ORAI2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ORAI2
Entrez Gene ID	80228
Full Name	ORAI calcium release-activated calcium modulator 2
Synonyms	C7orf19,CBCIP2,MEM142B,TMEM142B
General protein information	Preferred Names ORAI calcium release-activated calcium modulator 2 Names protein orai-2 CAP-binding protein complex interacting protein 2 H_NH0514P08.8 putative protein ORAI2-2 transmembrane protein 142B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q22.1
Disorder MIM:	610929

mRNA and Protein(s)

mRNA	Protein	Name
NM_001126340.2	NP_001119812.1	protein orai-2 isoform a
NM_001271819.1	NP_001258748.1	protein orai-2 isoform b
NM_001271819.2	NP_001258748.1	protein orai-2 isoform b
NM_032831.3	NP_116220.1	protein orai-2 isoform a
NM_001271818.1	NP_001258747.1	protein orai-2 isoform a
NM_032831.4	NP_116220.1	protein orai-2 isoform a
NM_001126340.3	NP_001119812.1	protein orai-2 isoform a

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ORAI2	XP_001155376.2
	ORAI2	XP_001108554.2
Rattus norvegicus (Norway rat)	Orai2	NP_001163874.1
Bos taurus (cattle)	ORAI2	NP_001178277.1
Mus musculus (house mouse)	Orai2	NP_848866.2
Homo sapiens (human)	ORAI2	NP_001119812.1
Gallus gallus (chicken)	ORAI2	NP_001025881.1
Xenopus tropicalis (tropical clawed frog)	orai1	NP_001096448.1
Canis lupus familiaris (dog)	ORAI2	XP_850105.1
Danio rerio (zebrafish)	orai2	NP_001159919.1

Gene Ontology
Bibliography

Related articles in PubMed

ORAI channels are critical for receptor-mediated endocytosis of albumin.
Zeng B, Chen GL, Garcia-Vaz E, Bhandari S, Daskoulidou N, Berglund LM, Jiang H, Hallett T, Zhou LP, Huang L, Xu ZH, Nair V, Nelson RG, Ju W, Kretzler M, Atkin SL, Gomez MF, Xu SZ
Nature communications8(1)1920(2017 Dec)

Orai1 and Orai2 mediate store-operated calcium entry that regulates HL60 cell migration and FAK phosphorylation.
Diez-Bello R, Jardin I, Salido GM, Rosado JA
Biochimica et biophysica acta1864(6)1064-1070(2017 06)

A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels.
Saul S, Gibhardt CS, Schmidt B, Lis A, Pasieka B, Conrad D, Jung P, Gaupp R, Wonnenberg B, Diler E, Stanisz H, Vogt T, Schwarz EC, Bischoff M, Herrmann M, Tschernig T, Kappl R, Rieger H, Niemeyer BA, Bogeski I
Science signaling9(418)ra26(2016 Mar)

Orai1-Orai2 complex is involved in store-operated calcium entry in chondrocyte cell lines.
Inayama M, Suzuki Y, Yamada S, Kurita T, Yamamura H, Ohya S, Giles WR, Imaizumi Y
Cell calcium57(5-6)337-47(2015 May)

Enhanced expression of Stim, Orai, and TRPC transcripts and proteins in endothelial progenitor cells isolated from patients with primary myelofibrosis.
Dragoni S, Laforenza U, Bonetti E, Reforgiato M, Poletto V, Lodola F, Bottino C, Guido D, Rappa A, Pareek S, Tomasello M, Guarrera MR, Cinelli MP, Aronica A, Guerra G, Barosi G, Tanzi F, Rosti V, Moccia F
PloS one9(3)e91099(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings provide evidence for a role for Orai1 and Orai2, in SOCE and migration in the human HL60 promyeloblastic cell line
Title: Orai1 and Orai2 mediate store-operated calcium entry that regulates HL60 cell migration and FAK phosphorylation.

results identified the ORAI-NOX2 feedback loop as a determinant of monocyte immune responses.
Title: A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels.

Orai1, Orai2 and STIM1 form functional Ca(2+) release-activated Ca(2+) channels in OUMS-27 cells (chondrocytes) and that these complexes are responsible for sustained Ca(2+) entry in response to agonist stimulation.
Title: Orai1-Orai2 complex is involved in store-operated calcium entry in chondrocyte cell lines.

