FAM57A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FAM57A
Entrez Gene ID	79850
Full Name	family with sequence similarity 57 member A
Synonyms	CT120
General protein information	Preferred Names family with sequence similarity 57 member A Names protein FAM57A membrane protein expressed in epithelial-like lung adenocarcinoma
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.3
Summary	The protein encoded by this gene is a membrane-associated protein that promotes lung carcinogenesis. The encoded protein may be involved in amino acid transport and glutathione metabolism since it can interact with a solute carrier family member (SLC3A2) and an isoform of gamma-glutamyltranspeptidase-like 3. An alternatively spliced variant encoding a protein that lacks a 32 aa internal segment showed the opposite effect, inhibiting lung cancer cell growth. Knockdown of this gene also inhibited lung carcinogenesis and tumor cell growth. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015].
Disorder MIM:	611627

mRNA and Protein(s)

mRNA	Protein	Name
NM_001318008.1	NP_001304937.1	TLC domain-containing protein 3A isoform 4
NM_024792.3	NP_079068.1	TLC domain-containing protein 3A isoform 1
NM_001318006.1	NP_001304935.1	TLC domain-containing protein 3A isoform 2
NM_001318007.1	NP_001304936.1	TLC domain-containing protein 3A isoform 3
NM_024792.2	NP_079068.1	protein FAM57A isoform 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	FAM57A	XP_537761.2
Mus musculus (house mouse)	Fam57a	NP_082049.1
Rattus norvegicus (Norway rat)	Fam57a	XP_002727842.2
Gallus gallus (chicken)	FAM57A	XP_425410.4
Homo sapiens (human)	FAM57A	NP_079068.1
	FAM57A	XP_001084389.2
Pan troglodytes (chimpanzee)	FAM57A	XP_003954518.1
Xenopus tropicalis (tropical clawed frog)	fam57a	NP_001016139.2
Bos taurus (cattle)	FAM57A	NP_001074985.1

Gene Ontology
Bibliography

Related articles in PubMed

Silencing of CT120 by antisense oligonucleotides could inhibit the lung cancer cells growth.
Li Z, Shao S, Xie S, Jiao F, Ma Y, Shi S
Irish journal of medical science179(2)217-23(2010 Jun)

Down-regulation of CT120A by RNA interference suppresses lung cancer cells growth and sensitizes to ultraviolet-induced apoptosis.
Pan D, Wei L, Yao M, Wan D, Gu J
Cancer letters235(1)26-33(2006 Apr)

Inhibitory effect of CT120B, an alternative splice variant of CT120A, on lung cancer cell growth.
Pan DN, Li JJ, Wei L, Yao M, Wan DF, Gu JR
Acta biochimica et biophysica Sinica37(9)588-92(2005 Sep)

Altered gene expression profiles of NIH3T3 cells regulated by human lung cancer associated gene CT120.
He XH, Li JJ, Xie YH, Tang YT, Yao GF, Qin WX, Wan DF, Gu JR
Cell research14(6)487-96(2004 Dec)

Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism.
He X, Di Y, Li J, Xie Y, Tang Y, Zhang F, Wei L, Zhang Y, Qin W, Huo K, Li Y, Wan D, Gu J
Biochemical and biophysical research communications297(3)528-36(2002 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The researchers found evidence that CT120 may be a key factor in tumor progression and that down-regulation of CT120 may be an effective treatment for lung neoplasms.
Title: Silencing of CT120 by antisense oligonucleotides could inhibit the lung cancer cells growth.

CT120B overexpression resulted in reduction of cell growth rate & inhibited tumorigenecity & anchorage-independent growth; findings suggest that the delayed G1/S phase transition might contribute to the inhibitory activities of CT120B on cell growth
Title: Inhibitory effect of CT120B, an alternative splice variant of CT120A, on lung cancer cell growth.

Molecular cloning and characterization of this novel membrane-associated gene involved in amino acid transport and glutathione metabolism
Title: Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism.

