COIL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COIL
Entrez Gene ID	8161
Full Name	coilin
Synonyms	CLN80,p80-coilin
General protein information	Preferred Names coilin Names coilin coilin p80 p80
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q22
Summary	The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008].
Disorder MIM:	600272

mRNA and Protein(s)

mRNA	Protein	Name
NM_004645.3	NP_004636.1	coilin
NM_004645.2	NP_004636.1	coilin

Pathways from BioSystems

Homologies

Homo sapiens (human)	COIL	NP_004636.1
	COIL	XP_001104670.1
Canis lupus familiaris (dog)	COIL	XP_537686.2
Rattus norvegicus (Norway rat)	Coil	NP_059056.1
Pan troglodytes (chimpanzee)	COIL	XP_511900.2
Bos taurus (cattle)	COIL	NP_001033601.1
Mus musculus (house mouse)	Coil	NP_057915.2

Gene Ontology
Bibliography

Related articles in PubMed

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA, Pelletier L, Aloy P, Hill DE, Vidal M, Roth FP
Molecular systems biology12(4)863(2016 Apr)

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle.
Cantarero L, Sanz-Garc?a M, Vinograd-Byk H, Renbaum P, Levy-Lahad E, Lazo PA
Scientific reports510543(2015 Jun)

Coilin: The first 25 years.
Machyna M, Neugebauer KM, Stan?k D
RNA biology12(6)590-6(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that annexin A2 overexpression in microsatellite instability (MIN) cells induces disassembly and colocalization of coilin with centromeres.
Title: Nuclear accumulation of annexin A2 contributes to chromosomal instability by coilin-mediated centromere damage.

VRK1 is a novel regulator of CBs dynamics and stability in cell cycle by protecting coilin from ubiquitination and degradation in the proteasome, and propose a model of CB dynamics.
Title: VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle.

Authors summarize what has been learned in the past 25 years about coilin's structure, post-transcriptional modifications, and interactions with RNA and proteins. [Review]
Title: Coilin: The first 25 years.

The study shows that coilin-KO human cells that lack Cajal bodies are phenotypically normal with respect to telomere homeostasis.
Title: Human cells lacking coilin and Cajal bodies are proficient in telomerase assembly, trafficking and telomere maintenance.

Coilin couples snRNA and snoRNA biogenesis, making cajal bodies the cellular hub of small ncRNA metabolism.
Title: The coilin interactome identifies hundreds of small noncoding RNAs that traffic through Cajal bodies.

The following COIL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COIL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25196	NM_004645.3 Latest version!	Homo sapiens coilin (COIL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu25196	NM_004645.2	Homo sapiens coilin (COIL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COIL ( NM_004645.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004636.1 Homo sapiens coilin (COIL), mRNA.