The higher amplitude of store-operated Ca2+ entry was associated to the over-expression for Stim2, Orai2-3, and TRPC1 while Stim2 levels remained constant and Stim1, Orai1, Orai3, TRPC1 and TRPC4 proteins were over-expressed in primary myelofibrosis.
Title: Enhanced expression of Stim, Orai, and TRPC transcripts and proteins in endothelial progenitor cells isolated from patients with primary myelofibrosis.

Orai1 but not Orai2 plays a major role in the influx of extracellular Ca2+ into and mediator release from HLMCs following their activation
Title: The contribution of Orai(CRACM)1 and Orai(CRACM)2 channels in store-operated Ca2+ entry and mediator release in human lung mast cells.

The following ORAI2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ORAI2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01955	NM_001126340.3 Latest version!	Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu01955	NM_032831.4 Latest version!	Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu01955	NM_001271818.1 Latest version!	Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu12597	NM_001271819.2 Latest version!	Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu12597	NM_001271819.1	Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu01955	NM_032831.3	Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu01955	NM_001126340.2	Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ORAI2 ( NM_001126340.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001119812.1 Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01955
Clone ID Related Accession (Same CDS sequence)	NM_001126340.2 , NM_032831.3 , NM_001271818.1 , NM_032831.4 , NM_001126340.3
Accession Version	NM_001126340.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 765bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-10
Organism	Homo sapiens(human)
Product	protein orai-2 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY064081.1 and AC093668.4. On Nov 28, 2012 this sequence version replaced NM_001126340.1. Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 2, and 3 all encode the same isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because transcript sequence consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.481556.1, SRR1163655.121592.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream ORF predicted to inhibit translation from upstream AUG ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTGCTG AGCTTAACGT GCCTATCGAC CCCTCTGCTC CTGCCTGCCC TGAGCCCGGC 
CATAAGGGCA TGGATTACCG GGACTGGGTC CGCCGCAGCT ACCTGGAACT GGTCACCTCT 
AACCACCACT CGGTACAGGC CCTGTCGTGG CGGAAGCTCT ACCTGAGCAG GGCCAAGCTG 
AAGGCCTCCA GCAGGACCTC CGCCCTCCTC TCCGGCTTTG CCATGGTGGC CATGGTGGAG 
GTGCAGCTGG AGACGCAGTA CCAGTACCCG CGGCCGCTGC TGATTGCCTT CAGCGCCTGC 
ACCACGGTGC TGGTGGCCGT GCACCTGTTC GCCCTCCTCA TCAGCACCTG CATCCTGCCC 
AATGTGGAGG CCGTGAGCAA CATCCACAAC CTGAACTCCA TCAGCGAGTC CCCGCATGAG 
CGCATGCACC CCTACATCGA GCTGGCCTGG GGCTTCTCCA CCGTGCTTGG CATCCTACTC 
TTCCTGGCCG AGGTGGTGCT GCTCTGCTGG ATCAAGTTCC TCCCCGTGGA TGCCCGGCGC 
CAGCCTGGCC CCCCACCTGG CCCTGGGAGT CACACGGGCT GGCAGGCCGC CCTGGTGTCC 
ACCATCATCA TGGTGCCCGT GGGCCTCATC TTCGTGGTCT TCACCATCCA CTTCTACCGC 
TCCCTGGTGC GCCACAAAAC GGAGCGCCAC AACCGCGAGA TCGAGGAGCT CCACAAGCTC 
AAGGTCCAGC TGGACGGGCA TGAGCGCAGC CTGCAGGTCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001119812.1
CDS	255..1019
Translation	MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVL

Target ORF information:

RefSeq Version	NM_001126340.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001126340.2

ORF Insert Sequence:

ATGAGTGCTG AGCTTAACGT GCCTATCGAC CCCTCTGCTC CTGCCTGCCC TGAGCCCGGC 
CATAAGGGCA TGGATTACCG GGACTGGGTC CGCCGCAGCT ACCTGGAACT GGTCACCTCT 
AACCACCACT CGGTACAGGC CCTGTCGTGG CGGAAGCTCT ACCTGAGCAG GGCCAAGCTG 
AAGGCCTCCA GCAGGACCTC CGCCCTCCTC TCCGGCTTTG CCATGGTGGC CATGGTGGAG 
GTGCAGCTGG AGACGCAGTA CCAGTACCCG CGGCCGCTGC TGATTGCCTT CAGCGCCTGC 
ACCACGGTGC TGGTGGCCGT GCACCTGTTC GCCCTCCTCA TCAGCACCTG CATCCTGCCC 
AATGTGGAGG CCGTGAGCAA CATCCACAAC CTGAACTCCA TCAGCGAGTC CCCGCATGAG 
CGCATGCACC CCTACATCGA GCTGGCCTGG GGCTTCTCCA CCGTGCTTGG CATCCTACTC 
TTCCTGGCCG AGGTGGTGCT GCTCTGCTGG ATCAAGTTCC TCCCCGTGGA TGCCCGGCGC 
CAGCCTGGCC CCCCACCTGG CCCTGGGAGT CACACGGGCT GGCAGGCCGC CCTGGTGTCC 
ACCATCATCA TGGTGCCCGT GGGCCTCATC TTCGTGGTCT TCACCATCCA CTTCTACCGC 
TCCCTGGTGC GCCACAAAAC GGAGCGCCAC AACCGCGAGA TCGAGGAGCT CCACAAGCTC 
AAGGTCCAGC TGGACGGGCA TGAGCGCAGC CTGCAGGTCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ORAI2 ( NM_032831.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_116220.1 Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu01955
Clone ID Related Accession (Same CDS sequence)	NM_001126340.2 , NM_032831.3 , NM_001271818.1 , NM_032831.4 , NM_001126340.3
Accession Version	NM_032831.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 765bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-12
Organism	Homo sapiens(human)
Product	protein orai-2 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY064081.1, AK027639.1 and AC093668.4. On Nov 28, 2012 this sequence version replaced NM_032831.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1, 2, and 3 all encode the same isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because transcript sequence consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of this transcript is supported byt transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK027639.1, SRR1163657.333429.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGCTG AGCTTAACGT GCCTATCGAC CCCTCTGCTC CTGCCTGCCC TGAGCCCGGC 
CATAAGGGCA TGGATTACCG GGACTGGGTC CGCCGCAGCT ACCTGGAACT GGTCACCTCT 
AACCACCACT CGGTACAGGC CCTGTCGTGG CGGAAGCTCT ACCTGAGCAG GGCCAAGCTG 
AAGGCCTCCA GCAGGACCTC CGCCCTCCTC TCCGGCTTTG CCATGGTGGC CATGGTGGAG 
GTGCAGCTGG AGACGCAGTA CCAGTACCCG CGGCCGCTGC TGATTGCCTT CAGCGCCTGC 
ACCACGGTGC TGGTGGCCGT GCACCTGTTC GCCCTCCTCA TCAGCACCTG CATCCTGCCC 
AATGTGGAGG CCGTGAGCAA CATCCACAAC CTGAACTCCA TCAGCGAGTC CCCGCATGAG 
CGCATGCACC CCTACATCGA GCTGGCCTGG GGCTTCTCCA CCGTGCTTGG CATCCTACTC 
TTCCTGGCCG AGGTGGTGCT GCTCTGCTGG ATCAAGTTCC TCCCCGTGGA TGCCCGGCGC 
CAGCCTGGCC CCCCACCTGG CCCTGGGAGT CACACGGGCT GGCAGGCCGC CCTGGTGTCC 
ACCATCATCA TGGTGCCCGT GGGCCTCATC TTCGTGGTCT TCACCATCCA CTTCTACCGC 
TCCCTGGTGC GCCACAAAAC GGAGCGCCAC AACCGCGAGA TCGAGGAGCT CCACAAGCTC 
AAGGTCCAGC TGGACGGGCA TGAGCGCAGC CTGCAGGTCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116220.1
CDS	146..910
Translation	MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVL

Target ORF information:

RefSeq Version	NM_032831.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032831.3

ORF Insert Sequence:

ATGAGTGCTG AGCTTAACGT GCCTATCGAC CCCTCTGCTC CTGCCTGCCC TGAGCCCGGC 
CATAAGGGCA TGGATTACCG GGACTGGGTC CGCCGCAGCT ACCTGGAACT GGTCACCTCT 
AACCACCACT CGGTACAGGC CCTGTCGTGG CGGAAGCTCT ACCTGAGCAG GGCCAAGCTG 
AAGGCCTCCA GCAGGACCTC CGCCCTCCTC TCCGGCTTTG CCATGGTGGC CATGGTGGAG 
GTGCAGCTGG AGACGCAGTA CCAGTACCCG CGGCCGCTGC TGATTGCCTT CAGCGCCTGC 
ACCACGGTGC TGGTGGCCGT GCACCTGTTC GCCCTCCTCA TCAGCACCTG CATCCTGCCC 
AATGTGGAGG CCGTGAGCAA CATCCACAAC CTGAACTCCA TCAGCGAGTC CCCGCATGAG 
CGCATGCACC CCTACATCGA GCTGGCCTGG GGCTTCTCCA CCGTGCTTGG CATCCTACTC 
TTCCTGGCCG AGGTGGTGCT GCTCTGCTGG ATCAAGTTCC TCCCCGTGGA TGCCCGGCGC 
CAGCCTGGCC CCCCACCTGG CCCTGGGAGT CACACGGGCT GGCAGGCCGC CCTGGTGTCC 
ACCATCATCA TGGTGCCCGT GGGCCTCATC TTCGTGGTCT TCACCATCCA CTTCTACCGC 
TCCCTGGTGC GCCACAAAAC GGAGCGCCAC AACCGCGAGA TCGAGGAGCT CCACAAGCTC 
AAGGTCCAGC TGGACGGGCA TGAGCGCAGC CTGCAGGTCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ORAI2 ( NM_001271818.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258747.1 Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu01955
Clone ID Related Accession (Same CDS sequence)	NM_001126340.2 , NM_032831.3 , NM_001271818.1 , NM_032831.4 , NM_001126340.3
Accession Version	NM_001271818.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 765bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	protein orai-2 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY064081.1, CN366874.1 and AC093668.4. Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, and 3 all encode the same isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.297326.1, CN366874.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream ORF predicted to inhibit translation from upstream AUG ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTGCTG AGCTTAACGT GCCTATCGAC CCCTCTGCTC CTGCCTGCCC TGAGCCCGGC 
CATAAGGGCA TGGATTACCG GGACTGGGTC CGCCGCAGCT ACCTGGAACT GGTCACCTCT 
AACCACCACT CGGTACAGGC CCTGTCGTGG CGGAAGCTCT ACCTGAGCAG GGCCAAGCTG 
AAGGCCTCCA GCAGGACCTC CGCCCTCCTC TCCGGCTTTG CCATGGTGGC CATGGTGGAG 
GTGCAGCTGG AGACGCAGTA CCAGTACCCG CGGCCGCTGC TGATTGCCTT CAGCGCCTGC 
ACCACGGTGC TGGTGGCCGT GCACCTGTTC GCCCTCCTCA TCAGCACCTG CATCCTGCCC 
AATGTGGAGG CCGTGAGCAA CATCCACAAC CTGAACTCCA TCAGCGAGTC CCCGCATGAG 
CGCATGCACC CCTACATCGA GCTGGCCTGG GGCTTCTCCA CCGTGCTTGG CATCCTACTC 
TTCCTGGCCG AGGTGGTGCT GCTCTGCTGG ATCAAGTTCC TCCCCGTGGA TGCCCGGCGC 
CAGCCTGGCC CCCCACCTGG CCCTGGGAGT CACACGGGCT GGCAGGCCGC CCTGGTGTCC 
ACCATCATCA TGGTGCCCGT GGGCCTCATC TTCGTGGTCT TCACCATCCA CTTCTACCGC 
TCCCTGGTGC GCCACAAAAC GGAGCGCCAC AACCGCGAGA TCGAGGAGCT CCACAAGCTC 
AAGGTCCAGC TGGACGGGCA TGAGCGCAGC CTGCAGGTCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258747.1
CDS	278..1042
Translation	MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVL

Target ORF information:

RefSeq Version	NM_001271818.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271818.1

ORF Insert Sequence:

ATGAGTGCTG AGCTTAACGT GCCTATCGAC CCCTCTGCTC CTGCCTGCCC TGAGCCCGGC 
CATAAGGGCA TGGATTACCG GGACTGGGTC CGCCGCAGCT ACCTGGAACT GGTCACCTCT 
AACCACCACT CGGTACAGGC CCTGTCGTGG CGGAAGCTCT ACCTGAGCAG GGCCAAGCTG 
AAGGCCTCCA GCAGGACCTC CGCCCTCCTC TCCGGCTTTG CCATGGTGGC CATGGTGGAG 
GTGCAGCTGG AGACGCAGTA CCAGTACCCG CGGCCGCTGC TGATTGCCTT CAGCGCCTGC 
ACCACGGTGC TGGTGGCCGT GCACCTGTTC GCCCTCCTCA TCAGCACCTG CATCCTGCCC 
AATGTGGAGG CCGTGAGCAA CATCCACAAC CTGAACTCCA TCAGCGAGTC CCCGCATGAG 
CGCATGCACC CCTACATCGA GCTGGCCTGG GGCTTCTCCA CCGTGCTTGG CATCCTACTC 
TTCCTGGCCG AGGTGGTGCT GCTCTGCTGG ATCAAGTTCC TCCCCGTGGA TGCCCGGCGC 
CAGCCTGGCC CCCCACCTGG CCCTGGGAGT CACACGGGCT GGCAGGCCGC CCTGGTGTCC 
ACCATCATCA TGGTGCCCGT GGGCCTCATC TTCGTGGTCT TCACCATCCA CTTCTACCGC 
TCCCTGGTGC GCCACAAAAC GGAGCGCCAC AACCGCGAGA TCGAGGAGCT CCACAAGCTC 
AAGGTCCAGC TGGACGGGCA TGAGCGCAGC CTGCAGGTCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ORAI2 ( NM_032831.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_116220.1 Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu01955
Clone ID Related Accession (Same CDS sequence)	NM_001126340.2 , NM_032831.3 , NM_001271818.1 , NM_032831.4 , NM_001126340.3
Accession Version	NM_032831.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 765bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-01
Organism	Homo sapiens(human)
Product	protein orai-2 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY064081.1, AK027639.1 and AC093668.4. On Jun 2, 2019 this sequence version replaced NM_032831.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1, 2, and 3 all encode the same isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because transcript sequence consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of this transcript is supported byt transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK027639.1, SRR1803614.206214.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGCTG AGCTTAACGT GCCTATCGAC CCCTCTGCTC CTGCCTGCCC TGAGCCCGGC 
CATAAGGGCA TGGATTACCG GGACTGGGTC CGCCGCAGCT ACCTGGAACT GGTCACCTCT 
AACCACCACT CGGTACAGGC CCTGTCGTGG CGGAAGCTCT ACCTGAGCAG GGCCAAGCTG 
AAGGCCTCCA GCAGGACCTC CGCCCTCCTC TCCGGCTTTG CCATGGTGGC CATGGTGGAG 
GTGCAGCTGG AGACGCAGTA CCAGTACCCG CGGCCGCTGC TGATTGCCTT CAGCGCCTGC 
ACCACGGTGC TGGTGGCCGT GCACCTGTTC GCCCTCCTCA TCAGCACCTG CATCCTGCCC 
AATGTGGAGG CCGTGAGCAA CATCCACAAC CTGAACTCCA TCAGCGAGTC CCCGCATGAG 
CGCATGCACC CCTACATCGA GCTGGCCTGG GGCTTCTCCA CCGTGCTTGG CATCCTACTC 
TTCCTGGCCG AGGTGGTGCT GCTCTGCTGG ATCAAGTTCC TCCCCGTGGA TGCCCGGCGC 
CAGCCTGGCC CCCCACCTGG CCCTGGGAGT CACACGGGCT GGCAGGCCGC CCTGGTGTCC 
ACCATCATCA TGGTGCCCGT GGGCCTCATC TTCGTGGTCT TCACCATCCA CTTCTACCGC 
TCCCTGGTGC GCCACAAAAC GGAGCGCCAC AACCGCGAGA TCGAGGAGCT CCACAAGCTC 
AAGGTCCAGC TGGACGGGCA TGAGCGCAGC CTGCAGGTCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116220.1
CDS	101..865
Translation	MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVL

Target ORF information:

RefSeq Version	NM_032831.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032831.4

ORF Insert Sequence:

ATGAGTGCTG AGCTTAACGT GCCTATCGAC CCCTCTGCTC CTGCCTGCCC TGAGCCCGGC 
CATAAGGGCA TGGATTACCG GGACTGGGTC CGCCGCAGCT ACCTGGAACT GGTCACCTCT 
AACCACCACT CGGTACAGGC CCTGTCGTGG CGGAAGCTCT ACCTGAGCAG GGCCAAGCTG 
AAGGCCTCCA GCAGGACCTC CGCCCTCCTC TCCGGCTTTG CCATGGTGGC CATGGTGGAG 
GTGCAGCTGG AGACGCAGTA CCAGTACCCG CGGCCGCTGC TGATTGCCTT CAGCGCCTGC 
ACCACGGTGC TGGTGGCCGT GCACCTGTTC GCCCTCCTCA TCAGCACCTG CATCCTGCCC 
AATGTGGAGG CCGTGAGCAA CATCCACAAC CTGAACTCCA TCAGCGAGTC CCCGCATGAG 
CGCATGCACC CCTACATCGA GCTGGCCTGG GGCTTCTCCA CCGTGCTTGG CATCCTACTC 
TTCCTGGCCG AGGTGGTGCT GCTCTGCTGG ATCAAGTTCC TCCCCGTGGA TGCCCGGCGC 
CAGCCTGGCC CCCCACCTGG CCCTGGGAGT CACACGGGCT GGCAGGCCGC CCTGGTGTCC 
ACCATCATCA TGGTGCCCGT GGGCCTCATC TTCGTGGTCT TCACCATCCA CTTCTACCGC 
TCCCTGGTGC GCCACAAAAC GGAGCGCCAC AACCGCGAGA TCGAGGAGCT CCACAAGCTC 
AAGGTCCAGC TGGACGGGCA TGAGCGCAGC CTGCAGGTCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ORAI2 ( NM_001126340.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001119812.1 Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 1, mRNA.

