CDK2AP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CDK2AP1
Entrez Gene ID	8099
Full Name	cyclin dependent kinase 2 associated protein 1
Synonyms	DOC1,DORC1,ST19,doc-1,p12DOC-1
General protein information	Preferred Names cyclin dependent kinase 2 associated protein 1 Names cyclin-dependent kinase 2-associated protein 1 CDK2-associated protein 1 Deleted in oral cancer-1 deleted in oral cancer 1 putative oral cancer suppressor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q24.31
Summary	The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012].
Disorder MIM:	602198

mRNA and Protein(s)

mRNA	Protein	Name
NM_001270433.1	NP_001257362.1	cyclin-dependent kinase 2-associated protein 1 isoform 2
NM_004642.3	NP_004633.1	cyclin-dependent kinase 2-associated protein 1 isoform 1
NM_001270433.2	NP_001257362.1	cyclin-dependent kinase 2-associated protein 1 isoform 2
NM_004642.4	NP_004633.1	cyclin-dependent kinase 2-associated protein 1 isoform 1
NM_001270434.1	NP_001257363.1	cyclin-dependent kinase 2-associated protein 1 isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	CDK2AP1	NP_004633.1
Danio rerio (zebrafish)	LOC100535265	XP_003199445.1
Bos taurus (cattle)	CDK2AP1	NP_001069837.1
Rattus norvegicus (Norway rat)	Cdk2ap1	NP_001107223.1
Pan troglodytes (chimpanzee)	CDK2AP1	XP_003952393.1
	CDK2AP1	XP_001100820.1
Mus musculus (house mouse)	Cdk2ap1	NP_038840.2
Xenopus tropicalis (tropical clawed frog)	cdk2ap1	NP_001016730.1
Canis lupus familiaris (dog)	CDK2AP1	NP_001234905.1
Gallus gallus (chicken)	CDK2AP1	NP_001034353.2

Gene Ontology
Bibliography

Related articles in PubMed

DOC1-Dependent Recruitment of NURD Reveals Antagonism with SWI/SNF during Epithelial-Mesenchymal Transition in Oral Cancer Cells.
Mohd-Sarip A, Teeuwssen M, Bot AG, De Herdt MJ, Willems SM, Baatenburg de Jong RJ, Looijenga LHJ, Zatreanu D, Bezstarosti K, van Riet J, Oole E, van Ijcken WFJ, van de Werken HJG, Demmers JA, Fodde R, Verrijzer CP
Cell reports20(1)61-75(2017 Jul)

p12CDK2-AP1 interacts with CD82 to regulate the proliferation and survival of human oral squamous cell carcinoma cells.
Chai J, Ju J, Zhang SW, Shen ZY, Liang L, Yang XM, Ma C, Ni QW, Sun MY
Oncology reports36(2)737-44(2016 Aug)

Knockdown of CDK2AP1 in primary human fibroblasts induces p53 dependent senescence.
Alsayegh KN, Gadepalli VS, Iyer S, Rao RR
PloS one10(3)e0120782(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The simultaneous overexpression of p12CDK2-AP1 and CD82 significantly suppressed the in vivo tumor growth.
Title: p12CDK2-AP1 interacts with CD82 to regulate the proliferation and survival of human oral squamous cell carcinoma cells.

knockdown of CDK2AP1 in primary human fibroblasts reduced proliferation and induced premature senescence, with the observed phenotype being p53 dependent
Title: Knockdown of CDK2AP1 in primary human fibroblasts induces p53 dependent senescence.

In summary, p12CDK2AP1 expression in myxofibrosarcoma cells induces G0/G1 arrest and mitochondria dependent proapoptotic activity and down-regulation of p12CDK2AP1 by shRNAi results in up-regulation of the CDK2 transcript and protein.
Title: Clinical aggressiveness of myxofibrosarcomas associates with down-regulation of p12CDK2AP1: prognostic implication of a putative tumor suppressor that induces cell cycle arrest and apoptosis via mitochondrial pathway.

Study reports that knockdown of CDK2AP1 by RNAi in glioma cells could effectively inhibit cell proliferation by inducing cell cycle arrest and apoptosis
Title: Knockdown of CDK2AP1 by RNA interference inhibits cell growth and tumorigenesis of human glioma.

CDK2AP1 plays an important role in modulating the growth and tumorigenesis of lung cancer cells.
Title: Cyclin-dependent kinase 2-associated protein 1 suppresses growth and tumorigenesis of lung cancer.