Price & Availability↑

CloneID	OHu25196
Clone ID Related Accession (Same CDS sequence)	NM_004645.3 , NM_004645.2
Accession Version	NM_004645.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1731bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	coilin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC004584.2, BC010385.1 and AW021880.1. On Nov 22, 2018 this sequence version replaced NM_004645.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.621235.1, BC010385.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000240316.5/ ENSP00000240316.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGCTT CCGAGACGGT TAGGCTACGG CTTCAATTTG ATTACCCGCC GCCAGCTACC 
CCGCACTGTA CGGCCTTCTG GCTTCTGGTC GACTTGAACA GATGCCGAGT CGTCACAGAT 
CTCATTAGTC TCATCCGCCA GCGCTTCGGC TTCAGTTCTG GGGCCTTCCT AGGCCTCTAC 
CTGGAGGGGG GGCTCTTGCC CCCCGCCGAG AGCGCGCGCC TTGTGAGAGA CAACGACTGC 
CTCAGAGTTA AATTAGAAGA GAGAGGAGTT GCTGAGAATT CTGTAGTCAT CAGTAATGGT 
GACATTAATT TATCTCTTAG AAAAGCAAAG AAGCGGGCAT TTCAGTTAGA GGAGGGTGAA 
GAAACTGAAC CAGATTGCAA ATATTCAAAG AAGCATTGGA AGAGTCGAGA GAACAATAAC 
AATAATGAGA AGGTCTTGGA TCTGGAACCA AAAGCTGTCA CAGATCAGAC TGTCAGCAAA 
AAAAACAAGA GAAAAAATAA AGCAACCTGT GGCACAGTGG GTGATGATAA CGAAGAGGCC 
AAAAGAAAAT CACCAAAGAA AAAGGAGAAA TGTGAATATA AAAAAAAGGC TAAGAATCCC 
AAGTCTCCGA AAGTACAGGC AGTGAAAGAC TGGGCCAATC AGAGATGTAG TTCTCCAAAA 
GGTTCTGCTA GAAACAGCCT TGTTAAAGCC AAAAGGAAAG GTAGTGTAAG CGTTTGCTCA 
AAAGAGAGTC CCAGTTCCTC CTCGGAGTCT GAATCTTGTG ATGAATCTAT CAGTGATGGT 
CCCAGCAAAG TCACTTTGGA GGCCAGAAAT TCCTCAGAGA AATTACCAAC TGAGTTATCA 
AAGGAAGAAC CCTCTACCAA AAATACAACT GCAGACAAAC TGGCTATAAA ACTTGGCTTT 
