BAALC cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BAALC
Entrez Gene ID	79870
Full Name	BAALC, MAP3K1 and KLF4 binding
General protein information	Preferred Names BAALC, MAP3K1 and KLF4 binding Names brain and acute leukemia cytoplasmic protein BAALC, MEKK1 and KLF4 binding brain and acute leukemia, cytoplasmic
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q22.3
Summary	This gene was identified by gene expression studies in patients with acute myeloid leukemia (AML). The gene is conserved among mammals and is not found in lower organisms. Tissues that express this gene develop from the neuroectoderm. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene; however, some of the transcript variants are found only in AML cell lines. [provided by RefSeq, Jul 2008].
Disorder MIM:	606602

mRNA and Protein(s)

mRNA	Protein	Name
NM_001024372.1	NP_001019543.1	brain and acute leukemia cytoplasmic protein isoform 2
NM_024812.2	NP_079088.1	brain and acute leukemia cytoplasmic protein isoform 1
NM_024812.3	NP_079088.1	brain and acute leukemia cytoplasmic protein isoform 1
NM_001364874.1	NP_001351803.1	brain and acute leukemia cytoplasmic protein isoform 3
NM_001024372.2	NP_001019543.1	brain and acute leukemia cytoplasmic protein isoform 2

Pathways from BioSystems

Homologies

	BAALC	XP_001084445.1
Canis lupus familiaris (dog)	BAALC	XP_849552.1
Rattus norvegicus (Norway rat)	Baalc	NP_658907.1
Gallus gallus (chicken)	BAALC	XP_418371.2
Homo sapiens (human)	BAALC	NP_079088.1
Pan troglodytes (chimpanzee)	BAALC	XP_001155565.2
Bos taurus (cattle)	BAALC	NP_001076977.1
Mus musculus (house mouse)	Baalc	NP_542371.1
Xenopus tropicalis (tropical clawed frog)	baalc	XP_002931581.2

Gene Ontology
Bibliography

Related articles in PubMed

Feasibility of BAALC gene expression for detection of minimal residual disease and risk stratification in normal karyotype acute myeloid leukaemia.
Weber S, Haferlach T, Alpermann T, Perglerov? K, Schnittger S, Haferlach C, Kern W
British journal of haematology175(5)904-916(2016 Dec)

Evaluation of rs62527607 [GT] single nucleotide polymorphism located in BAALC gene in children with acute leukemia using mismatch PCR-RFLP.
Nadimi M, Rahgozar S, Moafi A, Tavassoli M, Mesrian Tanha H
Cancer genetics209(7-8)348-53(2016 Jul-Aug)

The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia.
D?az-Bey? M, Brunet S, Nomded?u J, Cordeiro A, Tormo M, Escoda L, Ribera JM, Arnan M, Heras I, Gallardo D, Bargay J, Queipo de Llano MP, Salamero O, Mart? JM, Sampol A, Pedro C, Hoyos M, Pratcorona M, Castellano JJ, Nomdedeu M, Risue?o RM, Sierra J, Monz? M, Navarro A, Esteve J
Blood cancer journal5e352(2015 Oct)

Relation of BAALC and ERG Gene Expression with Overall Survival in Acute Myeloid Leukemia Cases.
Rashed RA, Kadry DY, El Taweel M, Abd El Wahab N, Abd El Hameed T
Asian Pacific journal of cancer prevention : APJCP16(17)7875-82(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

BAALC expression-based minimal residual disease detection during therapy may be considered a strategy to identify patients at high risk of relapse.
Title: Feasibility of BAALC gene expression for detection of minimal residual disease and risk stratification in normal karyotype acute myeloid leukaemia.

Study provide evidence for an association of rs62527607 [GT] SNP of BAALC gene with multidrug resistance in childhood ALL.
Title: Evaluation of rs62527607 [GT] single nucleotide polymorphism located in BAALC gene in children with acute leukemia using mismatch PCR-RFLP.

demonstrated that BAALC blocks ERK-mediated monocytic differentiation of acute myeloid leukemia cells by trapping Kruppel-like factor 4 (KLF4) in the cytoplasm and inhibiting its function in the nucleus
Title: BAALC potentiates oncogenic ERK pathway through interactions with MEKK1 and KLF4.

combined determination of both miR-3151 and BAALC improved this prognostic stratification, with patients with low levels of both parameters showing a better outcome compared with those patients harboring increased levels of one or both markers
Title: The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia.

