TUBB1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TUBB1
Entrez Gene ID	81027
Full Name	tubulin beta 1 class VI
General protein information	Preferred Names tubulin beta 1 class VI Names tubulin beta-1 chain tubulin, beta 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.32
Summary	This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.[provided by RefSeq, Jul 2010].
Disorder MIM:	612901
Disorder Html:	Macrothrombocytopenia, autosomal dominant, TUBB1-related, 613112 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_030773.4	NP_110400.1	tubulin beta-1 chain
NM_030773.3	NP_110400.1	tubulin beta-1 chain
XM_017028085.1	XP_016883574.1	tubulin beta-1 chain isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	TUBB1	NP_110400.1
Rattus norvegicus (Norway rat)	Tubb1	XP_003749686.1
Danio rerio (zebrafish)	tubb1	XP_005172182.1
Xenopus tropicalis (tropical clawed frog)	LOC100498230	XP_002941758.2
Pan troglodytes (chimpanzee)	TUBB1	XP_001140173.1
Canis lupus familiaris (dog)	TUBB1	XP_005635298.1
	TUBB1	XP_001082345.1
Gallus gallus (chicken)	TUBB1	NP_990776.1
Bos taurus (cattle)	TUBB1	NP_001137572.1
Mus musculus (house mouse)	Tubb1	NP_001074440.1

Gene Ontology
Bibliography

Related articles in PubMed

Down Regulation of the Munc18b-syntaxin-11 Complex and ?1-tubulin Impairs Secretion and Spreading in Neonatal Platelets.
Caparr?s-P?rez E, Teruel-Montoya R, Palma-Barquero V, Torregrosa JM, Blanco JE, Delgado JL, Lozano ML, Vicente V, Sola-Visner M, Rivera J, Mart?nez C, Ferrer-Mar?n F
Thrombosis and haemostasis117(11)2079-2091(2017 Nov)

A new mutation in TUBB1 associated with thrombocytopenia confirms that C-terminal part of ?1-tubulin plays a role in microtubule assembly.
Fiore M, Goulas C, Pillois X
Clinical genetics91(6)924-926(2017 Jun)

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

novel DCX mutation (p.D90G, NP_000546.2) appeared to be a major causative variant, whereas the novel mutation of TUBB1 (p.R62fsX, NP_110400.1) was found only in patients with more-severe intellectual disability in Familial pachygyria
Title: Familial pachygyria in both genders related to a DCX mutation.

Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze type.
Title: Mutations in Either TUBB or MAPRE2 Cause Circumferential Skin Creases Kunze Type.

TUBB1 R307H SNP is significantly associated with the degree of thrombocytopenia in congenital and acquired platelet disorders, and may affect platelets by altering microtubule behavior.
Title: ?-1 tubulin R307H SNP alters microtubule dynamics and affects severity of a hereditary thrombocytopenia.

Analysis of the TUBB1 gene revealed three known missense variants in heterozygous state which in combination might explain the beta1-tubulin defect.
Title: Congenital macrothrombocytopenia associated with a combination of functional polymorphisms in the TUBB1 gene.

Data indicate that ABCB1 protein, beta tubulin I and III (betaI, and betaIII tubulin) might contribute to the multidrug resistance (MDR) of MCF7/DOC and be potential therapeutic targets for overcoming MDR of breast cancer.
Title: Association of ABCB1, ? tubulin I, and III with multidrug resistance of MCF7/DOC subline from breast cancer cell line MCF7.

The following TUBB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TUBB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21629	NM_030773.4 Latest version!	Homo sapiens tubulin beta 1 class VI (TUBB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu93126	XM_017028085.1 Latest version!	Homo sapiens tubulin beta 1 class VI (TUBB1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu21629	NM_030773.3	Homo sapiens tubulin beta 1 class VI (TUBB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TUBB1 ( NM_030773.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_110400.1 Homo sapiens tubulin beta 1 class VI (TUBB1), mRNA.

