MAFK cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MAFK
Entrez Gene ID	7975
Full Name	MAF bZIP transcription factor K
Synonyms	NFE2U,P18
General protein information	Preferred Names MAF bZIP transcription factor K Names transcription factor MafK basic-leucine zipper transcription factor MafK erythroid transcription factor NF-E2 p18 subunit nuclear factor erythroid-2, ubiquitous (p18) v-maf avian musculoaponeurotic fibrosarcoma oncogene family, protein K v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K v-maf musculoaponeurotic fibrosarcoma oncogene homolog K
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p22.3
Summary	The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008].
Disorder MIM:	600197

mRNA and Protein(s)

mRNA	Protein	Name
XM_006715773.1	XP_006715836.1	transcription factor MafK isoform X1
NM_002360.4	NP_002351.1	transcription factor MafK
XM_006715773.2	XP_006715836.1	transcription factor MafK isoform X1
NM_002360.3	NP_002351.1	transcription factor MafK
XM_005249851.2	XP_005249908.2	transcription factor MafK isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	MAFK	NP_002351.1
Gallus gallus (chicken)	MAFK	NP_990087.1
Drosophila melanogaster (fruit fly)	maf-S	NP_611500.1
Xenopus tropicalis (tropical clawed frog)	mafk	NP_001090663.1
Canis lupus familiaris (dog)	MAFK	XP_003639134.1
Rattus norvegicus (Norway rat)	Mafk	NP_663706.2
Bos taurus (cattle)	MAFK	NP_001193229.1
Danio rerio (zebrafish)	mafk	NP_001002044.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010405	XP_311544.3
	LOC721769	XP_001117972.1
Mus musculus (house mouse)	Mafk	NP_034887.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic polymorphisms of
Arisawa T, Nakamura M, Otsuka T, Jing W, Sakurai N, Takano H, Hayashi T, Ota M, Nomura T, Hayashi R, Shimasaki T, Tahara T, Shibata T
World journal of gastroenterology23(29)5364-5370(2017 Aug)

The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB.
Okita Y, Kimura M, Xie R, Chen C, Shen LT, Kojima Y, Suzuki H, Muratani M, Saitoh M, Semba K, Heldin CH, Kato M
Science signaling10(474)(2017 Apr)

Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation.
Wang R, Zheng J, Zhang DS, Yang YH, Zhao ZF
Genetics and molecular research : GMR14(3)7315-25(2015 Jul)

MafK positively regulates NF-?B activity by enhancing CBP-mediated p65 acetylation.
Hwang YJ, Lee EW, Song J, Kim HR, Jun YC, Hwang KA
Scientific reports33242(2013 Nov)

Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis.
Tanigawa S, Lee CH, Lin CS, Ku CC, Hasegawa H, Qin S, Kawahara A, Korenori Y, Miyamori K, Noguchi M, Lee LH, Lin YC, Steve Lin CL, Nakamura Y, Jin C, Yamaguchi N, Eckner R, Hou DX, Yokoyama KK
Cell death & disease4e921(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings suggest that MAFK and its target gene GPNMB play important roles in the malignant progression of triple-negative breast cancer (TNBC) cells, offering potentially new therapeutic targets for TNBC patients.
Title: The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB.

Results suggested that Wnt1-induced MAFK expression promoted cell proliferation in MG63 cells, and that the role of MAFK in osteosarcoma might be closely linked to the Wnt signaling pathway.
Title: Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation.

MafK mediated p65 acetylation by CBP upon LPS stimulation, thereby facilitating recruitment of p65 to NF-kappaB promoters such as IL-8 and TNFalpha.
Title: MafK positively regulates NF-?B activity by enhancing CBP-mediated p65 acetylation.

Results suggest that JDP2 is an integral component of the Nrf2-MafK complex and that it modulates antioxidant and detoxification programs by acting via the ARE.
Title: Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis.

Data indicate that transcription factors MafK and Bach1 regulate expression of heme oxygenase-1 (HO-1).
Title: Transforming growth factor-? induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene.

The following MAFK gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAFK cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03039	NM_002360.4 Latest version!	Homo sapiens MAF bZIP transcription factor K (MAFK), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu03039	XM_006715773.2 Latest version!	Homo sapiens MAF bZIP transcription factor K (MAFK), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu03039	XM_005249851.2 Latest version!	Homo sapiens MAF bZIP transcription factor K (MAFK), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu03039	XM_006715773.1	Homo sapiens v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K (MAFK), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu03039	NM_002360.3	Homo sapiens MAF bZIP transcription factor K (MAFK), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MAFK ( NM_002360.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002351.1 Homo sapiens MAF bZIP transcription factor K (MAFK), mRNA.

