MLF2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MLF2
Entrez Gene ID	8079
Full Name	myeloid leukemia factor 2
Synonyms	NTN4
General protein information	Preferred Names myeloid leukemia factor 2 Names myeloid leukemia factor 2 myelodysplasia-myeloid leukemia factor 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.31
Disorder MIM:	601401

mRNA and Protein(s)

mRNA	Protein	Name
XM_024449201.1	XP_024304969.1	myeloid leukemia factor 2 isoform X1
NM_005439.2	NP_005430.1	myeloid leukemia factor 2

Pathways from BioSystems

Homologies

	MLF2	XP_001108789.1
Canis lupus familiaris (dog)	MLF2	XP_005637279.1
Homo sapiens (human)	MLF2	NP_005430.1
Pan troglodytes (chimpanzee)	MLF2	XP_003313506.1
Bos taurus (cattle)	MLF2	NP_001029628.1
Mus musculus (house mouse)	Mlf2	NP_663360.1
Gallus gallus (chicken)	MLF2	NP_001025947.1
Rattus norvegicus (Norway rat)	Mlf2	NP_001101359.1
Danio rerio (zebrafish)	mlf2	NP_001020687.1
Xenopus tropicalis (tropical clawed frog)	mlf2	NP_001025670.1

Gene Ontology
Bibliography

Related articles in PubMed

Modulation of mutant Huntingtin aggregates and toxicity by human myeloid leukemia factors.
Banerjee M, Datta M, Bhattacharyya NP
The international journal of biochemistry & cell biology821-9(2017 01)

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
Taipale M, Tucker G, Peng J, Krykbaeva I, Lin ZY, Larsen B, Choi H, Berger B, Gingras AC, Lindquist S
Cell158(2)434-448(2014 Jul)

Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling.
Dave B, Granados-Principal S, Zhu R, Benz S, Rabizadeh S, Soon-Shiong P, Yu KD, Shao Z, Li X, Gilcrease M, Lai Z, Chen Y, Huang TH, Shen H, Liu X, Ferrari M, Zhan M, Wong ST, Kumaraswami M, Mittal V, Chen X, Gross SS, Chang JC
Proceedings of the National Academy of Sciences of the United States of America111(24)8838-43(2014 Jun)

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
Blandin G, Marchand S, Charton K, Dani?le N, Gicquel E, Boucheteil JB, Bentaib A, Barrault L, Stockholm D, Bartoli M, Richard I
Skeletal muscle3(1)3(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mutation in HTT causes Huntington's disease (HD); aggregates of mutated HTT cause apoptosis in neurons of HD patients. Data suggest that both MLF1 and MLF2 preferentially interact with mutated N-terminal HTT; MLF1/MLF2 reduce number of neurons (Neuro2A cell line) containing mutant HTT aggregates and subsequent apoptosis. (HTT = Huntingtin protein; MLF = myeloid leukemia factor)
Title: Modulation of mutant Huntingtin aggregates and toxicity by human myeloid leukemia factors.

RPL39 and MLF2 have roles in tumor initiation and metastasis in breast cancer that involve nitric oxide synthase signaling
Title: Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.

The following MLF2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MLF2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu31804	NM_005439.2 Latest version!	Homo sapiens myeloid leukemia factor 2 (MLF2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu31804	XM_024449201.1 Latest version!	Homo sapiens myeloid leukemia factor 2 (MLF2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MLF2 ( NM_005439.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005430.1 Homo sapiens myeloid leukemia factor 2 (MLF2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31804
Clone ID Related Accession (Same CDS sequence)	XM_024449201.1 , NM_005439.2
Accession Version	NM_005439.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 747bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Homo sapiens(human)
Product	myeloid leukemia factor 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK289869.1 and BC002340.2. On Jan 9, 2009 this sequence version replaced NM_005439.1. Transcript Variant: This variant (1) is the protein-coding variant. ##Evidence-Data-START## Transcript exon combination :: AK289869.1, SRR1803611.361767.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159368 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTCCGCT TCATGAGGGA CGTGGAGCCT GAGGATCCCA TGTTCCTGAT GGATCCCTTT 
GCTATTCACC GTCAGCATAT GAGCCGTATG TTGTCAGGTG GCTTTGGATA TAGCCCCTTC 
CTCAGCATCA CAGATGGCAA CATGCCAGGG ACCAGGCCTG CCAGCCGCCG GATGCAGCAG 
GCTGGAGCTG TCTCCCCCTT TGGGATGCTG GGAATGTCGG GTGGTTTCAT GGACATGTTT 
GGGATGATGA ATGACATGAT TGGAAACATG GAACACATGA CAGCTGGAGG CAATTGCCAG 
ACCTTCTCAT CTTCCACTGT CATCTCCTAC TCCAATACGG GTGATGGTGC CCCCAAGGTC 
TACCAAGAGA CATCAGAGAT GCGCTCGGCA CCAGGCGGGA TCCGGGAGAC ACGGAGGACT 
GTTCGGGATT CAGACAGTGG ACTGGAGCAG ATGTCCATTG GGCATCACAT CCGGGACAGG 
GCTCACATCC TCCAGCGCTC CCGAAACCAT CGCACGGGGG ACCAGGAGGA GCGGCAGGAC 
TATATCAACC TGGATGAGAG TGAGGCCGCA GCGTTTGATG ACGAGTGGCG GCGGGAGACC 
TCCCGATTCC GGCAGCAGCG TCCCCTGGAG TTTCGGCGGC TTGAGTCCTC AGGGGCTGGG 
GGACGAAGGG CGGAGGGGCC TCCCCGCCTG GCCATCCAGG GACCTGAGGA CTCCCCTTCC 
CGACAGTCCC GCCGCTATGA CTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005430.1
CDS	64..810
Translation	MFRFMRDVEPEDPMFLMDPFAIHRQHMSRMLSGGFGYSPFLSITDGNMPGTRPASRRMQQAGAVSPFGMLGMSGGFMDMFGMMNDMIGNMEHMTAGGNCQTFSSSTVISYSNTGDGAPKVYQETSEMRSAPGGIRETRRTVRDSDSGLEQMSIGHHIRDRAHILQRSRNHRTGDQEERQDYINLDESEAAAFDDEWRRETSRFRQQRPLEFRRLESSGAGGRRAEGPPRLAIQGPEDSPSRQSRRYDW