AGCCTTACCC CCAGCAAGGG CAAGACCTCT GGAACAACAT CTTCCAGTTC AGACTCTAGT 
GCAGAGTCAG ACGACCAATG CTTGATGTCA TCGAGCACCC CGGAGTGTGC TGCGGGTTTC 
TTAAAGACAG TAGGCCTTTT TGCAGGAAGA GGTCGTCCAG GCCCAGGGCT GTCATCACAG 
ACTGCAGGTG CTGCTGGATG GAGGCGTTCT GGCTCAAATG GTGGTGGACA GGCTCCTGGT 
GCTTCTCCCA GTGTGTCTCT CCCTGCTAGT TTAGGAAGAG GATGGGGTAG AGAAGAGAAC 
CTTTTTTCTT GGAAGGGAGC TAAGGGACGG GGCATGCGGG GGAGAGGTCG AGGACGAGGG 
CATCCTGTTT CCTGTGTTGT AAATAGAAGC ACTGACAACC AGAGGCAACA GCAATTAAAT 
GACGTGGTAA AAAATTCATC TACTATTATC CAGAATCCAG TAGAGACACC CAAGAAGGAC 
TATAGTCTGT TACCACTGTT AGCAGCTGCC CCTCAAGTTG GAGAAAAGAT TGCATTTAAG 
CTTTTGGAGC TAACATCCAG TTACTCTCCT GATGTCTCTG ACTACAAGGA AGGAAGAATA 
TTAAGCCACA ATCCAGAGAC CCAGCAAGTA GATATAGAAA TTCTTTCATC CTTACCTGCC 
TTGAGAGAAC CTGGGAAATT TGATTTAGTT TATCACAATG AAAATGGAGC CGAGGTAGTG 
GAGTACGCTG TGACACAGGA GAGCAAGATC ACTGTATTTT GGAAAGAGTT GATTGACCCA 
AGACTGATTA TTGAATCTCC AAGTAACACA TCAAGTACAG AACCTGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004636.1
CDS	32..1762
Translation	MAASETVRLRLQFDYPPPATPHCTAFWLLVDLNRCRVVTDLISLIRQRFGFSSGAFLGLYLEGGLLPPAESARLVRDNDCLRVKLEERGVAENSVVISNGDINLSLRKAKKRAFQLEEGEETEPDCKYSKKHWKSRENNNNNEKVLDLEPKAVTDQTVSKKNKRKNKATCGTVGDDNEEAKRKSPKKKEKCEYKKKAKNPKSPKVQAVKDWANQRCSSPKGSARNSLVKAKRKGSVSVCSKESPSSSSESESCDESISDGPSKVTLEARNSSEKLPTELSKEEPSTKNTTADKLAIKLGFSLTPSKGKTSGTTSSSSDSSAESDDQCLMSSSTPECAAGFLKTVGLFAGRGRPGPGLSSQTAGAAGWRRSGSNGGGQAPGASPSVSLPASLGRGWGREENLFSWKGAKGRGMRGRGRGRGHPVSCVVNRSTDNQRQQQLNDVVKNSSTIIQNPVETPKKDYSLLPLLAAAPQVGEKIAFKLLELTSSYSPDVSDYKEGRILSHNPETQQVDIEILSSLPALREPGKFDLVYHNENGAEVVEYAVTQESKITVFWKELIDPRLIIESPSNTSSTEPA