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CloneID	OHu01955
Clone ID Related Accession (Same CDS sequence)	NM_001126340.2 , NM_032831.3 , NM_001271818.1 , NM_032831.4 , NM_001126340.3
Accession Version	NM_001126340.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 765bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	protein orai-2 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY064081.1 and AC093668.4. On Nov 23, 2018 this sequence version replaced NM_001126340.2. Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 2, and 3 all encode the same isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because transcript sequence consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.403215.1, SRR3476690.1076128.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream ORF predicted to inhibit translation from upstream AUG RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGTGCTG AGCTTAACGT GCCTATCGAC CCCTCTGCTC CTGCCTGCCC TGAGCCCGGC 
CATAAGGGCA TGGATTACCG GGACTGGGTC CGCCGCAGCT ACCTGGAACT GGTCACCTCT 
AACCACCACT CGGTACAGGC CCTGTCGTGG CGGAAGCTCT ACCTGAGCAG GGCCAAGCTG 
AAGGCCTCCA GCAGGACCTC CGCCCTCCTC TCCGGCTTTG CCATGGTGGC CATGGTGGAG 
GTGCAGCTGG AGACGCAGTA CCAGTACCCG CGGCCGCTGC TGATTGCCTT CAGCGCCTGC 
ACCACGGTGC TGGTGGCCGT GCACCTGTTC GCCCTCCTCA TCAGCACCTG CATCCTGCCC 
AATGTGGAGG CCGTGAGCAA CATCCACAAC CTGAACTCCA TCAGCGAGTC CCCGCATGAG 
CGCATGCACC CCTACATCGA GCTGGCCTGG GGCTTCTCCA CCGTGCTTGG CATCCTACTC 
TTCCTGGCCG AGGTGGTGCT GCTCTGCTGG ATCAAGTTCC TCCCCGTGGA TGCCCGGCGC 
CAGCCTGGCC CCCCACCTGG CCCTGGGAGT CACACGGGCT GGCAGGCCGC CCTGGTGTCC 
ACCATCATCA TGGTGCCCGT GGGCCTCATC TTCGTGGTCT TCACCATCCA CTTCTACCGC 
TCCCTGGTGC GCCACAAAAC GGAGCGCCAC AACCGCGAGA TCGAGGAGCT CCACAAGCTC 
AAGGTCCAGC TGGACGGGCA TGAGCGCAGC CTGCAGGTCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001119812.1
CDS	210..974
Translation	MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVL

Target ORF information:

RefSeq Version	NM_001126340.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001126340.3

ORF Insert Sequence:

ATGAGTGCTG AGCTTAACGT GCCTATCGAC CCCTCTGCTC CTGCCTGCCC TGAGCCCGGC 
CATAAGGGCA TGGATTACCG GGACTGGGTC CGCCGCAGCT ACCTGGAACT GGTCACCTCT 
AACCACCACT CGGTACAGGC CCTGTCGTGG CGGAAGCTCT ACCTGAGCAG GGCCAAGCTG 
AAGGCCTCCA GCAGGACCTC CGCCCTCCTC TCCGGCTTTG CCATGGTGGC CATGGTGGAG 
GTGCAGCTGG AGACGCAGTA CCAGTACCCG CGGCCGCTGC TGATTGCCTT CAGCGCCTGC 
ACCACGGTGC TGGTGGCCGT GCACCTGTTC GCCCTCCTCA TCAGCACCTG CATCCTGCCC 
AATGTGGAGG CCGTGAGCAA CATCCACAAC CTGAACTCCA TCAGCGAGTC CCCGCATGAG 
CGCATGCACC CCTACATCGA GCTGGCCTGG GGCTTCTCCA CCGTGCTTGG CATCCTACTC 
TTCCTGGCCG AGGTGGTGCT GCTCTGCTGG ATCAAGTTCC TCCCCGTGGA TGCCCGGCGC 
CAGCCTGGCC CCCCACCTGG CCCTGGGAGT CACACGGGCT GGCAGGCCGC CCTGGTGTCC 
ACCATCATCA TGGTGCCCGT GGGCCTCATC TTCGTGGTCT TCACCATCCA CTTCTACCGC 
TCCCTGGTGC GCCACAAAAC GGAGCGCCAC AACCGCGAGA TCGAGGAGCT CCACAAGCTC 
AAGGTCCAGC TGGACGGGCA TGAGCGCAGC CTGCAGGTCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ORAI2 ( NM_001271819.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258748.1 Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 4, mRNA.