The following FAM57A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FAM57A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04239	NM_024792.3 Latest version!	Homo sapiens TLC domain containing 3A (TLCD3A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu100311	NM_001318006.1 Latest version!	Homo sapiens TLC domain containing 3A (TLCD3A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu100226	NM_001318007.1 Latest version!	Homo sapiens TLC domain containing 3A (TLCD3A), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu100329	NM_001318008.1 Latest version!	Homo sapiens TLC domain containing 3A (TLCD3A), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu04239	NM_024792.2	Homo sapiens family with sequence similarity 57 member A (FAM57A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FAM57A ( NM_024792.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_079068.1 Homo sapiens TLC domain containing 3A (TLCD3A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04239
Clone ID Related Accession (Same CDS sequence)	NM_024792.3 , NM_024792.2
Accession Version	NM_024792.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-10
Organism	Homo sapiens(human)
Product	TLC domain-containing protein 3A isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN259418.1, AK025935.1, AA055841.1 and AC087392.10. On Nov 23, 2018 this sequence version replaced NM_024792.2. Transcript Variant: This variant (1, also known as CT120A) represents the longest transcript and encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1803616.31664.1, SRR3476690.1009455.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000308278.13/ ENSP00000312017.7 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGCTGA CGCTGGCCGG GGGCGCGCTC TTCTTCCCGG GGCTCTTCGC GCTCTGCACC 
TGGGCGCTGC GCCGCTCCCA GCCCGGATGG AGCCGCACCG ACTGCGTGAT GATCAGCACC 
AGGCTGGTTT CCTCGGTGCA CGCCGTGCTG GCCACCGGCT CGGGGATCGT CATCATTCGC 
TCCTGCGACG ACGTGATCAC CGGCAGGCAC TGGCTTGCCC GGGAATATGT GTGGTTTCTG 
ATTCCATACA TGATCTATGA CTCGTACGCC ATGTACCTCT GTGAATGGTG CCGAACCAGA 
GACCAGAACC GTGCGCCCTC CCTCACTCTT CGAAACTTCC TAAGTCGAAA CCGCCTCATG 
ATCACACATC ATGCGGTCAT TCTCTTTGTC CTTGTGCCAG TCGCACAGAG GCTCCGGGGA 
GACCTTGGGG ACTTCTTTGT CGGCTGCATC TTCACGGCAG AACTGAGCAC TCCGTTTGTG 
TCGCTGGGCA GGGTTCTGAT TCAGCTAAAG CAGCAGCACA CCCTTCTGTA CAAGGTGAAT 
GGAATCCTCA CGCTGGCCAC CTTCCTTTCC TGCCGGATCC TTCTCTTCCC CTTCATGTAC 
TGGTCCTATG GCCGCCAGCA GGGACTAAGC CTGCTCCAAG TACCCTTCAG CATCCCATTC 
TACTGCAACG TGGCCAATGC CTTCCTCGTA GCTCCTCAGA TCTACTGGTT CTGTCTGCTG 
TGCAGGAAGG CAGTCCGGCT CTTTGACACT CCCCAAGCCA AAAAGGATGG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079068.1
CDS	53..826
Translation	MLLTLAGGALFFPGLFALCTWALRRSQPGWSRTDCVMISTRLVSSVHAVLATGSGIVIIRSCDDVITGRHWLAREYVWFLIPYMIYDSYAMYLCEWCRTRDQNRAPSLTLRNFLSRNRLMITHHAVILFVLVPVAQRLRGDLGDFFVGCIFTAELSTPFVSLGRVLIQLKQQHTLLYKVNGILTLATFLSCRILLFPFMYWSYGRQQGLSLLQVPFSIPFYCNVANAFLVAPQIYWFCLLCRKAVRLFDTPQAKKDG

Target ORF information:

RefSeq Version	NM_024792.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TLC domain containing 3A (TLCD3A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024792.3

ORF Insert Sequence:

ATGCTGCTGA CGCTGGCCGG GGGCGCGCTC TTCTTCCCGG GGCTCTTCGC GCTCTGCACC 
TGGGCGCTGC GCCGCTCCCA GCCCGGATGG AGCCGCACCG ACTGCGTGAT GATCAGCACC 
AGGCTGGTTT CCTCGGTGCA CGCCGTGCTG GCCACCGGCT CGGGGATCGT CATCATTCGC 
TCCTGCGACG ACGTGATCAC CGGCAGGCAC TGGCTTGCCC GGGAATATGT GTGGTTTCTG 
ATTCCATACA TGATCTATGA CTCGTACGCC ATGTACCTCT GTGAATGGTG CCGAACCAGA 
GACCAGAACC GTGCGCCCTC CCTCACTCTT CGAAACTTCC TAAGTCGAAA CCGCCTCATG 
ATCACACATC ATGCGGTCAT TCTCTTTGTC CTTGTGCCAG TCGCACAGAG GCTCCGGGGA 
GACCTTGGGG ACTTCTTTGT CGGCTGCATC TTCACGGCAG AACTGAGCAC TCCGTTTGTG 
TCGCTGGGCA GGGTTCTGAT TCAGCTAAAG CAGCAGCACA CCCTTCTGTA CAAGGTGAAT 
GGAATCCTCA CGCTGGCCAC CTTCCTTTCC TGCCGGATCC TTCTCTTCCC CTTCATGTAC 
TGGTCCTATG GCCGCCAGCA GGGACTAAGC CTGCTCCAAG TACCCTTCAG CATCCCATTC 
TACTGCAACG TGGCCAATGC CTTCCTCGTA GCTCCTCAGA TCTACTGGTT CTGTCTGCTG 
TGCAGGAAGG CAGTCCGGCT CTTTGACACT CCCCAAGCCA AAAAGGATGG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FAM57A ( NM_024792.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_079068.1 Homo sapiens family with sequence similarity 57 member A (FAM57A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04239
Clone ID Related Accession (Same CDS sequence)	NM_024792.3 , NM_024792.2
Accession Version	NM_024792.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	protein FAM57A isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN259418.1, AK025935.1, AA055841.1 and AC087392.10. On Dec 19, 2015 this sequence version replaced NM_024792.1. Transcript Variant: This variant (1, also known as CT120A) represents the longest transcript and encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1803612.112557.1, SRR1803612.73636.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTGA CGCTGGCCGG GGGCGCGCTC TTCTTCCCGG GGCTCTTCGC GCTCTGCACC 
TGGGCGCTGC GCCGCTCCCA GCCCGGATGG AGCCGCACCG ACTGCGTGAT GATCAGCACC 
AGGCTGGTTT CCTCGGTGCA CGCCGTGCTG GCCACCGGCT CGGGGATCGT CATCATTCGC 
TCCTGCGACG ACGTGATCAC CGGCAGGCAC TGGCTTGCCC GGGAATATGT GTGGTTTCTG 
ATTCCATACA TGATCTATGA CTCGTACGCC ATGTACCTCT GTGAATGGTG CCGAACCAGA 
GACCAGAACC GTGCGCCCTC CCTCACTCTT CGAAACTTCC TAAGTCGAAA CCGCCTCATG 
ATCACACATC ATGCGGTCAT TCTCTTTGTC CTTGTGCCAG TCGCACAGAG GCTCCGGGGA 
GACCTTGGGG ACTTCTTTGT CGGCTGCATC TTCACGGCAG AACTGAGCAC TCCGTTTGTG 
TCGCTGGGCA GGGTTCTGAT TCAGCTAAAG CAGCAGCACA CCCTTCTGTA CAAGGTGAAT 
GGAATCCTCA CGCTGGCCAC CTTCCTTTCC TGCCGGATCC TTCTCTTCCC CTTCATGTAC 
TGGTCCTATG GCCGCCAGCA GGGACTAAGC CTGCTCCAAG TACCCTTCAG CATCCCATTC 
TACTGCAACG TGGCCAATGC CTTCCTCGTA GCTCCTCAGA TCTACTGGTT CTGTCTGCTG 
TGCAGGAAGG CAGTCCGGCT CTTTGACACT CCCCAAGCCA AAAAGGATGG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079068.1
CDS	103..876
Translation	MLLTLAGGALFFPGLFALCTWALRRSQPGWSRTDCVMISTRLVSSVHAVLATGSGIVIIRSCDDVITGRHWLAREYVWFLIPYMIYDSYAMYLCEWCRTRDQNRAPSLTLRNFLSRNRLMITHHAVILFVLVPVAQRLRGDLGDFFVGCIFTAELSTPFVSLGRVLIQLKQQHTLLYKVNGILTLATFLSCRILLFPFMYWSYGRQQGLSLLQVPFSIPFYCNVANAFLVAPQIYWFCLLCRKAVRLFDTPQAKKDG

