CCDC134 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCDC134
Entrez Gene ID	79879
Full Name	coiled-coil domain containing 134
General protein information	Preferred Names coiled-coil domain containing 134 Names coiled-coil domain-containing protein 134
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_024821.3	NP_079097.1	coiled-coil domain-containing protein 134 isoform 1 precursor
NM_024821.4	NP_079097.1	coiled-coil domain-containing protein 134 isoform 1 precursor
XM_005261748.3	XP_005261805.1	coiled-coil domain-containing protein 134 isoform X1
XM_005261748.2	XP_005261805.1	coiled-coil domain-containing protein 134 isoform X1
NM_001304797.1	NP_001291726.1	coiled-coil domain-containing protein 134 isoform 2 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CCDC134	XP_001170122.1
Xenopus tropicalis (tropical clawed frog)	ccdc134	NP_001016089.1
Homo sapiens (human)	CCDC134	NP_079097.1
Canis lupus familiaris (dog)	CCDC134	XP_003431540.1
Bos taurus (cattle)	CCDC134	NP_001192755.1
Mus musculus (house mouse)	Ccdc134	NP_766016.2
Rattus norvegicus (Norway rat)	Ccdc134	NP_001019526.1
Gallus gallus (chicken)	CCDC134	XP_003640423.1
	CCDC134	XP_001106175.2
Danio rerio (zebrafish)	si:dkey-167k11.5	XP_005171583.1
Danio rerio (zebrafish)	LOC100536187	XP_003201721.1

Gene Ontology
Bibliography

Related articles in PubMed

CCDC134 serves a crucial role in embryonic development.
Yu B, Zhang T, Xia P, Gong X, Qiu X, Huang J
International journal of molecular medicine41(1)381-390(2018 Jan)

Cytokine-like molecule CCDC134 contributes to CD8? T-cell effector functions in cancer immunotherapy.
Huang J, Xiao L, Gong X, Shao W, Yin Y, Liao Q, Meng Y, Zhang Y, Ma D, Qiu X
Cancer research74(20)5734-45(2014 Oct)

CCDC134 is down-regulated in gastric cancer and its silencing promotes cell migration and invasion of GES-1 and AGS cells via the MAPK pathway.
Zhong J, Zhao M, Luo Q, Ma Y, Liu J, Wang J, Yang M, Yuan X, Sang J, Huang C
Molecular and cellular biochemistry372(1-2)1-8(2013 Jan)

CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest.
Huang J, Zhang L, Liu W, Liao Q, Shi T, Xiao L, Hu F, Qiu X
Histochemistry and cell biology138(1)41-55(2012 Jul)

Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.
Kim S, Swaminathan S, Shen L, Risacher SL, Nho K, Foroud T, Shaw LM, Trojanowski JQ, Potkin SG, Huentelman MJ, Craig DW, DeChairo BM, Aisen PS, Petersen RC, Weiner MW, Saykin AJ,
Neurology76(1)69-79(2011 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CCDC134 promotes cell proliferation through the JAK3-STAT5 pathway.
Title: Cytokine-like molecule CCDC134 contributes to CD8? T-cell effector functions in cancer immunotherapy.

The attenuated expression of CCDC134 promoted the activation of Erk1/2 and JNK/SAPK, but had no effect on p38 in gastric cancer.
Title: CCDC134 is down-regulated in gastric cancer and its silencing promotes cell migration and invasion of GES-1 and AGS cells via the MAPK pathway.

CCDC134 might act as a novel regulator of hADA2a, and plays roles in the PCAF complex via hADA2a to affect its acetyltransferase activity and UV-induced DNA damage repair.
Title: CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest.

These results clearly indicate that CCDC134 is a novel member of the secretory family and down-regulates the Raf-1/MEK/ERK and JNK/ SAPK pathways.
Title: CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK.