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CloneID	OHu12597
Clone ID Related Accession (Same CDS sequence)	NM_001271819.1 , NM_001271819.2
Accession Version	NM_001271819.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 534bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-12
Organism	Homo sapiens(human)
Product	protein orai-2 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY064081.1, DC384892.1 and AC093668.4. Transcript Variant: This variant (4) uses an alternate splice junction and lacks an alternate exon in the 5' UTR compared to variant 3, initiating translation at an alternate downstream in-frame start codon. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK300574.1, DC384892.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGGAGG TGCAGCTGGA GACGCAGTAC CAGTACCCGC GGCCGCTGCT GATTGCCTTC 
AGCGCCTGCA CCACGGTGCT GGTGGCCGTG CACCTGTTCG CCCTCCTCAT CAGCACCTGC 
ATCCTGCCCA ATGTGGAGGC CGTGAGCAAC ATCCACAACC TGAACTCCAT CAGCGAGTCC 
CCGCATGAGC GCATGCACCC CTACATCGAG CTGGCCTGGG GCTTCTCCAC CGTGCTTGGC 
ATCCTACTCT TCCTGGCCGA GGTGGTGCTG CTCTGCTGGA TCAAGTTCCT CCCCGTGGAT 
GCCCGGCGCC AGCCTGGCCC CCCACCTGGC CCTGGGAGTC ACACGGGCTG GCAGGCCGCC 
CTGGTGTCCA CCATCATCAT GGTGCCCGTG GGCCTCATCT TCGTGGTCTT CACCATCCAC 
TTCTACCGCT CCCTGGTGCG CCACAAAACG GAGCGCCACA ACCGCGAGAT CGAGGAGCTC 
CACAAGCTCA AGGTCCAGCT GGACGGGCAT GAGCGCAGCC TGCAGGTCTT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258748.1
CDS	248..781
Translation	MVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVL

Target ORF information:

RefSeq Version	NM_001271819.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271819.1

ORF Insert Sequence:

ATGGTGGAGG TGCAGCTGGA GACGCAGTAC CAGTACCCGC GGCCGCTGCT GATTGCCTTC 
AGCGCCTGCA CCACGGTGCT GGTGGCCGTG CACCTGTTCG CCCTCCTCAT CAGCACCTGC 
ATCCTGCCCA ATGTGGAGGC CGTGAGCAAC ATCCACAACC TGAACTCCAT CAGCGAGTCC 
CCGCATGAGC GCATGCACCC CTACATCGAG CTGGCCTGGG GCTTCTCCAC CGTGCTTGGC 
ATCCTACTCT TCCTGGCCGA GGTGGTGCTG CTCTGCTGGA TCAAGTTCCT CCCCGTGGAT 
GCCCGGCGCC AGCCTGGCCC CCCACCTGGC CCTGGGAGTC ACACGGGCTG GCAGGCCGCC 
CTGGTGTCCA CCATCATCAT GGTGCCCGTG GGCCTCATCT TCGTGGTCTT CACCATCCAC 
TTCTACCGCT CCCTGGTGCG CCACAAAACG GAGCGCCACA ACCGCGAGAT CGAGGAGCTC 
CACAAGCTCA AGGTCCAGCT GGACGGGCAT GAGCGCAGCC TGCAGGTCTT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ORAI2 ( NM_001271819.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258748.1 Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu12597
Clone ID Related Accession (Same CDS sequence)	NM_001271819.1 , NM_001271819.2
Accession Version	NM_001271819.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 534bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-01
Organism	Homo sapiens(human)
Product	protein orai-2 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY064081.1, DC384892.1 and AC093668.4. On Jun 2, 2019 this sequence version replaced NM_001271819.1. Transcript Variant: This variant (4) uses an alternate splice junction and lacks an alternate exon in the 5' UTR compared to variant 3, initiating translation at an alternate downstream in-frame start codon. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.345653.1, SRR3476690.266082.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGGAGG TGCAGCTGGA GACGCAGTAC CAGTACCCGC GGCCGCTGCT GATTGCCTTC 
AGCGCCTGCA CCACGGTGCT GGTGGCCGTG CACCTGTTCG CCCTCCTCAT CAGCACCTGC 
ATCCTGCCCA ATGTGGAGGC CGTGAGCAAC ATCCACAACC TGAACTCCAT CAGCGAGTCC 
CCGCATGAGC GCATGCACCC CTACATCGAG CTGGCCTGGG GCTTCTCCAC CGTGCTTGGC 
ATCCTACTCT TCCTGGCCGA GGTGGTGCTG CTCTGCTGGA TCAAGTTCCT CCCCGTGGAT 
GCCCGGCGCC AGCCTGGCCC CCCACCTGGC CCTGGGAGTC ACACGGGCTG GCAGGCCGCC 
CTGGTGTCCA CCATCATCAT GGTGCCCGTG GGCCTCATCT TCGTGGTCTT CACCATCCAC 
TTCTACCGCT CCCTGGTGCG CCACAAAACG GAGCGCCACA ACCGCGAGAT CGAGGAGCTC 
CACAAGCTCA AGGTCCAGCT GGACGGGCAT GAGCGCAGCC TGCAGGTCTT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258748.1
CDS	203..736
Translation	MVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVL

Target ORF information:

RefSeq Version	NM_001271819.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271819.2

ORF Insert Sequence:

ATGGTGGAGG TGCAGCTGGA GACGCAGTAC CAGTACCCGC GGCCGCTGCT GATTGCCTTC 
AGCGCCTGCA CCACGGTGCT GGTGGCCGTG CACCTGTTCG CCCTCCTCAT CAGCACCTGC 
ATCCTGCCCA ATGTGGAGGC CGTGAGCAAC ATCCACAACC TGAACTCCAT CAGCGAGTCC 
CCGCATGAGC GCATGCACCC CTACATCGAG CTGGCCTGGG GCTTCTCCAC CGTGCTTGGC 
ATCCTACTCT TCCTGGCCGA GGTGGTGCTG CTCTGCTGGA TCAAGTTCCT CCCCGTGGAT 
GCCCGGCGCC AGCCTGGCCC CCCACCTGGC CCTGGGAGTC ACACGGGCTG GCAGGCCGCC 
CTGGTGTCCA CCATCATCAT GGTGCCCGTG GGCCTCATCT TCGTGGTCTT CACCATCCAC 
TTCTACCGCT CCCTGGTGCG CCACAAAACG GAGCGCCACA ACCGCGAGAT CGAGGAGCTC 
CACAAGCTCA AGGTCCAGCT GGACGGGCAT GAGCGCAGCC TGCAGGTCTT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ORAI channels are critical for receptor-mediated endocytosis of albumin.
Nature communications8(1)1920(2017 Dec)
Zeng B,Chen GL,Garcia-Vaz E,Bhandari S,Daskoulidou N,Berglund LM,Jiang H,Hallett T,Zhou LP,Huang L,Xu ZH,Nair V,Nelson RG,Ju W,Kretzler M,Atkin SL,Gomez MF,Xu SZ

Orai1 and Orai2 mediate store-operated calcium entry that regulates HL60 cell migration and FAK phosphorylation.
Biochimica et biophysica acta1864(6)1064-1070(2017 06)
Diez-Bello R,Jardin I,Salido GM,Rosado JA

A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels.
Science signaling9(418)ra26(2016 Mar)
Saul S,Gibhardt CS,Schmidt B,Lis A,Pasieka B,Conrad D,Jung P,Gaupp R,Wonnenberg B,Diler E,Stanisz H,Vogt T,Schwarz EC,Bischoff M,Herrmann M,Tschernig T,Kappl R,Rieger H,Niemeyer BA,Bogeski I

Orai1-Orai2 complex is involved in store-operated calcium entry in chondrocyte cell lines.
Cell calcium57(5-6)337-47(2015 May)
Inayama M,Suzuki Y,Yamada S,Kurita T,Yamamura H,Ohya S,Giles WR,Imaizumi Y

Enhanced expression of Stim, Orai, and TRPC transcripts and proteins in endothelial progenitor cells isolated from patients with primary myelofibrosis.
PloS one9(3)e91099(2014)
Dragoni S,Laforenza U,Bonetti E,Reforgiato M,Poletto V,Lodola F,Bottino C,Guido D,Rappa A,Pareek S,Tomasello M,Guarrera MR,Cinelli MP,Aronica A,Guerra G,Barosi G,Tanzi F,Rosti V,Moccia F

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ORAI2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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