BBS10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BBS10
Entrez Gene ID	79738
Full Name	Bardet-Biedl syndrome 10
Synonyms	C12orf58
General protein information	Preferred Names Bardet-Biedl syndrome 10 Names Bardet-Biedl syndrome 10 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q21.2
Summary	This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and cognitive disability. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes. Mutations in this gene cause Bardet-Biedl syndrome type 10. [provided by RefSeq, Jan 2010].
Disorder MIM:	610148
Disorder Html:	Bardet-Biedl syndrome 10, 615987 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_024685.3	NP_078961.3	Bardet-Biedl syndrome 10 protein
NM_024685.4	NP_078961.3	Bardet-Biedl syndrome 10 protein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	BBS10	XP_003432026.2
Bos taurus (cattle)	BBS10	XP_002707864.1
Gallus gallus (chicken)	BBS10	XP_416107.4
Homo sapiens (human)	BBS10	NP_078961.3
	BBS10	XP_001081978.1
Mus musculus (house mouse)	Bbs10	NP_082190.1
Rattus norvegicus (Norway rat)	Bbs10	NP_001102756.1
Xenopus tropicalis (tropical clawed frog)	bbs10	XP_004913011.1
Pan troglodytes (chimpanzee)	BBS10	XP_001161619.1
Danio rerio (zebrafish)	bbs10	NP_001082932.1

Gene Ontology
Bibliography

Related articles in PubMed

Sequence variants in four genes underlying Bardet-Biedl syndrome in consanguineous families.
Ullah A, Umair M, Yousaf M, Khan SA, Nazim-Ud-Din M, Shah K, Ahmad F, Azeem Z, Ali G, Alhaddad B, Rafique A, Jan A, Haack TB, Strom TM, Meitinger T, Ghous T, Ahmad W
Molecular vision23482-494(2017)

A novel test for recessive contributions to complex diseases implicates Bardet-Biedl syndrome gene BBS10 in idiopathic type 2 diabetes and obesity.
Lim ET, Liu YP, Chan Y, Tiinamaija T, K?r?j?m?ki A, Madsen E, , Altshuler DM, Raychaudhuri S, Groop L, Flannick J, Hirschhorn JN, Katsanis N, Daly MJ
American journal of human genetics95(5)509-20(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we report here, for the first time, in Indian population, a novel, different profile of mutations in BBS genes (BBS3, BBS9, BBS10 and BBS2) compared to worldwide (BBS1 and 10) reports.
Title: Mutation spectrum in BBS genes guided by homozygosity mapping in an Indian cohort.

novel BBS10 mutations in Bardet-Biedl syndrome patients in Spain
Title: Overview of Bardet-Biedl syndrome in Spain: identification of novel mutations in BBS1, BBS10 and BBS12 genes.

A rare variant (c.1189A>G [p.Ile397Val]; rs202042386) confers risk of type 2 diabetes in a recessive state.
Title: A novel test for recessive contributions to complex diseases implicates Bardet-Biedl syndrome gene BBS10 in idiopathic type 2 diabetes and obesity.

Novel mutation (c.1181_1182insGCATTTATACC) in BBS10 (p.S396Lfs*6) found in Tunisian families with Bardet-Biedl syndrome.
Title: Clinical and genetic characterization of Bardet-Biedl syndrome in Tunisia: defining a strategy for molecular diagnosis.

We report two affected brothers from a consanguineous Pakistani Punjabi family, both the brothers were homozygous for c.1958_1967del, which is a novel deletion in BBS10 that is likely to be causing the Bardet-Biedl syndrome in this family.
Title: A novel homozygous 10 nucleotide deletion in BBS10 causes Bardet-Biedl syndrome in a Pakistani family.

The following BBS10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BBS10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25733	NM_024685.4 Latest version!	Homo sapiens Bardet-Biedl syndrome 10 (BBS10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
View Old Accession Versions >>
OHu25733	NM_024685.3	Homo sapiens Bardet-Biedl syndrome 10 (BBS10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BBS10 ( NM_024685.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_078961.3 Homo sapiens Bardet-Biedl syndrome 10 (BBS10), mRNA.