Target ORF information:

RefSeq Version	NM_005439.2
Organism	Homo sapiens(human)
Definition	Homo sapiens myeloid leukemia factor 2 (MLF2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005439.2

ORF Insert Sequence:

ATGTTCCGCT TCATGAGGGA CGTGGAGCCT GAGGATCCCA TGTTCCTGAT GGATCCCTTT 
GCTATTCACC GTCAGCATAT GAGCCGTATG TTGTCAGGTG GCTTTGGATA TAGCCCCTTC 
CTCAGCATCA CAGATGGCAA CATGCCAGGG ACCAGGCCTG CCAGCCGCCG GATGCAGCAG 
GCTGGAGCTG TCTCCCCCTT TGGGATGCTG GGAATGTCGG GTGGTTTCAT GGACATGTTT 
GGGATGATGA ATGACATGAT TGGAAACATG GAACACATGA CAGCTGGAGG CAATTGCCAG 
ACCTTCTCAT CTTCCACTGT CATCTCCTAC TCCAATACGG GTGATGGTGC CCCCAAGGTC 
TACCAAGAGA CATCAGAGAT GCGCTCGGCA CCAGGCGGGA TCCGGGAGAC ACGGAGGACT 
GTTCGGGATT CAGACAGTGG ACTGGAGCAG ATGTCCATTG GGCATCACAT CCGGGACAGG 
GCTCACATCC TCCAGCGCTC CCGAAACCAT CGCACGGGGG ACCAGGAGGA GCGGCAGGAC 
TATATCAACC TGGATGAGAG TGAGGCCGCA GCGTTTGATG ACGAGTGGCG GCGGGAGACC 
TCCCGATTCC GGCAGCAGCG TCCCCTGGAG TTTCGGCGGC TTGAGTCCTC AGGGGCTGGG 
GGACGAAGGG CGGAGGGGCC TCCCCGCCTG GCCATCCAGG GACCTGAGGA CTCCCCTTCC 
CGACAGTCCC GCCGCTATGA CTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MLF2 ( XM_024449201.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024304969.1 Homo sapiens myeloid leukemia factor 2 (MLF2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu31804
Clone ID Related Accession (Same CDS sequence)	XM_024449201.1 , NM_005439.2
Accession Version	XM_024449201.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 747bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	myeloid leukemia factor 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTCCGCT TCATGAGGGA CGTGGAGCCT GAGGATCCCA TGTTCCTGAT GGATCCCTTT 
GCTATTCACC GTCAGCATAT GAGCCGTATG TTGTCAGGTG GCTTTGGATA TAGCCCCTTC 
CTCAGCATCA CAGATGGCAA CATGCCAGGG ACCAGGCCTG CCAGCCGCCG GATGCAGCAG 
GCTGGAGCTG TCTCCCCCTT TGGGATGCTG GGAATGTCGG GTGGTTTCAT GGACATGTTT 
GGGATGATGA ATGACATGAT TGGAAACATG GAACACATGA CAGCTGGAGG CAATTGCCAG 
ACCTTCTCAT CTTCCACTGT CATCTCCTAC TCCAATACGG GTGATGGTGC CCCCAAGGTC 
TACCAAGAGA CATCAGAGAT GCGCTCGGCA CCAGGCGGGA TCCGGGAGAC ACGGAGGACT 
GTTCGGGATT CAGACAGTGG ACTGGAGCAG ATGTCCATTG GGCATCACAT CCGGGACAGG 
GCTCACATCC TCCAGCGCTC CCGAAACCAT CGCACGGGGG ACCAGGAGGA GCGGCAGGAC 
TATATCAACC TGGATGAGAG TGAGGCCGCA GCGTTTGATG ACGAGTGGCG GCGGGAGACC 
TCCCGATTCC GGCAGCAGCG TCCCCTGGAG TTTCGGCGGC TTGAGTCCTC AGGGGCTGGG 
GGACGAAGGG CGGAGGGGCC TCCCCGCCTG GCCATCCAGG GACCTGAGGA CTCCCCTTCC 
CGACAGTCCC GCCGCTATGA CTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024304969.1
CDS	232..978
Translation	MFRFMRDVEPEDPMFLMDPFAIHRQHMSRMLSGGFGYSPFLSITDGNMPGTRPASRRMQQAGAVSPFGMLGMSGGFMDMFGMMNDMIGNMEHMTAGGNCQTFSSSTVISYSNTGDGAPKVYQETSEMRSAPGGIRETRRTVRDSDSGLEQMSIGHHIRDRAHILQRSRNHRTGDQEERQDYINLDESEAAAFDDEWRRETSRFRQQRPLEFRRLESSGAGGRRAEGPPRLAIQGPEDSPSRQSRRYDW

