SCD5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SCD5
Entrez Gene ID	79966
Full Name	stearoyl-CoA desaturase 5
Synonyms	ACOD4,FADS4,HSCD5,SCD2,SCD4
General protein information	Preferred Names stearoyl-CoA desaturase 5 Names stearoyl-CoA desaturase 5 acyl-CoA-desaturase 4 stearoyl-CoA 9-desaturase stearoyl-CoA desaturase 2 stearoyl-CoA desaturase 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q21.22
Summary	Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008].
Disorder MIM:	608370

mRNA and Protein(s)

mRNA	Protein	Name
NM_024906.2	NP_079182.2	stearoyl-CoA desaturase 5 isoform b
NM_001037582.3	NP_001032671.2	stearoyl-CoA desaturase 5 isoform a
NM_001037582.2	NP_001032671.2	stearoyl-CoA desaturase 5 isoform a

Pathways from BioSystems

Homologies

Arabidopsis thaliana (thale cress)	AT1G06120	NP_172102.1
Arabidopsis thaliana (thale cress)	AT1G06100	NP_172100.1
Arabidopsis thaliana (thale cress)	AT3G15870	NP_188208.4
Pan troglodytes (chimpanzee)	SCD5	XP_001141318.1
Arabidopsis thaliana (thale cress)	ADS1	NP_172098.1
Arabidopsis thaliana (thale cress)	AT1G06090	NP_172099.1
Bos taurus (cattle)	SCD5	NP_001070413.1
Gallus gallus (chicken)	SCD5	XP_420557.4
Arabidopsis thaliana (thale cress)	DS2	NP_565721.1
Homo sapiens (human)	SCD5	NP_001032671.2
Danio rerio (zebrafish)	scd	XP_005173059.1
Arabidopsis thaliana (thale cress)	AT1G06360	NP_172125.1
Canis lupus familiaris (dog)	SCD5	XP_544953.2
Arabidopsis thaliana (thale cress)	FAD5	NP_566529.1
Arabidopsis thaliana (thale cress)	AT1G06350	NP_172124.2
	SCD5	XP_001086993.1
Drosophila melanogaster (fruit fly)	desat1	NP_731712.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001713	XP_003435913.1

Gene Ontology
Bibliography

Related articles in PubMed

SCD5-induced oleic acid production reduces melanoma malignancy by intracellular retention of SPARC and cathepsin B.
Bellenghi M, Puglisi R, Pedini F, De Feo A, Felicetti F, Bottero L, Sangaletti S, Errico MC, Petrini M, Gesumundo C, Denaro M, Felli N, Pasquini L, Tripodo C, Colombo MP, Car? A, Mattia G
The Journal of pathology236(3)315-25(2015 Jul)

Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2.
Sieber J, Weins A, Kampe K, Gruber S, Lindenmeyer MT, Cohen CD, Orellana JM, Mundel P, Jehle AW
The American journal of pathology183(3)735-44(2013 Sep)

StearoylCoA desaturase-5: a novel regulator of neuronal cell proliferation and differentiation.
Sinner DI, Kim GJ, Henderson GC, Igal RA
PloS one7(6)e39787(2012)

Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease.
Astarita G, Jung KM, Vasilevko V, Dipatrizio NV, Martin SK, Cribbs DH, Head E, Cotman CW, Piomelli D
PloS one6(10)e24777(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SCD5 appears to functionally connect tumour cells and the surrounding stroma toward modification of the tumour microenvironment, with consequences on tumour spread and resistance to treatment.
Title: SCD5-induced oleic acid production reduces melanoma malignancy by intracellular retention of SPARC and cathepsin B.

The protective effect of TO901317 was lost after gene silencing of Scd-1/-2, thereby confirming that the protective effect of TO901317 is mediated by Scd-1/-2.
Title: Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2.

Data suggest that, by a coordinated modulation of key lipogenic pathways and transduction signaling cascades, SCD5 participates in the regulation of neuronal cell growth and differentiation.
Title: StearoylCoA desaturase-5: a novel regulator of neuronal cell proliferation and differentiation.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.

