DEFB126 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DEFB126
Entrez Gene ID	81623
Full Name	defensin beta 126
Synonyms	C20orf8,DEFB-26,DEFB26,HBD26,bA530N10.1,hBD-26
General protein information	Preferred Names defensin beta 126 Names beta-defensin 126 epididymal secretory protein ESP13.2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20p13
Summary	Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. The encoded protein is highly similar to an epididymal-specific secretory protein (ESP13.2) from cynomolgus monkey. Mutation of this gene is associated with impaired sperm function. [provided by RefSeq, Nov 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_030931.3	NP_112193.1	beta-defensin 126 preproprotein
NM_030931.4	NP_112193.1	beta-defensin 126 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	DEFB126	NP_112193.1
	LOC714089	XP_001111242.1
Pan troglodytes (chimpanzee)	DEFB126	NP_001123243.1

Gene Ontology
Bibliography

Related articles in PubMed

Another functional frame-shift polymorphism of DEFB126 (rs11467497) associated with male infertility.
Duan S, Shi C, Chen G, Zheng JF, Wu B, Diao H, Ji L, Gu Y, Xin A, Wu Y, Zhou W, Miao M, Xu L, Li Z, Yuan Y, Wang P, Shi H
Journal of cellular and molecular medicine19(5)1077-84(2015 May)

Human beta-defensin DEFB126 is capable of inhibiting LPS-mediated inflammation.
Liu H, Yu H, Gu Y, Xin A, Zhang Y, Diao H, Lin D
Applied microbiology and biotechnology97(8)3395-408(2013 Apr)

Multifunctional glycoprotein DEFB126--a curious story of defensin-clad spermatozoa.
Tollner TL, Bevins CL, Cherr GN
Nature reviews. Urology9(7)365-75(2012 Jun)

A common mutation in the defensin DEFB126 causes impaired sperm function and subfertility.
Tollner TL, Venners SA, Hollox EJ, Yudin AI, Liu X, Tang G, Xing H, Kays RJ, Lau T, Overstreet JW, Xu X, Bevins CL, Cherr GN
Science translational medicine3(92)92ra65(2011 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate a significant contribution of the frame-shift polymorphism of defensin beta 126 (DEFB126) rs11467497 to male infertility.
Title: Another functional frame-shift polymorphism of DEFB126 (rs11467497) associated with male infertility.

These results demonstrate that the DEFB126 core peptide has critical functions in parallel to its C-terminal tail by showing LPS-binding activity, anti-inflammatory effects and intracellular regulatory function. In addition, DEFB126 displays antimicrobial activity against E. coli, S. aureus, and C. elegans.
Title: Human beta-defensin DEFB126 is capable of inhibiting LPS-mediated inflammation.

This review shows how DEFB126 is critical for efficient transport of sperm in the female reproductive tract, preventing their recognition by the female immune system.
Title: Multifunctional glycoprotein DEFB126--a curious story of defensin-clad spermatozoa.

DEFB126 genotype and lectin binding were correlated with sperm performance in the penetration assays.
Title: A common mutation in the defensin DEFB126 causes impaired sperm function and subfertility.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Polymorphisms in innate immunity genes and risk of childhood leukemia.

The following DEFB126 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEFB126 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00666	NM_030931.4 Latest version!	Homo sapiens defensin beta 126 (DEFB126), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu00666	NM_030931.3	Homo sapiens defensin beta 126 (DEFB126), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DEFB126 ( NM_030931.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_112193.1 Homo sapiens defensin beta 126 (DEFB126), mRNA.

Price & Availability↑

CloneID	OHu00666
Clone ID Related Accession (Same CDS sequence)	NM_030931.3 , NM_030931.4
Accession Version	NM_030931.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 336bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-06-02
Organism	Homo sapiens(human)
Product	beta-defensin 126 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX108307.1 and AA400429.1. On Jul 31, 2013 this sequence version replaced NM_030931.2. ##Evidence-Data-START## Transcript exon combination :: BX108307.1, CO408416.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 23229569 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGTCCC TACTGTTCAC CCTTGCAGTT TTTATGCTCC TGGCCCAATT GGTCTCAGGT 
AATTGGTATG TGAAAAAGTG TCTAAACGAC GTTGGAATTT GCAAGAAGAA GTGCAAACCT 
GAAGAGATGC ATGTAAAGAA TGGTTGGGCA ATGTGCGGCA AACAAAGGGA CTGCTGTGTT 
CCAGCTGACA GACGTGCTAA TTATCCTGTT TTCTGTGTCC AGACAAAGAC TACAAGAATT 
TCAACAGTAA CAGCAACAAC AGCAACAACA ACTTTGATGA TGACTACTGC TTCGATGTCT 
TCGATGGCTC CTACCCCCGT TTCTCCCACT GGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112193.1
CDS	77..412
Translation	MKSLLFTLAVFMLLAQLVSGNWYVKKCLNDVGICKKKCKPEEMHVKNGWAMCGKQRDCCVPADRRANYPVFCVQTKTTRISTVTATTATTTLMMTTASMSSMAPTPVSPTG