Price & Availability↑

CloneID	OHu25733
Clone ID Related Accession (Same CDS sequence)	NM_024685.3 , NM_024685.4
Accession Version	NM_024685.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2172bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	Bardet-Biedl syndrome 10 protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA095453.1, BC026355.1, DR155669.1, BC013795.1 and AI673014.1. This sequence is a reference standard in the RefSeqGene project. On May 24, 2006 this sequence version replaced NM_024685.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA223063.1, SRR1660805.180875.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTAAGTT CTATGGCCGC TGCAGGGTCT GTGAAGGCGG CGTTGCAGGT GGCCGAGGTG 
CTGGAAGCCA TCGTGAGCTG CTGCGTGGGG CCCGAGGGAC GGCAAGTTTT GTGTACGAAG 
CCCACTGGCG AGGTGCTTCT CAGCCGGAAT GGAGGCCGCC TCCTGGAGGC GCTACACTTA 
GAGCATCCCA TAGCCAGGAT GATAGTGGAC TGTGTTTCCA GTCATCTCAA AAAAACAGGA 
GATGGTGCAA AAACATTTAT TATCTTTCTT TGCCATTTGC TTAGAGGACT TCATGCAATC 
ACAGACAGAG AAAAGGATCC TTTGATGTGT GAAAACATTC AAACCCATGG AAGGCATTGG 
AAAAATTGTT CTCGGTGGAA ATTTATTTCC CAGGCTCTCC TAACGTTTCA GACACAAATA 
TTAGACGGTA TTATGGACCA GTACCTAAGT AGACACTTTT TGTCTATCTT TTCGTCTGCT 
AAAGAGAGAA CATTGTGTAG GAGCTCTTTA GAGTTGCTCT TAGAAGCATA CTTTTGTGGA 
AGAGTGGGAA GAAATAATCA TAAATTTATT TCACAGTTGA TGTGTGACTA CTTTTTCAAG 
TGTATGACTT GTAAAAGTGG GATTGGTGTA TTTGAGTTAG TGGATGACCA TTTTGTAGAG 
TTGAATGTTG GTGTCACTGG CCTTCCTGTT TCAGATTCCA GGATCATAGC TGGTCTTGTG 
CTTCAGAAAG ATTTTTCTGT GTACCGCCCA GCAGATGGTG ACATGCGAAT GGTGATAGTA 
ACAGAAACCA TTCAGCCTCT TTTTTCCACT TCTGGATCAG AGTTTATTCT AAATTCAGAA 
GCACAGTTTC AGACATCTCA ATTTTGGATT ATGGAAAAGA CAAAAGCAAT AATGAAACAT 
CTACATAGTC AGAATGTAAA ATTGCTCATA TCTAGTGTGA AACAACCAGA TTTAGTTAGT 
TATTATGCAG GGGTGAATGG CATATCAGTG GTTGAGTGTT TATCATCAGA AGAAGTTTCT 
CTTATCCGGA GGATCATTGG TCTTTCTCCA TTTGTACCAC CACAGGCCTT TTCGCAGTGT 
GAAATACCTA ACACTGCTTT GGTGAAATTT TGTAAACCTC TTATCCTTAG ATCCAAAAGA 