Target ORF information:

RefSeq Version	NM_024792.2
Organism	Homo sapiens(human)
Definition	Homo sapiens family with sequence similarity 57 member A (FAM57A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024792.2

ORF Insert Sequence:

ATGCTGCTGA CGCTGGCCGG GGGCGCGCTC TTCTTCCCGG GGCTCTTCGC GCTCTGCACC 
TGGGCGCTGC GCCGCTCCCA GCCCGGATGG AGCCGCACCG ACTGCGTGAT GATCAGCACC 
AGGCTGGTTT CCTCGGTGCA CGCCGTGCTG GCCACCGGCT CGGGGATCGT CATCATTCGC 
TCCTGCGACG ACGTGATCAC CGGCAGGCAC TGGCTTGCCC GGGAATATGT GTGGTTTCTG 
ATTCCATACA TGATCTATGA CTCGTACGCC ATGTACCTCT GTGAATGGTG CCGAACCAGA 
GACCAGAACC GTGCGCCCTC CCTCACTCTT CGAAACTTCC TAAGTCGAAA CCGCCTCATG 
ATCACACATC ATGCGGTCAT TCTCTTTGTC CTTGTGCCAG TCGCACAGAG GCTCCGGGGA 
GACCTTGGGG ACTTCTTTGT CGGCTGCATC TTCACGGCAG AACTGAGCAC TCCGTTTGTG 
TCGCTGGGCA GGGTTCTGAT TCAGCTAAAG CAGCAGCACA CCCTTCTGTA CAAGGTGAAT 
GGAATCCTCA CGCTGGCCAC CTTCCTTTCC TGCCGGATCC TTCTCTTCCC CTTCATGTAC 
TGGTCCTATG GCCGCCAGCA GGGACTAAGC CTGCTCCAAG TACCCTTCAG CATCCCATTC 
TACTGCAACG TGGCCAATGC CTTCCTCGTA GCTCCTCAGA TCTACTGGTT CTGTCTGCTG 
TGCAGGAAGG CAGTCCGGCT CTTTGACACT CCCCAAGCCA AAAAGGATGG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FAM57A ( NM_001318006.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001304935.1 Homo sapiens TLC domain containing 3A (TLCD3A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu100311
Clone ID Related Accession (Same CDS sequence)	NM_001318006.1
Accession Version	NM_001318006.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-10
Organism	Homo sapiens(human)
Product	TLC domain-containing protein 3A isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN259418.1, BC026023.1, AA055841.1 and AC087392.10. Transcript Variant: This variant (2, also known as CT120B) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: BC026023.1, BG333142.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTGA CGCTGGCCGG GGGCGCGCTC TTCTTCCCGG GGCTCTTCGC GCTCTGCACC 
TGGGCGCTGC GCCGCTCCCA GCCCGGATGG AGCCGCACCG ACTGCGTGAT GATCAGCACC 
AGGCTGGTTT CCTCGGTGCA CGCCGTGCTG GCCACCGGCT CGGGGATCGT CATCATTCGC 
TCCTGCGACG ACGTGATCAC CGGCAGGCAC TGGCTTGCCC GGGAATATGT GTGGTTTCTG 
ATTCCATACA TGATCTATGA CTCGTACGCC ATGTACCTCT GTGAATGGTG CCGAACCAGA 
GACCAGAACC GTGCGCCCTC CCTCACTCTT CGAAACTTCC TAAGTCGAAA CCGCCTCATG 
ATCACACATC ATGCGGTCAT TCTCTTTGTC CTTGTGCCAG TCGCACAGCT AAAGCAGCAG 
CACACCCTTC TGTACAAGGT GAATGGAATC CTCACGCTGG CCACCTTCCT TTCCTGCCGG 
ATCCTTCTCT TCCCCTTCAT GTACTGGTCC TATGGCCGCC AGCAGGGACT AAGCCTGCTC 
CAAGTACCCT TCAGCATCCC ATTCTACTGC AACGTGGCCA ATGCCTTCCT CGTAGCTCCT 
CAGATCTACT GGTTCTGTCT GCTGTGCAGG AAGGCAGTCC GGCTCTTTGA CACTCCCCAA 
GCCAAAAAGG ATGGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304935.1
CDS	103..780
Translation	MLLTLAGGALFFPGLFALCTWALRRSQPGWSRTDCVMISTRLVSSVHAVLATGSGIVIIRSCDDVITGRHWLAREYVWFLIPYMIYDSYAMYLCEWCRTRDQNRAPSLTLRNFLSRNRLMITHHAVILFVLVPVAQLKQQHTLLYKVNGILTLATFLSCRILLFPFMYWSYGRQQGLSLLQVPFSIPFYCNVANAFLVAPQIYWFCLLCRKAVRLFDTPQAKKDG