The following CCDC134 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCDC134 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04246	NM_024821.4 Latest version!	Homo sapiens coiled-coil domain containing 134 (CCDC134), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04246	XM_005261748.3 Latest version!	Homo sapiens coiled-coil domain containing 134 (CCDC134), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu72328	NM_001304797.1 Latest version!	Homo sapiens coiled-coil domain containing 134 (CCDC134), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu04246	NM_024821.3	Homo sapiens coiled-coil domain containing 134 (CCDC134), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04246	XM_005261748.2	Homo sapiens coiled-coil domain containing 134 (CCDC134), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCDC134 ( NM_024821.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_079097.1 Homo sapiens coiled-coil domain containing 134 (CCDC134), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04246
Clone ID Related Accession (Same CDS sequence)	NM_024821.3 , NM_024821.4 , XM_005261748.3 , XM_005261748.2
Accession Version	NM_024821.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 690bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-03
Organism	Homo sapiens(human)
Product	coiled-coil domain-containing protein 134 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY013338.1, BX473493.1, BC017693.2 and CB240942.1. On Feb 10, 2015 this sequence version replaced NM_024821.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1803612.252220.1, SRR1803614.154027.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCTTC TTCAATTCCT GGCCTTCCTC TTTGTCCTGC TTTTGTCTGG GATGGGAGCC 
ACAGGCACCT TGAGGACCTC CCTGGACCCA AGCCTGGAGA TCTACAAGAA GATGTTTGAG 
GTGAAGCGGC GGGAGCAGCT GTTGGCACTG AAGAACCTGG CACAGCTGAA CGACATCCAC 
CAGCAGTACA AGATCCTTGA TGTCATGCTC AAGGGGCTCT TTAAGGTGCT GGAGGACTCC 
CGGACAGTGC TCACCGCTGC TGATGTGCTC CCAGATGGGC CCTTCCCCCA GGACGAGAAG 
CTGAAGGATG CTTTCTCCCA CGTGGTGGAG AACACGGCCT TCTTCGGCGA TGTGGTGCTG 
CGCTTCCCGA GGATTGTGCA CTATTACTTT GACCACAACT CCAACTGGAA CCTCCTCATC 
CGCTGGGGTA TCAGTTTCTG CAACCAGACA GGCGTCTTCA ACCAGGGGCC CCACTCGCCC 
ATCCTCAGCC TGATGGCCCA GGAGCTGGGG ATCAGTGAGA AAGACTCCAA CTTCCAGAAC 
CCATTTAAAA TCGACCGCAC AGAGTTCATT CCCAGCACTG ACCCTTTCCA GAAGGCCCTG 
AGAGAAGAAG AGAAACGCCG AAAGAAAGAG GAGAAGCGGA AGGAGATCCG AAAAGGCCCA 
AGGATCTCCA GATCCCAGTC TGAGTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079097.1
CDS	162..851
Translation	MDLLQFLAFLFVLLLSGMGATGTLRTSLDPSLEIYKKMFEVKRREQLLALKNLAQLNDIHQQYKILDVMLKGLFKVLEDSRTVLTAADVLPDGPFPQDEKLKDAFSHVVENTAFFGDVVLRFPRIVHYYFDHNSNWNLLIRWGISFCNQTGVFNQGPHSPILSLMAQELGISEKDSNFQNPFKIDRTEFIPSTDPFQKALREEEKRRKKEEKRKEIRKGPRISRSQSEL

Target ORF information:

RefSeq Version	NM_024821.3
Organism	Homo sapiens(human)
Definition	Homo sapiens coiled-coil domain containing 134 (CCDC134), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024821.3

ORF Insert Sequence:

ATGGACCTTC TTCAATTCCT GGCCTTCCTC TTTGTCCTGC TTTTGTCTGG GATGGGAGCC 
ACAGGCACCT TGAGGACCTC CCTGGACCCA AGCCTGGAGA TCTACAAGAA GATGTTTGAG 
GTGAAGCGGC GGGAGCAGCT GTTGGCACTG AAGAACCTGG CACAGCTGAA CGACATCCAC 
CAGCAGTACA AGATCCTTGA TGTCATGCTC AAGGGGCTCT TTAAGGTGCT GGAGGACTCC 
CGGACAGTGC TCACCGCTGC TGATGTGCTC CCAGATGGGC CCTTCCCCCA GGACGAGAAG 
CTGAAGGATG CTTTCTCCCA CGTGGTGGAG AACACGGCCT TCTTCGGCGA TGTGGTGCTG 
CGCTTCCCGA GGATTGTGCA CTATTACTTT GACCACAACT CCAACTGGAA CCTCCTCATC 
CGCTGGGGTA TCAGTTTCTG CAACCAGACA GGCGTCTTCA ACCAGGGGCC CCACTCGCCC 
ATCCTCAGCC TGATGGCCCA GGAGCTGGGG ATCAGTGAGA AAGACTCCAA CTTCCAGAAC 
CCATTTAAAA TCGACCGCAC AGAGTTCATT CCCAGCACTG ACCCTTTCCA GAAGGCCCTG 
AGAGAAGAAG AGAAACGCCG AAAGAAAGAG GAGAAGCGGA AGGAGATCCG AAAAGGCCCA 
AGGATCTCCA GATCCCAGTC TGAGTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCDC134 ( NM_024821.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_079097.1 Homo sapiens coiled-coil domain containing 134 (CCDC134), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04246
Clone ID Related Accession (Same CDS sequence)	NM_024821.3 , NM_024821.4 , XM_005261748.3 , XM_005261748.2
Accession Version	NM_024821.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 690bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	coiled-coil domain-containing protein 134 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX473493.1, BC017693.2 and CB240942.1. On Nov 22, 2018 this sequence version replaced NM_024821.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AK026002.1, SRR1803612.252220.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000255784.5/ ENSP00000255784.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACCTTC TTCAATTCCT GGCCTTCCTC TTTGTCCTGC TTTTGTCTGG GATGGGAGCC 
ACAGGCACCT TGAGGACCTC CCTGGACCCA AGCCTGGAGA TCTACAAGAA GATGTTTGAG 
GTGAAGCGGC GGGAGCAGCT GTTGGCACTG AAGAACCTGG CACAGCTGAA CGACATCCAC 
CAGCAGTACA AGATCCTTGA TGTCATGCTC AAGGGGCTCT TTAAGGTGCT GGAGGACTCC 
CGGACAGTGC TCACCGCTGC TGATGTGCTC CCAGATGGGC CCTTCCCCCA GGACGAGAAG 
CTGAAGGATG CTTTCTCCCA CGTGGTGGAG AACACGGCCT TCTTCGGCGA TGTGGTGCTG 
CGCTTCCCGA GGATTGTGCA CTATTACTTT GACCACAACT CCAACTGGAA CCTCCTCATC 
CGCTGGGGTA TCAGTTTCTG CAACCAGACA GGCGTCTTCA ACCAGGGGCC CCACTCGCCC 
ATCCTCAGCC TGATGGCCCA GGAGCTGGGG ATCAGTGAGA AAGACTCCAA CTTCCAGAAC 
CCATTTAAAA TCGACCGCAC AGAGTTCATT CCCAGCACTG ACCCTTTCCA GAAGGCCCTG 
AGAGAAGAAG AGAAACGCCG AAAGAAAGAG GAGAAGCGGA AGGAGATCCG AAAAGGCCCA 
AGGATCTCCA GATCCCAGTC TGAGTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079097.1
CDS	105..794
Translation	MDLLQFLAFLFVLLLSGMGATGTLRTSLDPSLEIYKKMFEVKRREQLLALKNLAQLNDIHQQYKILDVMLKGLFKVLEDSRTVLTAADVLPDGPFPQDEKLKDAFSHVVENTAFFGDVVLRFPRIVHYYFDHNSNWNLLIRWGISFCNQTGVFNQGPHSPILSLMAQELGISEKDSNFQNPFKIDRTEFIPSTDPFQKALREEEKRRKKEEKRKEIRKGPRISRSQSEL

Target ORF information:

RefSeq Version	NM_024821.4
Organism	Homo sapiens(human)
Definition	Homo sapiens coiled-coil domain containing 134 (CCDC134), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024821.4

ORF Insert Sequence:

ATGGACCTTC TTCAATTCCT GGCCTTCCTC TTTGTCCTGC TTTTGTCTGG GATGGGAGCC 
ACAGGCACCT TGAGGACCTC CCTGGACCCA AGCCTGGAGA TCTACAAGAA GATGTTTGAG 
GTGAAGCGGC GGGAGCAGCT GTTGGCACTG AAGAACCTGG CACAGCTGAA CGACATCCAC 
CAGCAGTACA AGATCCTTGA TGTCATGCTC AAGGGGCTCT TTAAGGTGCT GGAGGACTCC 
CGGACAGTGC TCACCGCTGC TGATGTGCTC CCAGATGGGC CCTTCCCCCA GGACGAGAAG 
CTGAAGGATG CTTTCTCCCA CGTGGTGGAG AACACGGCCT TCTTCGGCGA TGTGGTGCTG 
CGCTTCCCGA GGATTGTGCA CTATTACTTT GACCACAACT CCAACTGGAA CCTCCTCATC 
CGCTGGGGTA TCAGTTTCTG CAACCAGACA GGCGTCTTCA ACCAGGGGCC CCACTCGCCC 
ATCCTCAGCC TGATGGCCCA GGAGCTGGGG ATCAGTGAGA AAGACTCCAA CTTCCAGAAC 
CCATTTAAAA TCGACCGCAC AGAGTTCATT CCCAGCACTG ACCCTTTCCA GAAGGCCCTG 
AGAGAAGAAG AGAAACGCCG AAAGAAAGAG GAGAAGCGGA AGGAGATCCG AAAAGGCCCA 
AGGATCTCCA GATCCCAGTC TGAGTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCDC134 ( XM_005261748.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005261805.1 Homo sapiens coiled-coil domain containing 134 (CCDC134), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu04246
Clone ID Related Accession (Same CDS sequence)	NM_024821.3 , NM_024821.4 , XM_005261748.3 , XM_005261748.2
Accession Version	XM_005261748.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 690bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	coiled-coil domain-containing protein 134 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000022.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005261748.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACCTTC TTCAATTCCT GGCCTTCCTC TTTGTCCTGC TTTTGTCTGG GATGGGAGCC 
ACAGGCACCT TGAGGACCTC CCTGGACCCA AGCCTGGAGA TCTACAAGAA GATGTTTGAG 
GTGAAGCGGC GGGAGCAGCT GTTGGCACTG AAGAACCTGG CACAGCTGAA CGACATCCAC 
CAGCAGTACA AGATCCTTGA TGTCATGCTC AAGGGGCTCT TTAAGGTGCT GGAGGACTCC 
CGGACAGTGC TCACCGCTGC TGATGTGCTC CCAGATGGGC CCTTCCCCCA GGACGAGAAG 
CTGAAGGATG CTTTCTCCCA CGTGGTGGAG AACACGGCCT TCTTCGGCGA TGTGGTGCTG 
CGCTTCCCGA GGATTGTGCA CTATTACTTT GACCACAACT CCAACTGGAA CCTCCTCATC 
CGCTGGGGTA TCAGTTTCTG CAACCAGACA GGCGTCTTCA ACCAGGGGCC CCACTCGCCC 
ATCCTCAGCC TGATGGCCCA GGAGCTGGGG ATCAGTGAGA AAGACTCCAA CTTCCAGAAC 
CCATTTAAAA TCGACCGCAC AGAGTTCATT CCCAGCACTG ACCCTTTCCA GAAGGCCCTG 
AGAGAAGAAG AGAAACGCCG AAAGAAAGAG GAGAAGCGGA AGGAGATCCG AAAAGGCCCA 
AGGATCTCCA GATCCCAGTC TGAGTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005261805.1
CDS	252..941
Translation	MDLLQFLAFLFVLLLSGMGATGTLRTSLDPSLEIYKKMFEVKRREQLLALKNLAQLNDIHQQYKILDVMLKGLFKVLEDSRTVLTAADVLPDGPFPQDEKLKDAFSHVVENTAFFGDVVLRFPRIVHYYFDHNSNWNLLIRWGISFCNQTGVFNQGPHSPILSLMAQELGISEKDSNFQNPFKIDRTEFIPSTDPFQKALREEEKRRKKEEKRKEIRKGPRISRSQSEL

Target ORF information:

RefSeq Version	XM_005261748.3
Organism	Homo sapiens(human)
Definition	Homo sapiens coiled-coil domain containing 134 (CCDC134), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005261748.3

ORF Insert Sequence:

ATGGACCTTC TTCAATTCCT GGCCTTCCTC TTTGTCCTGC TTTTGTCTGG GATGGGAGCC 
ACAGGCACCT TGAGGACCTC CCTGGACCCA AGCCTGGAGA TCTACAAGAA GATGTTTGAG 
GTGAAGCGGC GGGAGCAGCT GTTGGCACTG AAGAACCTGG CACAGCTGAA CGACATCCAC 
CAGCAGTACA AGATCCTTGA TGTCATGCTC AAGGGGCTCT TTAAGGTGCT GGAGGACTCC 
CGGACAGTGC TCACCGCTGC TGATGTGCTC CCAGATGGGC CCTTCCCCCA GGACGAGAAG 
CTGAAGGATG CTTTCTCCCA CGTGGTGGAG AACACGGCCT TCTTCGGCGA TGTGGTGCTG 
CGCTTCCCGA GGATTGTGCA CTATTACTTT GACCACAACT CCAACTGGAA CCTCCTCATC 
CGCTGGGGTA TCAGTTTCTG CAACCAGACA GGCGTCTTCA ACCAGGGGCC CCACTCGCCC 
ATCCTCAGCC TGATGGCCCA GGAGCTGGGG ATCAGTGAGA AAGACTCCAA CTTCCAGAAC 
CCATTTAAAA TCGACCGCAC AGAGTTCATT CCCAGCACTG ACCCTTTCCA GAAGGCCCTG 
AGAGAAGAAG AGAAACGCCG AAAGAAAGAG GAGAAGCGGA AGGAGATCCG AAAAGGCCCA 
AGGATCTCCA GATCCCAGTC TGAGTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCDC134 ( XM_005261748.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005261805.1 Homo sapiens coiled-coil domain containing 134 (CCDC134), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu04246
Clone ID Related Accession (Same CDS sequence)	NM_024821.3 , NM_024821.4 , XM_005261748.3 , XM_005261748.2
Accession Version	XM_005261748.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 690bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	coiled-coil domain-containing protein 134 isoform X1
Comment