The following SCD5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SCD5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24251	NM_024906.2 Latest version!	Homo sapiens stearoyl-CoA desaturase 5 (SCD5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu11373	NM_001037582.3 Latest version!	Homo sapiens stearoyl-CoA desaturase 5 (SCD5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
View Old Accession Versions >>
OHu11373	NM_001037582.2	Homo sapiens stearoyl-CoA desaturase 5 (SCD5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SCD5 ( NM_024906.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_079182.2 Homo sapiens stearoyl-CoA desaturase 5 (SCD5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu24251
Clone ID Related Accession (Same CDS sequence)	NM_024906.2
Accession Version	NM_024906.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 771bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	stearoyl-CoA desaturase 5 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC073413.6. On Jun 5, 2007 this sequence version replaced NM_024906.1. Transcript Variant: This variant (2) has multiple differences in the 3' coding region, compared to variant 1, which result in a protein (isoform B) with a shorter and distinct C-terminus, compared to isoform A. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK024685.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142853, SAMEA2144335 [ECO:0000350] ##Evidence-Data-END##

ATGCCAGGCC CGGCCACCGA CGCGGGGAAG ATCCCTTTCT GCGACGCCAA GGAAGAAATC 
CGTGCCGGGC TCGAAAGCTC TGAGGGCGGC GGCGGCCCGG AGAGGCCAGG CGCGCGCGGG 
CAGCGGCAGA ACATCGTCTG GAGGAATGTC GTCCTGATGA GCTTGCTCCA CTTGGGGGCC 
GTGTACTCCC TGGTGCTCAT CCCCAAAGCC AAGCCACTCA CTCTGCTCTG GGCCTACTTC 
TGCTTCCTCC TGGCCGCTCT GGGTGTGACA GCTGGTGCCC ATCGCTTGTG GAGCCACAGG 
TCCTACCGGG CCAAGCTGCC TCTGAGGATA TTTCTGGCTG TCGCCAACTC CATGGCTTTC 
CAGAATGACA TCTTCGAGTG GTCCAGGGAC CACCGAGCCC ACCACAAGTA CTCAGAGACG 
GATGCTGACC CCCACAATGC CCGCCGGGGC TTCTTCTTCT CCCATATTGG GTGGCTGTTT 
GTTCGCAAGC ATCGAGATGT TATTGAGAAG GGGAGAAAGC TTGACGTCAC TGACCTGCTT 
GCTGATCCTG TGGTCCGGAT CCAGAGAAAT ACACAGCACA TCCAGAAAGA AGGAAGAGCT 
CTCAATCAAG AGGCAGCGTG TGAGATGCTT CGTGAATGGC ATCAAGGGCA TATATTGAAA 
GTCACCCTTC CCGGATTACA CATTTTAGCT TTGTTACATA CTCATTGTAA CCACTCCGAA 
AAGTGCTGCT TGATGCTGCG TGCTCTTTCT GTGTCCCTGG AGGTATTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079182.2
CDS	321..1091
Translation	MPGPATDAGKIPFCDAKEEIRAGLESSEGGGGPERPGARGQRQNIVWRNVVLMSLLHLGAVYSLVLIPKAKPLTLLWAYFCFLLAALGVTAGAHRLWSHRSYRAKLPLRIFLAVANSMAFQNDIFEWSRDHRAHHKYSETDADPHNARRGFFFSHIGWLFVRKHRDVIEKGRKLDVTDLLADPVVRIQRNTQHIQKEGRALNQEAACEMLREWHQGHILKVTLPGLHILALLHTHCNHSEKCCLMLRALSVSLEVF

Target ORF information:

RefSeq Version	NM_024906.2
Organism	Homo sapiens(human)
Definition	Homo sapiens stearoyl-CoA desaturase 5 (SCD5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024906.2

ORF Insert Sequence:

ATGCCAGGCC CGGCCACCGA CGCGGGGAAG ATCCCTTTCT GCGACGCCAA GGAAGAAATC 
CGTGCCGGGC TCGAAAGCTC TGAGGGCGGC GGCGGCCCGG AGAGGCCAGG CGCGCGCGGG 
CAGCGGCAGA ACATCGTCTG GAGGAATGTC GTCCTGATGA GCTTGCTCCA CTTGGGGGCC 
GTGTACTCCC TGGTGCTCAT CCCCAAAGCC AAGCCACTCA CTCTGCTCTG GGCCTACTTC 
TGCTTCCTCC TGGCCGCTCT GGGTGTGACA GCTGGTGCCC ATCGCTTGTG GAGCCACAGG 
TCCTACCGGG CCAAGCTGCC TCTGAGGATA TTTCTGGCTG TCGCCAACTC CATGGCTTTC 
CAGAATGACA TCTTCGAGTG GTCCAGGGAC CACCGAGCCC ACCACAAGTA CTCAGAGACG 
GATGCTGACC CCCACAATGC CCGCCGGGGC TTCTTCTTCT CCCATATTGG GTGGCTGTTT 
GTTCGCAAGC ATCGAGATGT TATTGAGAAG GGGAGAAAGC TTGACGTCAC TGACCTGCTT 
GCTGATCCTG TGGTCCGGAT CCAGAGAAAT ACACAGCACA TCCAGAAAGA AGGAAGAGCT 
CTCAATCAAG AGGCAGCGTG TGAGATGCTT CGTGAATGGC ATCAAGGGCA TATATTGAAA 
GTCACCCTTC CCGGATTACA CATTTTAGCT TTGTTACATA CTCATTGTAA CCACTCCGAA 
AAGTGCTGCT TGATGCTGCG TGCTCTTTCT GTGTCCCTGG AGGTATTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SCD5 ( NM_001037582.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001032671.2 Homo sapiens stearoyl-CoA desaturase 5 (SCD5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu11373
Clone ID Related Accession (Same CDS sequence)	NM_001037582.3 , NM_001037582.2
Accession Version	NM_001037582.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	stearoyl-CoA desaturase 5 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB479400.1, AF389338.1, DR763368.1 and BC048971.1. On Nov 23, 2018 this sequence version replaced NM_001037582.2. Transcript Variant: This variant (1) represents the longer transcript and encoded the longer isoform (A). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.747918.1, SRR1660809.146785.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000319540.9/ ENSP00000316329.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCAGGCC CGGCCACCGA CGCGGGGAAG ATCCCTTTCT GCGACGCCAA GGAAGAAATC 
CGTGCCGGGC TCGAAAGCTC TGAGGGCGGC GGCGGCCCGG AGAGGCCAGG CGCGCGCGGG 
CAGCGGCAGA ACATCGTCTG GAGGAATGTC GTCCTGATGA GCTTGCTCCA CTTGGGGGCC 
GTGTACTCCC TGGTGCTCAT CCCCAAAGCC AAGCCACTCA CTCTGCTCTG GGCCTACTTC 
TGCTTCCTCC TGGCCGCTCT GGGTGTGACA GCTGGTGCCC ATCGCTTGTG GAGCCACAGG 
TCCTACCGGG CCAAGCTGCC TCTGAGGATA TTTCTGGCTG TCGCCAACTC CATGGCTTTC 
CAGAATGACA TCTTCGAGTG GTCCAGGGAC CACCGAGCCC ACCACAAGTA CTCAGAGACG 
GATGCTGACC CCCACAATGC CCGCCGGGGC TTCTTCTTCT CCCATATTGG GTGGCTGTTT 
GTTCGCAAGC ATCGAGATGT TATTGAGAAG GGGAGAAAGC TTGACGTCAC TGACCTGCTT 
GCTGATCCTG TGGTCCGGAT CCAGAGAAAG TACTATAAGA TCTCCGTGGT GCTCATGTGC 
TTTGTGGTCC CCACGCTGGT GCCCTGGTAC ATCTGGGGAG AGAGTCTGTG GAATTCCTAC 
TTCTTGGCCT CTATTCTCCG CTATACCATC TCACTCAACA TCAGCTGGCT GGTCAACAGC 
GCCGCCCACA TGTATGGAAA CCGGCCCTAT GACAAGCACA TCAGCCCTCG GCAGAACCCA 
CTCGTCGCTC TGGGTGCCAT TGGTGAAGGC TTCCATAATT ACCATCACAC CTTTCCCTTT 
GACTACTCTG CGAGTGAATT TGGCTTAAAT TTTAACCCAA CCACCTGGTT CATTGATTTC 
ATGTGCTGGC TGGGGCTGGC CACTGACCGC AAACGGGCAA CCAAGCCGAT GATCGAGGCC 
CGGAAGGCCA GGACTGGAGA CAGCAGTGCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032671.2
CDS	260..1252
Translation	MPGPATDAGKIPFCDAKEEIRAGLESSEGGGGPERPGARGQRQNIVWRNVVLMSLLHLGAVYSLVLIPKAKPLTLLWAYFCFLLAALGVTAGAHRLWSHRSYRAKLPLRIFLAVANSMAFQNDIFEWSRDHRAHHKYSETDADPHNARRGFFFSHIGWLFVRKHRDVIEKGRKLDVTDLLADPVVRIQRKYYKISVVLMCFVVPTLVPWYIWGESLWNSYFLASILRYTISLNISWLVNSAAHMYGNRPYDKHISPRQNPLVALGAIGEGFHNYHHTFPFDYSASEFGLNFNPTTWFIDFMCWLGLATDRKRATKPMIEARKARTGDSSA

