ULBP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ULBP1
Entrez Gene ID	80329
Full Name	UL16 binding protein 1
Synonyms	N2DL-1,NKG2DL1,RAET1I
General protein information	Preferred Names UL16 binding protein 1 Names UL16-binding protein 1 NKG2D ligand 1 alcan-beta retinoic acid early transcript 1I
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q25.1
Summary	The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].
Disorder MIM:	605697

mRNA and Protein(s)

mRNA	Protein	Name
NM_025218.4	NP_079494.1	UL16-binding protein 1 isoform 1 precursor
NM_001317089.2	NP_001304018.1	UL16-binding protein 1 isoform 2 precursor
NM_025218.3	NP_079494.1	UL16-binding protein 1 isoform 1 precursor
XM_017011322.1	XP_016866811.1	UL16-binding protein 1 isoform X1
NM_001317089.1	NP_001304018.1	UL16-binding protein 1 isoform 2 precursor

Pathways from BioSystems

Homologies

	LOC694216	XP_001082138.1
Pan troglodytes (chimpanzee)	ULBP1	XP_001134754.1
Mus musculus (house mouse)	Ulbp1	NP_084251.1
Homo sapiens (human)	ULBP1	NP_079494.1

Gene Ontology
Bibliography

Related articles in PubMed

A disease-linked
Zuo J, Willcox CR, Mohammed F, Davey M, Hunter S, Khan K, Antoun A, Katakia P, Croudace J, Inman C, Parry H, Briggs D, Malladi R, Willcox BE, Moss P
Science signaling10(481)(2017 May)

Downregulation of the stress-induced ligand ULBP1 following SV40 infection confers viral evasion from NK cell cytotoxicity.
Bauman Y, Drayman N, Ben-Nun-Shaul O, Vitenstein A, Yamin R, Ophir Y, Oppenheim A, Mandelboim O
Oncotarget7(13)15369-81(2016 Mar)

A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells.
Gowen BG, Chim B, Marceau CD, Greene TT, Burr P, Gonzalez JR, Hesser CR, Dietzen PA, Russell T, Iannello A, Coscoy L, Sentman CL, Carette JE, Muljo SA, Raulet DH
eLife4(2015 Nov)

Immunohistochemical validation and expression profiling of NKG2D ligands in a wide spectrum of human epithelial neoplasms.
Fujita H, Hatanaka Y, Sutoh Y, Suzuki Y, Oba K, Hatanaka KC, Mitsuhashi T, Otsuka N, Fugo K, Kasahara M, Matsuno Y
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society63(3)217-27(2015 03)

MICA/B and ULBP1 NKG2D ligands are independent predictors of good prognosis in cervical cancer.
Cho H, Chung JY, Kim S, Braunschweig T, Kang TH, Kim J, Chung EJ, Hewitt SM, Kim JH
BMC cancer14957(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we show that Simian Virus 40 (SV40)...evades NK cell attack through the down regulation of...ULBP1
Title: Downregulation of the stress-induced ligand ULBP1 following SV40 infection confers viral evasion from NK cell cytotoxicity.

ATF4 drives ULBP1 gene expression in cancer cell lines, while the RNA-binding protein RBM4 supports ULBP1 expression by suppressing a novel alternatively spliced isoform of ULBP1 mRNA.
Title: A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells.

expression determines intrinsic acute myeloid leukemia susceptibility to allogeneic V[gamma]9V[delta]2 T cells
Title: A comprehensive analysis of primary acute myeloid leukemia identifies biomarkers predicting susceptibility to human allogeneic V?9V?2 T cells.

This study provides for the first time, the c-Myc dependent regulation of NKG2D ligands, ULBP1/2/3 in acute myeloid leukemia.
Title: c-Myc regulates expression of NKG2D ligands ULBP1/2/3 in AML and modulates their susceptibility to NK-mediated lysis.