The following CDK2AP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDK2AP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24735	NM_001270434.1 Latest version!	Homo sapiens cyclin dependent kinase 2 associated protein 1 (CDK2AP1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu24735	NM_001270433.2 Latest version!	Homo sapiens cyclin dependent kinase 2 associated protein 1 (CDK2AP1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu24765	NM_004642.4 Latest version!	Homo sapiens cyclin dependent kinase 2 associated protein 1 (CDK2AP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu24735	NM_001270433.1	Homo sapiens cyclin dependent kinase 2 associated protein 1 (CDK2AP1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu24765	NM_004642.3	Homo sapiens cyclin dependent kinase 2 associated protein 1 (CDK2AP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDK2AP1 ( NM_001270433.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001257362.1 Homo sapiens cyclin dependent kinase 2 associated protein 1 (CDK2AP1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu24735
Clone ID Related Accession (Same CDS sequence)	NM_001270433.1 , NM_001270433.2 , NM_001270434.1
Accession Version	NM_001270433.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 2-associated protein 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP290637.1, AF006484.1 and AA477326.1. Transcript Variant: This variant (2) differs in the 5' UTR and coding region and represents the use of an alternate promoter, compared to variant 1. This difference results in the use of an in-frame downstream start codon and a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein (isoform 2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.208377.1, SRR1163658.157076.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAACGT CTTCACAGTA CCGCCAGCTG CTCAGTGACT ACGGGCCACC GTCCCTAGGC 
TACACCCAGG GAACTGGGAA CAGCCAGGTG CCCCAAAGCA AATACGCGGA GCTGCTGGCC 
ATCATTGAAG AGCTGGGGAA GGAGATCAGA CCCACGTACG CAGGGAGCAA GAGTGCCATG 
GAGAGGCTGA AGCGCGGCAT CATTCACGCT AGAGGACTGG TTCGGGAGTG CTTGGCAGAA 
ACGGAACGGA ATGCCAGATC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001257362.1
CDS	88..351
Translation	MATSSQYRQLLSDYGPPSLGYTQGTGNSQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS

Target ORF information:

RefSeq Version	NM_001270433.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 2 associated protein 1 (CDK2AP1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001270433.1

ORF Insert Sequence:

ATGGCAACGT CTTCACAGTA CCGCCAGCTG CTCAGTGACT ACGGGCCACC GTCCCTAGGC 
TACACCCAGG GAACTGGGAA CAGCCAGGTG CCCCAAAGCA AATACGCGGA GCTGCTGGCC 
ATCATTGAAG AGCTGGGGAA GGAGATCAGA CCCACGTACG CAGGGAGCAA GAGTGCCATG 
GAGAGGCTGA AGCGCGGCAT CATTCACGCT AGAGGACTGG TTCGGGAGTG CTTGGCAGAA 
ACGGAACGGA ATGCCAGATC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDK2AP1 ( NM_001270433.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001257362.1 Homo sapiens cyclin dependent kinase 2 associated protein 1 (CDK2AP1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu24735
Clone ID Related Accession (Same CDS sequence)	NM_001270433.1 , NM_001270433.2 , NM_001270434.1
Accession Version	NM_001270433.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-14
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 2-associated protein 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC068768.31, BP290637.1, AF006484.1 and AA477326.1. On Jun 1, 2019 this sequence version replaced NM_001270433.1. Transcript Variant: This variant (2) differs in the 5' UTR and coding region and represents the use of an alternate promoter, compared to variant 1. This difference results in the use of an in-frame downstream start codon and a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein (isoform 2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.391458.1, SRR1163657.208377.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAACGT CTTCACAGTA CCGCCAGCTG CTCAGTGACT ACGGGCCACC GTCCCTAGGC 
TACACCCAGG GAACTGGGAA CAGCCAGGTG CCCCAAAGCA AATACGCGGA GCTGCTGGCC 
ATCATTGAAG AGCTGGGGAA GGAGATCAGA CCCACGTACG CAGGGAGCAA GAGTGCCATG 
GAGAGGCTGA AGCGCGGCAT CATTCACGCT AGAGGACTGG TTCGGGAGTG CTTGGCAGAA 
ACGGAACGGA ATGCCAGATC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001257362.1
CDS	137..400
Translation	MATSSQYRQLLSDYGPPSLGYTQGTGNSQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS

Target ORF information:

RefSeq Version	NM_001270433.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 2 associated protein 1 (CDK2AP1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001270433.2

