UBTD1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UBTD1
Entrez Gene ID	80019
Full Name	ubiquitin domain containing 1
General protein information	Preferred Names ubiquitin domain containing 1 Names ubiquitin domain-containing protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q24.1-q24.2
Summary	The degradation of many proteins is carried out by the ubiquitin pathway in which proteins are targeted for degradation by covalent conjugation of the polypeptide ubiquitin. This gene encodes a protein that belongs to the ubiquitin family of proteins. The encoded protein is thought to regulate E2 ubiquitin conjugating enzymes belonging to the UBE2D family. [provided by RefSeq, Mar 2014].
Disorder MIM:	616388

mRNA and Protein(s)

mRNA	Protein	Name
NM_024954.5	NP_079230.1	ubiquitin domain-containing protein 1
NM_024954.4	NP_079230.1	ubiquitin domain-containing protein 1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	UBTD1	XP_429110.4
Canis lupus familiaris (dog)	UBTD1	XP_005637648.1
Bos taurus (cattle)	UBTD1	NP_001029433.1
Arabidopsis thaliana (thale cress)	AT5G45740	NP_199386.2
Pan troglodytes (chimpanzee)	UBTD1	XP_001146890.2
	UBTD1	XP_001104303.1
Rattus norvegicus (Norway rat)	Ubtd1	NP_001013171.1
Xenopus tropicalis (tropical clawed frog)	ubtd1	NP_001005656.1
Mus musculus (house mouse)	Ubtd1	NP_663475.1
Danio rerio (zebrafish)	ubtd1a	NP_001082870.1
Homo sapiens (human)	UBTD1	NP_079230.1
Danio rerio (zebrafish)	ubtd1b	NP_001025436.1

Gene Ontology
Bibliography

Related articles in PubMed

UBTD1 induces cellular senescence through an UBTD1-Mdm2/p53 positive feedback loop.
Zhang XW, Wang XF, Ni SJ, Qin W, Zhao LQ, Hua RX, Lu YW, Li J, Dimri GP, Guo WJ
The Journal of pathology235(4)656-67(2015 Mar)

The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes.
Uhler JP, Sp?hr H, Farge G, Clavel S, Larsson NG, Falkenberg M, Samuelsson T, Gustafsson CM
Biochemical and biophysical research communications443(1)7-12(2014 Jan)

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.
Markson G, Kiel C, Hyde R, Brown S, Charalabous P, Bremm A, Semple J, Woodsmith J, Duley S, Salehi-Ashtiani K, Vidal M, Komander D, Serrano L, Lehner P, Sanderson CM
Genome research19(10)1905-11(2009 Oct)

A germline-specific class of small RNAs binds mammalian Piwi proteins.
Girard A, Sachidanandam R, Hannon GJ, Carmell MA
Nature442(7099)199-202(2006 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Establish UBTD1 as a regulator of cellular senescence that mediates p53 function, and provide insights into the mechanism of Mdm2 inhibition that impacts p53 dynamics during cellular senescence and tumourigenesis.
Title: UBTD1 induces cellular senescence through an UBTD1-Mdm2/p53 positive feedback loop.

Biochemical characterization of recombinant UBTD1 and UBE2D demonstrated that the two proteins form a stable, stoichiometric complex that can be purified to near homogeneity.
Title: The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes.

The following UBTD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UBTD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23529	NM_024954.5 Latest version!	Homo sapiens ubiquitin domain containing 1 (UBTD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu23529	NM_024954.4	Homo sapiens ubiquitin domain containing 1 (UBTD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UBTD1 ( NM_024954.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_079230.1 Homo sapiens ubiquitin domain containing 1 (UBTD1), mRNA.

