TRIM8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TRIM8
Entrez Gene ID	81603
Full Name	tripartite motif containing 8
Synonyms	GERP,RNF27
General protein information	Preferred Names tripartite motif containing 8 Names probable E3 ubiquitin-protein ligase TRIM8 RING-type E3 ubiquitin transferase TRIM8 glioblastoma-expressed RING finger protein ring finger protein 27 tripartite motif protein TRIM8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q24.32
Summary	This gene encodes a member of the tripartite motif (TRIM) protein family. Based on similarities to other proteins, the encoded protein is suspected to be an E3 ubiquitin-protein ligase. Regulation of this gene may be altered in some cancers. Mutations resulting in a truncated protein product have been observed in early-onset epileptic encephalopathy (EOEE). [provided by RefSeq, Sep 2016].
Disorder MIM:	606125

mRNA and Protein(s)

mRNA	Protein	Name
NM_001345950.1	NP_001332879.1	E3 ubiquitin-protein ligase TRIM8 isoform 2
NM_030912.2	NP_112174.2	E3 ubiquitin-protein ligase TRIM8 isoform 1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	trim8a	NP_001265783.1
Mus musculus (house mouse)	Trim8	NP_444330.2
Rattus norvegicus (Norway rat)	Trim8	NP_001121555.1
	TRIM8	XP_001113109.1
Bos taurus (cattle)	TRIM8	NP_001178405.1
Gallus gallus (chicken)	TRIM8	NP_001026404.1
Xenopus tropicalis (tropical clawed frog)	trim8	NP_001027512.1
Pan troglodytes (chimpanzee)	TRIM8	XP_003951785.1
Canis lupus familiaris (dog)	TRIM8	XP_543993.3
Danio rerio (zebrafish)	trim8	NP_001038379.1
Homo sapiens (human)	TRIM8	NP_112174.2

Gene Ontology
Bibliography

Related articles in PubMed

TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours.
Mastropasqua F, Marzano F, Valletti A, Aiello I, Di Tullio G, Morgano A, Liuni S, Ranieri E, Guerrini L, Gasparre G, Sbis? E, Pesole G, Moschetta A, Caratozzolo MF, Tullo A
Molecular cancer16(1)67(2017 03)

TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3.
Zhang C, Mukherjee S, Tucker-Burden C, Ross JL, Chau MJ, Kong J, Brat DJ
Molecular oncology11(3)280-294(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we provided evidence that TRIM8 and its regulators miR-17-5p and miR-106b-5 participate to a feedback loop controlling cell proliferation through the reciprocal modulation of p53, miR-34a and N-MYC.
Title: TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours.

TRIM8 activates STAT3 by suppressing the expression of PIAS3, an inhibitor of STAT3, most likely through E3-mediated ubiquitination and proteasomal degradation.
Title: TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3.

A pathogenic effect of a heterozygous truncating mutation in the tripartite motif containing 8 (TRIM8) gene on the postnatal development of the human brain.
Title: De Novo Truncating Mutation of TRIM8 Causes Early-Onset Epileptic Encephalopathy.

Our study provides evidences that TRIM8 may participate in the carcinogenesis and progression of glioma and that the transcriptional repression of TRIM8 might have potential value for predicting poor prognosis in glioma patients.
Title: TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival.

These findings provide the first mechanistic link between TRIM8 and the drug resistance of clear cell Renal Cell Carcinoma
Title: TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma.