TATGTTCATC TAGGCTTGAT AAGCACATGT GCATTTATAC CACACTCTAT AGTTCTTTGT 
GGACCAGTGC ATGGTCTCAT TGAACAACAT GAGGATGCTT TACATGGAGC ACTTAAAATG 
CTTCGGCAAT TATTTAAAGA CCTTGATCTA AATTACATGA CACAAACCAA TGACCAAAAT 
GGCACTTCAA GTCTTTTTAT TTATAAGAAC AGTGGAGAAA GTTATCAAGC ACCAGATCCT 
GGTAATGGCT CAATACAAAG GCCTTATCAG GACACAGTTG CAGAGAACAA AGATGCATTG 
GAAAAAACTC AAACATATTT AAAAGTACAT TCTAATTTGG TAATTCCAGA TGTAGAATTA 
GAAACATATA TTCCGTATTC AACCCCCACA CTGACACCAA CAGATACATT CCAAACAGTT 
GAAACGCTGA CATGTTTGTC TTTGGAAAGA AACAGGCTAA CTGATTATTA TGAACCATTA 
CTCAAGAACA ATTCCACTGC TTATTCAACA AGGGGAAATA GAATAGAAAT TTCTTACGAA 
AATTTACAGG TCACAAATAT TACTAGAAAG GGAAGCATGT TACCAGTGAG CTGTAAGTTA 
CCGAATATGG GTACTTCCCA GAGTTACCTT TCCTCATCTA TGCCAGCTGG TTGTGTTTTG 
CCAGTAGGTG GTAATTTTGA GATCTTGTTA CATTACTATC TTCTCAATTA TGCCAAAAAA 
TGCCATCAAT CAGAAGAAAC CATGGTTAGT ATGATAATAG CTAATGCACT TTTAGGCATT 
CCCAAAGTCC TTTATAAATC TAAAACAGGA AAGTACAGCT TTCCACATAC ATATATAAGA 
GCTGTCCATG CACTGCAAAC CAATCAACCC TTGGTAAGCA GTCAGACAGG TTTGGAATCA 
GTAATGGGTA AATACCAGCT ACTAACTTCA GTTCTTCAGT GTTTGACAAA AATATTAACC 
ATTGACATGG TAATCACTGT TAAGAGACAC CCTCAGAAAG TTCACAATCA AGATTCAGAA 
GATGAACTAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_078961.3
CDS	85..2256
Translation	MLSSMAAAGSVKAALQVAEVLEAIVSCCVGPEGRQVLCTKPTGEVLLSRNGGRLLEALHLEHPIARMIVDCVSSHLKKTGDGAKTFIIFLCHLLRGLHAITDREKDPLMCENIQTHGRHWKNCSRWKFISQALLTFQTQILDGIMDQYLSRHFLSIFSSAKERTLCRSSLELLLEAYFCGRVGRNNHKFISQLMCDYFFKCMTCKSGIGVFELVDDHFVELNVGVTGLPVSDSRIIAGLVLQKDFSVYRPADGDMRMVIVTETIQPLFSTSGSEFILNSEAQFQTSQFWIMEKTKAIMKHLHSQNVKLLISSVKQPDLVSYYAGVNGISVVECLSSEEVSLIRRIIGLSPFVPPQAFSQCEIPNTALVKFCKPLILRSKRYVHLGLISTCAFIPHSIVLCGPVHGLIEQHEDALHGALKMLRQLFKDLDLNYMTQTNDQNGTSSLFIYKNSGESYQAPDPGNGSIQRPYQDTVAENKDALEKTQTYLKVHSNLVIPDVELETYIPYSTPTLTPTDTFQTVETLTCLSLERNRLTDYYEPLLKNNSTAYSTRGNRIEISYENLQVTNITRKGSMLPVSCKLPNMGTSQSYLSSSMPAGCVLPVGGNFEILLHYYLLNYAKKCHQSEETMVSMIIANALLGIPKVLYKSKTGKYSFPHTYIRAVHALQTNQPLVSSQTGLESVMGKYQLLTSVLQCLTKILTIDMVITVKRHPQKVHNQDSEDEL