Price & Availability↑

CloneID	OHu03039
Clone ID Related Accession (Same CDS sequence)	XM_006715773.1 , NM_002360.4 , XM_006715773.2 , NM_002360.3 , XM_005249851.2
Accession Version	NM_002360.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 471bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	transcription factor MafK
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC093734.3 and AF059194.1. On Nov 24, 2018 this sequence version replaced NM_002360.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.455354.1, ERR279825.9361.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000343242.9/ ENSP00000344903.4 RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACGACTA ATCCCAAACC GAATAAGGCA TTAAAGGTCA AGAAGGAGGC GGGCGAGAAC 
GCCCCGGTGC TCAGCGATGA TGAGCTGGTG TCCATGTCGG TGCGGGAGCT GAACCAGCAC 
CTGCGGGGTC TCACCAAGGA GGAGGTGACC CGCCTGAAGC AGCGTCGGCG CACACTCAAG 
AACCGCGGCT ACGCGGCCAG CTGCCGCATC AAGCGGGTGA CGCAGAAGGA GGAGCTGGAG 
CGGCAGCGCG TGGAGCTGCA GCAGGAGGTG GAGAAGCTGG CGCGTGAGAA CAGCAGCATG 
CGGCTGGAGC TGGACGCCCT GCGCTCCAAG TACGAGGCGC TGCAGACCTT CGCGCGCACC 
GTGGCCCGGG GACCTGTGGC GCCCTCCAAG GTGGCCACCA CCAGCGTCAT CACCATCGTC 
AAGTCCACCG AGCTCTCCTC CACCTCCGTG CCCTTCTCGG CTGCATCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002351.1
CDS	242..712
Translation	MTTNPKPNKALKVKKEAGENAPVLSDDELVSMSVRELNQHLRGLTKEEVTRLKQRRRTLKNRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRLELDALRSKYEALQTFARTVARGPVAPSKVATTSVITIVKSTELSSTSVPFSAAS

Target ORF information:

RefSeq Version	NM_002360.4
Organism	Homo sapiens(human)
Definition	Homo sapiens MAF bZIP transcription factor K (MAFK), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002360.4

ORF Insert Sequence:

ATGACGACTA ATCCCAAACC GAATAAGGCA TTAAAGGTCA AGAAGGAGGC GGGCGAGAAC 
GCCCCGGTGC TCAGCGATGA TGAGCTGGTG TCCATGTCGG TGCGGGAGCT GAACCAGCAC 
CTGCGGGGTC TCACCAAGGA GGAGGTGACC CGCCTGAAGC AGCGTCGGCG CACACTCAAG 
AACCGCGGCT ACGCGGCCAG CTGCCGCATC AAGCGGGTGA CGCAGAAGGA GGAGCTGGAG 
CGGCAGCGCG TGGAGCTGCA GCAGGAGGTG GAGAAGCTGG CGCGTGAGAA CAGCAGCATG 
CGGCTGGAGC TGGACGCCCT GCGCTCCAAG TACGAGGCGC TGCAGACCTT CGCGCGCACC 
GTGGCCCGGG GACCTGTGGC GCCCTCCAAG GTGGCCACCA CCAGCGTCAT CACCATCGTC 
AAGTCCACCG AGCTCTCCTC CACCTCCGTG CCCTTCTCGG CTGCATCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAFK ( NM_002360.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002351.1 Homo sapiens MAF bZIP transcription factor K (MAFK), mRNA.