Findings define the involvement of p53 in the regulation of ULBP1 and ULBP2 which enhance NK cell-mediated target recognition.
Title: Human NK cells are alerted to induction of p53 in cancer cells by upregulation of the NKG2D ligands ULBP1 and ULBP2.

The following ULBP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ULBP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu96818	XM_017011322.1 Latest version!	Homo sapiens UL16 binding protein 1 (ULBP1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu04424	NM_025218.4 Latest version!	Homo sapiens UL16 binding protein 1 (ULBP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu101925	NM_001317089.2 Latest version!	Homo sapiens UL16 binding protein 1 (ULBP1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu04424	NM_025218.3	Homo sapiens UL16 binding protein 1 (ULBP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu101925	NM_001317089.1	Homo sapiens UL16 binding protein 1 (ULBP1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ULBP1 ( XM_017011322.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016866811.1 Homo sapiens UL16 binding protein 1 (ULBP1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu96818
Clone ID Related Accession (Same CDS sequence)	XM_017011322.1
Accession Version	XM_017011322.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	UL16-binding protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAGCGG CCGCCAGCCC CGCGTTCCTT CTGTGCCTCC CGCTTCTGCA CCTGCTGTCT 
GGCTGGTCCC GGGCAGGATG GGTCGACACA CACTGTCTTT GCTATGACTT CATCATCACT 
CCTAAGTCCA GACCTGAACC ACAGTGGTGT GAAGTTCAAG GCCTGGTGGA TGAAAGGCCT 
TTTCTTCACT ATGACTGTGT TAACCACAAG GCCAAAGCCT TTGCTTCTCT GGGGAAGAAA 
GTCAATGTCA CAAAAACCTG GGAAGAACAA ACTGAAACAC TAAGAGACGT GGTGGATTTC 
CTTAAAGGGC AACTGCTTGA CATTCAAGTG GAGAATTTAA TACCCATTGA GCCCCTCACC 
CTGCAGGCCA GGATGTCTTG TGAGCATGAA GCCCATGGAC ACGGCAGAGG ATCTTGGCAG 
TTCCTCTTCA ATGGACAGAA GTTCCTCCTC TTTGACTCAA ACAACAGAAA GTGGACAGCA 
CTTCATCCTG GAGCCAAGAA GATGACAGAG AAGTGGGAGA AGAACAGGGA TGTGACCATG 
TTCTTCCAGA AGATTTCACT GGGGGATTGT AAGATGTGGC TTGAAGAATT TTTGATGTAC 
TGGGAACAAA TGCTGGATCC AACAAGTGGA AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016866811.1
CDS	77..712
Translation	MAAAASPAFLLCLPLLHLLSGWSRAGWVDTHCLCYDFIITPKSRPEPQWCEVQGLVDERPFLHYDCVNHKAKAFASLGKKVNVTKTWEEQTETLRDVVDFLKGQLLDIQVENLIPIEPLTLQARMSCEHEAHGHGRGSWQFLFNGQKFLLFDSNNRKWTALHPGAKKMTEKWEKNRDVTMFFQKISLGDCKMWLEEFLMYWEQMLDPTSGK

Target ORF information:

RefSeq Version	XM_017011322.1
Organism	Homo sapiens(human)
Definition	Homo sapiens UL16 binding protein 1 (ULBP1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017011322.1

ORF Insert Sequence:

ATGGCAGCGG CCGCCAGCCC CGCGTTCCTT CTGTGCCTCC CGCTTCTGCA CCTGCTGTCT 
GGCTGGTCCC GGGCAGGATG GGTCGACACA CACTGTCTTT GCTATGACTT CATCATCACT 
CCTAAGTCCA GACCTGAACC ACAGTGGTGT GAAGTTCAAG GCCTGGTGGA TGAAAGGCCT 
TTTCTTCACT ATGACTGTGT TAACCACAAG GCCAAAGCCT TTGCTTCTCT GGGGAAGAAA 
GTCAATGTCA CAAAAACCTG GGAAGAACAA ACTGAAACAC TAAGAGACGT GGTGGATTTC 
CTTAAAGGGC AACTGCTTGA CATTCAAGTG GAGAATTTAA TACCCATTGA GCCCCTCACC 
CTGCAGGCCA GGATGTCTTG TGAGCATGAA GCCCATGGAC ACGGCAGAGG ATCTTGGCAG 
TTCCTCTTCA ATGGACAGAA GTTCCTCCTC TTTGACTCAA ACAACAGAAA GTGGACAGCA 
CTTCATCCTG GAGCCAAGAA GATGACAGAG AAGTGGGAGA AGAACAGGGA TGTGACCATG 
TTCTTCCAGA AGATTTCACT GGGGGATTGT AAGATGTGGC TTGAAGAATT TTTGATGTAC 
TGGGAACAAA TGCTGGATCC AACAAGTGGA AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ULBP1 ( NM_025218.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_079494.1 Homo sapiens UL16 binding protein 1 (ULBP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04424
Clone ID Related Accession (Same CDS sequence)	NM_025218.4 , NM_025218.3
Accession Version	NM_025218.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	UL16-binding protein 1 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL355497.14, AK292519.1, BC035416.1 and BM670923.1. On Nov 22, 2018 this sequence version replaced NM_025218.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.75865.1, SRR1803613.91261.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000229708.4/ ENSP00000229708.2 RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGCGG CCGCCAGCCC CGCGTTCCTT CTGTGCCTCC CGCTTCTGCA CCTGCTGTCT 
GGCTGGTCCC GGGCAGGATG GGTCGACACA CACTGTCTTT GCTATGACTT CATCATCACT 
CCTAAGTCCA GACCTGAACC ACAGTGGTGT GAAGTTCAAG GCCTGGTGGA TGAAAGGCCT 
TTTCTTCACT ATGACTGTGT TAACCACAAG GCCAAAGCCT TTGCTTCTCT GGGGAAGAAA 
GTCAATGTCA CAAAAACCTG GGAAGAACAA ACTGAAACAC TAAGAGACGT GGTGGATTTC 
CTTAAAGGGC AACTGCTTGA CATTCAAGTG GAGAATTTAA TACCCATTGA GCCCCTCACC 
CTGCAGGCCA GGATGTCTTG TGAGCATGAA GCCCATGGAC ACGGCAGAGG ATCTTGGCAG 
TTCCTCTTCA ATGGACAGAA GTTCCTCCTC TTTGACTCAA ACAACAGAAA GTGGACAGCA 
CTTCATCCTG GAGCCAAGAA GATGACAGAG AAGTGGGAGA AGAACAGGGA TGTGACCATG 
TTCTTCCAGA AGATTTCACT GGGGGATTGT AAGATGTGGC TTGAAGAATT TTTGATGTAC 
TGGGAACAAA TGCTGGATCC AACAAAACCA CCCTCTCTGG CCCCAGGCAC AACCCAACCC 
AAGGCCATGG CCACCACCCT CAGTCCCTGG AGCCTTCTCA TCATCTTCCT CTGCTTCATT 
CTAGCTGGCA GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079494.1
CDS	108..842
Translation	MAAAASPAFLLCLPLLHLLSGWSRAGWVDTHCLCYDFIITPKSRPEPQWCEVQGLVDERPFLHYDCVNHKAKAFASLGKKVNVTKTWEEQTETLRDVVDFLKGQLLDIQVENLIPIEPLTLQARMSCEHEAHGHGRGSWQFLFNGQKFLLFDSNNRKWTALHPGAKKMTEKWEKNRDVTMFFQKISLGDCKMWLEEFLMYWEQMLDPTKPPSLAPGTTQPKAMATTLSPWSLLIIFLCFILAGR

Target ORF information:

RefSeq Version	NM_025218.4
Organism	Homo sapiens(human)
Definition	Homo sapiens UL16 binding protein 1 (ULBP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025218.4