BAALC and ERG genes are specific significant molecular markers in acute myeloid leukemia disease progression, response to treatment and survival.
Title: Relation of BAALC and ERG Gene Expression with Overall Survival in Acute Myeloid Leukemia Cases.

The following BAALC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BAALC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04270	NM_001024372.2 Latest version!	Homo sapiens BAALC binder of MAP3K1 and KLF4 (BAALC), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu29600	NM_024812.3 Latest version!	Homo sapiens BAALC binder of MAP3K1 and KLF4 (BAALC), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu106798	NM_001364874.1 Latest version!	Homo sapiens BAALC binder of MAP3K1 and KLF4 (BAALC), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu29600	NM_024812.2	Homo sapiens BAALC, MAP3K1 and KLF4 binding (BAALC), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04270	NM_001024372.1	Homo sapiens BAALC binder of MAP3K1 and KLF4 (BAALC), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BAALC ( NM_001024372.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001019543.1 Homo sapiens BAALC binder of MAP3K1 and KLF4 (BAALC), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04270
Clone ID Related Accession (Same CDS sequence)	NM_001024372.1 , NM_001024372.2
Accession Version	NM_001024372.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 165bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-27
Organism	Homo sapiens(human)
Product	brain and acute leukemia cytoplasmic protein isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI548687.1 and BC035038.2. Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus when compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035038.2, SRR1803611.278029.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGGGCTGCG GCGGGAGCCG GGCGGATGCC ATCGAGCCCC GCTACTACGA GAGCTGGACC 
CGGGAGACAG AATCCACCTG GCTCACCTAC ACCGACTCGG ACGCGCCGCC CAGCGCCGCC 
GCCCCGGACA GCGGCCCCGA AGCGGGCGGC CTGCACTCGG GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001019543.1
CDS	206..370
Translation	MGCGGSRADAIEPRYYESWTRETESTWLTYTDSDAPPSAAAPDSGPEAGGLHSG

Target ORF information:

RefSeq Version	NM_001024372.1
Organism	Homo sapiens(human)
Definition	Homo sapiens BAALC binder of MAP3K1 and KLF4 (BAALC), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001024372.1

ORF Insert Sequence:

1
61
121

ATGGGCTGCG GCGGGAGCCG GGCGGATGCC ATCGAGCCCC GCTACTACGA GAGCTGGACC 
CGGGAGACAG AATCCACCTG GCTCACCTAC ACCGACTCGG ACGCGCCGCC CAGCGCCGCC 
GCCCCGGACA GCGGCCCCGA AGCGGGCGGC CTGCACTCGG GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BAALC ( NM_001024372.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001019543.1 Homo sapiens BAALC binder of MAP3K1 and KLF4 (BAALC), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04270
Clone ID Related Accession (Same CDS sequence)	NM_001024372.1 , NM_001024372.2
Accession Version	NM_001024372.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 165bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	brain and acute leukemia cytoplasmic protein isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI548687.1 and BC035038.2. On Jun 1, 2019 this sequence version replaced NM_001024372.1. Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus when compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035038.2, SRR1803615.171010.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGGGCTGCG GCGGGAGCCG GGCGGATGCC ATCGAGCCCC GCTACTACGA GAGCTGGACC 
CGGGAGACAG AATCCACCTG GCTCACCTAC ACCGACTCGG ACGCGCCGCC CAGCGCCGCC 
GCCCCGGACA GCGGCCCCGA AGCGGGCGGC CTGCACTCGG GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001019543.1
CDS	174..338
Translation	MGCGGSRADAIEPRYYESWTRETESTWLTYTDSDAPPSAAAPDSGPEAGGLHSG

Target ORF information:

RefSeq Version	NM_001024372.2
Organism	Homo sapiens(human)
Definition	Homo sapiens BAALC binder of MAP3K1 and KLF4 (BAALC), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001024372.2

ORF Insert Sequence:

1
61
121

ATGGGCTGCG GCGGGAGCCG GGCGGATGCC ATCGAGCCCC GCTACTACGA GAGCTGGACC 
CGGGAGACAG AATCCACCTG GCTCACCTAC ACCGACTCGG ACGCGCCGCC CAGCGCCGCC 
GCCCCGGACA GCGGCCCCGA AGCGGGCGGC CTGCACTCGG GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BAALC ( NM_024812.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_079088.1 Homo sapiens BAALC, MAP3K1 and KLF4 binding (BAALC), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29600
Clone ID Related Accession (Same CDS sequence)	NM_024812.2 , NM_024812.3
Accession Version	NM_024812.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	brain and acute leukemia cytoplasmic protein isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI548687.1, AK022077.1 and BC035038.2. On Jun 3, 2005 this sequence version replaced NM_024812.1. Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK022077.1, SRR1803617.104271.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCTGCG GCGGGAGCCG GGCGGATGCC ATCGAGCCCC GCTACTACGA GAGCTGGACC 
CGGGAGACAG AATCCACCTG GCTCACCTAC ACCGACTCGG ACGCGCCGCC CAGCGCCGCC 
GCCCCGGACA GCGGCCCCGA AGCGGGCGGC CTGCACTCGG GCATGCTGGA AGATGGACTG 
CCCTCCAATG GTGTGCCCCG ATCTACAGCC CCAGGTGGAA TACCCAACCC AGAGAAGAAG 
ACGAACTGTG AGACCCAGTG CCCAAATCCC CAGAGCCTCA GCTCAGGCCC TCTGACCCAG 
AAACAGAATG GCCTTCAGAC CACAGAGGCT AAAAGAGATG CTAAGAGAAT GCCTGCAAAA 
GAAGTCACCA TTAATGTAAC AGATAGCATC CAACAGATGG ACAGAAGTCG AAGAATCACA 
AAGAACTGTG TCAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079088.1
CDS	206..643
Translation	MGCGGSRADAIEPRYYESWTRETESTWLTYTDSDAPPSAAAPDSGPEAGGLHSGMLEDGLPSNGVPRSTAPGGIPNPEKKTNCETQCPNPQSLSSGPLTQKQNGLQTTEAKRDAKRMPAKEVTINVTDSIQQMDRSRRITKNCVN

Target ORF information:

RefSeq Version	NM_024812.2
Organism	Homo sapiens(human)
Definition	Homo sapiens BAALC, MAP3K1 and KLF4 binding (BAALC), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024812.2

ORF Insert Sequence:

ATGGGCTGCG GCGGGAGCCG GGCGGATGCC ATCGAGCCCC GCTACTACGA GAGCTGGACC 
CGGGAGACAG AATCCACCTG GCTCACCTAC ACCGACTCGG ACGCGCCGCC CAGCGCCGCC 
GCCCCGGACA GCGGCCCCGA AGCGGGCGGC CTGCACTCGG GCATGCTGGA AGATGGACTG 
CCCTCCAATG GTGTGCCCCG ATCTACAGCC CCAGGTGGAA TACCCAACCC AGAGAAGAAG 
ACGAACTGTG AGACCCAGTG CCCAAATCCC CAGAGCCTCA GCTCAGGCCC TCTGACCCAG 
AAACAGAATG GCCTTCAGAC CACAGAGGCT AAAAGAGATG CTAAGAGAAT GCCTGCAAAA 
GAAGTCACCA TTAATGTAAC AGATAGCATC CAACAGATGG ACAGAAGTCG AAGAATCACA 
AAGAACTGTG TCAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BAALC ( NM_024812.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_079088.1 Homo sapiens BAALC binder of MAP3K1 and KLF4 (BAALC), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29600
Clone ID Related Accession (Same CDS sequence)	NM_024812.2 , NM_024812.3
Accession Version	NM_024812.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	brain and acute leukemia cytoplasmic protein isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI548687.1, AK022077.1 and BC035038.2. On Nov 22, 2018 this sequence version replaced NM_024812.2. Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP213551.1, AK022077.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000309982.10/ ENSP00000312457.5 RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCTGCG GCGGGAGCCG GGCGGATGCC ATCGAGCCCC GCTACTACGA GAGCTGGACC 
CGGGAGACAG AATCCACCTG GCTCACCTAC ACCGACTCGG ACGCGCCGCC CAGCGCCGCC 
GCCCCGGACA GCGGCCCCGA AGCGGGCGGC CTGCACTCGG GCATGCTGGA AGATGGACTG 
CCCTCCAATG GTGTGCCCCG ATCTACAGCC CCAGGTGGAA TACCCAACCC AGAGAAGAAG 
ACGAACTGTG AGACCCAGTG CCCAAATCCC CAGAGCCTCA GCTCAGGCCC TCTGACCCAG 
AAACAGAATG GCCTTCAGAC CACAGAGGCT AAAAGAGATG CTAAGAGAAT GCCTGCAAAA 
GAAGTCACCA TTAATGTAAC AGATAGCATC CAACAGATGG ACAGAAGTCG AAGAATCACA 
AAGAACTGTG TCAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079088.1
CDS	174..611
Translation	MGCGGSRADAIEPRYYESWTRETESTWLTYTDSDAPPSAAAPDSGPEAGGLHSGMLEDGLPSNGVPRSTAPGGIPNPEKKTNCETQCPNPQSLSSGPLTQKQNGLQTTEAKRDAKRMPAKEVTINVTDSIQQMDRSRRITKNCVN

Target ORF information:

RefSeq Version	NM_024812.3
Organism	Homo sapiens(human)
Definition	Homo sapiens BAALC binder of MAP3K1 and KLF4 (BAALC), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024812.3

ORF Insert Sequence:

ATGGGCTGCG GCGGGAGCCG GGCGGATGCC ATCGAGCCCC GCTACTACGA GAGCTGGACC 
CGGGAGACAG AATCCACCTG GCTCACCTAC ACCGACTCGG ACGCGCCGCC CAGCGCCGCC 
GCCCCGGACA GCGGCCCCGA AGCGGGCGGC CTGCACTCGG GCATGCTGGA AGATGGACTG 
CCCTCCAATG GTGTGCCCCG ATCTACAGCC CCAGGTGGAA TACCCAACCC AGAGAAGAAG 
ACGAACTGTG AGACCCAGTG CCCAAATCCC CAGAGCCTCA GCTCAGGCCC TCTGACCCAG 
AAACAGAATG GCCTTCAGAC CACAGAGGCT AAAAGAGATG CTAAGAGAAT GCCTGCAAAA 
GAAGTCACCA TTAATGTAAC AGATAGCATC CAACAGATGG ACAGAAGTCG AAGAATCACA 
AAGAACTGTG TCAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BAALC ( NM_001364874.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001351803.1 Homo sapiens BAALC binder of MAP3K1 and KLF4 (BAALC), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu106798
Clone ID Related Accession (Same CDS sequence)	NM_001364874.1
Accession Version	NM_001364874.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	brain and acute leukemia cytoplasmic protein isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK022077.1, BI602606.1 and BC035038.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.229774.1, SRR1660807.55001.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCTGCG GCGGGAGCCG GGCGGATGCC ATCGAGCCCC GCTACTACGA GAGCTGGACC 
CGGGAGACAG AATCCACCTG GCTCACCTAC ACCGACTCGG ACGCGCCGCC CAGCGCCGCC 
GCCCCGGACA GCGGCCCCGA AGCGGGCGGC CTGCACTCGG TTCTGGAGGC TGAGAAGTCC 
AAGATCAAGG CACCAACAGA TTCAGTGTCT GATGAAGGCT TGTTCTCTGC TTCAAAGATG 
GCACCTCTTG CTGTGTTCTC ACATGGCATG CTGGAAGATG GACTGCCCTC CAATGGTGTG 
CCCCGATCTA CAGCCCCAGG TGGAATACCC AACCCAGAGA AGAAGACGAA CTGTGAGACC 
CAGTGCCCAA ATCCCCAGAG CCTCAGCTCA GGCCCTCTGA CCCAGAAACA GAATGGCCTT 
CAGACCACAG AGGCTAAAAG AGATGCTAAG AGAATGCCTG CAAAAGAAGT CACCATTAAT 
GTAACAGATA GCATCCAACA GATGGACAGA AGTCGAAGAA TCACAAAGAA CTGTGTCAAC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001351803.1
CDS	174..716
Translation	MGCGGSRADAIEPRYYESWTRETESTWLTYTDSDAPPSAAAPDSGPEAGGLHSVLEAEKSKIKAPTDSVSDEGLFSASKMAPLAVFSHGMLEDGLPSNGVPRSTAPGGIPNPEKKTNCETQCPNPQSLSSGPLTQKQNGLQTTEAKRDAKRMPAKEVTINVTDSIQQMDRSRRITKNCVN