Price & Availability↑

CloneID	OHu03039
Clone ID Related Accession (Same CDS sequence)	XM_006715773.1 , NM_002360.4 , XM_006715773.2 , NM_002360.3 , XM_005249851.2
Accession Version	NM_002360.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 471bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	transcription factor MafK
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF059194.1 and AC093734.3. On Nov 23, 2005 this sequence version replaced NM_002360.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279825.9361.1, SRR1163658.455354.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGACTA ATCCCAAACC GAATAAGGCA TTAAAGGTCA AGAAGGAGGC GGGCGAGAAC 
GCCCCGGTGC TCAGCGATGA TGAGCTGGTG TCCATGTCGG TGCGGGAGCT GAACCAGCAC 
CTGCGGGGTC TCACCAAGGA GGAGGTGACC CGCCTGAAGC AGCGTCGGCG CACACTCAAG 
AACCGCGGCT ACGCGGCCAG CTGCCGCATC AAGCGGGTGA CGCAGAAGGA GGAGCTGGAG 
CGGCAGCGCG TGGAGCTGCA GCAGGAGGTG GAGAAGCTGG CGCGTGAGAA CAGCAGCATG 
CGGCTGGAGC TGGACGCCCT GCGCTCCAAG TACGAGGCGC TGCAGACCTT CGCGCGCACC 
GTGGCCCGGG GACCTGTGGC GCCCTCCAAG GTGGCCACCA CCAGCGTCAT CACCATCGTC 
AAGTCCACCG AGCTCTCCTC CACCTCCGTG CCCTTCTCGG CTGCATCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002351.1
CDS	212..682
Translation	MTTNPKPNKALKVKKEAGENAPVLSDDELVSMSVRELNQHLRGLTKEEVTRLKQRRRTLKNRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRLELDALRSKYEALQTFARTVARGPVAPSKVATTSVITIVKSTELSSTSVPFSAAS

Target ORF information:

RefSeq Version	NM_002360.3
Organism	Homo sapiens(human)
Definition	Homo sapiens MAF bZIP transcription factor K (MAFK), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002360.3

ORF Insert Sequence:

ATGACGACTA ATCCCAAACC GAATAAGGCA TTAAAGGTCA AGAAGGAGGC GGGCGAGAAC 
GCCCCGGTGC TCAGCGATGA TGAGCTGGTG TCCATGTCGG TGCGGGAGCT GAACCAGCAC 
CTGCGGGGTC TCACCAAGGA GGAGGTGACC CGCCTGAAGC AGCGTCGGCG CACACTCAAG 
AACCGCGGCT ACGCGGCCAG CTGCCGCATC AAGCGGGTGA CGCAGAAGGA GGAGCTGGAG 
CGGCAGCGCG TGGAGCTGCA GCAGGAGGTG GAGAAGCTGG CGCGTGAGAA CAGCAGCATG 
CGGCTGGAGC TGGACGCCCT GCGCTCCAAG TACGAGGCGC TGCAGACCTT CGCGCGCACC 
GTGGCCCGGG GACCTGTGGC GCCCTCCAAG GTGGCCACCA CCAGCGTCAT CACCATCGTC 
AAGTCCACCG AGCTCTCCTC CACCTCCGTG CCCTTCTCGG CTGCATCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAFK ( XM_006715773.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_006715836.1 Homo sapiens v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K (MAFK), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu03039
Clone ID Related Accession (Same CDS sequence)	XM_006715773.1 , NM_002360.4 , XM_006715773.2 , NM_002360.3 , XM_005249851.2
Accession Version	XM_006715773.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 471bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	transcription factor MafK isoform X1
Comment

ATGACGACTA ATCCCAAACC GAATAAGGCA TTAAAGGTCA AGAAGGAGGC GGGCGAGAAC 
GCCCCGGTGC TCAGCGATGA TGAGCTGGTG TCCATGTCGG TGCGGGAGCT GAACCAGCAC 
CTGCGGGGTC TCACCAAGGA GGAGGTGACC CGCCTGAAGC AGCGTCGGCG CACACTCAAG 
AACCGCGGCT ACGCGGCCAG CTGCCGCATC AAGCGGGTGA CGCAGAAGGA GGAGCTGGAG 
CGGCAGCGCG TGGAGCTGCA GCAGGAGGTG GAGAAGCTGG CGCGTGAGAA CAGCAGCATG 
CGGCTGGAGC TGGACGCCCT GCGCTCCAAG TACGAGGCGC TGCAGACCTT CGCGCGCACC 
GTGGCCCGGG GACCTGTGGC GCCCTCCAAG GTGGCCACCA CCAGCGTCAT CACCATCGTC 
AAGTCCACCG AGCTCTCCTC CACCTCCGTG CCCTTCTCGG CTGCATCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006715836.1
Translation	MTTNPKPNKALKVKKEAGENAPVLSDDELVSMSVRELNQHLRGLTKEEVTRLKQRRRTLKNRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRLELDALRSKYEALQTFARTVARGPVAPSKVATTSVITIVKSTELSSTSVPFSAAS

Target ORF information:

RefSeq Version	XM_006715773.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K (MAFK), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006715773.1

ORF Insert Sequence:

ATGACGACTA ATCCCAAACC GAATAAGGCA TTAAAGGTCA AGAAGGAGGC GGGCGAGAAC 
GCCCCGGTGC TCAGCGATGA TGAGCTGGTG TCCATGTCGG TGCGGGAGCT GAACCAGCAC 
CTGCGGGGTC TCACCAAGGA GGAGGTGACC CGCCTGAAGC AGCGTCGGCG CACACTCAAG 
AACCGCGGCT ACGCGGCCAG CTGCCGCATC AAGCGGGTGA CGCAGAAGGA GGAGCTGGAG 
CGGCAGCGCG TGGAGCTGCA GCAGGAGGTG GAGAAGCTGG CGCGTGAGAA CAGCAGCATG 
CGGCTGGAGC TGGACGCCCT GCGCTCCAAG TACGAGGCGC TGCAGACCTT CGCGCGCACC 
GTGGCCCGGG GACCTGTGGC GCCCTCCAAG GTGGCCACCA CCAGCGTCAT CACCATCGTC 
AAGTCCACCG AGCTCTCCTC CACCTCCGTG CCCTTCTCGG CTGCATCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAFK ( XM_006715773.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006715836.1 Homo sapiens MAF bZIP transcription factor K (MAFK), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu03039
Clone ID Related Accession (Same CDS sequence)	XM_006715773.1 , NM_002360.4 , XM_006715773.2 , NM_002360.3 , XM_005249851.2
Accession Version	XM_006715773.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 471bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	transcription factor MafK isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006715773.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACGACTA ATCCCAAACC GAATAAGGCA TTAAAGGTCA AGAAGGAGGC GGGCGAGAAC 
GCCCCGGTGC TCAGCGATGA TGAGCTGGTG TCCATGTCGG TGCGGGAGCT GAACCAGCAC 
CTGCGGGGTC TCACCAAGGA GGAGGTGACC CGCCTGAAGC AGCGTCGGCG CACACTCAAG 
AACCGCGGCT ACGCGGCCAG CTGCCGCATC AAGCGGGTGA CGCAGAAGGA GGAGCTGGAG 
CGGCAGCGCG TGGAGCTGCA GCAGGAGGTG GAGAAGCTGG CGCGTGAGAA CAGCAGCATG 
CGGCTGGAGC TGGACGCCCT GCGCTCCAAG TACGAGGCGC TGCAGACCTT CGCGCGCACC 
GTGGCCCGGG GACCTGTGGC GCCCTCCAAG GTGGCCACCA CCAGCGTCAT CACCATCGTC 
AAGTCCACCG AGCTCTCCTC CACCTCCGTG CCCTTCTCGG CTGCATCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006715836.1
CDS	265..735
Translation	MTTNPKPNKALKVKKEAGENAPVLSDDELVSMSVRELNQHLRGLTKEEVTRLKQRRRTLKNRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRLELDALRSKYEALQTFARTVARGPVAPSKVATTSVITIVKSTELSSTSVPFSAAS

Target ORF information:

RefSeq Version	XM_006715773.2
Organism	Homo sapiens(human)
Definition	Homo sapiens MAF bZIP transcription factor K (MAFK), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006715773.2

ORF Insert Sequence:

ATGACGACTA ATCCCAAACC GAATAAGGCA TTAAAGGTCA AGAAGGAGGC GGGCGAGAAC 
GCCCCGGTGC TCAGCGATGA TGAGCTGGTG TCCATGTCGG TGCGGGAGCT GAACCAGCAC 
CTGCGGGGTC TCACCAAGGA GGAGGTGACC CGCCTGAAGC AGCGTCGGCG CACACTCAAG 
AACCGCGGCT ACGCGGCCAG CTGCCGCATC AAGCGGGTGA CGCAGAAGGA GGAGCTGGAG 
CGGCAGCGCG TGGAGCTGCA GCAGGAGGTG GAGAAGCTGG CGCGTGAGAA CAGCAGCATG 
CGGCTGGAGC TGGACGCCCT GCGCTCCAAG TACGAGGCGC TGCAGACCTT CGCGCGCACC 
GTGGCCCGGG GACCTGTGGC GCCCTCCAAG GTGGCCACCA CCAGCGTCAT CACCATCGTC 
AAGTCCACCG AGCTCTCCTC CACCTCCGTG CCCTTCTCGG CTGCATCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAFK ( XM_005249851.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005249908.2 Homo sapiens MAF bZIP transcription factor K (MAFK), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu03039
Clone ID Related Accession (Same CDS sequence)	XM_006715773.1 , NM_002360.4 , XM_006715773.2 , NM_002360.3 , XM_005249851.2
Accession Version	XM_005249851.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 471bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	transcription factor MafK isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005249851.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACGACTA ATCCCAAACC GAATAAGGCA TTAAAGGTCA AGAAGGAGGC GGGCGAGAAC 
GCCCCGGTGC TCAGCGATGA TGAGCTGGTG TCCATGTCGG TGCGGGAGCT GAACCAGCAC 
CTGCGGGGTC TCACCAAGGA GGAGGTGACC CGCCTGAAGC AGCGTCGGCG CACACTCAAG 
AACCGCGGCT ACGCGGCCAG CTGCCGCATC AAGCGGGTGA CGCAGAAGGA GGAGCTGGAG 
CGGCAGCGCG TGGAGCTGCA GCAGGAGGTG GAGAAGCTGG CGCGTGAGAA CAGCAGCATG 
CGGCTGGAGC TGGACGCCCT GCGCTCCAAG TACGAGGCGC TGCAGACCTT CGCGCGCACC 
GTGGCCCGGG GACCTGTGGC GCCCTCCAAG GTGGCCACCA CCAGCGTCAT CACCATCGTC 
AAGTCCACCG AGCTCTCCTC CACCTCCGTG CCCTTCTCGG CTGCATCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005249908.2
CDS	256..726
Translation	MTTNPKPNKALKVKKEAGENAPVLSDDELVSMSVRELNQHLRGLTKEEVTRLKQRRRTLKNRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRLELDALRSKYEALQTFARTVARGPVAPSKVATTSVITIVKSTELSSTSVPFSAAS

Target ORF information:

RefSeq Version	XM_005249851.2
Organism	Homo sapiens(human)
Definition	Homo sapiens MAF bZIP transcription factor K (MAFK), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005249851.2

ORF Insert Sequence:

ATGACGACTA ATCCCAAACC GAATAAGGCA TTAAAGGTCA AGAAGGAGGC GGGCGAGAAC 
GCCCCGGTGC TCAGCGATGA TGAGCTGGTG TCCATGTCGG TGCGGGAGCT GAACCAGCAC 
CTGCGGGGTC TCACCAAGGA GGAGGTGACC CGCCTGAAGC AGCGTCGGCG CACACTCAAG 
AACCGCGGCT ACGCGGCCAG CTGCCGCATC AAGCGGGTGA CGCAGAAGGA GGAGCTGGAG 
CGGCAGCGCG TGGAGCTGCA GCAGGAGGTG GAGAAGCTGG CGCGTGAGAA CAGCAGCATG 
CGGCTGGAGC TGGACGCCCT GCGCTCCAAG TACGAGGCGC TGCAGACCTT CGCGCGCACC 
GTGGCCCGGG GACCTGTGGC GCCCTCCAAG GTGGCCACCA CCAGCGTCAT CACCATCGTC 
AAGTCCACCG AGCTCTCCTC CACCTCCGTG CCCTTCTCGG CTGCATCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic polymorphisms of
World journal of gastroenterology23(29)5364-5370(2017 Aug)
Arisawa T,Nakamura M,Otsuka T,Jing W,Sakurai N,Takano H,Hayashi T,Ota M,Nomura T,Hayashi R,Shimasaki T,Tahara T,Shibata T

The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB.
Science signaling10(474)(2017 Apr)
Okita Y,Kimura M,Xie R,Chen C,Shen LT,Kojima Y,Suzuki H,Muratani M,Saitoh M,Semba K,Heldin CH,Kato M

Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation.
Genetics and molecular research : GMR14(3)7315-25(2015 Jul)
Wang R,Zheng J,Zhang DS,Yang YH,Zhao ZF

MafK positively regulates NF-?B activity by enhancing CBP-mediated p65 acetylation.
Scientific reports33242(2013 Nov)
Hwang YJ,Lee EW,Song J,Kim HR,Jun YC,Hwang KA

Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis.
Cell death & disease4e921(2013 Nov)
Tanigawa S,Lee CH,Lin CS,Ku CC,Hasegawa H,Qin S,Kawahara A,Korenori Y,Miyamori K,Noguchi M,Lee LH,Lin YC,Steve Lin CL,Nakamura Y,Jin C,Yamaguchi N,Eckner R,Hou DX,Yokoyama KK

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MAFK cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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