The following TRIM8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TRIM8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu31101	NM_030912.2 Latest version!	Homo sapiens tripartite motif containing 8 (TRIM8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu72942	NM_001345950.1 Latest version!	Homo sapiens tripartite motif containing 8 (TRIM8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TRIM8 ( NM_030912.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_112174.2 Homo sapiens tripartite motif containing 8 (TRIM8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31101
Clone ID Related Accession (Same CDS sequence)	NM_030912.2
Accession Version	NM_030912.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1656bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-30
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase TRIM8 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG746631.1, AF220034.1 and AA907931.1. This sequence is a reference standard in the RefSeqGene project. On Jun 5, 2007 this sequence version replaced NM_030912.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.48616.1, SRR1660805.86483.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAGA ATTGGAAGAA CTGCTTCGAG GAGGAGCTCA TCTGCCCTAT CTGCCTGCAC 
GTTTTCGTGG AGCCAGTGCA GCTGCCGTGC AAACACAACT TCTGCCGGGG CTGCATCGGC 
GAGGCGTGGG CCAAGGACAG CGGCCTCGTA CGCTGCCCAG AGTGCAACCA GGCCTACAAC 
CAGAAGCCGG GCCTGGAGAA GAACCTGAAG CTCACCAACA TCGTGGAGAA GTTCAATGCC 
CTGCACGTGG AGAAGCCGCC GGCGGCGCTG CACTGCGTGT TCTGCCGCCG CGGCCCCCCG 
CTGCCCGCGC AGAAGGTCTG CCTGCGCTGC GAGGCGCCCT GCTGCCAGTC CCACGTGCAG 
ACGCACCTGC AGCAGCCCTC CACCGCCCGC GGGCACCTCC TGGTGGAGGC GGACGACGTG 
CGGGCCTGGA GCTGCCCGCA GCACAACGCC TACCGCCTCT ACCACTGCGA GGCCGAGCAG 
GTGGCCGTGT GCCAGTACTG CTGCTACTAC AGCGGCGCGC ATCAGGGACA CTCGGTGTGC 
GACGTGGAGA TCCGAAGGAA TGAAATCCGG AAGATGCTCA TGAAGCAGCA GGACCGGCTG 
GAGGAGCGAG AGCAGGACAT TGAGGACCAG CTGTACAAAC TCGAGTCAGA CAAGCGCCTG 
GTGGAGGAGA AAGTGAACCA ACTGAAGGAG GAAGTTCGGC TGCAGTACGA GAAGCTGCAC 
CAGCTGCTGG ACGAGGACCT GCGGCAGACA GTGGAGGTCC TAGACAAGGC CCAGGCCAAG 
TTCTGCAGCG AGAACGCAGC GCAGGCGCTG CACCTCGGGG AGCGCATGCA GGAGGCCAAG 
AAGCTGCTGG GCTCCCTGCA GCTGCTCTTT GATAAGACGG AGGATGTCAG CTTCATGAAG 
AACACCAAGT CTGTGAAAAT CCTGATGGAC AGGACCCAGA CCTGCACGAG CAGCAGCCTT 
TCCCCCACTA AGATCGGCCA CCTGAACTCC AAGCTCTTCC TGAACGAAGT GGCCAAGAAG 
GAGAAGCAGC TGCGGAAAAT GCTAGAAGGC CCCTTCAGCA CGCCGGTGCC CTTCCTGCAG 
AGTGTCCCCC TGTACCCTTG CGGCGTGAGC AGCTCTGGGG CGGAAAAGCG CAAGCACTCA 
ACGGCCTTCC CAGAGGCCAG TTTCCTAGAG ACGTCGTCGG GCCCTGTGGG CGGCCAGTAC 
GGGGCGGCGG GCACAGCCAG CGGTGAGGGC CAGTCTGGGC AGCCCCTGGG GCCCTGCAGC 
TCCACGCAGC ACTTGGTGGC CCTGCCGGGC GGCGCCCAAC CAGTGCACTC AAGCCCCGTG 
TTCCCCCCAT CGCAGTATCC CAATGGCTCC GCCGCCCAGC AGCCCATGCT CCCCCAGTAT 
GGCGGCCGCA AGATTCTCGT CTGTTCTGTG GACAACTGTT ACTGTTCTTC CGTGGCCAAC 
CATGGCGGCC ACCAGCCCTA CCCCCGCTCC GGCCACTTTC CCTGGACAGT GCCCTCGCAG 
GAGTACTCAC ACCCGCTCCC GCCCACACCC TCCGTCCCCC AGTCCCTTCC CAGCCTGGCG 
GTCAGAGACT GGCTTGACGC CTCCCAGCAG CCCGGCCACC AGGATTTCTA CAGGGTGTAT 
GGGCAGCCGT CCACCAAACA CTACGTGACG AGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112174.2
CDS	124..1779
Translation	MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPECNQAYNQKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCRRGPPLPAQKVCLRCEAPCCQSHVQTHLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQYCCYYSGAHQGHSVCDVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLESDKRLVEEKVNQLKEEVRLQYEKLHQLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERMQEAKKLLGSLQLLFDKTEDVSFMKNTKSVKILMDRTQTCTSSSLSPTKIGHLNSKLFLNEVAKKEKQLRKMLEGPFSTPVPFLQSVPLYPCGVSSSGAEKRKHSTAFPEASFLETSSGPVGGQYGAAGTASGEGQSGQPLGPCSSTQHLVALPGGAQPVHSSPVFPPSQYPNGSAAQQPMLPQYGGRKILVCSVDNCYCSSVANHGGHQPYPRSGHFPWTVPSQEYSHPLPPTPSVPQSLPSLAVRDWLDASQQPGHQDFYRVYGQPSTKHYVTS

Target ORF information:

RefSeq Version	NM_030912.2
Organism	Homo sapiens(human)
Definition	Homo sapiens tripartite motif containing 8 (TRIM8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030912.2

ORF Insert Sequence:

ATGGCGGAGA ATTGGAAGAA CTGCTTCGAG GAGGAGCTCA TCTGCCCTAT CTGCCTGCAC 
GTTTTCGTGG AGCCAGTGCA GCTGCCGTGC AAACACAACT TCTGCCGGGG CTGCATCGGC 
GAGGCGTGGG CCAAGGACAG CGGCCTCGTA CGCTGCCCAG AGTGCAACCA GGCCTACAAC 
CAGAAGCCGG GCCTGGAGAA GAACCTGAAG CTCACCAACA TCGTGGAGAA GTTCAATGCC 
CTGCACGTGG AGAAGCCGCC GGCGGCGCTG CACTGCGTGT TCTGCCGCCG CGGCCCCCCG 
CTGCCCGCGC AGAAGGTCTG CCTGCGCTGC GAGGCGCCCT GCTGCCAGTC CCACGTGCAG 
ACGCACCTGC AGCAGCCCTC CACCGCCCGC GGGCACCTCC TGGTGGAGGC GGACGACGTG 
CGGGCCTGGA GCTGCCCGCA GCACAACGCC TACCGCCTCT ACCACTGCGA GGCCGAGCAG 
GTGGCCGTGT GCCAGTACTG CTGCTACTAC AGCGGCGCGC ATCAGGGACA CTCGGTGTGC 
GACGTGGAGA TCCGAAGGAA TGAAATCCGG AAGATGCTCA TGAAGCAGCA GGACCGGCTG 
GAGGAGCGAG AGCAGGACAT TGAGGACCAG CTGTACAAAC TCGAGTCAGA CAAGCGCCTG 
GTGGAGGAGA AAGTGAACCA ACTGAAGGAG GAAGTTCGGC TGCAGTACGA GAAGCTGCAC 
CAGCTGCTGG ACGAGGACCT GCGGCAGACA GTGGAGGTCC TAGACAAGGC CCAGGCCAAG 
TTCTGCAGCG AGAACGCAGC GCAGGCGCTG CACCTCGGGG AGCGCATGCA GGAGGCCAAG 
AAGCTGCTGG GCTCCCTGCA GCTGCTCTTT GATAAGACGG AGGATGTCAG CTTCATGAAG 
AACACCAAGT CTGTGAAAAT CCTGATGGAC AGGACCCAGA CCTGCACGAG CAGCAGCCTT 
TCCCCCACTA AGATCGGCCA CCTGAACTCC AAGCTCTTCC TGAACGAAGT GGCCAAGAAG 
GAGAAGCAGC TGCGGAAAAT GCTAGAAGGC CCCTTCAGCA CGCCGGTGCC CTTCCTGCAG 
AGTGTCCCCC TGTACCCTTG CGGCGTGAGC AGCTCTGGGG CGGAAAAGCG CAAGCACTCA 
ACGGCCTTCC CAGAGGCCAG TTTCCTAGAG ACGTCGTCGG GCCCTGTGGG CGGCCAGTAC 
GGGGCGGCGG GCACAGCCAG CGGTGAGGGC CAGTCTGGGC AGCCCCTGGG GCCCTGCAGC 
TCCACGCAGC ACTTGGTGGC CCTGCCGGGC GGCGCCCAAC CAGTGCACTC AAGCCCCGTG 
TTCCCCCCAT CGCAGTATCC CAATGGCTCC GCCGCCCAGC AGCCCATGCT CCCCCAGTAT 
GGCGGCCGCA AGATTCTCGT CTGTTCTGTG GACAACTGTT ACTGTTCTTC CGTGGCCAAC 
CATGGCGGCC ACCAGCCCTA CCCCCGCTCC GGCCACTTTC CCTGGACAGT GCCCTCGCAG 
GAGTACTCAC ACCCGCTCCC GCCCACACCC TCCGTCCCCC AGTCCCTTCC CAGCCTGGCG 
GTCAGAGACT GGCTTGACGC CTCCCAGCAG CCCGGCCACC AGGATTTCTA CAGGGTGTAT 
GGGCAGCCGT CCACCAAACA CTACGTGACG AGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TRIM8 ( NM_001345950.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001332879.1 Homo sapiens tripartite motif containing 8 (TRIM8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu72942
Clone ID Related Accession (Same CDS sequence)	NM_001345950.1
Accession Version	NM_001345950.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1560bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-30