ORF Insert Sequence:

ATGGCAGCGG CCGCCAGCCC CGCGTTCCTT CTGTGCCTCC CGCTTCTGCA CCTGCTGTCT 
GGCTGGTCCC GGGCAGGATG GGTCGACACA CACTGTCTTT GCTATGACTT CATCATCACT 
CCTAAGTCCA GACCTGAACC ACAGTGGTGT GAAGTTCAAG GCCTGGTGGA TGAAAGGCCT 
TTTCTTCACT ATGACTGTGT TAACCACAAG GCCAAAGCCT TTGCTTCTCT GGGGAAGAAA 
GTCAATGTCA CAAAAACCTG GGAAGAACAA ACTGAAACAC TAAGAGACGT GGTGGATTTC 
CTTAAAGGGC AACTGCTTGA CATTCAAGTG GAGAATTTAA TACCCATTGA GCCCCTCACC 
CTGCAGGCCA GGATGTCTTG TGAGCATGAA GCCCATGGAC ACGGCAGAGG ATCTTGGCAG 
TTCCTCTTCA ATGGACAGAA GTTCCTCCTC TTTGACTCAA ACAACAGAAA GTGGACAGCA 
CTTCATCCTG GAGCCAAGAA GATGACAGAG AAGTGGGAGA AGAACAGGGA TGTGACCATG 
TTCTTCCAGA AGATTTCACT GGGGGATTGT AAGATGTGGC TTGAAGAATT TTTGATGTAC 
TGGGAACAAA TGCTGGATCC AACAAAACCA CCCTCTCTGG CCCCAGGCAC AACCCAACCC 
AAGGCCATGG CCACCACCCT CAGTCCCTGG AGCCTTCTCA TCATCTTCCT CTGCTTCATT 
CTAGCTGGCA GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ULBP1 ( NM_025218.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_079494.1 Homo sapiens UL16 binding protein 1 (ULBP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04424
Clone ID Related Accession (Same CDS sequence)	NM_025218.4 , NM_025218.3
Accession Version	NM_025218.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	UL16-binding protein 1 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK292519.1, BC035416.1 and BM670923.1. On Nov 14, 2015 this sequence version replaced NM_025218.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292519.1, SRR1803613.76498.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCGG CCGCCAGCCC CGCGTTCCTT CTGTGCCTCC CGCTTCTGCA CCTGCTGTCT 
GGCTGGTCCC GGGCAGGATG GGTCGACACA CACTGTCTTT GCTATGACTT CATCATCACT 
CCTAAGTCCA GACCTGAACC ACAGTGGTGT GAAGTTCAAG GCCTGGTGGA TGAAAGGCCT 
TTTCTTCACT ATGACTGTGT TAACCACAAG GCCAAAGCCT TTGCTTCTCT GGGGAAGAAA 
GTCAATGTCA CAAAAACCTG GGAAGAACAA ACTGAAACAC TAAGAGACGT GGTGGATTTC 
CTTAAAGGGC AACTGCTTGA CATTCAAGTG GAGAATTTAA TACCCATTGA GCCCCTCACC 
CTGCAGGCCA GGATGTCTTG TGAGCATGAA GCCCATGGAC ACGGCAGAGG ATCTTGGCAG 
TTCCTCTTCA ATGGACAGAA GTTCCTCCTC TTTGACTCAA ACAACAGAAA GTGGACAGCA 
CTTCATCCTG GAGCCAAGAA GATGACAGAG AAGTGGGAGA AGAACAGGGA TGTGACCATG 
TTCTTCCAGA AGATTTCACT GGGGGATTGT AAGATGTGGC TTGAAGAATT TTTGATGTAC 
TGGGAACAAA TGCTGGATCC AACAAAACCA CCCTCTCTGG CCCCAGGCAC AACCCAACCC 
AAGGCCATGG CCACCACCCT CAGTCCCTGG AGCCTTCTCA TCATCTTCCT CTGCTTCATT 
CTAGCTGGCA GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079494.1
CDS	77..811
Translation	MAAAASPAFLLCLPLLHLLSGWSRAGWVDTHCLCYDFIITPKSRPEPQWCEVQGLVDERPFLHYDCVNHKAKAFASLGKKVNVTKTWEEQTETLRDVVDFLKGQLLDIQVENLIPIEPLTLQARMSCEHEAHGHGRGSWQFLFNGQKFLLFDSNNRKWTALHPGAKKMTEKWEKNRDVTMFFQKISLGDCKMWLEEFLMYWEQMLDPTKPPSLAPGTTQPKAMATTLSPWSLLIIFLCFILAGR