Target ORF information:

RefSeq Version	NM_030931.3
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 126 (DEFB126), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030931.3

ORF Insert Sequence:

ATGAAGTCCC TACTGTTCAC CCTTGCAGTT TTTATGCTCC TGGCCCAATT GGTCTCAGGT 
AATTGGTATG TGAAAAAGTG TCTAAACGAC GTTGGAATTT GCAAGAAGAA GTGCAAACCT 
GAAGAGATGC ATGTAAAGAA TGGTTGGGCA ATGTGCGGCA AACAAAGGGA CTGCTGTGTT 
CCAGCTGACA GACGTGCTAA TTATCCTGTT TTCTGTGTCC AGACAAAGAC TACAAGAATT 
TCAACAGTAA CAGCAACAAC AGCAACAACA ACTTTGATGA TGACTACTGC TTCGATGTCT 
TCGATGGCTC CTACCCCCGT TTCTCCCACT GGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEFB126 ( NM_030931.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_112193.1 Homo sapiens defensin beta 126 (DEFB126), mRNA.

Price & Availability↑

CloneID	OHu00666
Clone ID Related Accession (Same CDS sequence)	NM_030931.3 , NM_030931.4
Accession Version	NM_030931.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 336bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-12
Organism	Homo sapiens(human)
Product	beta-defensin 126 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX108307.1 and AA400429.1. On Nov 23, 2018 this sequence version replaced NM_030931.3. ##Evidence-Data-START## Transcript exon combination :: AK225987.1, BX108307.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000382398.4/ ENSP00000371835.3 Protein has antimicrobial activity :: PMID: 23229569 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGTCCC TACTGTTCAC CCTTGCAGTT TTTATGCTCC TGGCCCAATT GGTCTCAGGT 
AATTGGTATG TGAAAAAGTG TCTAAACGAC GTTGGAATTT GCAAGAAGAA GTGCAAACCT 
GAAGAGATGC ATGTAAAGAA TGGTTGGGCA ATGTGCGGCA AACAAAGGGA CTGCTGTGTT 
CCAGCTGACA GACGTGCTAA TTATCCTGTT TTCTGTGTCC AGACAAAGAC TACAAGAATT 
TCAACAGTAA CAGCAACAAC AGCAACAACA ACTTTGATGA TGACTACTGC TTCGATGTCT 
TCGATGGCTC CTACCCCCGT TTCTCCCACT GGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112193.1
CDS	40..375
Translation	MKSLLFTLAVFMLLAQLVSGNWYVKKCLNDVGICKKKCKPEEMHVKNGWAMCGKQRDCCVPADRRANYPVFCVQTKTTRISTVTATTATTTLMMTTASMSSMAPTPVSPTG

Target ORF information:

RefSeq Version	NM_030931.4
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 126 (DEFB126), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030931.4

ORF Insert Sequence:

ATGAAGTCCC TACTGTTCAC CCTTGCAGTT TTTATGCTCC TGGCCCAATT GGTCTCAGGT 
AATTGGTATG TGAAAAAGTG TCTAAACGAC GTTGGAATTT GCAAGAAGAA GTGCAAACCT 
GAAGAGATGC ATGTAAAGAA TGGTTGGGCA ATGTGCGGCA AACAAAGGGA CTGCTGTGTT 
CCAGCTGACA GACGTGCTAA TTATCCTGTT TTCTGTGTCC AGACAAAGAC TACAAGAATT 
TCAACAGTAA CAGCAACAAC AGCAACAACA ACTTTGATGA TGACTACTGC TTCGATGTCT 
TCGATGGCTC CTACCCCCGT TTCTCCCACT GGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Another functional frame-shift polymorphism of DEFB126 (rs11467497) associated with male infertility.
Journal of cellular and molecular medicine19(5)1077-84(2015 May)
Duan S,Shi C,Chen G,Zheng JF,Wu B,Diao H,Ji L,Gu Y,Xin A,Wu Y,Zhou W,Miao M,Xu L,Li Z,Yuan Y,Wang P,Shi H

Human beta-defensin DEFB126 is capable of inhibiting LPS-mediated inflammation.
Applied microbiology and biotechnology97(8)3395-408(2013 Apr)
Liu H,Yu H,Gu Y,Xin A,Zhang Y,Diao H,Lin D

Multifunctional glycoprotein DEFB126--a curious story of defensin-clad spermatozoa.
Nature reviews. Urology9(7)365-75(2012 Jun)
Tollner TL,Bevins CL,Cherr GN

A common mutation in the defensin DEFB126 causes impaired sperm function and subfertility.
Science translational medicine3(92)92ra65(2011 Jul)
Tollner TL,Venners SA,Hollox EJ,Yudin AI,Liu X,Tang G,Xing H,Kays RJ,Lau T,Overstreet JW,Xu X,Bevins CL,Cherr GN

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DEFB126 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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