Target ORF information:

RefSeq Version	NM_024685.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Bardet-Biedl syndrome 10 (BBS10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024685.3

ORF Insert Sequence:

ATGTTAAGTT CTATGGCCGC TGCAGGGTCT GTGAAGGCGG CGTTGCAGGT GGCCGAGGTG 
CTGGAAGCCA TCGTGAGCTG CTGCGTGGGG CCCGAGGGAC GGCAAGTTTT GTGTACGAAG 
CCCACTGGCG AGGTGCTTCT CAGCCGGAAT GGAGGCCGCC TCCTGGAGGC GCTACACTTA 
GAGCATCCCA TAGCCAGGAT GATAGTGGAC TGTGTTTCCA GTCATCTCAA AAAAACAGGA 
GATGGTGCAA AAACATTTAT TATCTTTCTT TGCCATTTGC TTAGAGGACT TCATGCAATC 
ACAGACAGAG AAAAGGATCC TTTGATGTGT GAAAACATTC AAACCCATGG AAGGCATTGG 
AAAAATTGTT CTCGGTGGAA ATTTATTTCC CAGGCTCTCC TAACGTTTCA GACACAAATA 
TTAGACGGTA TTATGGACCA GTACCTAAGT AGACACTTTT TGTCTATCTT TTCGTCTGCT 
AAAGAGAGAA CATTGTGTAG GAGCTCTTTA GAGTTGCTCT TAGAAGCATA CTTTTGTGGA 
AGAGTGGGAA GAAATAATCA TAAATTTATT TCACAGTTGA TGTGTGACTA CTTTTTCAAG 
TGTATGACTT GTAAAAGTGG GATTGGTGTA TTTGAGTTAG TGGATGACCA TTTTGTAGAG 
TTGAATGTTG GTGTCACTGG CCTTCCTGTT TCAGATTCCA GGATCATAGC TGGTCTTGTG 
CTTCAGAAAG ATTTTTCTGT GTACCGCCCA GCAGATGGTG ACATGCGAAT GGTGATAGTA 
ACAGAAACCA TTCAGCCTCT TTTTTCCACT TCTGGATCAG AGTTTATTCT AAATTCAGAA 
GCACAGTTTC AGACATCTCA ATTTTGGATT ATGGAAAAGA CAAAAGCAAT AATGAAACAT 
CTACATAGTC AGAATGTAAA ATTGCTCATA TCTAGTGTGA AACAACCAGA TTTAGTTAGT 
TATTATGCAG GGGTGAATGG CATATCAGTG GTTGAGTGTT TATCATCAGA AGAAGTTTCT 
CTTATCCGGA GGATCATTGG TCTTTCTCCA TTTGTACCAC CACAGGCCTT TTCGCAGTGT 
GAAATACCTA ACACTGCTTT GGTGAAATTT TGTAAACCTC TTATCCTTAG ATCCAAAAGA 
TATGTTCATC TAGGCTTGAT AAGCACATGT GCATTTATAC CACACTCTAT AGTTCTTTGT 
GGACCAGTGC ATGGTCTCAT TGAACAACAT GAGGATGCTT TACATGGAGC ACTTAAAATG 
CTTCGGCAAT TATTTAAAGA CCTTGATCTA AATTACATGA CACAAACCAA TGACCAAAAT 
GGCACTTCAA GTCTTTTTAT TTATAAGAAC AGTGGAGAAA GTTATCAAGC ACCAGATCCT 
GGTAATGGCT CAATACAAAG GCCTTATCAG GACACAGTTG CAGAGAACAA AGATGCATTG 
GAAAAAACTC AAACATATTT AAAAGTACAT TCTAATTTGG TAATTCCAGA TGTAGAATTA 
GAAACATATA TTCCGTATTC AACCCCCACA CTGACACCAA CAGATACATT CCAAACAGTT 
GAAACGCTGA CATGTTTGTC TTTGGAAAGA AACAGGCTAA CTGATTATTA TGAACCATTA 
CTCAAGAACA ATTCCACTGC TTATTCAACA AGGGGAAATA GAATAGAAAT TTCTTACGAA 
AATTTACAGG TCACAAATAT TACTAGAAAG GGAAGCATGT TACCAGTGAG CTGTAAGTTA 
CCGAATATGG GTACTTCCCA GAGTTACCTT TCCTCATCTA TGCCAGCTGG TTGTGTTTTG 
CCAGTAGGTG GTAATTTTGA GATCTTGTTA CATTACTATC TTCTCAATTA TGCCAAAAAA 
TGCCATCAAT CAGAAGAAAC CATGGTTAGT ATGATAATAG CTAATGCACT TTTAGGCATT 
CCCAAAGTCC TTTATAAATC TAAAACAGGA AAGTACAGCT TTCCACATAC ATATATAAGA 
GCTGTCCATG CACTGCAAAC CAATCAACCC TTGGTAAGCA GTCAGACAGG TTTGGAATCA 
GTAATGGGTA AATACCAGCT ACTAACTTCA GTTCTTCAGT GTTTGACAAA AATATTAACC 
ATTGACATGG TAATCACTGT TAAGAGACAC CCTCAGAAAG TTCACAATCA AGATTCAGAA 
GATGAACTAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BBS10 ( NM_024685.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_078961.3 Homo sapiens Bardet-Biedl syndrome 10 (BBS10), mRNA.