Target ORF information:

RefSeq Version	NM_001318006.1
Organism	Homo sapiens(human)
Definition	Homo sapiens TLC domain containing 3A (TLCD3A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318006.1

ORF Insert Sequence:

ATGCTGCTGA CGCTGGCCGG GGGCGCGCTC TTCTTCCCGG GGCTCTTCGC GCTCTGCACC 
TGGGCGCTGC GCCGCTCCCA GCCCGGATGG AGCCGCACCG ACTGCGTGAT GATCAGCACC 
AGGCTGGTTT CCTCGGTGCA CGCCGTGCTG GCCACCGGCT CGGGGATCGT CATCATTCGC 
TCCTGCGACG ACGTGATCAC CGGCAGGCAC TGGCTTGCCC GGGAATATGT GTGGTTTCTG 
ATTCCATACA TGATCTATGA CTCGTACGCC ATGTACCTCT GTGAATGGTG CCGAACCAGA 
GACCAGAACC GTGCGCCCTC CCTCACTCTT CGAAACTTCC TAAGTCGAAA CCGCCTCATG 
ATCACACATC ATGCGGTCAT TCTCTTTGTC CTTGTGCCAG TCGCACAGCT AAAGCAGCAG 
CACACCCTTC TGTACAAGGT GAATGGAATC CTCACGCTGG CCACCTTCCT TTCCTGCCGG 
ATCCTTCTCT TCCCCTTCAT GTACTGGTCC TATGGCCGCC AGCAGGGACT AAGCCTGCTC 
CAAGTACCCT TCAGCATCCC ATTCTACTGC AACGTGGCCA ATGCCTTCCT CGTAGCTCCT 
CAGATCTACT GGTTCTGTCT GCTGTGCAGG AAGGCAGTCC GGCTCTTTGA CACTCCCCAA 
GCCAAAAAGG ATGGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FAM57A ( NM_001318007.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001304936.1 Homo sapiens TLC domain containing 3A (TLCD3A), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu100226
Clone ID Related Accession (Same CDS sequence)	NM_001318007.1
Accession Version	NM_001318007.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-10
Organism	Homo sapiens(human)
Product	TLC domain-containing protein 3A isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN259418.1, BX389422.1, AK025935.1, AA055841.1 and AC087392.10. Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.103983.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2147975 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTGA CGCTGGCCGG GGGCGCGCTC TTCTTCCCGG GGCTCTTCGC GCTCTGCACC 
TGGGCGCTGC GCCGCTCCCA GCCCGGATGG AGCCGCACCG ACTGCGTGAT GATCAGCACC 
AGGCTGGTTT CCTCGGTGCA CGCCGTGCTG GCCACCGGCT CGGGGATCGT CATCATTCGC 
TCCTGCGACG ACGTGATCAC CGGCAGAGGC TCCGGGGAGA CCTTGGGGAC TTCTTTGTCG 
GCTGCATCTT CACGGCAGAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304936.1
CDS	103..366
Translation	MLLTLAGGALFFPGLFALCTWALRRSQPGWSRTDCVMISTRLVSSVHAVLATGSGIVIIRSCDDVITGRGSGETLGTSLSAASSRQN