ORF Insert Sequence:

ATGGCAACGT CTTCACAGTA CCGCCAGCTG CTCAGTGACT ACGGGCCACC GTCCCTAGGC 
TACACCCAGG GAACTGGGAA CAGCCAGGTG CCCCAAAGCA AATACGCGGA GCTGCTGGCC 
ATCATTGAAG AGCTGGGGAA GGAGATCAGA CCCACGTACG CAGGGAGCAA GAGTGCCATG 
GAGAGGCTGA AGCGCGGCAT CATTCACGCT AGAGGACTGG TTCGGGAGTG CTTGGCAGAA 
ACGGAACGGA ATGCCAGATC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDK2AP1 ( NM_001270434.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001257363.1 Homo sapiens cyclin dependent kinase 2 associated protein 1 (CDK2AP1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu24735
Clone ID Related Accession (Same CDS sequence)	NM_001270433.1 , NM_001270433.2 , NM_001270434.1
Accession Version	NM_001270434.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 2-associated protein 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AA295789.1, N41298.1, AF006484.1 and AA477326.1. Transcript Variant: This variant (3) differs in the 5' UTR and coding region and represents the use of an alternate promoter, compared to variant 1. This difference results in the use of an in-frame downstream start codon and a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein (isoform 2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HY125358.1, SRR7410570.510698.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAACGT CTTCACAGTA CCGCCAGCTG CTCAGTGACT ACGGGCCACC GTCCCTAGGC 
TACACCCAGG GAACTGGGAA CAGCCAGGTG CCCCAAAGCA AATACGCGGA GCTGCTGGCC 
ATCATTGAAG AGCTGGGGAA GGAGATCAGA CCCACGTACG CAGGGAGCAA GAGTGCCATG 
GAGAGGCTGA AGCGCGGCAT CATTCACGCT AGAGGACTGG TTCGGGAGTG CTTGGCAGAA 
ACGGAACGGA ATGCCAGATC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001257363.1
CDS	116..379
Translation	MATSSQYRQLLSDYGPPSLGYTQGTGNSQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS

Target ORF information:

RefSeq Version	NM_001270434.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 2 associated protein 1 (CDK2AP1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001270434.1

ORF Insert Sequence:

ATGGCAACGT CTTCACAGTA CCGCCAGCTG CTCAGTGACT ACGGGCCACC GTCCCTAGGC 
TACACCCAGG GAACTGGGAA CAGCCAGGTG CCCCAAAGCA AATACGCGGA GCTGCTGGCC 
ATCATTGAAG AGCTGGGGAA GGAGATCAGA CCCACGTACG CAGGGAGCAA GAGTGCCATG 
GAGAGGCTGA AGCGCGGCAT CATTCACGCT AGAGGACTGG TTCGGGAGTG CTTGGCAGAA 
ACGGAACGGA ATGCCAGATC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDK2AP1 ( NM_004642.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004633.1 Homo sapiens cyclin dependent kinase 2 associated protein 1 (CDK2AP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24765
Clone ID Related Accession (Same CDS sequence)	NM_004642.3 , NM_004642.4
Accession Version	NM_004642.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 348bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 2-associated protein 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF006484.1 and AA477326.1. On Jul 7, 2012 this sequence version replaced NM_004642.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF006484.1, SRR1163655.489660.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153980, SAMEA2155371 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTTACA AACCGAACTT GGCCGCGCAC ATGCCCGCCG CCGCCCTCAA CGCCGCTGGG 
AGTGTCCACT CGCCTTCCAC CAGCATGGCA ACGTCTTCAC AGTACCGCCA GCTGCTCAGT 
GACTACGGGC CACCGTCCCT AGGCTACACC CAGGGAACTG GGAACAGCCA GGTGCCCCAA 
AGCAAATACG CGGAGCTGCT GGCCATCATT GAAGAGCTGG GGAAGGAGAT CAGACCCACG 
TACGCAGGGA GCAAGAGTGC CATGGAGAGG CTGAAGCGCG GCATCATTCA CGCTAGAGGA 
CTGGTTCGGG AGTGCTTGGC AGAAACGGAA CGGAATGCCA GATCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004633.1
CDS	523..870
Translation	MSYKPNLAAHMPAAALNAAGSVHSPSTSMATSSQYRQLLSDYGPPSLGYTQGTGNSQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS

Target ORF information:

RefSeq Version	NM_004642.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 2 associated protein 1 (CDK2AP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004642.3