Target ORF information:

RefSeq Version	NM_001364874.1
Organism	Homo sapiens(human)
Definition	Homo sapiens BAALC binder of MAP3K1 and KLF4 (BAALC), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001364874.1

ORF Insert Sequence:

ATGGGCTGCG GCGGGAGCCG GGCGGATGCC ATCGAGCCCC GCTACTACGA GAGCTGGACC 
CGGGAGACAG AATCCACCTG GCTCACCTAC ACCGACTCGG ACGCGCCGCC CAGCGCCGCC 
GCCCCGGACA GCGGCCCCGA AGCGGGCGGC CTGCACTCGG TTCTGGAGGC TGAGAAGTCC 
AAGATCAAGG CACCAACAGA TTCAGTGTCT GATGAAGGCT TGTTCTCTGC TTCAAAGATG 
GCACCTCTTG CTGTGTTCTC ACATGGCATG CTGGAAGATG GACTGCCCTC CAATGGTGTG 
CCCCGATCTA CAGCCCCAGG TGGAATACCC AACCCAGAGA AGAAGACGAA CTGTGAGACC 
CAGTGCCCAA ATCCCCAGAG CCTCAGCTCA GGCCCTCTGA CCCAGAAACA GAATGGCCTT 
CAGACCACAG AGGCTAAAAG AGATGCTAAG AGAATGCCTG CAAAAGAAGT CACCATTAAT 
GTAACAGATA GCATCCAACA GATGGACAGA AGTCGAAGAA TCACAAAGAA CTGTGTCAAC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Feasibility of BAALC gene expression for detection of minimal residual disease and risk stratification in normal karyotype acute myeloid leukaemia.
British journal of haematology175(5)904-916(2016 Dec)
Weber S,Haferlach T,Alpermann T,Perglerov? K,Schnittger S,Haferlach C,Kern W

Evaluation of rs62527607 [GT] single nucleotide polymorphism located in BAALC gene in children with acute leukemia using mismatch PCR-RFLP.
Cancer genetics209(7-8)348-53(2016 Jul-Aug)
Nadimi M,Rahgozar S,Moafi A,Tavassoli M,Mesrian Tanha H

The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia.
Blood cancer journal5e352(2015 Oct)
D?az-Bey? M,Brunet S,Nomded?u J,Cordeiro A,Tormo M,Escoda L,Ribera JM,Arnan M,Heras I,Gallardo D,Bargay J,Queipo de Llano MP,Salamero O,Mart? JM,Sampol A,Pedro C,Hoyos M,Pratcorona M,Castellano JJ,Nomdedeu M,Risue?o RM,Sierra J,Monz? M,Navarro A,Esteve J

Relation of BAALC and ERG Gene Expression with Overall Survival in Acute Myeloid Leukemia Cases.
Asian Pacific journal of cancer prevention : APJCP16(17)7875-82(2015)
Rashed RA,Kadry DY,El Taweel M,Abd El Wahab N,Abd El Hameed T

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BAALC cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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