SPX cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SPX
Entrez Gene ID	80763
Full Name	spexin hormone
Synonyms	C12orf39
General protein information	Preferred Names spexin hormone Names spexin NPQ neuropeptide Q
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 12 Map Location: 12p12.1
Summary	The protein encoded by this gene is a hormone involved in modulation of cardiovascular and renal function. It has also been shown in rats to cause weight loss. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_030572.4	NP_085049.1	spexin precursor
NM_030572.3	NP_085049.1	spexin precursor
NM_030572.2	NP_085049.1	spexin precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	LOC691138	NP_001077402.2
Danio rerio (zebrafish)	LOC101882535	XP_005164831.1
Homo sapiens (human)	C12orf39	NP_085049.1
Bos taurus (cattle)	C5H12orf39	NP_001068875.1
Pan troglodytes (chimpanzee)	C12H12orf39	XP_001144591.2
Canis lupus familiaris (dog)	C27H12orf39	XP_005637487.1
Mus musculus (house mouse)	B230216G23Rik	NP_001229274.1

Gene Ontology
Bibliography

Related articles in PubMed

Serum levels of spexin and kisspeptin negatively correlate with obesity and insulin resistance in women.
Ko?odziejskii PA, Pruszy?ska-Oszma?ek E, Korek E, Sassek M, Szczepankiewicz D, Kaczmarek P, Nogowski L, Ma?kowiak P, Nowak KW, Krauss H, Strowski MZ
Physiological research(2017 Nov)

Effect of obesity and type 2 diabetes, and glucose ingestion on circulating spexin concentration in adolescents.
Hodges SK, Teague AM, Dasari PS, Short KR
Pediatric diabetes(2017 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Lower circulating levels of Spexin in obese children compared with their normal-weight counterparts and the ability to discriminate obese and normal-weight groups based on Spexin concentration enabled us to suggest a potential role for this novel peptide in childhood obesity.
Title: Decreased Circulating Levels of Spexin in Obese Children.

The results suggest that C12orf39, CSTA, and CALCB are novel ATF4 target genes, and that C12orf39 promoter activity is activated by ATF4 through amino acid response element.
Title: Searching for novel ATF4 target genes in human hepatoma cells by microarray analysis.

Circulating spexin levels are low in T2DM patients and negatively related to blood glucose and lipids suggesting that the peptide may play a role in glucose and lipid metabolism in T2DM.
Title: Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes.

Data from ligand-receptor interaction studies suggest that human spexin-1 and zebrafish spexin-2 activate galanin receptors GALR2/GALR3 (but not GALR1); thus spexins appear to be natural ligands for human/Xenopus/zebrafish GALR2/GALR3.
Title: Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III.

newly identified peptides derived from the NPQ/spexin precursor contribute to CNS-mediated control of arterial blood pressure and salt and water balance and modulate nociceptive responses
Title: Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception.

The following SPX gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SPX cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16354	NM_030572.4 Latest version!	Homo sapiens spexin hormone (SPX), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu16354	NM_030572.3	Homo sapiens spexin hormone (SPX), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu16354	NM_030572.2	Homo sapiens spexin hormone (SPX), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SPX ( NM_030572.4 ) cDNA ORF clone, Homo sapiens(Human) -> NP_085049.1 Homo sapiens spexin hormone (SPX), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16354
Clone ID Related Accession (Same CDS sequence)	NM_030572.4 , NM_030572.3 , NM_030572.2
Accession Version	NM_030572.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-09
Organism	Homo sapiens(human)
Product	spexin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA380664.1, AK075342.1, DB159488.1, AC006559.6 and CR742701.1. On Nov 23, 2018 this sequence version replaced NM_030572.3. Transcript Variant: This variant (1) represents the protein-coding transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK075342.1, AK027273.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000256969.7/ ENSP00000256969.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGGGAC TCAGAAGTCT GGCAGCAACA ACCTTGGCTC TTTTCCTGGT GTTTGTTTTC 
CTGGGAAACT CCAGCTGCGC TCCGCAGAGA CTGTTGGAGA GAAGGAACTG GACTCCTCAA 
GCTATGCTCT ACCTGAAAGG GGCACAGGGT CGCCGCTTCA TCTCCGACCA GAGCCGGAGA 
AAGGACCTCT CCGACCGGCC ACTGCCGGAA AGACGAAGCC CAAATCCCCA ACTACTAACT 
ATTCCGGAGG CAGCAACCAT CTTACTGGCG TCCCTTCAGA AATCACCAGA AGATGAAGAA 
AAAAACTTTG ATCAAACCAG ATTCCTGGAA GACAGTCTGC TTAACTGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_085049.1
CDS	178..528
Translation	MKGLRSLAATTLALFLVFVFLGNSSCAPQRLLERRNWTPQAMLYLKGAQGRRFISDQSRRKDLSDRPLPERRSPNPQLLTIPEAATILLASLQKSPEDEEKNFDQTRFLEDSLLNW