Price & Availability↑

CloneID	OHu21629
Clone ID Related Accession (Same CDS sequence)	NM_030773.4 , NM_030773.3
Accession Version	NM_030773.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1356bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Homo sapiens(human)
Product	tubulin beta-1 chain
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ292757.1 and AL109840.24. On Aug 31, 2019 this sequence version replaced NM_030773.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ292757.1, BC033679.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGTGAAA TTGTCCATAT TCAGATTGGC CAGTGTGGCA ACCAGATCGG AGCCAAGTTC 
TGGGAGATGA TTGGTGAGGA ACACGGGATC GACTTGGCTG GGAGCGACCG CGGGGCCTCG 
GCCTTGCAGC TGGAGAGAAT CAGCGTGTAC TACAACGAAG CCTACGGTAG GAAATATGTG 
CCCCGAGCAG TCTTGGTGGA CCTAGAACCT GGGACGATGG ACAGCATTCG ATCTAGCAAA 
TTAGGAGCTC TCTTTCAACC CGACAGTTTT GTCCATGGTA ACTCTGGGGC TGGCAACAAC 
TGGGCCAAAG GCCACTACAC GGAGGGAGCC GAGCTGATCG AGAATGTCCT AGAGGTGGTG 
AGGCACGAGA GTGAGAGCTG TGACTGCCTG CAGGGCTTCC AGATCGTCCA CTCCCTGGGC 
GGGGGCACAG GCTCCGGGAT GGGCACTCTG CTCATGAACA AGATTAGAGA GGAGTACCCG 
GACCGGATCA TGAATTCCTT CAGCGTCATG CCTTCTCCCA AGGTGTCGGA CACTGTGGTG 
GAGCCCTACA ACGCGGTTCT GTCTATCCAC CAGCTGATTG AGAATGCAGA TGCCTGTTTC 
TGCATTGACA ATGAGGCCCT CTATGACATC TGCTTCCGTA CCCTGAAGCT GACGACACCC 
ACCTATGGGG ATCTCAACCA CCTAGTGTCC TTGACCATGA GCGGCATAAC CACCTCCCTC 
CGGTTCCCGG GTCAGCTCAA CGCAGACCTG CGCAAGCTGG CGGTGAACAT GGTCCCCTTC 
CCCCGCCTGC ACTTCTTTAT GCCCGGCTTT GCCCCACTCA CGGCCCAGGG CAGCCAGCAG 
TACCGAGCCC TCTCCGTGGC CGAGCTCACC CAGCAGATGT TCGATGCCCG CAATACCATG 
GCTGCCTGTG ACCTCCGCCG TGGCCGCTAC CTCACAGTGG CCTGCATTTT CCGGGGCAAG 
ATGTCCACCA AGGAAGTGGA CCAGCAACTG CTCTCCGTGC AGACCAGGAA CAGCAGCTGC 
TTTGTGGAGT GGATTCCCAA CAACGTCAAG GTGGCTGTCT GCGACATCCC GCCCCGGGGG 
CTGAGCATGG CCGCCACCTT CATTGGCAAC AACACGGCCA TCCAAGAGAT CTTTAATAGG 
GTCTCTGAGC ATTTCTCAGC CATGTTCAAA AGGAAAGCTT TTGTGCACTG GTACACCAGC 
GAAGGGATGG ACATAAACGA ATTTGGGGAA GCTGAAAATA ACATCCATGA TTTGGTATCC 
GAGTACCAAC AATTTCAAGA TGCCAAAGCA GTTCTAGAGG AAGATGAAGA GGTCACGGAG 
GAGGCAGAAA TGGAGCCAGA AGATAAGGGA CATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110400.1
CDS	95..1450
Translation	MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYVPRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVVRHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTMAACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRGLSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVSEYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH

Target ORF information:

RefSeq Version	NM_030773.4
Organism	Homo sapiens(human)
Definition	Homo sapiens tubulin beta 1 class VI (TUBB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030773.4

ORF Insert Sequence:

ATGCGTGAAA TTGTCCATAT TCAGATTGGC CAGTGTGGCA ACCAGATCGG AGCCAAGTTC 
TGGGAGATGA TTGGTGAGGA ACACGGGATC GACTTGGCTG GGAGCGACCG CGGGGCCTCG 
GCCTTGCAGC TGGAGAGAAT CAGCGTGTAC TACAACGAAG CCTACGGTAG GAAATATGTG 
CCCCGAGCAG TCTTGGTGGA CCTAGAACCT GGGACGATGG ACAGCATTCG ATCTAGCAAA 
TTAGGAGCTC TCTTTCAACC CGACAGTTTT GTCCATGGTA ACTCTGGGGC TGGCAACAAC 
TGGGCCAAAG GCCACTACAC GGAGGGAGCC GAGCTGATCG AGAATGTCCT AGAGGTGGTG 
AGGCACGAGA GTGAGAGCTG TGACTGCCTG CAGGGCTTCC AGATCGTCCA CTCCCTGGGC 
GGGGGCACAG GCTCCGGGAT GGGCACTCTG CTCATGAACA AGATTAGAGA GGAGTACCCG 
GACCGGATCA TGAATTCCTT CAGCGTCATG CCTTCTCCCA AGGTGTCGGA CACTGTGGTG 
GAGCCCTACA ACGCGGTTCT GTCTATCCAC CAGCTGATTG AGAATGCAGA TGCCTGTTTC 
TGCATTGACA ATGAGGCCCT CTATGACATC TGCTTCCGTA CCCTGAAGCT GACGACACCC 
ACCTATGGGG ATCTCAACCA CCTAGTGTCC TTGACCATGA GCGGCATAAC CACCTCCCTC 
CGGTTCCCGG GTCAGCTCAA CGCAGACCTG CGCAAGCTGG CGGTGAACAT GGTCCCCTTC 
CCCCGCCTGC ACTTCTTTAT GCCCGGCTTT GCCCCACTCA CGGCCCAGGG CAGCCAGCAG 
TACCGAGCCC TCTCCGTGGC CGAGCTCACC CAGCAGATGT TCGATGCCCG CAATACCATG 
GCTGCCTGTG ACCTCCGCCG TGGCCGCTAC CTCACAGTGG CCTGCATTTT CCGGGGCAAG 
ATGTCCACCA AGGAAGTGGA CCAGCAACTG CTCTCCGTGC AGACCAGGAA CAGCAGCTGC 
TTTGTGGAGT GGATTCCCAA CAACGTCAAG GTGGCTGTCT GCGACATCCC GCCCCGGGGG 
CTGAGCATGG CCGCCACCTT CATTGGCAAC AACACGGCCA TCCAAGAGAT CTTTAATAGG 
GTCTCTGAGC ATTTCTCAGC CATGTTCAAA AGGAAAGCTT TTGTGCACTG GTACACCAGC 
GAAGGGATGG ACATAAACGA ATTTGGGGAA GCTGAAAATA ACATCCATGA TTTGGTATCC 
GAGTACCAAC AATTTCAAGA TGCCAAAGCA GTTCTAGAGG AAGATGAAGA GGTCACGGAG 
GAGGCAGAAA TGGAGCCAGA AGATAAGGGA CATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TUBB1 ( NM_030773.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_110400.1 Homo sapiens tubulin beta 1 class VI (TUBB1), mRNA.