Price & Availability↑

CloneID	OHu23529
Clone ID Related Accession (Same CDS sequence)	NM_024954.5 , NM_024954.4
Accession Version	NM_024954.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	ubiquitin domain-containing protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM922594.1, BC007331.2, AL359388.32 and CB306542.1. On Nov 23, 2018 this sequence version replaced NM_024954.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.82500.1, SRR3476690.423648.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370664.4/ ENSP00000359698.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCAACT GCGTGGGGAG ACAGCGCCGG GAGAGGCCGG CAGCCCCGGG ACACCCCCGC 
AAGCGAGCAG GACGCAATGA GCCCCTGAAG AAAGAGCGGC TTAAGTGGAA GAGCGACTAC 
CCCATGACTG ACGGGCAGCT GCGGAGCAAA CGGGATGAGT TCTGGGACAC AGCGCCTGCC 
TTCGAGGGCC GCAAGGAGAT CTGGGATGCC CTCAAGGCTG CCGCCTATGC TGCTGAAGCC 
AACGACCACG AGCTGGCCCA GGCCATCCTG GATGGAGCCA GCATCACCCT GCCTCATGGC 
ACCCTCTGTG AATGCTACGA TGAGCTGGGC AATCGCTACC AGCTGCCCAT CTACTGCCTG 
TCACCGCCGG TGAACCTGCT GCTGGAGCAC ACGGAGGAGG AGAGCCTGGA GCCCCCCGAG 
CCTCCACCCA GCGTGCGCCG TGAGTTCCCG CTGAAGGTGC GCCTGTCCAC GGGCAAGGAC 
GTGAGGCTCA GCGCCAGCCT GCCCGACACA GTGGGGCAGC TCAAGAGGCA GCTGCACGCC 
CAGGAGGGCA TCGAGCCATC GTGGCAGCGG TGGTTCTTCT CCGGGAAGCT GCTCACAGAC 
CGCACACGGC TCCAGGAGAC CAAGATCCAG AAAGATTTTG TCATCCAGGT CATCATCAAC 
CAGCCCCCAC CACCCCAGGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079230.1
CDS	281..964
Translation	MGNCVGRQRRERPAAPGHPRKRAGRNEPLKKERLKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAYAAEANDHELAQAILDGASITLPHGTLCECYDELGNRYQLPIYCLSPPVNLLLEHTEEESLEPPEPPPSVRREFPLKVRLSTGKDVRLSASLPDTVGQLKRQLHAQEGIEPSWQRWFFSGKLLTDRTRLQETKIQKDFVIQVIINQPPPPQD

Target ORF information:

RefSeq Version	NM_024954.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquitin domain containing 1 (UBTD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024954.5

ORF Insert Sequence:

ATGGGCAACT GCGTGGGGAG ACAGCGCCGG GAGAGGCCGG CAGCCCCGGG ACACCCCCGC 
AAGCGAGCAG GACGCAATGA GCCCCTGAAG AAAGAGCGGC TTAAGTGGAA GAGCGACTAC 
CCCATGACTG ACGGGCAGCT GCGGAGCAAA CGGGATGAGT TCTGGGACAC AGCGCCTGCC 
TTCGAGGGCC GCAAGGAGAT CTGGGATGCC CTCAAGGCTG CCGCCTATGC TGCTGAAGCC 
AACGACCACG AGCTGGCCCA GGCCATCCTG GATGGAGCCA GCATCACCCT GCCTCATGGC 
ACCCTCTGTG AATGCTACGA TGAGCTGGGC AATCGCTACC AGCTGCCCAT CTACTGCCTG 
TCACCGCCGG TGAACCTGCT GCTGGAGCAC ACGGAGGAGG AGAGCCTGGA GCCCCCCGAG 
CCTCCACCCA GCGTGCGCCG TGAGTTCCCG CTGAAGGTGC GCCTGTCCAC GGGCAAGGAC 
GTGAGGCTCA GCGCCAGCCT GCCCGACACA GTGGGGCAGC TCAAGAGGCA GCTGCACGCC 
CAGGAGGGCA TCGAGCCATC GTGGCAGCGG TGGTTCTTCT CCGGGAAGCT GCTCACAGAC 
CGCACACGGC TCCAGGAGAC CAAGATCCAG AAAGATTTTG TCATCCAGGT CATCATCAAC 
CAGCCCCCAC CACCCCAGGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UBTD1 ( NM_024954.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_079230.1 Homo sapiens ubiquitin domain containing 1 (UBTD1), mRNA.