Target ORF information:

RefSeq Version	NM_030572.4
Organism	Homo sapiens(human)
Definition	Homo sapiens spexin hormone (SPX), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030572.4

ORF Insert Sequence:

ATGAAGGGAC TCAGAAGTCT GGCAGCAACA ACCTTGGCTC TTTTCCTGGT GTTTGTTTTC 
CTGGGAAACT CCAGCTGCGC TCCGCAGAGA CTGTTGGAGA GAAGGAACTG GACTCCTCAA 
GCTATGCTCT ACCTGAAAGG GGCACAGGGT CGCCGCTTCA TCTCCGACCA GAGCCGGAGA 
AAGGACCTCT CCGACCGGCC ACTGCCGGAA AGACGAAGCC CAAATCCCCA ACTACTAACT 
ATTCCGGAGG CAGCAACCAT CTTACTGGCG TCCCTTCAGA AATCACCAGA AGATGAAGAA 
AAAAACTTTG ATCAAACCAG ATTCCTGGAA GACAGTCTGC TTAACTGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPX ( NM_030572.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_085049.1 Homo sapiens spexin hormone (SPX), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16354
Clone ID Related Accession (Same CDS sequence)	NM_030572.4 , NM_030572.3 , NM_030572.2
Accession Version	NM_030572.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-07-09
Organism	Homo sapiens(human)
Product	spexin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA380664.1, AK075342.1, DB159488.1, AC006559.6 and CR742701.1. On Feb 18, 2016 this sequence version replaced NM_030572.2. Transcript Variant: This variant (1) represents the protein-coding transcript. ##Evidence-Data-START## Transcript exon combination :: DA380664.1, AK075342.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGGGAC TCAGAAGTCT GGCAGCAACA ACCTTGGCTC TTTTCCTGGT GTTTGTTTTC 
CTGGGAAACT CCAGCTGCGC TCCGCAGAGA CTGTTGGAGA GAAGGAACTG GACTCCTCAA 
GCTATGCTCT ACCTGAAAGG GGCACAGGGT CGCCGCTTCA TCTCCGACCA GAGCCGGAGA 
AAGGACCTCT CCGACCGGCC ACTGCCGGAA AGACGAAGCC CAAATCCCCA ACTACTAACT 
ATTCCGGAGG CAGCAACCAT CTTACTGGCG TCCCTTCAGA AATCACCAGA AGATGAAGAA 
AAAAACTTTG ATCAAACCAG ATTCCTGGAA GACAGTCTGC TTAACTGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_085049.1
CDS	217..567
Translation	MKGLRSLAATTLALFLVFVFLGNSSCAPQRLLERRNWTPQAMLYLKGAQGRRFISDQSRRKDLSDRPLPERRSPNPQLLTIPEAATILLASLQKSPEDEEKNFDQTRFLEDSLLNW

Target ORF information:

RefSeq Version	NM_030572.3
Organism	Homo sapiens(human)
Definition	Homo sapiens spexin hormone (SPX), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030572.3