Price & Availability↑

CloneID	OHu21629
Clone ID Related Accession (Same CDS sequence)	NM_030773.4 , NM_030773.3
Accession Version	NM_030773.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1356bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	tubulin beta-1 chain
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ292757.1 and AL109840.24. This sequence is a reference standard in the RefSeqGene project. On Jul 21, 2010 this sequence version replaced NM_030773.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ292757.1, BC033679.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144333, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGTGAAA TTGTCCATAT TCAGATTGGC CAGTGTGGCA ACCAGATCGG AGCCAAGTTC 
TGGGAGATGA TTGGTGAGGA ACACGGGATC GACTTGGCTG GGAGCGACCG CGGGGCCTCG 
GCCTTGCAGC TGGAGAGAAT CAGCGTGTAC TACAACGAAG CCTACGGTAG GAAATATGTG 
CCCCGAGCAG TCTTGGTGGA CCTAGAACCT GGGACGATGG ACAGCATTCG ATCTAGCAAA 
TTAGGAGCTC TCTTTCAACC CGACAGTTTT GTCCATGGTA ACTCTGGGGC TGGCAACAAC 
TGGGCCAAAG GCCACTACAC GGAGGGAGCC GAGCTGATCG AGAATGTCCT AGAGGTGGTG 
AGGCACGAGA GTGAGAGCTG TGACTGCCTG CAGGGCTTCC AGATCGTCCA CTCCCTGGGC 
GGGGGCACAG GCTCCGGGAT GGGCACTCTG CTCATGAACA AGATTAGAGA GGAGTACCCG 
GACCGGATCA TGAATTCCTT CAGCGTCATG CCTTCTCCCA AGGTGTCGGA CACTGTGGTG 
GAGCCCTACA ACGCGGTTCT GTCTATCCAC CAGCTGATTG AGAATGCAGA TGCCTGTTTC 
TGCATTGACA ATGAGGCCCT CTATGACATC TGCTTCCGTA CCCTGAAGCT GACGACACCC 
ACCTATGGGG ATCTCAACCA CCTAGTGTCC TTGACCATGA GCGGCATAAC CACCTCCCTC 
CGGTTCCCGG GTCAGCTCAA CGCAGACCTG CGCAAGCTGG CGGTGAACAT GGTCCCCTTC 
CCCCGCCTGC ACTTCTTTAT GCCCGGCTTT GCCCCACTCA CGGCCCAGGG CAGCCAGCAG 
TACCGAGCCC TCTCCGTGGC CGAGCTCACC CAGCAGATGT TCGATGCCCG CAATACCATG 
GCTGCCTGTG ACCTCCGCCG TGGCCGCTAC CTCACAGTGG CCTGCATTTT CCGGGGCAAG 
ATGTCCACCA AGGAAGTGGA CCAGCAACTG CTCTCCGTGC AGACCAGGAA CAGCAGCTGC 
TTTGTGGAGT GGATTCCCAA CAACGTCAAG GTGGCTGTCT GCGACATCCC GCCCCGGGGG 
CTGAGCATGG CCGCCACCTT CATTGGCAAC AACACGGCCA TCCAAGAGAT CTTTAATAGG 
GTCTCTGAGC ATTTCTCAGC CATGTTCAAA AGGAAAGCTT TTGTGCACTG GTACACCAGC 
GAAGGGATGG ACATAAACGA ATTTGGGGAA GCTGAAAATA ACATCCATGA TTTGGTATCC 
GAGTACCAAC AATTTCAAGA TGCCAAAGCA GTTCTAGAGG AAGATGAAGA GGTCACGGAG 
GAGGCAGAAA TGGAGCCAGA AGATAAGGGA CATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110400.1
CDS	270..1625
Translation	MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYVPRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVVRHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTMAACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRGLSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVSEYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH

Target ORF information:

RefSeq Version	NM_030773.3
Organism	Homo sapiens(human)
Definition	Homo sapiens tubulin beta 1 class VI (TUBB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030773.3

ORF Insert Sequence:

ATGCGTGAAA TTGTCCATAT TCAGATTGGC CAGTGTGGCA ACCAGATCGG AGCCAAGTTC 
TGGGAGATGA TTGGTGAGGA ACACGGGATC GACTTGGCTG GGAGCGACCG CGGGGCCTCG 
GCCTTGCAGC TGGAGAGAAT CAGCGTGTAC TACAACGAAG CCTACGGTAG GAAATATGTG 
CCCCGAGCAG TCTTGGTGGA CCTAGAACCT GGGACGATGG ACAGCATTCG ATCTAGCAAA 
TTAGGAGCTC TCTTTCAACC CGACAGTTTT GTCCATGGTA ACTCTGGGGC TGGCAACAAC 
TGGGCCAAAG GCCACTACAC GGAGGGAGCC GAGCTGATCG AGAATGTCCT AGAGGTGGTG 
AGGCACGAGA GTGAGAGCTG TGACTGCCTG CAGGGCTTCC AGATCGTCCA CTCCCTGGGC 
GGGGGCACAG GCTCCGGGAT GGGCACTCTG CTCATGAACA AGATTAGAGA GGAGTACCCG 
GACCGGATCA TGAATTCCTT CAGCGTCATG CCTTCTCCCA AGGTGTCGGA CACTGTGGTG 
GAGCCCTACA ACGCGGTTCT GTCTATCCAC CAGCTGATTG AGAATGCAGA TGCCTGTTTC 
TGCATTGACA ATGAGGCCCT CTATGACATC TGCTTCCGTA CCCTGAAGCT GACGACACCC 
ACCTATGGGG ATCTCAACCA CCTAGTGTCC TTGACCATGA GCGGCATAAC CACCTCCCTC 
CGGTTCCCGG GTCAGCTCAA CGCAGACCTG CGCAAGCTGG CGGTGAACAT GGTCCCCTTC 
CCCCGCCTGC ACTTCTTTAT GCCCGGCTTT GCCCCACTCA CGGCCCAGGG CAGCCAGCAG 
TACCGAGCCC TCTCCGTGGC CGAGCTCACC CAGCAGATGT TCGATGCCCG CAATACCATG 
GCTGCCTGTG ACCTCCGCCG TGGCCGCTAC CTCACAGTGG CCTGCATTTT CCGGGGCAAG 
ATGTCCACCA AGGAAGTGGA CCAGCAACTG CTCTCCGTGC AGACCAGGAA CAGCAGCTGC 
TTTGTGGAGT GGATTCCCAA CAACGTCAAG GTGGCTGTCT GCGACATCCC GCCCCGGGGG 
CTGAGCATGG CCGCCACCTT CATTGGCAAC AACACGGCCA TCCAAGAGAT CTTTAATAGG 
GTCTCTGAGC ATTTCTCAGC CATGTTCAAA AGGAAAGCTT TTGTGCACTG GTACACCAGC 
GAAGGGATGG ACATAAACGA ATTTGGGGAA GCTGAAAATA ACATCCATGA TTTGGTATCC 
GAGTACCAAC AATTTCAAGA TGCCAAAGCA GTTCTAGAGG AAGATGAAGA GGTCACGGAG 
GAGGCAGAAA TGGAGCCAGA AGATAAGGGA CATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TUBB1 ( XM_017028085.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016883574.1 Homo sapiens tubulin beta 1 class VI (TUBB1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu93126
Clone ID Related Accession (Same CDS sequence)	XM_017028085.1