Target ORF information:

RefSeq Version	NM_004645.3
Organism	Homo sapiens(human)
Definition	Homo sapiens coilin (COIL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004645.3

ORF Insert Sequence:

ATGGCAGCTT CCGAGACGGT TAGGCTACGG CTTCAATTTG ATTACCCGCC GCCAGCTACC 
CCGCACTGTA CGGCCTTCTG GCTTCTGGTC GACTTGAACA GATGCCGAGT CGTCACAGAT 
CTCATTAGTC TCATCCGCCA GCGCTTCGGC TTCAGTTCTG GGGCCTTCCT AGGCCTCTAC 
CTGGAGGGGG GGCTCTTGCC CCCCGCCGAG AGCGCGCGCC TTGTGAGAGA CAACGACTGC 
CTCAGAGTTA AATTAGAAGA GAGAGGAGTT GCTGAGAATT CTGTAGTCAT CAGTAATGGT 
GACATTAATT TATCTCTTAG AAAAGCAAAG AAGCGGGCAT TTCAGTTAGA GGAGGGTGAA 
GAAACTGAAC CAGATTGCAA ATATTCAAAG AAGCATTGGA AGAGTCGAGA GAACAATAAC 
AATAATGAGA AGGTCTTGGA TCTGGAACCA AAAGCTGTCA CAGATCAGAC TGTCAGCAAA 
AAAAACAAGA GAAAAAATAA AGCAACCTGT GGCACAGTGG GTGATGATAA CGAAGAGGCC 
AAAAGAAAAT CACCAAAGAA AAAGGAGAAA TGTGAATATA AAAAAAAGGC TAAGAATCCC 
AAGTCTCCGA AAGTACAGGC AGTGAAAGAC TGGGCCAATC AGAGATGTAG TTCTCCAAAA 
GGTTCTGCTA GAAACAGCCT TGTTAAAGCC AAAAGGAAAG GTAGTGTAAG CGTTTGCTCA 
AAAGAGAGTC CCAGTTCCTC CTCGGAGTCT GAATCTTGTG ATGAATCTAT CAGTGATGGT 
CCCAGCAAAG TCACTTTGGA GGCCAGAAAT TCCTCAGAGA AATTACCAAC TGAGTTATCA 
AAGGAAGAAC CCTCTACCAA AAATACAACT GCAGACAAAC TGGCTATAAA ACTTGGCTTT 
AGCCTTACCC CCAGCAAGGG CAAGACCTCT GGAACAACAT CTTCCAGTTC AGACTCTAGT 
GCAGAGTCAG ACGACCAATG CTTGATGTCA TCGAGCACCC CGGAGTGTGC TGCGGGTTTC 
TTAAAGACAG TAGGCCTTTT TGCAGGAAGA GGTCGTCCAG GCCCAGGGCT GTCATCACAG 
ACTGCAGGTG CTGCTGGATG GAGGCGTTCT GGCTCAAATG GTGGTGGACA GGCTCCTGGT 
GCTTCTCCCA GTGTGTCTCT CCCTGCTAGT TTAGGAAGAG GATGGGGTAG AGAAGAGAAC 
CTTTTTTCTT GGAAGGGAGC TAAGGGACGG GGCATGCGGG GGAGAGGTCG AGGACGAGGG 
CATCCTGTTT CCTGTGTTGT AAATAGAAGC ACTGACAACC AGAGGCAACA GCAATTAAAT 
GACGTGGTAA AAAATTCATC TACTATTATC CAGAATCCAG TAGAGACACC CAAGAAGGAC 
TATAGTCTGT TACCACTGTT AGCAGCTGCC CCTCAAGTTG GAGAAAAGAT TGCATTTAAG 
CTTTTGGAGC TAACATCCAG TTACTCTCCT GATGTCTCTG ACTACAAGGA AGGAAGAATA 
TTAAGCCACA ATCCAGAGAC CCAGCAAGTA GATATAGAAA TTCTTTCATC CTTACCTGCC 
TTGAGAGAAC CTGGGAAATT TGATTTAGTT TATCACAATG AAAATGGAGC CGAGGTAGTG 
GAGTACGCTG TGACACAGGA GAGCAAGATC ACTGTATTTT GGAAAGAGTT GATTGACCCA 
AGACTGATTA TTGAATCTCC AAGTAACACA TCAAGTACAG AACCTGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COIL ( NM_004645.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004636.1 Homo sapiens coilin (COIL), mRNA.