Target ORF information:

RefSeq Version	NM_001037582.3
Organism	Homo sapiens(human)
Definition	Homo sapiens stearoyl-CoA desaturase 5 (SCD5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037582.3

ORF Insert Sequence:

ATGCCAGGCC CGGCCACCGA CGCGGGGAAG ATCCCTTTCT GCGACGCCAA GGAAGAAATC 
CGTGCCGGGC TCGAAAGCTC TGAGGGCGGC GGCGGCCCGG AGAGGCCAGG CGCGCGCGGG 
CAGCGGCAGA ACATCGTCTG GAGGAATGTC GTCCTGATGA GCTTGCTCCA CTTGGGGGCC 
GTGTACTCCC TGGTGCTCAT CCCCAAAGCC AAGCCACTCA CTCTGCTCTG GGCCTACTTC 
TGCTTCCTCC TGGCCGCTCT GGGTGTGACA GCTGGTGCCC ATCGCTTGTG GAGCCACAGG 
TCCTACCGGG CCAAGCTGCC TCTGAGGATA TTTCTGGCTG TCGCCAACTC CATGGCTTTC 
CAGAATGACA TCTTCGAGTG GTCCAGGGAC CACCGAGCCC ACCACAAGTA CTCAGAGACG 
GATGCTGACC CCCACAATGC CCGCCGGGGC TTCTTCTTCT CCCATATTGG GTGGCTGTTT 
GTTCGCAAGC ATCGAGATGT TATTGAGAAG GGGAGAAAGC TTGACGTCAC TGACCTGCTT 
GCTGATCCTG TGGTCCGGAT CCAGAGAAAG TACTATAAGA TCTCCGTGGT GCTCATGTGC 
TTTGTGGTCC CCACGCTGGT GCCCTGGTAC ATCTGGGGAG AGAGTCTGTG GAATTCCTAC 
TTCTTGGCCT CTATTCTCCG CTATACCATC TCACTCAACA TCAGCTGGCT GGTCAACAGC 
GCCGCCCACA TGTATGGAAA CCGGCCCTAT GACAAGCACA TCAGCCCTCG GCAGAACCCA 
CTCGTCGCTC TGGGTGCCAT TGGTGAAGGC TTCCATAATT ACCATCACAC CTTTCCCTTT 
GACTACTCTG CGAGTGAATT TGGCTTAAAT TTTAACCCAA CCACCTGGTT CATTGATTTC 
ATGTGCTGGC TGGGGCTGGC CACTGACCGC AAACGGGCAA CCAAGCCGAT GATCGAGGCC 
CGGAAGGCCA GGACTGGAGA CAGCAGTGCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SCD5 ( NM_001037582.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001032671.2 Homo sapiens stearoyl-CoA desaturase 5 (SCD5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu11373
Clone ID Related Accession (Same CDS sequence)	NM_001037582.3 , NM_001037582.2
