LY6G6C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LY6G6C
Entrez Gene ID	80740
Full Name	lymphocyte antigen 6 family member G6C
Synonyms	C6orf24,G6c,NG24
General protein information	Preferred Names lymphocyte antigen 6 family member G6C Names lymphocyte antigen 6 complex locus protein G6c lymphocyte antigen 6 complex, locus G6C lymphocyte antigen-6 G6C
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.33
Summary	LY6G6C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Mar 2008].
Disorder MIM:	610435

mRNA and Protein(s)

mRNA	Protein	Name
NM_025261.2	NP_079537.1	lymphocyte antigen 6 complex locus protein G6c precursor
NM_025261.3	NP_079537.1	lymphocyte antigen 6 complex locus protein G6c precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	LY6G6C	NP_079537.1
Mus musculus (house mouse)	Ly6g6c	NP_075952.1
Rattus norvegicus (Norway rat)	Ly6g6c	NP_001001969.1
	LY6G6C	XP_001112897.1
Canis lupus familiaris (dog)	LY6G6C	XP_849111.1
Bos taurus (cattle)	LY6G6C	NP_001071324.1

Gene Ontology
Bibliography

Related articles in PubMed

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, , ,
American journal of human genetics85(5)628-42(2009 Nov)

High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA
PLoS genetics5(10)e1000696(2009 Oct)

Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands.
Mallya M, Campbell RD, Aguado B
Protein science : a publication of the Protein Society15(10)2244-56(2006 Oct)

Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.
Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L
Genome research13(12)2621-36(2003 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

Observational study of gene-disease association. (HuGE Navigator)
Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.

The following LY6G6C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LY6G6C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55979	NM_025261.3 Latest version!	Homo sapiens lymphocyte antigen 6 family member G6C (LY6G6C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu55979	NM_025261.2	Homo sapiens lymphocyte antigen 6 family member G6C (LY6G6C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LY6G6C ( NM_025261.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_079537.1 Homo sapiens lymphocyte antigen 6 family member G6C (LY6G6C), mRNA.

Price & Availability↑

CloneID	OHu55979
Clone ID Related Accession (Same CDS sequence)	NM_025261.2 , NM_025261.3
Accession Version	NM_025261.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 378bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	lymphocyte antigen 6 complex locus protein G6c precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY359119.1 and BC036302.1. On Aug 26, 2011 this sequence version replaced NM_025261.1. ##Evidence-Data-START## Transcript exon combination :: BC036302.1, ERR279836.7569.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAAGCCC TTATGCTGCT CACCCTGTCT GTTCTGCTCT GCTGGGTCTC AGCTGACATT 
CGCTGTCACT CCTGCTACAA GGTCCCTGTG CTGGGCTGTG TGGACCGGCA GTCCTGCCGC 
CTGGAGCCAG GACAGCAATG CCTGACAACA CATGCATACC TTGGTAAGAT GTGGGTTTTC 
TCCAATCTGC GCTGTGGCAC ACCAGAAGAG CCCTGTCAGG AGGCCTTCAA CCAAACCAAC 
CGCAAGCTGG GTCTGACATA TAACACCACC TGCTGCAACA AGGACAACTG CAACAGCGCA 
GGACCCCGGC CCACTCCAGC CCTGGGCCTT GTCTTCCTTA CCTCCTTGGC TGGCCTTGGC 
CTCTGGCTGC TGCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079537.1
CDS	56..433
Translation	MKALMLLTLSVLLCWVSADIRCHSCYKVPVLGCVDRQSCRLEPGQQCLTTHAYLGKMWVFSNLRCGTPEEPCQEAFNQTNRKLGLTYNTTCCNKDNCNSAGPRPTPALGLVFLTSLAGLGLWLLH

Target ORF information:

RefSeq Version	NM_025261.2
Organism	Homo sapiens(human)
Definition	Homo sapiens lymphocyte antigen 6 family member G6C (LY6G6C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025261.2

ORF Insert Sequence:

ATGAAAGCCC TTATGCTGCT CACCCTGTCT GTTCTGCTCT GCTGGGTCTC AGCTGACATT 
CGCTGTCACT CCTGCTACAA GGTCCCTGTG CTGGGCTGTG TGGACCGGCA GTCCTGCCGC 
CTGGAGCCAG GACAGCAATG CCTGACAACA CATGCATACC TTGGTAAGAT GTGGGTTTTC 
TCCAATCTGC GCTGTGGCAC ACCAGAAGAG CCCTGTCAGG AGGCCTTCAA CCAAACCAAC 
CGCAAGCTGG GTCTGACATA TAACACCACC TGCTGCAACA AGGACAACTG CAACAGCGCA 
GGACCCCGGC CCACTCCAGC CCTGGGCCTT GTCTTCCTTA CCTCCTTGGC TGGCCTTGGC 
CTCTGGCTGC TGCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LY6G6C ( NM_025261.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_079537.1 Homo sapiens lymphocyte antigen 6 family member G6C (LY6G6C), mRNA.