ORF Insert Sequence:

ATGAAGGGAC TCAGAAGTCT GGCAGCAACA ACCTTGGCTC TTTTCCTGGT GTTTGTTTTC 
CTGGGAAACT CCAGCTGCGC TCCGCAGAGA CTGTTGGAGA GAAGGAACTG GACTCCTCAA 
GCTATGCTCT ACCTGAAAGG GGCACAGGGT CGCCGCTTCA TCTCCGACCA GAGCCGGAGA 
AAGGACCTCT CCGACCGGCC ACTGCCGGAA AGACGAAGCC CAAATCCCCA ACTACTAACT 
ATTCCGGAGG CAGCAACCAT CTTACTGGCG TCCCTTCAGA AATCACCAGA AGATGAAGAA 
AAAAACTTTG ATCAAACCAG ATTCCTGGAA GACAGTCTGC TTAACTGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPX ( NM_030572.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_085049.1 Homo sapiens spexin hormone (SPX), mRNA.

Price & Availability↑

CloneID	OHu16354
Clone ID Related Accession (Same CDS sequence)	NM_030572.4 , NM_030572.3 , NM_030572.2
Accession Version	NM_030572.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	spexin precursor
Comment

ATGAAGGGAC TCAGAAGTCT GGCAGCAACA ACCTTGGCTC TTTTCCTGGT GTTTGTTTTC 
CTGGGAAACT CCAGCTGCGC TCCGCAGAGA CTGTTGGAGA GAAGGAACTG GACTCCTCAA 
GCTATGCTCT ACCTGAAAGG GGCACAGGGT CGCCGCTTCA TCTCCGACCA GAGCCGGAGA 
AAGGACCTCT CCGACCGGCC ACTGCCGGAA AGACGAAGCC CAAATCCCCA ACTACTAACT 
ATTCCGGAGG CAGCAACCAT CTTACTGGCG TCCCTTCAGA AATCACCAGA AGATGAAGAA 
AAAAACTTTG ATCAAACCAG ATTCCTGGAA GACAGTCTGC TTAACTGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_085049.1
Translation	MKGLRSLAATTLALFLVFVFLGNSSCAPQRLLERRNWTPQAMLYLKGAQGRRFISDQSRRKDLSDRPLPERRSPNPQLLTIPEAATILLASLQKSPEDEEKNFDQTRFLEDSLLNW

Target ORF information:

RefSeq Version	NM_030572.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens spexin hormone (SPX), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030572.2

ORF Insert Sequence:

ATGAAGGGAC TCAGAAGTCT GGCAGCAACA ACCTTGGCTC TTTTCCTGGT GTTTGTTTTC 
CTGGGAAACT CCAGCTGCGC TCCGCAGAGA CTGTTGGAGA GAAGGAACTG GACTCCTCAA 
GCTATGCTCT ACCTGAAAGG GGCACAGGGT CGCCGCTTCA TCTCCGACCA GAGCCGGAGA 
AAGGACCTCT CCGACCGGCC ACTGCCGGAA AGACGAAGCC CAAATCCCCA ACTACTAACT 
ATTCCGGAGG CAGCAACCAT CTTACTGGCG TCCCTTCAGA AATCACCAGA AGATGAAGAA 
AAAAACTTTG ATCAAACCAG ATTCCTGGAA GACAGTCTGC TTAACTGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Serum levels of spexin and kisspeptin negatively correlate with obesity and insulin resistance in women.
Physiological research(2017 Nov)
Ko?odziejskii PA,Pruszy?ska-Oszma?ek E,Korek E,Sassek M,Szczepankiewicz D,Kaczmarek P,Nogowski L,Ma?kowiak P,Nowak KW,Krauss H,Strowski MZ

Effect of obesity and type 2 diabetes, and glucose ingestion on circulating spexin concentration in adolescents.
Pediatric diabetes(2017 Jun)
Hodges SK,Teague AM,Dasari PS,Short KR

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SPX cDNA ORF clone, Homo sapiens(Human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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