGGCCCAG AGGTGGACAG CTGGTCCCTG 
GGTGTTCTCC TCTACATCCT GGTGCATGGC ACCATGCCCT TTGATGGGCA TGACCATAAG 
ATCCTAGTGA AACAGATCAG CAACGGGGCC TACCGGGAGC CACCTAAACC CTCTGATGCC 
TGTGGCCTGA TCCGGTGGCT GTTGATGGTG AACCCCACCC GCCGGGCCAC CCTGGAGGAT 
GTGGCCAGTC ACTGGTGGGT CAACTGGGGC TACGCCACCC GAGTGGGAGA GCAGGAGGCT 
CCGCATGAGG GTGGGCACCC TGGCAGTGAC TCTGCCCGCG CCTCCATGGC TGACTGGCTC 
CGGCGTTCCT CCCGCCCCCT CCTGGAGAAT GGGGCCAAGG TGTGCAGCTT CTTCAAGCAG 
CATGCACCTG GTGGGGGAAG CACCACCCCT GGCCTGGAGC GCCAGCATTC GCTCAAGAAG 
TCCCGCAAGG AGAATGACAT GGCCCAGTCT CTCCACAGTG ACACGGCTGA TGACACTGCC 
CATCGCCCTG GCAAGAGCAA CCTCAAGCTG CCAAAGGGCA TTCTCAAGAA GAAGGTGTCA 
GCCTCTGCAG AAGGGGTACA GGAGGACCCT CCGGAGCTCA GCCCAATCCC TGCGAGCCCA 
GGGCAGGCTG CCCCCCTGCT CCCCAAGAAG GGCATTCTCA AGAAGCCCCG ACAGCGCGAG 
TCTGGCTACT ACTCCTCTCC CGAGCCCAGT GAATCTGGGG AGCTCTTGGA CGCAGGCGAC 
GTGTTTGTGA GTGGGGATCC CAAGGAGCAG AAGCCTCCGC AAGCTTCAGG GCTGCTCCTC 
CATCGCAAAG GCATCCTCAA ACTCAATGGC AAGTTCTCCC AGACAGCCTT GGAGCTCGCG 
GCCCCCACCA CCTTCGGCTC CCTGGATGAA CTCGCCCCAC CTCGCCCCCT GGCCCGGGCC 
AGCCGACCCT CAGGGGCTGT GAGCGAGGAC AGCATCCTGT CCTCTGAGTC CTTTGACCAG 
CTGGACTTGC CTGAACGGCT CCCAGAGCCC CCACTGCGGG GCTGTGTGTC TGTGGACAAC 
CTCACGGGGC TTGAGGAGCC CCCCTCAGAG GGCCCTGGAA GCTGCCTGAG GCGCTGGCGG 
CAGGATCCTT TGGGGGACAG CTGCTTTTCC CTGACAGACT GCCAGGAGGT GACAGCGACC 
TACCGACAGG CACTGAGGGT CTGCTCAAAG CTCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NUAK2 ( NM_030952.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_112214.3 Homo sapiens NUAK family kinase 2 (NUAK2), mRNA.