ATGGACCTTC TTCAATTCCT GGCCTTCCTC TTTGTCCTGC TTTTGTCTGG GATGGGAGCC 
ACAGGCACCT TGAGGACCTC CCTGGACCCA AGCCTGGAGA TCTACAAGAA GATGTTTGAG 
GTGAAGCGGC GGGAGCAGCT GTTGGCACTG AAGAACCTGG CACAGCTGAA CGACATCCAC 
CAGCAGTACA AGATCCTTGA TGTCATGCTC AAGGGGCTCT TTAAGGTGCT GGAGGACTCC 
CGGACAGTGC TCACCGCTGC TGATGTGCTC CCAGATGGGC CCTTCCCCCA GGACGAGAAG 
CTGAAGGATG CTTTCTCCCA CGTGGTGGAG AACACGGCCT TCTTCGGCGA TGTGGTGCTG 
CGCTTCCCGA GGATTGTGCA CTATTACTTT GACCACAACT CCAACTGGAA CCTCCTCATC 
CGCTGGGGTA TCAGTTTCTG CAACCAGACA GGCGTCTTCA ACCAGGGGCC CCACTCGCCC 
ATCCTCAGCC TGATGGCCCA GGAGCTGGGG ATCAGTGAGA AAGACTCCAA CTTCCAGAAC 
CCATTTAAAA TCGACCGCAC AGAGTTCATT CCCAGCACTG ACCCTTTCCA GAAGGCCCTG 
AGAGAAGAAG AGAAACGCCG AAAGAAAGAG GAGAAGCGGA AGGAGATCCG AAAAGGCCCA 
AGGATCTCCA GATCCCAGTC TGAGTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005261805.1
Translation	MDLLQFLAFLFVLLLSGMGATGTLRTSLDPSLEIYKKMFEVKRREQLLALKNLAQLNDIHQQYKILDVMLKGLFKVLEDSRTVLTAADVLPDGPFPQDEKLKDAFSHVVENTAFFGDVVLRFPRIVHYYFDHNSNWNLLIRWGISFCNQTGVFNQGPHSPILSLMAQELGISEKDSNFQNPFKIDRTEFIPSTDPFQKALREEEKRRKKEEKRKEIRKGPRISRSQSEL

Target ORF information:

RefSeq Version	XM_005261748.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens coiled-coil domain containing 134 (CCDC134), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005261748.2

ORF Insert Sequence:

ATGGACCTTC TTCAATTCCT GGCCTTCCTC TTTGTCCTGC TTTTGTCTGG GATGGGAGCC 
ACAGGCACCT TGAGGACCTC CCTGGACCCA AGCCTGGAGA TCTACAAGAA GATGTTTGAG 
GTGAAGCGGC GGGAGCAGCT GTTGGCACTG AAGAACCTGG CACAGCTGAA CGACATCCAC 
CAGCAGTACA AGATCCTTGA TGTCATGCTC AAGGGGCTCT TTAAGGTGCT GGAGGACTCC 
CGGACAGTGC TCACCGCTGC TGATGTGCTC CCAGATGGGC CCTTCCCCCA GGACGAGAAG 
CTGAAGGATG CTTTCTCCCA CGTGGTGGAG AACACGGCCT TCTTCGGCGA TGTGGTGCTG 
CGCTTCCCGA GGATTGTGCA CTATTACTTT GACCACAACT CCAACTGGAA CCTCCTCATC 
CGCTGGGGTA TCAGTTTCTG CAACCAGACA GGCGTCTTCA ACCAGGGGCC CCACTCGCCC 
ATCCTCAGCC TGATGGCCCA GGAGCTGGGG ATCAGTGAGA AAGACTCCAA CTTCCAGAAC 
CCATTTAAAA TCGACCGCAC AGAGTTCATT CCCAGCACTG ACCCTTTCCA GAAGGCCCTG 
AGAGAAGAAG AGAAACGCCG AAAGAAAGAG GAGAAGCGGA AGGAGATCCG AAAAGGCCCA 
AGGATCTCCA GATCCCAGTC TGAGTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCDC134 ( NM_001304797.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291726.1 Homo sapiens coiled-coil domain containing 134 (CCDC134), transcript variant 2, mRNA.