Price & Availability↑

CloneID	OHu25733
Clone ID Related Accession (Same CDS sequence)	NM_024685.3 , NM_024685.4
Accession Version	NM_024685.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2172bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-14
Organism	Homo sapiens(human)
Product	Bardet-Biedl syndrome 10 protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC026355.1, DR155669.1, BC013795.1, AI673014.1 and CA414269.1. This sequence is a reference standard in the RefSeqGene project. On Jul 26, 2018 this sequence version replaced NM_024685.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.9515.1, SRR1660805.180875.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000650064.2/ ENSP00000497413.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTAAGTT CTATGGCCGC TGCAGGGTCT GTGAAGGCGG CGTTGCAGGT GGCCGAGGTG 
CTGGAAGCCA TCGTGAGCTG CTGCGTGGGG CCCGAGGGAC GGCAAGTTTT GTGTACGAAG 
CCCACTGGCG AGGTGCTTCT CAGCCGGAAT GGAGGCCGCC TCCTGGAGGC GCTACACTTA 
GAGCATCCCA TAGCCAGGAT GATAGTGGAC TGTGTTTCCA GTCATCTCAA AAAAACAGGA 
GATGGTGCAA AAACATTTAT TATCTTTCTT TGCCATTTGC TTAGAGGACT TCATGCAATC 
ACAGACAGAG AAAAGGATCC TTTGATGTGT GAAAACATTC AAACCCATGG AAGGCATTGG 
AAAAATTGTT CTCGGTGGAA ATTTATTTCC CAGGCTCTCC TAACGTTTCA GACACAAATA 
TTAGACGGTA TTATGGACCA GTACCTAAGT AGACACTTTT TGTCTATCTT TTCGTCTGCT 
AAAGAGAGAA CATTGTGTAG GAGCTCTTTA GAGTTGCTCT TAGAAGCATA CTTTTGTGGA 
AGAGTGGGAA GAAATAATCA TAAATTTATT TCACAGTTGA TGTGTGACTA CTTTTTCAAG 
TGTATGACTT GTAAAAGTGG GATTGGTGTA TTTGAGTTAG TGGATGACCA TTTTGTAGAG 
TTGAATGTTG GTGTCACTGG CCTTCCTGTT TCAGATTCCA GGATCATAGC TGGTCTTGTG 
CTTCAGAAAG ATTTTTCTGT GTACCGCCCA GCAGATGGTG ACATGCGAAT GGTGATAGTA 
ACAGAAACCA TTCAGCCTCT TTTTTCCACT TCTGGATCAG AGTTTATTCT AAATTCAGAA 
GCACAGTTTC AGACATCTCA ATTTTGGATT ATGGAAAAGA CAAAAGCAAT AATGAAACAT 
CTACATAGTC AGAATGTAAA ATTGCTCATA TCTAGTGTGA AACAACCAGA TTTAGTTAGT 
TATTATGCAG GGGTGAATGG CATATCAGTG GTTGAGTGTT TATCATCAGA AGAAGTTTCT 
CTTATCCGGA GGATCATTGG TCTTTCTCCA TTTGTACCAC CACAGGCCTT TTCGCAGTGT 