Accession Version	NM_001037582.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	stearoyl-CoA desaturase 5 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB479400.1, AF389338.1, DR763368.1, BC048971.1 and CB155881.1. On Jun 5, 2007 this sequence version replaced NM_001037582.1. Transcript Variant: This variant (1) represents the longer transcript and encoded the longer isoform (A). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.265372.1, SRR1660809.75618.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGCCAGGCC CGGCCACCGA CGCGGGGAAG ATCCCTTTCT GCGACGCCAA GGAAGAAATC 
CGTGCCGGGC TCGAAAGCTC TGAGGGCGGC GGCGGCCCGG AGAGGCCAGG CGCGCGCGGG 
CAGCGGCAGA ACATCGTCTG GAGGAATGTC GTCCTGATGA GCTTGCTCCA CTTGGGGGCC 
GTGTACTCCC TGGTGCTCAT CCCCAAAGCC AAGCCACTCA CTCTGCTCTG GGCCTACTTC 
TGCTTCCTCC TGGCCGCTCT GGGTGTGACA GCTGGTGCCC ATCGCTTGTG GAGCCACAGG 
TCCTACCGGG CCAAGCTGCC TCTGAGGATA TTTCTGGCTG TCGCCAACTC CATGGCTTTC 
CAGAATGACA TCTTCGAGTG GTCCAGGGAC CACCGAGCCC ACCACAAGTA CTCAGAGACG 
GATGCTGACC CCCACAATGC CCGCCGGGGC TTCTTCTTCT CCCATATTGG GTGGCTGTTT 
GTTCGCAAGC ATCGAGATGT TATTGAGAAG GGGAGAAAGC TTGACGTCAC TGACCTGCTT 
GCTGATCCTG TGGTCCGGAT CCAGAGAAAG TACTATAAGA TCTCCGTGGT GCTCATGTGC 
TTTGTGGTCC CCACGCTGGT GCCCTGGTAC ATCTGGGGAG AGAGTCTGTG GAATTCCTAC 
TTCTTGGCCT CTATTCTCCG CTATACCATC TCACTCAACA TCAGCTGGCT GGTCAACAGC 
GCCGCCCACA TGTATGGAAA CCGGCCCTAT GACAAGCACA TCAGCCCTCG GCAGAACCCA 
CTCGTCGCTC TGGGTGCCAT TGGTGAAGGC TTCCATAATT ACCATCACAC CTTTCCCTTT 
GACTACTCTG CGAGTGAATT TGGCTTAAAT TTTAACCCAA CCACCTGGTT CATTGATTTC 
ATGTGCTGGC TGGGGCTGGC CACTGACCGC AAACGGGCAA CCAAGCCGAT GATCGAGGCC 
CGGAAGGCCA GGACTGGAGA CAGCAGTGCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032671.2
CDS	321..1313
Translation	MPGPATDAGKIPFCDAKEEIRAGLESSEGGGGPERPGARGQRQNIVWRNVVLMSLLHLGAVYSLVLIPKAKPLTLLWAYFCFLLAALGVTAGAHRLWSHRSYRAKLPLRIFLAVANSMAFQNDIFEWSRDHRAHHKYSETDADPHNARRGFFFSHIGWLFVRKHRDVIEKGRKLDVTDLLADPVVRIQRKYYKISVVLMCFVVPTLVPWYIWGESLWNSYFLASILRYTISLNISWLVNSAAHMYGNRPYDKHISPRQNPLVALGAIGEGFHNYHHTFPFDYSASEFGLNFNPTTWFIDFMCWLGLATDRKRATKPMIEARKARTGDSSA