Target ORF information:

RefSeq Version	NM_001318007.1
Organism	Homo sapiens(human)
Definition	Homo sapiens TLC domain containing 3A (TLCD3A), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318007.1

ORF Insert Sequence:

ATGCTGCTGA CGCTGGCCGG GGGCGCGCTC TTCTTCCCGG GGCTCTTCGC GCTCTGCACC 
TGGGCGCTGC GCCGCTCCCA GCCCGGATGG AGCCGCACCG ACTGCGTGAT GATCAGCACC 
AGGCTGGTTT CCTCGGTGCA CGCCGTGCTG GCCACCGGCT CGGGGATCGT CATCATTCGC 
TCCTGCGACG ACGTGATCAC CGGCAGAGGC TCCGGGGAGA CCTTGGGGAC TTCTTTGTCG 
GCTGCATCTT CACGGCAGAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FAM57A ( NM_001318008.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001304937.1 Homo sapiens TLC domain containing 3A (TLCD3A), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu100329
Clone ID Related Accession (Same CDS sequence)	NM_001318008.1
Accession Version	NM_001318008.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 210bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-10
Organism	Homo sapiens(human)
Product	TLC domain-containing protein 3A isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN259418.1, AK025935.1, AA055841.1 and AC087392.10. Transcript Variant: This variant (4) lacks two alternate exons compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.141890.1, CN259418.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144120, SAMEA2145240 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTGA CGCTGGCCGG GGGCGCGCTC TTCTTCCCGG GGCTCTTCGC GCTCTGCACC 
TGGGCGCTGC GCCGCTCCCA GCCCGGATGG AGCCGCACCG ACTGCGTGAT GATCAGCACC 
AGGCTGGTTT CCTCGGTGCA CGCCGTGCTG GCCACCGGCT CGGGGATCGT CATCATTCGC 
TCCTGCGACG ACGTGATCAC CGGCAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304937.1
CDS	103..312
Translation	MLLTLAGGALFFPGLFALCTWALRRSQPGWSRTDCVMISTRLVSSVHAVLATGSGIVIIRSCDDVITGS

Target ORF information:

RefSeq Version	NM_001318008.1
Organism	Homo sapiens(human)
Definition	Homo sapiens TLC domain containing 3A (TLCD3A), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318008.1

ORF Insert Sequence:

ATGCTGCTGA CGCTGGCCGG GGGCGCGCTC TTCTTCCCGG GGCTCTTCGC GCTCTGCACC 
TGGGCGCTGC GCCGCTCCCA GCCCGGATGG AGCCGCACCG ACTGCGTGAT GATCAGCACC 
AGGCTGGTTT CCTCGGTGCA CGCCGTGCTG GCCACCGGCT CGGGGATCGT CATCATTCGC 
TCCTGCGACG ACGTGATCAC CGGCAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Silencing of CT120 by antisense oligonucleotides could inhibit the lung cancer cells growth.
Irish journal of medical science179(2)217-23(2010 Jun)
Li Z,Shao S,Xie S,Jiao F,Ma Y,Shi S

Down-regulation of CT120A by RNA interference suppresses lung cancer cells growth and sensitizes to ultraviolet-induced apoptosis.
Cancer letters235(1)26-33(2006 Apr)
Pan D,Wei L,Yao M,Wan D,Gu J

Inhibitory effect of CT120B, an alternative splice variant of CT120A, on lung cancer cell growth.
Acta biochimica et biophysica Sinica37(9)588-92(2005 Sep)
Pan DN,Li JJ,Wei L,Yao M,Wan DF,Gu JR

Altered gene expression profiles of NIH3T3 cells regulated by human lung cancer associated gene CT120.
Cell research14(6)487-96(2004 Dec)
He XH,Li JJ,Xie YH,Tang YT,Yao GF,Qin WX,Wan DF,Gu JR

Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism.
Biochemical and biophysical research communications297(3)528-36(2002 Sep)
He X,Di Y,Li J,Xie Y,Tang Y,Zhang F,Wei L,Zhang Y,Qin W,Huo K,Li Y,Wan D,Gu J

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FAM57A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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