Target ORF information:

RefSeq Version	NM_025218.3
Organism	Homo sapiens(human)
Definition	Homo sapiens UL16 binding protein 1 (ULBP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025218.3

ORF Insert Sequence:

ATGGCAGCGG CCGCCAGCCC CGCGTTCCTT CTGTGCCTCC CGCTTCTGCA CCTGCTGTCT 
GGCTGGTCCC GGGCAGGATG GGTCGACACA CACTGTCTTT GCTATGACTT CATCATCACT 
CCTAAGTCCA GACCTGAACC ACAGTGGTGT GAAGTTCAAG GCCTGGTGGA TGAAAGGCCT 
TTTCTTCACT ATGACTGTGT TAACCACAAG GCCAAAGCCT TTGCTTCTCT GGGGAAGAAA 
GTCAATGTCA CAAAAACCTG GGAAGAACAA ACTGAAACAC TAAGAGACGT GGTGGATTTC 
CTTAAAGGGC AACTGCTTGA CATTCAAGTG GAGAATTTAA TACCCATTGA GCCCCTCACC 
CTGCAGGCCA GGATGTCTTG TGAGCATGAA GCCCATGGAC ACGGCAGAGG ATCTTGGCAG 
TTCCTCTTCA ATGGACAGAA GTTCCTCCTC TTTGACTCAA ACAACAGAAA GTGGACAGCA 
CTTCATCCTG GAGCCAAGAA GATGACAGAG AAGTGGGAGA AGAACAGGGA TGTGACCATG 
TTCTTCCAGA AGATTTCACT GGGGGATTGT AAGATGTGGC TTGAAGAATT TTTGATGTAC 
TGGGAACAAA TGCTGGATCC AACAAAACCA CCCTCTCTGG CCCCAGGCAC AACCCAACCC 
AAGGCCATGG CCACCACCCT CAGTCCCTGG AGCCTTCTCA TCATCTTCCT CTGCTTCATT 
CTAGCTGGCA GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ULBP1 ( NM_001317089.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001304018.1 Homo sapiens UL16 binding protein 1 (ULBP1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu101925
Clone ID Related Accession (Same CDS sequence)	NM_001317089.2 , NM_001317089.1
Accession Version	NM_001317089.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 195bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	UL16-binding protein 1 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL355497.14, AK292519.1, DB462306.1, BC035416.1 and BM670923.1. On May 31, 2019 this sequence version replaced NM_001317089.1. Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DB462306.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCGG CCGCCAGCCC CGCGTTCCTT CTGTGCCTCC CGCTTCTGCA CCTGCTGTCT 
GGCTGGTCCC GGGCAGGATG GGTCGAACCA CCCTCTCTGG CCCCAGGCAC AACCCAACCC 
AAGGCCATGG CCACCACCCT CAGTCCCTGG AGCCTTCTCA TCATCTTCCT CTGCTTCATT 
CTAGCTGGCA GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304018.1
CDS	108..302
Translation	MAAAASPAFLLCLPLLHLLSGWSRAGWVEPPSLAPGTTQPKAMATTLSPWSLLIIFLCFILAGR

Target ORF information:

RefSeq Version	NM_001317089.2
Organism	Homo sapiens(human)
Definition	Homo sapiens UL16 binding protein 1 (ULBP1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001317089.2