Target ORF information:

RefSeq Version	NM_001037582.2
Organism	Homo sapiens(human)
Definition	Homo sapiens stearoyl-CoA desaturase 5 (SCD5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037582.2

ORF Insert Sequence:

ATGCCAGGCC CGGCCACCGA CGCGGGGAAG ATCCCTTTCT GCGACGCCAA GGAAGAAATC 
CGTGCCGGGC TCGAAAGCTC TGAGGGCGGC GGCGGCCCGG AGAGGCCAGG CGCGCGCGGG 
CAGCGGCAGA ACATCGTCTG GAGGAATGTC GTCCTGATGA GCTTGCTCCA CTTGGGGGCC 
GTGTACTCCC TGGTGCTCAT CCCCAAAGCC AAGCCACTCA CTCTGCTCTG GGCCTACTTC 
TGCTTCCTCC TGGCCGCTCT GGGTGTGACA GCTGGTGCCC ATCGCTTGTG GAGCCACAGG 
TCCTACCGGG CCAAGCTGCC TCTGAGGATA TTTCTGGCTG TCGCCAACTC CATGGCTTTC 
CAGAATGACA TCTTCGAGTG GTCCAGGGAC CACCGAGCCC ACCACAAGTA CTCAGAGACG 
GATGCTGACC CCCACAATGC CCGCCGGGGC TTCTTCTTCT CCCATATTGG GTGGCTGTTT 
GTTCGCAAGC ATCGAGATGT TATTGAGAAG GGGAGAAAGC TTGACGTCAC TGACCTGCTT 
GCTGATCCTG TGGTCCGGAT CCAGAGAAAG TACTATAAGA TCTCCGTGGT GCTCATGTGC 
TTTGTGGTCC CCACGCTGGT GCCCTGGTAC ATCTGGGGAG AGAGTCTGTG GAATTCCTAC 
TTCTTGGCCT CTATTCTCCG CTATACCATC TCACTCAACA TCAGCTGGCT GGTCAACAGC 
GCCGCCCACA TGTATGGAAA CCGGCCCTAT GACAAGCACA TCAGCCCTCG GCAGAACCCA 
CTCGTCGCTC TGGGTGCCAT TGGTGAAGGC TTCCATAATT ACCATCACAC CTTTCCCTTT 
GACTACTCTG CGAGTGAATT TGGCTTAAAT TTTAACCCAA CCACCTGGTT CATTGATTTC 
ATGTGCTGGC TGGGGCTGGC CACTGACCGC AAACGGGCAA CCAAGCCGAT GATCGAGGCC 
CGGAAGGCCA GGACTGGAGA CAGCAGTGCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SCD5-induced oleic acid production reduces melanoma malignancy by intracellular retention of SPARC and cathepsin B.
The Journal of pathology236(3)315-25(2015 Jul)
Bellenghi M,Puglisi R,Pedini F,De Feo A,Felicetti F,Bottero L,Sangaletti S,Errico MC,Petrini M,Gesumundo C,Denaro M,Felli N,Pasquini L,Tripodo C,Colombo MP,Car? A,Mattia G

Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2.
The American journal of pathology183(3)735-44(2013 Sep)
Sieber J,Weins A,Kampe K,Gruber S,Lindenmeyer MT,Cohen CD,Orellana JM,Mundel P,Jehle AW

StearoylCoA desaturase-5: a novel regulator of neuronal cell proliferation and differentiation.
PloS one7(6)e39787(2012)
Sinner DI,Kim GJ,Henderson GC,Igal RA

Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease.
PloS one6(10)e24777(2011)
Astarita G,Jung KM,Vasilevko V,Dipatrizio NV,Martin SK,Cribbs DH,Head E,Cotman CW,Piomelli D

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SCD5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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