Price & Availability↑

CloneID	OHu23529
Clone ID Related Accession (Same CDS sequence)	NM_024954.5 , NM_024954.4
Accession Version	NM_024954.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	ubiquitin domain-containing protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM922594.1, AL359388.32, BC007331.2 and CB306542.1. On Mar 29, 2014 this sequence version replaced NM_024954.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: ERR279873.3120.1, BC007331.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAACT GCGTGGGGAG ACAGCGCCGG GAGAGGCCGG CAGCCCCGGG ACACCCCCGC 
AAGCGAGCAG GACGCAATGA GCCCCTGAAG AAAGAGCGGC TTAAGTGGAA GAGCGACTAC 
CCCATGACTG ACGGGCAGCT GCGGAGCAAA CGGGATGAGT TCTGGGACAC AGCGCCTGCC 
TTCGAGGGCC GCAAGGAGAT CTGGGATGCC CTCAAGGCTG CCGCCTATGC TGCTGAAGCC 
AACGACCACG AGCTGGCCCA GGCCATCCTG GATGGAGCCA GCATCACCCT GCCTCATGGC 
ACCCTCTGTG AATGCTACGA TGAGCTGGGC AATCGCTACC AGCTGCCCAT CTACTGCCTG 
TCACCGCCGG TGAACCTGCT GCTGGAGCAC ACGGAGGAGG AGAGCCTGGA GCCCCCCGAG 
CCTCCACCCA GCGTGCGCCG TGAGTTCCCG CTGAAGGTGC GCCTGTCCAC GGGCAAGGAC 
GTGAGGCTCA GCGCCAGCCT GCCCGACACA GTGGGGCAGC TCAAGAGGCA GCTGCACGCC 
CAGGAGGGCA TCGAGCCATC GTGGCAGCGG TGGTTCTTCT CCGGGAAGCT GCTCACAGAC 
CGCACACGGC TCCAGGAGAC CAAGATCCAG AAAGATTTTG TCATCCAGGT CATCATCAAC 
CAGCCCCCAC CACCCCAGGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079230.1
CDS	323..1006
Translation	MGNCVGRQRRERPAAPGHPRKRAGRNEPLKKERLKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAYAAEANDHELAQAILDGASITLPHGTLCECYDELGNRYQLPIYCLSPPVNLLLEHTEEESLEPPEPPPSVRREFPLKVRLSTGKDVRLSASLPDTVGQLKRQLHAQEGIEPSWQRWFFSGKLLTDRTRLQETKIQKDFVIQVIINQPPPPQD

Target ORF information:

RefSeq Version	NM_024954.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquitin domain containing 1 (UBTD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024954.4

ORF Insert Sequence:

ATGGGCAACT GCGTGGGGAG ACAGCGCCGG GAGAGGCCGG CAGCCCCGGG ACACCCCCGC 
AAGCGAGCAG GACGCAATGA GCCCCTGAAG AAAGAGCGGC TTAAGTGGAA GAGCGACTAC 
CCCATGACTG ACGGGCAGCT GCGGAGCAAA CGGGATGAGT TCTGGGACAC AGCGCCTGCC 
TTCGAGGGCC GCAAGGAGAT CTGGGATGCC CTCAAGGCTG CCGCCTATGC TGCTGAAGCC 
AACGACCACG AGCTGGCCCA GGCCATCCTG GATGGAGCCA GCATCACCCT GCCTCATGGC 
ACCCTCTGTG AATGCTACGA TGAGCTGGGC AATCGCTACC AGCTGCCCAT CTACTGCCTG 
TCACCGCCGG TGAACCTGCT GCTGGAGCAC ACGGAGGAGG AGAGCCTGGA GCCCCCCGAG 
CCTCCACCCA GCGTGCGCCG TGAGTTCCCG CTGAAGGTGC GCCTGTCCAC GGGCAAGGAC 
GTGAGGCTCA GCGCCAGCCT GCCCGACACA GTGGGGCAGC TCAAGAGGCA GCTGCACGCC 
CAGGAGGGCA TCGAGCCATC GTGGCAGCGG TGGTTCTTCT CCGGGAAGCT GCTCACAGAC 
CGCACACGGC TCCAGGAGAC CAAGATCCAG AAAGATTTTG TCATCCAGGT CATCATCAAC 
CAGCCCCCAC CACCCCAGGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

UBTD1 induces cellular senescence through an UBTD1-Mdm2/p53 positive feedback loop.
The Journal of pathology235(4)656-67(2015 Mar)
Zhang XW,Wang XF,Ni SJ,Qin W,Zhao LQ,Hua RX,Lu YW,Li J,Dimri GP,Guo WJ

The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes.
Biochemical and biophysical research communications443(1)7-12(2014 Jan)
Uhler JP,Sp?hr H,Farge G,Clavel S,Larsson NG,Falkenberg M,Samuelsson T,Gustafsson CM

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.
Genome research19(10)1905-11(2009 Oct)
Markson G,Kiel C,Hyde R,Brown S,Charalabous P,Bremm A,Semple J,Woodsmith J,Duley S,Salehi-Ashtiani K,Vidal M,Komander D,Serrano L,Lehner P,Sanderson CM

A germline-specific class of small RNAs binds mammalian Piwi proteins.
Nature442(7099)199-202(2006 Jul)
Girard A,Sachidanandam R,Hannon GJ,Carmell MA

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UBTD1 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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