Accession Version	XM_017028085.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1290bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	tubulin beta-1 chain isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATTGGTG AGGAACACGG GATCGACTTG GCTGGGAGCG ACCGCGGGGC CTCGGCCTTG 
CAGCTGGAGA GAATCAGCGT GTACTACAAC GAAGCCTACG GTAGGAAATA TGTGCCCCGA 
GCAGTCTTGG TGGACCTAGA ACCTGGGACG ATGGACAGCA TTCGATCTAG CAAATTAGGA 
GCTCTCTTTC AACCCGACAG TTTTGTCCAT GGTAACTCTG GGGCTGGCAA CAACTGGGCC 
AAAGGCCACT ACACGGAGGG AGCCGAGCTG ATCGAGAATG TCCTAGAGGT GGTGAGGCAC 
GAGAGTGAGA GCTGTGACTG CCTGCAGGGC TTCCAGATCG TCCACTCCCT GGGCGGGGGC 
ACAGGCTCCG GGATGGGCAC TCTGCTCATG AACAAGATTA GAGAGGAGTA CCCGGACCGG 
ATCATGAATT CCTTCAGCGT CATGCCTTCT CCCAAGGTGT CGGACACTGT GGTGGAGCCC 
TACAACGCGG TTCTGTCTAT CCACCAGCTG ATTGAGAATG CAGATGCCTG TTTCTGCATT 
GACAATGAGG CCCTCTATGA CATCTGCTTC CGTACCCTGA AGCTGACGAC ACCCACCTAT 
GGGGATCTCA ACCACCTAGT GTCCTTGACC ATGAGCGGCA TAACCACCTC CCTCCGGTTC 
CCGGGTCAGC TCAACGCAGA CCTGCGCAAG CTGGCGGTGA ACATGGTCCC CTTCCCCCGC 
CTGCACTTCT TTATGCCCGG CTTTGCCCCA CTCACGGCCC AGGGCAGCCA GCAGTACCGA 
GCCCTCTCCG TGGCCGAGCT CACCCAGCAG ATGTTCGATG CCCGCAATAC CATGGCTGCC 
TGTGACCTCC GCCGTGGCCG CTACCTCACA GTGGCCTGCA TTTTCCGGGG CAAGATGTCC 
ACCAAGGAAG TGGACCAGCA ACTGCTCTCC GTGCAGACCA GGAACAGCAG CTGCTTTGTG 
GAGTGGATTC CCAACAACGT CAAGGTGGCT GTCTGCGACA TCCCGCCCCG GGGGCTGAGC 
ATGGCCGCCA CCTTCATTGG CAACAACACG GCCATCCAAG AGATCTTTAA TAGGGTCTCT 
GAGCATTTCT CAGCCATGTT CAAAAGGAAA GCTTTTGTGC ACTGGTACAC CAGCGAAGGG 
ATGGACATAA ACGAATTTGG GGAAGCTGAA AATAACATCC ATGATTTGGT ATCCGAGTAC 
CAACAATTTC AAGATGCCAA AGCAGTTCTA GAGGAAGATG AAGAGGTCAC GGAGGAGGCA 
GAAATGGAGC CAGAAGATAA GGGACATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016883574.1
CDS	530..1819
Translation	MIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYVPRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVVRHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTMAACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRGLSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVSEYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH

Target ORF information:

RefSeq Version	XM_017028085.1
Organism	Homo sapiens(human)
Definition	Homo sapiens tubulin beta 1 class VI (TUBB1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017028085.1

ORF Insert Sequence:

ATGATTGGTG AGGAACACGG GATCGACTTG GCTGGGAGCG ACCGCGGGGC CTCGGCCTTG 
CAGCTGGAGA GAATCAGCGT GTACTACAAC GAAGCCTACG GTAGGAAATA TGTGCCCCGA 
GCAGTCTTGG TGGACCTAGA ACCTGGGACG ATGGACAGCA TTCGATCTAG CAAATTAGGA 
GCTCTCTTTC AACCCGACAG TTTTGTCCAT GGTAACTCTG GGGCTGGCAA CAACTGGGCC 
AAAGGCCACT ACACGGAGGG AGCCGAGCTG ATCGAGAATG TCCTAGAGGT GGTGAGGCAC 
GAGAGTGAGA GCTGTGACTG CCTGCAGGGC TTCCAGATCG TCCACTCCCT GGGCGGGGGC 
ACAGGCTCCG GGATGGGCAC TCTGCTCATG AACAAGATTA GAGAGGAGTA CCCGGACCGG 
ATCATGAATT CCTTCAGCGT CATGCCTTCT CCCAAGGTGT CGGACACTGT GGTGGAGCCC 
TACAACGCGG TTCTGTCTAT CCACCAGCTG ATTGAGAATG CAGATGCCTG TTTCTGCATT 
GACAATGAGG CCCTCTATGA CATCTGCTTC CGTACCCTGA AGCTGACGAC ACCCACCTAT 
GGGGATCTCA ACCACCTAGT GTCCTTGACC ATGAGCGGCA TAACCACCTC CCTCCGGTTC 
CCGGGTCAGC TCAACGCAGA CCTGCGCAAG CTGGCGGTGA ACATGGTCCC CTTCCCCCGC 
CTGCACTTCT TTATGCCCGG CTTTGCCCCA CTCACGGCCC AGGGCAGCCA GCAGTACCGA 
GCCCTCTCCG TGGCCGAGCT CACCCAGCAG ATGTTCGATG CCCGCAATAC CATGGCTGCC 
TGTGACCTCC GCCGTGGCCG CTACCTCACA GTGGCCTGCA TTTTCCGGGG CAAGATGTCC 
ACCAAGGAAG TGGACCAGCA ACTGCTCTCC GTGCAGACCA GGAACAGCAG CTGCTTTGTG 
GAGTGGATTC CCAACAACGT CAAGGTGGCT GTCTGCGACA TCCCGCCCCG GGGGCTGAGC 
ATGGCCGCCA CCTTCATTGG CAACAACACG GCCATCCAAG AGATCTTTAA TAGGGTCTCT 
GAGCATTTCT CAGCCATGTT CAAAAGGAAA GCTTTTGTGC ACTGGTACAC CAGCGAAGGG 
ATGGACATAA ACGAATTTGG GGAAGCTGAA AATAACATCC ATGATTTGGT ATCCGAGTAC 
CAACAATTTC AAGATGCCAA AGCAGTTCTA GAGGAAGATG AAGAGGTCAC GGAGGAGGCA 
GAAATGGAGC CAGAAGATAA GGGACATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Down Regulation of the Munc18b-syntaxin-11 Complex and ?1-tubulin Impairs Secretion and Spreading in Neonatal Platelets.
Thrombosis and haemostasis117(11)2079-2091(2017 Nov)
Caparr?s-P?rez E,Teruel-Montoya R,Palma-Barquero V,Torregrosa JM,Blanco JE,Delgado JL,Lozano ML,Vicente V,Sola-Visner M,Rivera J,Mart?nez C,Ferrer-Mar?n F

A new mutation in TUBB1 associated with thrombocytopenia confirms that C-terminal part of ?1-tubulin plays a role in microtubule assembly.
Clinical genetics91(6)924-926(2017 Jun)
Fiore M,Goulas C,Pillois X

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Nature communications711491(2016 May)
Boldt K,van Reeuwijk J,Lu Q,Koutroumpas K,Nguyen TM,Texier Y,van Beersum SE,Horn N,Willer JR,Mans DA,Dougherty G,Lamers IJ,Coene KL,Arts HH,Betts MJ,Beyer T,Bolat E,Gloeckner CJ,Haidari K,Hetterschijt L,Iaconis D,Jenkins D,Klose F,Knapp B,Latour B,Letteboer SJ,Marcelis CL,Mitic D,Morleo M,Oud MM,Riemersma M,Rix S,Terhal PA,Toedt G,van Dam TJ,de Vrieze E,Wissinger Y,Wu KM,Apic G,Beales PL,Blacque OE,Gibson TJ,Huynen MA,Katsanis N,Kremer H,Omran H,van Wijk E,Wolfrum U,Kepes F,Davis EE,Franco B,Giles RH,Ueffing M,Russell RB,Roepman R,

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TUBB1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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