Price & Availability↑

CloneID	OHu107490
Clone ID Related Accession (Same CDS sequence)	NM_030952.3
Accession Version	NM_030952.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1887bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	NUAK family SNF1-like kinase 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC098933.2. On Dec 20, 2018 this sequence version replaced NM_030952.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK074830.1, AL136891.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367157.6/ ENSP00000356125.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGTCGC TGGTTTTCGC GCGGCGCTCC GGCCCCACTC CCTCGGCCGC AGAGCTAGCC 
CGGCCGCTGG CGGAAGGGCT GATCAAGTCG CCCAAGCCCC TAATGAAGAA GCAGGCGGTG 
AAGCGGCACC ACCACAAGCA CAACCTGCGG CACCGCTACG AGTTCCTGGA GACCCTGGGC 
AAAGGCACCT ACGGGAAGGT GAAGAAGGCG CGGGAGAGCT CGGGGCGCCT GGTGGCCATC 
AAGTCAATCC GGAAGGACAA AATCAAAGAT GAGCAAGATC TGATGCACAT ACGGAGGGAG 
ATTGAGATCA TGTCATCACT CAACCACCCT CACATCATTG CCATCCATGA AGTGTTTGAG 
AACAGCAGCA AGATCGTGAT CGTCATGGAG TATGCCAGCC GGGGCGACCT TTATGACTAC 
ATCAGCGAGC GGCAGCAGCT CAGTGAGCGC GAAGCTAGGC ATTTCTTCCG GCAGATCGTC 
TCTGCCGTGC ACTATTGCCA TCAGAACAGA GTTGTCCACC GAGATCTCAA GCTGGAGAAC 
ATCCTCTTGG ATGCCAATGG GAATATCAAG ATTGCTGACT TCGGTCTCTC CAACCTCTAC 
CATCAAGGCA AGTTCCTGCA GACATTCTGT GGGAGCCCCC TCTATGCCTC GCCAGAGATT 
GTCAATGGGA AGCCCTACAC AGGCCCAGAG GTGGACAGCT GGTCCCTGGG TGTTCTCCTC 
TACATCCTGG TGCATGGCAC CATGCCCTTT GATGGGCATG ACCATAAGAT CCTAGTGAAA 
CAGATCAGCA ACGGGGCCTA CCGGGAGCCA CCTAAACCCT CTGATGCCTG TGGCCTGATC 
CGGTGGCTGT TGATGGTGAA CCCCACCCGC CGGGCCACCC TGGAGGATGT GGCCAGTCAC 
TGGTGGGTCA ACTGGGGCTA CGCCACCCGA GTGGGAGAGC AGGAGGCTCC GCATGAGGGT 
GGGCACCCTG GCAGTGACTC TGCCCGCGCC TCCATGGCTG ACTGGCTCCG GCGTTCCTCC 
CGCCCCCTCC TGGAGAATGG GGCCAAGGTG TGCAGCTTCT TCAAGCAGCA TGCACCTGGT 
GGGGGAAGCA CCACCCCTGG CCTGGAGCGC CAGCATTCGC TCAAGAAGTC CCGCAAGGAG 
AATGACATGG CCCAGTCTCT CCACAGTGAC ACGGCTGATG ACACTGCCCA TCGCCCTGGC 
AAGAGCAACC TCAAGCTGCC AAAGGGCATT CTCAAGAAGA AGGTGTCAGC CTCTGCAGAA 
GGGGTACAGG AGGACCCTCC GGAGCTCAGC CCAATCCCTG CGAGCCCAGG GCAGGCTGCC 
CCCCTGCTCC CCAAGAAGGG CATTCTCAAG AAGCCCCGAC AGCGCGAGTC TGGCTACTAC 
TCCTCTCCCG AGCCCAGTGA ATCTGGGGAG CTCTTGGACG CAGGCGACGT GTTTGTGAGT 
GGGGATCCCA AGGAGCAGAA GCCTCCGCAA GCTTCAGGGC TGCTCCTCCA TCGCAAAGGC 
ATCCTCAAAC TCAATGGCAA GTTCTCCCAG ACAGCCTTGG AGCTCGCGGC CCCCACCACC 
TTCGGCTCCC TGGATGAACT CGCCCCACCT CGCCCCCTGG CCCGGGCCAG CCGACCCTCA 
GGGGCTGTGA GCGAGGACAG CATCCTGTCC TCTGAGTCCT TTGACCAGCT GGACTTGCCT 
GAACGGCTCC CAGAGCCCCC ACTGCGGGGC TGTGTGTCTG TGGACAACCT CACGGGGCTT 
GAGGAGCCCC CCTCAGAGGG CCCTGGAAGC TGCCTGAGGC GCTGGCGGCA GGATCCTTTG 
GGGGACAGCT GCTTTTCCCT GACAGACTGC CAGGAGGTGA CAGCGACCTA CCGACAGGCA 
CTGAGGGTCT GCTCAAAGCT CACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112214.3
CDS	118..2004
Translation	MESLVFARRSGPTPSAAELARPLAEGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLGKGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDACGLIRWLLMVNPTRRATLEDVASHWWVNWGYATRVGEQEAPHEGGHPGSDSARASMADWLRRSSRPLLENGAKVCSFFKQHAPGGGSTTPGLERQHSLKKSRKENDMAQSLHSDTADDTAHRPGKSNLKLPKGILKKKVSASAEGVQEDPPELSPIPASPGQAAPLLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVFVSGDPKEQKPPQASGLLLHRKGILKLNGKFSQTALELAAPTTFGSLDELAPPRPLARASRPSGAVSEDSILSSESFDQLDLPERLPEPPLRGCVSVDNLTGLEEPPSEGPGSCLRRWRQDPLGDSCFSLTDCQEVTATYRQALRVCSKLT

Target ORF information:

RefSeq Version	NM_030952.3
Organism	Homo sapiens(human)
Definition	Homo sapiens NUAK family kinase 2 (NUAK2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030952.3

ORF Insert Sequence:

ATGGAGTCGC TGGTTTTCGC GCGGCGCTCC GGCCCCACTC CCTCGGCCGC AGAGCTAGCC 
CGGCCGCTGG CGGAAGGGCT GATCAAGTCG CCCAAGCCCC TAATGAAGAA GCAGGCGGTG 
AAGCGGCACC ACCACAAGCA CAACCTGCGG CACCGCTACG AGTTCCTGGA GACCCTGGGC 
AAAGGCACCT ACGGGAAGGT GAAGAAGGCG CGGGAGAGCT CGGGGCGCCT GGTGGCCATC 
AAGTCAATCC GGAAGGACAA AATCAAAGAT GAGCAAGATC TGATGCACAT ACGGAGGGAG 
ATTGAGATCA TGTCATCACT CAACCACCCT CACATCATTG CCATCCATGA AGTGTTTGAG 
AACAGCAGCA AGATCGTGAT CGTCATGGAG TATGCCAGCC GGGGCGACCT TTATGACTAC 
ATCAGCGAGC GGCAGCAGCT CAGTGAGCGC GAAGCTAGGC ATTTCTTCCG GCAGATCGTC 
TCTGCCGTGC ACTATTGCCA TCAGAACAGA GTTGTCCACC GAGATCTCAA GCTGGAGAAC 
ATCCTCTTGG ATGCCAATGG GAATATCAAG ATTGCTGACT TCGGTCTCTC CAACCTCTAC 
CATCAAGGCA AGTTCCTGCA GACATTCTGT GGGAGCCCCC TCTATGCCTC GCCAGAGATT 
GTCAATGGGA AGCCCTACAC AGGCCCAGAG GTGGACAGCT GGTCCCTGGG TGTTCTCCTC 
TACATCCTGG TGCATGGCAC CATGCCCTTT GATGGGCATG ACCATAAGAT CCTAGTGAAA 
CAGATCAGCA ACGGGGCCTA CCGGGAGCCA CCTAAACCCT CTGATGCCTG TGGCCTGATC 
CGGTGGCTGT TGATGGTGAA CCCCACCCGC CGGGCCACCC TGGAGGATGT GGCCAGTCAC 
TGGTGGGTCA ACTGGGGCTA CGCCACCCGA GTGGGAGAGC AGGAGGCTCC GCATGAGGGT 
GGGCACCCTG GCAGTGACTC TGCCCGCGCC TCCATGGCTG ACTGGCTCCG GCGTTCCTCC 
CGCCCCCTCC TGGAGAATGG GGCCAAGGTG TGCAGCTTCT TCAAGCAGCA TGCACCTGGT 
GGGGGAAGCA CCACCCCTGG CCTGGAGCGC CAGCATTCGC TCAAGAAGTC CCGCAAGGAG 
AATGACATGG CCCAGTCTCT CCACAGTGAC ACGGCTGATG ACACTGCCCA TCGCCCTGGC 
AAGAGCAACC TCAAGCTGCC AAAGGGCATT CTCAAGAAGA AGGTGTCAGC CTCTGCAGAA 
GGGGTACAGG AGGACCCTCC GGAGCTCAGC CCAATCCCTG CGAGCCCAGG GCAGGCTGCC 
CCCCTGCTCC CCAAGAAGGG CATTCTCAAG AAGCCCCGAC AGCGCGAGTC TGGCTACTAC 
TCCTCTCCCG AGCCCAGTGA ATCTGGGGAG CTCTTGGACG CAGGCGACGT GTTTGTGAGT 
GGGGATCCCA AGGAGCAGAA GCCTCCGCAA GCTTCAGGGC TGCTCCTCCA TCGCAAAGGC 
ATCCTCAAAC TCAATGGCAA GTTCTCCCAG ACAGCCTTGG AGCTCGCGGC CCCCACCACC 
TTCGGCTCCC TGGATGAACT CGCCCCACCT CGCCCCCTGG CCCGGGCCAG CCGACCCTCA 
GGGGCTGTGA GCGAGGACAG CATCCTGTCC TCTGAGTCCT TTGACCAGCT GGACTTGCCT 
GAACGGCTCC CAGAGCCCCC ACTGCGGGGC TGTGTGTCTG TGGACAACCT CACGGGGCTT 
GAGGAGCCCC CCTCAGAGGG CCCTGGAAGC TGCCTGAGGC GCTGGCGGCA GGATCCTTTG 
GGGGACAGCT GCTTTTCCCT GACAGACTGC CAGGAGGTGA CAGCGACCTA CCGACAGGCA 
CTGAGGGTCT GCTCAAAGCT CACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sucrose Non-Fermenting Related Kinase Regulates Both Adipose Inflammation and Energy Homeostasis in Mice and Humans.
Diabetes(2018 Jan)
Li J,Feng B,Nie Y,Jiao P,Lin X,Huang M,An R,He Q,Zhou HE,Salomon A,Sigrist KS,Wu Z,Liu S,Xu H

miR-143 inhibits oncogenic traits by degrading NUAK2 in glioblastoma.
International journal of molecular medicine37(6)1627-35(2016 Jun)
Fu TG,Wang L,Li W,Li JZ,Li J

Sucrose non-fermenting AMPK related kinase/Pentraxin 3 and DNA damage axis: a gateway to cardiovascular disease in systemic lupus erythematosus among Egyptian patients.
Annals of clinical biochemistry53(Pt 2)240-51(2016 Mar)
Zineldeen DH,Keshk WA,Ghazy AH,El-Barbary AM

NUAK2 Amplification Coupled with PTEN Deficiency Promotes Melanoma Development via CDK Activation.
Cancer research75(13)2708-15(2015 Jul)
Namiki T,Yaguchi T,Nakamura K,Valencia JC,Coelho SG,Yin L,Kawaguchi M,Vieira WD,Kaneko Y,Tanemura A,Katayama I,Yokozeki H,Kawakami Y,Hearing VJ

The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-? signaling.
Journal of hepatology59(5)942-8(2013 Nov)
Goto K,Lin W,Zhang L,Jilg N,Shao RX,Schaefer EA,Zhao H,Fusco DN,Peng LF,Kato N,Chung RT

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NUAK2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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