ORF Insert Sequence:

ATGGCAGCGG CCGCCAGCCC CGCGTTCCTT CTGTGCCTCC CGCTTCTGCA CCTGCTGTCT 
GGCTGGTCCC GGGCAGGATG GGTCGAACCA CCCTCTCTGG CCCCAGGCAC AACCCAACCC 
AAGGCCATGG CCACCACCCT CAGTCCCTGG AGCCTTCTCA TCATCTTCCT CTGCTTCATT 
CTAGCTGGCA GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ULBP1 ( NM_001317089.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001304018.1 Homo sapiens UL16 binding protein 1 (ULBP1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu101925
Clone ID Related Accession (Same CDS sequence)	NM_001317089.2 , NM_001317089.1
Accession Version	NM_001317089.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 195bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-30
Organism	Homo sapiens(human)
Product	UL16-binding protein 1 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK292519.1, DB462306.1, BC035416.1 and BM670923.1. Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DB462306.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCGG CCGCCAGCCC CGCGTTCCTT CTGTGCCTCC CGCTTCTGCA CCTGCTGTCT 
GGCTGGTCCC GGGCAGGATG GGTCGAACCA CCCTCTCTGG CCCCAGGCAC AACCCAACCC 
AAGGCCATGG CCACCACCCT CAGTCCCTGG AGCCTTCTCA TCATCTTCCT CTGCTTCATT 
CTAGCTGGCA GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304018.1
CDS	77..271
Translation	MAAAASPAFLLCLPLLHLLSGWSRAGWVEPPSLAPGTTQPKAMATTLSPWSLLIIFLCFILAGR

Target ORF information:

RefSeq Version	NM_001317089.1
Organism	Homo sapiens(human)
Definition	Homo sapiens UL16 binding protein 1 (ULBP1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001317089.1

ORF Insert Sequence:

ATGGCAGCGG CCGCCAGCCC CGCGTTCCTT CTGTGCCTCC CGCTTCTGCA CCTGCTGTCT 
GGCTGGTCCC GGGCAGGATG GGTCGAACCA CCCTCTCTGG CCCCAGGCAC AACCCAACCC 
AAGGCCATGG CCACCACCCT CAGTCCCTGG AGCCTTCTCA TCATCTTCCT CTGCTTCATT 
CTAGCTGGCA GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A disease-linked
Science signaling10(481)(2017 May)
Zuo J,Willcox CR,Mohammed F,Davey M,Hunter S,Khan K,Antoun A,Katakia P,Croudace J,Inman C,Parry H,Briggs D,Malladi R,Willcox BE,Moss P

Downregulation of the stress-induced ligand ULBP1 following SV40 infection confers viral evasion from NK cell cytotoxicity.
Oncotarget7(13)15369-81(2016 Mar)
Bauman Y,Drayman N,Ben-Nun-Shaul O,Vitenstein A,Yamin R,Ophir Y,Oppenheim A,Mandelboim O

A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells.
eLife4(2015 Nov)
Gowen BG,Chim B,Marceau CD,Greene TT,Burr P,Gonzalez JR,Hesser CR,Dietzen PA,Russell T,Iannello A,Coscoy L,Sentman CL,Carette JE,Muljo SA,Raulet DH

Immunohistochemical validation and expression profiling of NKG2D ligands in a wide spectrum of human epithelial neoplasms.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society63(3)217-27(2015 03)
Fujita H,Hatanaka Y,Sutoh Y,Suzuki Y,Oba K,Hatanaka KC,Mitsuhashi T,Otsuka N,Fugo K,Kasahara M,Matsuno Y

MICA/B and ULBP1 NKG2D ligands are independent predictors of good prognosis in cervical cancer.
BMC cancer14957(2014 Dec)
Cho H,Chung JY,Kim S,Braunschweig T,Kang TH,Kim J,Chung EJ,Hewitt SM,Kim JH

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ULBP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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