Price & Availability↑

CloneID	OHu25196
Clone ID Related Accession (Same CDS sequence)	NM_004645.3 , NM_004645.2
Accession Version	NM_004645.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1731bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	coilin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC004584.2, BC010385.1 and AW021880.1. On Jan 15, 2005 this sequence version replaced NM_004645.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC010385.1, SRR1803617.172155.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCTT CCGAGACGGT TAGGCTACGG CTTCAATTTG ATTACCCGCC GCCAGCTACC 
CCGCACTGTA CGGCCTTCTG GCTTCTGGTC GACTTGAACA GATGCCGAGT CGTCACAGAT 
CTCATTAGTC TCATCCGCCA GCGCTTCGGC TTCAGTTCTG GGGCCTTCCT AGGCCTCTAC 
CTGGAGGGGG GGCTCTTGCC CCCCGCCGAG AGCGCGCGCC TTGTGAGAGA CAACGACTGC 
CTCAGAGTTA AATTAGAAGA GAGAGGAGTT GCTGAGAATT CTGTAGTCAT CAGTAATGGT 
GACATTAATT TATCTCTTAG AAAAGCAAAG AAGCGGGCAT TTCAGTTAGA GGAGGGTGAA 
GAAACTGAAC CAGATTGCAA ATATTCAAAG AAGCATTGGA AGAGTCGAGA GAACAATAAC 
AATAATGAGA AGGTCTTGGA TCTGGAACCA AAAGCTGTCA CAGATCAGAC TGTCAGCAAA 
AAAAACAAGA GAAAAAATAA AGCAACCTGT GGCACAGTGG GTGATGATAA CGAAGAGGCC 
AAAAGAAAAT CACCAAAGAA AAAGGAGAAA TGTGAATATA AAAAAAAGGC TAAGAATCCC 
AAGTCTCCGA AAGTACAGGC AGTGAAAGAC TGGGCCAATC AGAGATGTAG TTCTCCAAAA 
GGTTCTGCTA GAAACAGCCT TGTTAAAGCC AAAAGGAAAG GTAGTGTAAG CGTTTGCTCA 
AAAGAGAGTC CCAGTTCCTC CTCGGAGTCT GAATCTTGTG ATGAATCTAT CAGTGATGGT 
CCCAGCAAAG TCACTTTGGA GGCCAGAAAT TCCTCAGAGA AATTACCAAC TGAGTTATCA 
AAGGAAGAAC CCTCTACCAA AAATACAACT GCAGACAAAC TGGCTATAAA ACTTGGCTTT 
AGCCTTACCC CCAGCAAGGG CAAGACCTCT GGAACAACAT CTTCCAGTTC AGACTCTAGT 
GCAGAGTCAG ACGACCAATG CTTGATGTCA TCGAGCACCC CGGAGTGTGC TGCGGGTTTC 
TTAAAGACAG TAGGCCTTTT TGCAGGAAGA GGTCGTCCAG GCCCAGGGCT GTCATCACAG 
ACTGCAGGTG CTGCTGGATG GAGGCGTTCT GGCTCAAATG GTGGTGGACA GGCTCCTGGT 
GCTTCTCCCA GTGTGTCTCT CCCTGCTAGT TTAGGAAGAG GATGGGGTAG AGAAGAGAAC 
CTTTTTTCTT GGAAGGGAGC TAAGGGACGG GGCATGCGGG GGAGAGGTCG AGGACGAGGG 
CATCCTGTTT CCTGTGTTGT AAATAGAAGC ACTGACAACC AGAGGCAACA GCAATTAAAT 
GACGTGGTAA AAAATTCATC TACTATTATC CAGAATCCAG TAGAGACACC CAAGAAGGAC 
TATAGTCTGT TACCACTGTT AGCAGCTGCC CCTCAAGTTG GAGAAAAGAT TGCATTTAAG 
CTTTTGGAGC TAACATCCAG TTACTCTCCT GATGTCTCTG ACTACAAGGA AGGAAGAATA 
TTAAGCCACA ATCCAGAGAC CCAGCAAGTA GATATAGAAA TTCTTTCATC CTTACCTGCC 
TTGAGAGAAC CTGGGAAATT TGATTTAGTT TATCACAATG AAAATGGAGC CGAGGTAGTG 
GAGTACGCTG TGACACAGGA GAGCAAGATC ACTGTATTTT GGAAAGAGTT GATTGACCCA 
AGACTGATTA TTGAATCTCC AAGTAACACA TCAAGTACAG AACCTGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004636.1
CDS	32..1762
Translation	MAASETVRLRLQFDYPPPATPHCTAFWLLVDLNRCRVVTDLISLIRQRFGFSSGAFLGLYLEGGLLPPAESARLVRDNDCLRVKLEERGVAENSVVISNGDINLSLRKAKKRAFQLEEGEETEPDCKYSKKHWKSRENNNNNEKVLDLEPKAVTDQTVSKKNKRKNKATCGTVGDDNEEAKRKSPKKKEKCEYKKKAKNPKSPKVQAVKDWANQRCSSPKGSARNSLVKAKRKGSVSVCSKESPSSSSESESCDESISDGPSKVTLEARNSSEKLPTELSKEEPSTKNTTADKLAIKLGFSLTPSKGKTSGTTSSSSDSSAESDDQCLMSSSTPECAAGFLKTVGLFAGRGRPGPGLSSQTAGAAGWRRSGSNGGGQAPGASPSVSLPASLGRGWGREENLFSWKGAKGRGMRGRGRGRGHPVSCVVNRSTDNQRQQQLNDVVKNSSTIIQNPVETPKKDYSLLPLLAAAPQVGEKIAFKLLELTSSYSPDVSDYKEGRILSHNPETQQVDIEILSSLPALREPGKFDLVYHNENGAEVVEYAVTQESKITVFWKELIDPRLIIESPSNTSSTEPA