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase TRIM8 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL391121.29. Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ923995.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAGA ATTGGAAGAA CTGCTTCGAG GAGGAGCTCA TCTGCCCTAT CTGCCTGCAC 
GTTTTCGTGG AGCCAGTGCA GCTGCCGTGC AAACACAACT TCTGCCGGGG CTGCATCGGC 
GAGGCGTGGG CCAAGGACAG CGGCCTCGTA CGCTGCCCAG AGTGCAACCA GGCCTACAAC 
CAGAAGCCGG GCCTGGAGAA GAACCTGAAG CTCACCAACA TCGTGGAGAA GTTCAATGCC 
CTGCACGTGG AGAAGCCGCC GGCGGCGCTG CACTGCGTGT TCTGCCGCCG CGGCCCCCCG 
CTGCCCGCGC AGAAGGTCTG CCTGCGCTGC GAGGCGCCCT GCTGCCAGTC CCACGTGCAG 
ACGCACCTGC AGCAGCCCTC CACCGCCCGC GGGCACCTCC TGGTGGAGGC GGACGACGTG 
CGGGCCTGGA GCTGCCCGCA GCACAACGCC TACCGCCTCT ACCACTGCGA GGCCGAGCAG 
GTGGCCGTGT GCCAGTACTG CTGCTACTAC AGCGGCGCGC ATCAGGGACA CTCGGTGTGC 
GACGTGGAGA TCCGAAGGAA TGAAATCCGG GAGAAAGTGA ACCAACTGAA GGAGGAAGTT 
CGGCTGCAGT ACGAGAAGCT GCACCAGCTG CTGGACGAGG ACCTGCGGCA GACAGTGGAG 
GTCCTAGACA AGGCCCAGGC CAAGTTCTGC AGCGAGAACG CAGCGCAGGC GCTGCACCTC 
GGGGAGCGCA TGCAGGAGGC CAAGAAGCTG CTGGGCTCCC TGCAGCTGCT CTTTGATAAG 
ACGGAGGATG TCAGCTTCAT GAAGAACACC AAGTCTGTGA AAATCCTGAT GGACAGGACC 
CAGACCTGCA CGAGCAGCAG CCTTTCCCCC ACTAAGATCG GCCACCTGAA CTCCAAGCTC 
TTCCTGAACG AAGTGGCCAA GAAGGAGAAG CAGCTGCGGA AAATGCTAGA AGGCCCCTTC 
AGCACGCCGG TGCCCTTCCT GCAGAGTGTC CCCCTGTACC CTTGCGGCGT GAGCAGCTCT 
GGGGCGGAAA AGCGCAAGCA CTCAACGGCC TTCCCAGAGG CCAGTTTCCT AGAGACGTCG 
TCGGGCCCTG TGGGCGGCCA GTACGGGGCG GCGGGCACAG CCAGCGGTGA GGGCCAGTCT 
GGGCAGCCCC TGGGGCCCTG CAGCTCCACG CAGCACTTGG TGGCCCTGCC GGGCGGCGCC 
CAACCAGTGC ACTCAAGCCC CGTGTTCCCC CCATCGCAGT ATCCCAATGG CTCCGCCGCC 
CAGCAGCCCA TGCTCCCCCA GTATGGCGGC CGCAAGATTC TCGTCTGTTC TGTGGACAAC 
TGTTACTGTT CTTCCGTGGC CAACCATGGC GGCCACCAGC CCTACCCCCG CTCCGGCCAC 
TTTCCCTGGA CAGTGCCCTC GCAGGAGTAC TCACACCCGC TCCCGCCCAC ACCCTCCGTC 
CCCCAGTCCC TTCCCAGCCT GGCGGTCAGA GACTGGCTTG ACGCCTCCCA GCAGCCCGGC 
CACCAGGATT TCTACAGGGT GTATGGGCAG CCGTCCACCA AACACTACGT GACGAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001332879.1
CDS	124..1683
Translation	MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPECNQAYNQKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCRRGPPLPAQKVCLRCEAPCCQSHVQTHLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQYCCYYSGAHQGHSVCDVEIRRNEIREKVNQLKEEVRLQYEKLHQLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERMQEAKKLLGSLQLLFDKTEDVSFMKNTKSVKILMDRTQTCTSSSLSPTKIGHLNSKLFLNEVAKKEKQLRKMLEGPFSTPVPFLQSVPLYPCGVSSSGAEKRKHSTAFPEASFLETSSGPVGGQYGAAGTASGEGQSGQPLGPCSSTQHLVALPGGAQPVHSSPVFPPSQYPNGSAAQQPMLPQYGGRKILVCSVDNCYCSSVANHGGHQPYPRSGHFPWTVPSQEYSHPLPPTPSVPQSLPSLAVRDWLDASQQPGHQDFYRVYGQPSTKHYVTS