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CloneID	OHu72328
Clone ID Related Accession (Same CDS sequence)	NM_001304797.1
Accession Version	NM_001304797.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-07-14
Organism	Homo sapiens(human)
Product	coiled-coil domain-containing protein 134 isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY013338.1, AK299311.1 and CB240942.1. Transcript Variant: This variant (2) lacks three alternate exons, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK299311.1, DC372414.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149004, SAMEA2162823 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCTTC TTCAATTCCT GGCCTTCCTC TTTGTCCTGC TTTTGTCTGG GATGGGAGCC 
ACAGGCACCT TGAGGACCTC CCTGGACCCA AGCCTGGAGA TCTACAAGAA GATGTTTGAG 
GTGAAGCGGC GGGAGCAGCT GTTGGCACTG AAGAACCTGG CACAGCTGAA CGACATCCAC 
CAGCAGTACA AGATCCTTGA TGTCATGCTC AAGGGGCTCT TTAAGTTCAT TCCCAGCACT 
GACCCTTTCC AGAAGGCCCT GAGAGAAGAA GAGAAACGCC GAAAGAAAGA GGAGAAGCGG 
AAGGAGATCC GAAAAGGCCC AAGGATCTCC AGATCCCAGT CTGAGTTATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291726.1
CDS	162..512
Translation	MDLLQFLAFLFVLLLSGMGATGTLRTSLDPSLEIYKKMFEVKRREQLLALKNLAQLNDIHQQYKILDVMLKGLFKFIPSTDPFQKALREEEKRRKKEEKRKEIRKGPRISRSQSEL

Target ORF information:

RefSeq Version	NM_001304797.1
Organism	Homo sapiens(human)
Definition	Homo sapiens coiled-coil domain containing 134 (CCDC134), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304797.1

ORF Insert Sequence:

ATGGACCTTC TTCAATTCCT GGCCTTCCTC TTTGTCCTGC TTTTGTCTGG GATGGGAGCC 
ACAGGCACCT TGAGGACCTC CCTGGACCCA AGCCTGGAGA TCTACAAGAA GATGTTTGAG 
GTGAAGCGGC GGGAGCAGCT GTTGGCACTG AAGAACCTGG CACAGCTGAA CGACATCCAC 
CAGCAGTACA AGATCCTTGA TGTCATGCTC AAGGGGCTCT TTAAGTTCAT TCCCAGCACT 
GACCCTTTCC AGAAGGCCCT GAGAGAAGAA GAGAAACGCC GAAAGAAAGA GGAGAAGCGG 
AAGGAGATCC GAAAAGGCCC AAGGATCTCC AGATCCCAGT CTGAGTTATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CCDC134 serves a crucial role in embryonic development.
International journal of molecular medicine41(1)381-390(2018 Jan)
Yu B,Zhang T,Xia P,Gong X,Qiu X,Huang J

Cytokine-like molecule CCDC134 contributes to CD8? T-cell effector functions in cancer immunotherapy.
Cancer research74(20)5734-45(2014 Oct)
Huang J,Xiao L,Gong X,Shao W,Yin Y,Liao Q,Meng Y,Zhang Y,Ma D,Qiu X

CCDC134 is down-regulated in gastric cancer and its silencing promotes cell migration and invasion of GES-1 and AGS cells via the MAPK pathway.
Molecular and cellular biochemistry372(1-2)1-8(2013 Jan)
Zhong J,Zhao M,Luo Q,Ma Y,Liu J,Wang J,Yang M,Yuan X,Sang J,Huang C

CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest.
Histochemistry and cell biology138(1)41-55(2012 Jul)
Huang J,Zhang L,Liu W,Liao Q,Shi T,Xiao L,Hu F,Qiu X

Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.
Neurology76(1)69-79(2011 Jan)
Kim S,Swaminathan S,Shen L,Risacher SL,Nho K,Foroud T,Shaw LM,Trojanowski JQ,Potkin SG,Huentelman MJ,Craig DW,DeChairo BM,Aisen PS,Petersen RC,Weiner MW,Saykin AJ,

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CCDC134 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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