Target ORF information:

RefSeq Version	XM_024449201.1
Organism	Homo sapiens(human)
Definition	Homo sapiens myeloid leukemia factor 2 (MLF2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024449201.1

ORF Insert Sequence:

ATGTTCCGCT TCATGAGGGA CGTGGAGCCT GAGGATCCCA TGTTCCTGAT GGATCCCTTT 
GCTATTCACC GTCAGCATAT GAGCCGTATG TTGTCAGGTG GCTTTGGATA TAGCCCCTTC 
CTCAGCATCA CAGATGGCAA CATGCCAGGG ACCAGGCCTG CCAGCCGCCG GATGCAGCAG 
GCTGGAGCTG TCTCCCCCTT TGGGATGCTG GGAATGTCGG GTGGTTTCAT GGACATGTTT 
GGGATGATGA ATGACATGAT TGGAAACATG GAACACATGA CAGCTGGAGG CAATTGCCAG 
ACCTTCTCAT CTTCCACTGT CATCTCCTAC TCCAATACGG GTGATGGTGC CCCCAAGGTC 
TACCAAGAGA CATCAGAGAT GCGCTCGGCA CCAGGCGGGA TCCGGGAGAC ACGGAGGACT 
GTTCGGGATT CAGACAGTGG ACTGGAGCAG ATGTCCATTG GGCATCACAT CCGGGACAGG 
GCTCACATCC TCCAGCGCTC CCGAAACCAT CGCACGGGGG ACCAGGAGGA GCGGCAGGAC 
TATATCAACC TGGATGAGAG TGAGGCCGCA GCGTTTGATG ACGAGTGGCG GCGGGAGACC 
TCCCGATTCC GGCAGCAGCG TCCCCTGGAG TTTCGGCGGC TTGAGTCCTC AGGGGCTGGG 
GGACGAAGGG CGGAGGGGCC TCCCCGCCTG GCCATCCAGG GACCTGAGGA CTCCCCTTCC 
CGACAGTCCC GCCGCTATGA CTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Modulation of mutant Huntingtin aggregates and toxicity by human myeloid leukemia factors.
The international journal of biochemistry & cell biology821-9(2017 01)
Banerjee M,Datta M,Bhattacharyya NP

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
Cell158(2)434-448(2014 Jul)
Taipale M,Tucker G,Peng J,Krykbaeva I,Lin ZY,Larsen B,Choi H,Berger B,Gingras AC,Lindquist S

Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling.
Proceedings of the National Academy of Sciences of the United States of America111(24)8838-43(2014 Jun)
Dave B,Granados-Principal S,Zhu R,Benz S,Rabizadeh S,Soon-Shiong P,Yu KD,Shao Z,Li X,Gilcrease M,Lai Z,Chen Y,Huang TH,Shen H,Liu X,Ferrari M,Zhan M,Wong ST,Kumaraswami M,Mittal V,Chen X,Gross SS,Chang JC

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
Skeletal muscle3(1)3(2013 Feb)
Blandin G,Marchand S,Charton K,Dani?le N,Gicquel E,Boucheteil JB,Bentaib A,Barrault L,Stockholm D,Bartoli M,Richard I

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MLF2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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