Target ORF information:

RefSeq Version	NM_001345950.1
Organism	Homo sapiens(human)
Definition	Homo sapiens tripartite motif containing 8 (TRIM8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001345950.1

ORF Insert Sequence:

ATGGCGGAGA ATTGGAAGAA CTGCTTCGAG GAGGAGCTCA TCTGCCCTAT CTGCCTGCAC 
GTTTTCGTGG AGCCAGTGCA GCTGCCGTGC AAACACAACT TCTGCCGGGG CTGCATCGGC 
GAGGCGTGGG CCAAGGACAG CGGCCTCGTA CGCTGCCCAG AGTGCAACCA GGCCTACAAC 
CAGAAGCCGG GCCTGGAGAA GAACCTGAAG CTCACCAACA TCGTGGAGAA GTTCAATGCC 
CTGCACGTGG AGAAGCCGCC GGCGGCGCTG CACTGCGTGT TCTGCCGCCG CGGCCCCCCG 
CTGCCCGCGC AGAAGGTCTG CCTGCGCTGC GAGGCGCCCT GCTGCCAGTC CCACGTGCAG 
ACGCACCTGC AGCAGCCCTC CACCGCCCGC GGGCACCTCC TGGTGGAGGC GGACGACGTG 
CGGGCCTGGA GCTGCCCGCA GCACAACGCC TACCGCCTCT ACCACTGCGA GGCCGAGCAG 
GTGGCCGTGT GCCAGTACTG CTGCTACTAC AGCGGCGCGC ATCAGGGACA CTCGGTGTGC 
GACGTGGAGA TCCGAAGGAA TGAAATCCGG GAGAAAGTGA ACCAACTGAA GGAGGAAGTT 
CGGCTGCAGT ACGAGAAGCT GCACCAGCTG CTGGACGAGG ACCTGCGGCA GACAGTGGAG 
GTCCTAGACA AGGCCCAGGC CAAGTTCTGC AGCGAGAACG CAGCGCAGGC GCTGCACCTC 
GGGGAGCGCA TGCAGGAGGC CAAGAAGCTG CTGGGCTCCC TGCAGCTGCT CTTTGATAAG 
ACGGAGGATG TCAGCTTCAT GAAGAACACC AAGTCTGTGA AAATCCTGAT GGACAGGACC 
CAGACCTGCA CGAGCAGCAG CCTTTCCCCC ACTAAGATCG GCCACCTGAA CTCCAAGCTC 
TTCCTGAACG AAGTGGCCAA GAAGGAGAAG CAGCTGCGGA AAATGCTAGA AGGCCCCTTC 
AGCACGCCGG TGCCCTTCCT GCAGAGTGTC CCCCTGTACC CTTGCGGCGT GAGCAGCTCT 
GGGGCGGAAA AGCGCAAGCA CTCAACGGCC TTCCCAGAGG CCAGTTTCCT AGAGACGTCG 
TCGGGCCCTG TGGGCGGCCA GTACGGGGCG GCGGGCACAG CCAGCGGTGA GGGCCAGTCT 
GGGCAGCCCC TGGGGCCCTG CAGCTCCACG CAGCACTTGG TGGCCCTGCC GGGCGGCGCC 
CAACCAGTGC ACTCAAGCCC CGTGTTCCCC CCATCGCAGT ATCCCAATGG CTCCGCCGCC 
CAGCAGCCCA TGCTCCCCCA GTATGGCGGC CGCAAGATTC TCGTCTGTTC TGTGGACAAC 
TGTTACTGTT CTTCCGTGGC CAACCATGGC GGCCACCAGC CCTACCCCCG CTCCGGCCAC 
TTTCCCTGGA CAGTGCCCTC GCAGGAGTAC TCACACCCGC TCCCGCCCAC ACCCTCCGTC 
CCCCAGTCCC TTCCCAGCCT GGCGGTCAGA GACTGGCTTG ACGCCTCCCA GCAGCCCGGC 
CACCAGGATT TCTACAGGGT GTATGGGCAG CCGTCCACCA AACACTACGT GACGAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours.
Molecular cancer16(1)67(2017 03)
Mastropasqua F,Marzano F,Valletti A,Aiello I,Di Tullio G,Morgano A,Liuni S,Ranieri E,Guerrini L,Gasparre G,Sbis? E,Pesole G,Moschetta A,Caratozzolo MF,Tullo A

TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3.
Molecular oncology11(3)280-294(2017 Mar)
Zhang C,Mukherjee S,Tucker-Burden C,Ross JL,Chau MJ,Kong J,Brat DJ

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TRIM8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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