GAAATACCTA ACACTGCTTT GGTGAAATTT TGTAAACCTC TTATCCTTAG ATCCAAAAGA 
TATGTTCATC TAGGCTTGAT AAGCACATGT GCATTTATAC CACACTCTAT AGTTCTTTGT 
GGACCAGTGC ATGGTCTCAT TGAACAACAT GAGGATGCTT TACATGGAGC ACTTAAAATG 
CTTCGGCAAT TATTTAAAGA CCTTGATCTA AATTACATGA CACAAACCAA TGACCAAAAT 
GGCACTTCAA GTCTTTTTAT TTATAAGAAC AGTGGAGAAA GTTATCAAGC ACCAGATCCT 
GGTAATGGCT CAATACAAAG GCCTTATCAG GACACAGTTG CAGAGAACAA AGATGCATTG 
GAAAAAACTC AAACATATTT AAAAGTACAT TCTAATTTGG TAATTCCAGA TGTAGAATTA 
GAAACATATA TTCCGTATTC AACCCCCACA CTGACACCAA CAGATACATT CCAAACAGTT 
GAAACGCTGA CATGTTTGTC TTTGGAAAGA AACAGGCTAA CTGATTATTA TGAACCATTA 
CTCAAGAACA ATTCCACTGC TTATTCAACA AGGGGAAATA GAATAGAAAT TTCTTACGAA 
AATTTACAGG TCACAAATAT TACTAGAAAG GGAAGCATGT TACCAGTGAG CTGTAAGTTA 
CCGAATATGG GTACTTCCCA GAGTTACCTT TCCTCATCTA TGCCAGCTGG TTGTGTTTTG 
CCAGTAGGTG GTAATTTTGA GATCTTGTTA CATTACTATC TTCTCAATTA TGCCAAAAAA 
TGCCATCAAT CAGAAGAAAC CATGGTTAGT ATGATAATAG CTAATGCACT TTTAGGCATT 
CCCAAAGTCC TTTATAAATC TAAAACAGGA AAGTACAGCT TTCCACATAC ATATATAAGA 
GCTGTCCATG CACTGCAAAC CAATCAACCC TTGGTAAGCA GTCAGACAGG TTTGGAATCA 
GTAATGGGTA AATACCAGCT ACTAACTTCA GTTCTTCAGT GTTTGACAAA AATATTAACC 
ATTGACATGG TAATCACTGT TAAGAGACAC CCTCAGAAAG TTCACAATCA AGATTCAGAA 
GATGAACTAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_078961.3
CDS	58..2229
Translation	MLSSMAAAGSVKAALQVAEVLEAIVSCCVGPEGRQVLCTKPTGEVLLSRNGGRLLEALHLEHPIARMIVDCVSSHLKKTGDGAKTFIIFLCHLLRGLHAITDREKDPLMCENIQTHGRHWKNCSRWKFISQALLTFQTQILDGIMDQYLSRHFLSIFSSAKERTLCRSSLELLLEAYFCGRVGRNNHKFISQLMCDYFFKCMTCKSGIGVFELVDDHFVELNVGVTGLPVSDSRIIAGLVLQKDFSVYRPADGDMRMVIVTETIQPLFSTSGSEFILNSEAQFQTSQFWIMEKTKAIMKHLHSQNVKLLISSVKQPDLVSYYAGVNGISVVECLSSEEVSLIRRIIGLSPFVPPQAFSQCEIPNTALVKFCKPLILRSKRYVHLGLISTCAFIPHSIVLCGPVHGLIEQHEDALHGALKMLRQLFKDLDLNYMTQTNDQNGTSSLFIYKNSGESYQAPDPGNGSIQRPYQDTVAENKDALEKTQTYLKVHSNLVIPDVELETYIPYSTPTLTPTDTFQTVETLTCLSLERNRLTDYYEPLLKNNSTAYSTRGNRIEISYENLQVTNITRKGSMLPVSCKLPNMGTSQSYLSSSMPAGCVLPVGGNFEILLHYYLLNYAKKCHQSEETMVSMIIANALLGIPKVLYKSKTGKYSFPHTYIRAVHALQTNQPLVSSQTGLESVMGKYQLLTSVLQCLTKILTIDMVITVKRHPQKVHNQDSEDEL