Price & Availability↑

CloneID	OHu55979
Clone ID Related Accession (Same CDS sequence)	NM_025261.2 , NM_025261.3
Accession Version	NM_025261.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 378bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	lymphocyte antigen 6 complex locus protein G6c precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL662899.5, AY359119.1 and BC036302.1. On Nov 22, 2018 this sequence version replaced NM_025261.2. ##Evidence-Data-START## Transcript exon combination :: BC036302.1, AY359119.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000375819.3/ ENSP00000364978.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAAGCCC TTATGCTGCT CACCCTGTCT GTTCTGCTCT GCTGGGTCTC AGCTGACATT 
CGCTGTCACT CCTGCTACAA GGTCCCTGTG CTGGGCTGTG TGGACCGGCA GTCCTGCCGC 
CTGGAGCCAG GACAGCAATG CCTGACAACA CATGCATACC TTGGTAAGAT GTGGGTTTTC 
TCCAATCTGC GCTGTGGCAC ACCAGAAGAG CCCTGTCAGG AGGCCTTCAA CCAAACCAAC 
CGCAAGCTGG GTCTGACATA TAACACCACC TGCTGCAACA AGGACAACTG CAACAGCGCA 
GGACCCCGGC CCACTCCAGC CCTGGGCCTT GTCTTCCTTA CCTCCTTGGC TGGCCTTGGC 
CTCTGGCTGC TGCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079537.1
CDS	68..445
Translation	MKALMLLTLSVLLCWVSADIRCHSCYKVPVLGCVDRQSCRLEPGQQCLTTHAYLGKMWVFSNLRCGTPEEPCQEAFNQTNRKLGLTYNTTCCNKDNCNSAGPRPTPALGLVFLTSLAGLGLWLLH

Target ORF information:

RefSeq Version	NM_025261.3
Organism	Homo sapiens(human)
Definition	Homo sapiens lymphocyte antigen 6 family member G6C (LY6G6C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025261.3

ORF Insert Sequence:

ATGAAAGCCC TTATGCTGCT CACCCTGTCT GTTCTGCTCT GCTGGGTCTC AGCTGACATT 
CGCTGTCACT CCTGCTACAA GGTCCCTGTG CTGGGCTGTG TGGACCGGCA GTCCTGCCGC 
CTGGAGCCAG GACAGCAATG CCTGACAACA CATGCATACC TTGGTAAGAT GTGGGTTTTC 
TCCAATCTGC GCTGTGGCAC ACCAGAAGAG CCCTGTCAGG AGGCCTTCAA CCAAACCAAC 
CGCAAGCTGG GTCTGACATA TAACACCACC TGCTGCAACA AGGACAACTG CAACAGCGCA 
GGACCCCGGC CCACTCCAGC CCTGGGCCTT GTCTTCCTTA CCTCCTTGGC TGGCCTTGGC 
CTCTGGCTGC TGCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
American journal of human genetics85(5)628-42(2009 Nov)
Talmud PJ,Drenos F,Shah S,Shah T,Palmen J,Verzilli C,Gaunt TR,Pallas J,Lovering R,Li K,Casas JP,Sofat R,Kumari M,Rodriguez S,Johnson T,Newhouse SJ,Dominiczak A,Samani NJ,Caulfield M,Sever P,Stanton A,Shields DC,Padmanabhan S,Melander O,Hastie C,Delles C,Ebrahim S,Marmot MG,Smith GD,Lawlor DA,Munroe PB,Day IN,Kivimaki M,Whittaker J,Humphries SE,Hingorani AD,,,

High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
PLoS genetics5(10)e1000696(2009 Oct)
Barcellos LF,May SL,Ramsay PP,Quach HL,Lane JA,Nititham J,Noble JA,Taylor KE,Quach DL,Chung SA,Kelly JA,Moser KL,Behrens TW,Seldin MF,Thomson G,Harley JB,Gaffney PM,Criswell LA

Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands.
Protein science : a publication of the Protein Society15(10)2244-56(2006 Oct)
Mallya M,Campbell RD,Aguado B

Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.
Genome research13(12)2621-36(2003 Dec)
Xie T,Rowen L,Aguado B,Ahearn ME,Madan A,Qin S,Campbell RD,Hood L

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LY6G6C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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