Target ORF information:

RefSeq Version	NM_004645.2
Organism	Homo sapiens(human)
Definition	Homo sapiens coilin (COIL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004645.2

ORF Insert Sequence:

ATGGCAGCTT CCGAGACGGT TAGGCTACGG CTTCAATTTG ATTACCCGCC GCCAGCTACC 
CCGCACTGTA CGGCCTTCTG GCTTCTGGTC GACTTGAACA GATGCCGAGT CGTCACAGAT 
CTCATTAGTC TCATCCGCCA GCGCTTCGGC TTCAGTTCTG GGGCCTTCCT AGGCCTCTAC 
CTGGAGGGGG GGCTCTTGCC CCCCGCCGAG AGCGCGCGCC TTGTGAGAGA CAACGACTGC 
CTCAGAGTTA AATTAGAAGA GAGAGGAGTT GCTGAGAATT CTGTAGTCAT CAGTAATGGT 
GACATTAATT TATCTCTTAG AAAAGCAAAG AAGCGGGCAT TTCAGTTAGA GGAGGGTGAA 
GAAACTGAAC CAGATTGCAA ATATTCAAAG AAGCATTGGA AGAGTCGAGA GAACAATAAC 
AATAATGAGA AGGTCTTGGA TCTGGAACCA AAAGCTGTCA CAGATCAGAC TGTCAGCAAA 
AAAAACAAGA GAAAAAATAA AGCAACCTGT GGCACAGTGG GTGATGATAA CGAAGAGGCC 
AAAAGAAAAT CACCAAAGAA AAAGGAGAAA TGTGAATATA AAAAAAAGGC TAAGAATCCC 
AAGTCTCCGA AAGTACAGGC AGTGAAAGAC TGGGCCAATC AGAGATGTAG TTCTCCAAAA 
GGTTCTGCTA GAAACAGCCT TGTTAAAGCC AAAAGGAAAG GTAGTGTAAG CGTTTGCTCA 
AAAGAGAGTC CCAGTTCCTC CTCGGAGTCT GAATCTTGTG ATGAATCTAT CAGTGATGGT 
CCCAGCAAAG TCACTTTGGA GGCCAGAAAT TCCTCAGAGA AATTACCAAC TGAGTTATCA 
AAGGAAGAAC CCTCTACCAA AAATACAACT GCAGACAAAC TGGCTATAAA ACTTGGCTTT 
AGCCTTACCC CCAGCAAGGG CAAGACCTCT GGAACAACAT CTTCCAGTTC AGACTCTAGT 
GCAGAGTCAG ACGACCAATG CTTGATGTCA TCGAGCACCC CGGAGTGTGC TGCGGGTTTC 
TTAAAGACAG TAGGCCTTTT TGCAGGAAGA GGTCGTCCAG GCCCAGGGCT GTCATCACAG 
ACTGCAGGTG CTGCTGGATG GAGGCGTTCT GGCTCAAATG GTGGTGGACA GGCTCCTGGT 
GCTTCTCCCA GTGTGTCTCT CCCTGCTAGT TTAGGAAGAG GATGGGGTAG AGAAGAGAAC 
CTTTTTTCTT GGAAGGGAGC TAAGGGACGG GGCATGCGGG GGAGAGGTCG AGGACGAGGG 
CATCCTGTTT CCTGTGTTGT AAATAGAAGC ACTGACAACC AGAGGCAACA GCAATTAAAT 
GACGTGGTAA AAAATTCATC TACTATTATC CAGAATCCAG TAGAGACACC CAAGAAGGAC 
TATAGTCTGT TACCACTGTT AGCAGCTGCC CCTCAAGTTG GAGAAAAGAT TGCATTTAAG 
CTTTTGGAGC TAACATCCAG TTACTCTCCT GATGTCTCTG ACTACAAGGA AGGAAGAATA 
TTAAGCCACA ATCCAGAGAC CCAGCAAGTA GATATAGAAA TTCTTTCATC CTTACCTGCC 
TTGAGAGAAC CTGGGAAATT TGATTTAGTT TATCACAATG AAAATGGAGC CGAGGTAGTG 
GAGTACGCTG TGACACAGGA GAGCAAGATC ACTGTATTTT GGAAAGAGTT GATTGACCCA 
AGACTGATTA TTGAATCTCC AAGTAACACA TCAAGTACAG AACCTGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Molecular systems biology12(4)863(2016 Apr)
Yachie N,Petsalaki E,Mellor JC,Weile J,Jacob Y,Verby M,Ozturk SB,Li S,Cote AG,Mosca R,Knapp JJ,Ko M,Yu A,Gebbia M,Sahni N,Yi S,Tyagi T,Sheykhkarimli D,Roth JF,Wong C,Musa L,Snider J,Liu YC,Yu H,Braun P,Stagljar I,Hao T,Calderwood MA,Pelletier L,Aloy P,Hill DE,Vidal M,Roth FP

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle.
Scientific reports510543(2015 Jun)
Cantarero L,Sanz-Garc?a M,Vinograd-Byk H,Renbaum P,Levy-Lahad E,Lazo PA

Coilin: The first 25 years.
RNA biology12(6)590-6(2015)
Machyna M,Neugebauer KM,Stan?k D

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COIL cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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