ORF Insert Sequence:

ATGTCTTACA AACCGAACTT GGCCGCGCAC ATGCCCGCCG CCGCCCTCAA CGCCGCTGGG 
AGTGTCCACT CGCCTTCCAC CAGCATGGCA ACGTCTTCAC AGTACCGCCA GCTGCTCAGT 
GACTACGGGC CACCGTCCCT AGGCTACACC CAGGGAACTG GGAACAGCCA GGTGCCCCAA 
AGCAAATACG CGGAGCTGCT GGCCATCATT GAAGAGCTGG GGAAGGAGAT CAGACCCACG 
TACGCAGGGA GCAAGAGTGC CATGGAGAGG CTGAAGCGCG GCATCATTCA CGCTAGAGGA 
CTGGTTCGGG AGTGCTTGGC AGAAACGGAA CGGAATGCCA GATCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDK2AP1 ( NM_004642.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004633.1 Homo sapiens cyclin dependent kinase 2 associated protein 1 (CDK2AP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24765
Clone ID Related Accession (Same CDS sequence)	NM_004642.3 , NM_004642.4
Accession Version	NM_004642.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 348bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 2-associated protein 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF006484.1 and AA477326.1. On Nov 22, 2018 this sequence version replaced NM_004642.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.443845.1, SRR1163655.234279.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2153980 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000261692.7/ ENSP00000261692.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTTACA AACCGAACTT GGCCGCGCAC ATGCCCGCCG CCGCCCTCAA CGCCGCTGGG 
AGTGTCCACT CGCCTTCCAC CAGCATGGCA ACGTCTTCAC AGTACCGCCA GCTGCTCAGT 
GACTACGGGC CACCGTCCCT AGGCTACACC CAGGGAACTG GGAACAGCCA GGTGCCCCAA 
AGCAAATACG CGGAGCTGCT GGCCATCATT GAAGAGCTGG GGAAGGAGAT CAGACCCACG 
TACGCAGGGA GCAAGAGTGC CATGGAGAGG CTGAAGCGCG GCATCATTCA CGCTAGAGGA 
CTGGTTCGGG AGTGCTTGGC AGAAACGGAA CGGAATGCCA GATCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004633.1
CDS	239..586
Translation	MSYKPNLAAHMPAAALNAAGSVHSPSTSMATSSQYRQLLSDYGPPSLGYTQGTGNSQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS

Target ORF information:

RefSeq Version	NM_004642.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 2 associated protein 1 (CDK2AP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004642.4

ORF Insert Sequence:

ATGTCTTACA AACCGAACTT GGCCGCGCAC ATGCCCGCCG CCGCCCTCAA CGCCGCTGGG 
AGTGTCCACT CGCCTTCCAC CAGCATGGCA ACGTCTTCAC AGTACCGCCA GCTGCTCAGT 
GACTACGGGC CACCGTCCCT AGGCTACACC CAGGGAACTG GGAACAGCCA GGTGCCCCAA 
AGCAAATACG CGGAGCTGCT GGCCATCATT GAAGAGCTGG GGAAGGAGAT CAGACCCACG 
TACGCAGGGA GCAAGAGTGC CATGGAGAGG CTGAAGCGCG GCATCATTCA CGCTAGAGGA 
CTGGTTCGGG AGTGCTTGGC AGAAACGGAA CGGAATGCCA GATCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DOC1-Dependent Recruitment of NURD Reveals Antagonism with SWI/SNF during Epithelial-Mesenchymal Transition in Oral Cancer Cells.
Cell reports20(1)61-75(2017 Jul)
Mohd-Sarip A,Teeuwssen M,Bot AG,De Herdt MJ,Willems SM,Baatenburg de Jong RJ,Looijenga LHJ,Zatreanu D,Bezstarosti K,van Riet J,Oole E,van Ijcken WFJ,van de Werken HJG,Demmers JA,Fodde R,Verrijzer CP

p12CDK2-AP1 interacts with CD82 to regulate the proliferation and survival of human oral squamous cell carcinoma cells.
Oncology reports36(2)737-44(2016 Aug)
Chai J,Ju J,Zhang SW,Shen ZY,Liang L,Yang XM,Ma C,Ni QW,Sun MY

Knockdown of CDK2AP1 in primary human fibroblasts induces p53 dependent senescence.
PloS one10(3)e0120782(2015)
Alsayegh KN,Gadepalli VS,Iyer S,Rao RR

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CDK2AP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

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