Target ORF information:

RefSeq Version	NM_024685.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Bardet-Biedl syndrome 10 (BBS10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024685.4

ORF Insert Sequence:

ATGTTAAGTT CTATGGCCGC TGCAGGGTCT GTGAAGGCGG CGTTGCAGGT GGCCGAGGTG 
CTGGAAGCCA TCGTGAGCTG CTGCGTGGGG CCCGAGGGAC GGCAAGTTTT GTGTACGAAG 
CCCACTGGCG AGGTGCTTCT CAGCCGGAAT GGAGGCCGCC TCCTGGAGGC GCTACACTTA 
GAGCATCCCA TAGCCAGGAT GATAGTGGAC TGTGTTTCCA GTCATCTCAA AAAAACAGGA 
GATGGTGCAA AAACATTTAT TATCTTTCTT TGCCATTTGC TTAGAGGACT TCATGCAATC 
ACAGACAGAG AAAAGGATCC TTTGATGTGT GAAAACATTC AAACCCATGG AAGGCATTGG 
AAAAATTGTT CTCGGTGGAA ATTTATTTCC CAGGCTCTCC TAACGTTTCA GACACAAATA 
TTAGACGGTA TTATGGACCA GTACCTAAGT AGACACTTTT TGTCTATCTT TTCGTCTGCT 
AAAGAGAGAA CATTGTGTAG GAGCTCTTTA GAGTTGCTCT TAGAAGCATA CTTTTGTGGA 
AGAGTGGGAA GAAATAATCA TAAATTTATT TCACAGTTGA TGTGTGACTA CTTTTTCAAG 
TGTATGACTT GTAAAAGTGG GATTGGTGTA TTTGAGTTAG TGGATGACCA TTTTGTAGAG 
TTGAATGTTG GTGTCACTGG CCTTCCTGTT TCAGATTCCA GGATCATAGC TGGTCTTGTG 
CTTCAGAAAG ATTTTTCTGT GTACCGCCCA GCAGATGGTG ACATGCGAAT GGTGATAGTA 
ACAGAAACCA TTCAGCCTCT TTTTTCCACT TCTGGATCAG AGTTTATTCT AAATTCAGAA 
GCACAGTTTC AGACATCTCA ATTTTGGATT ATGGAAAAGA CAAAAGCAAT AATGAAACAT 
CTACATAGTC AGAATGTAAA ATTGCTCATA TCTAGTGTGA AACAACCAGA TTTAGTTAGT 
TATTATGCAG GGGTGAATGG CATATCAGTG GTTGAGTGTT TATCATCAGA AGAAGTTTCT 
CTTATCCGGA GGATCATTGG TCTTTCTCCA TTTGTACCAC CACAGGCCTT TTCGCAGTGT 
GAAATACCTA ACACTGCTTT GGTGAAATTT TGTAAACCTC TTATCCTTAG ATCCAAAAGA 
TATGTTCATC TAGGCTTGAT AAGCACATGT GCATTTATAC CACACTCTAT AGTTCTTTGT 
GGACCAGTGC ATGGTCTCAT TGAACAACAT GAGGATGCTT TACATGGAGC ACTTAAAATG 
CTTCGGCAAT TATTTAAAGA CCTTGATCTA AATTACATGA CACAAACCAA TGACCAAAAT 
GGCACTTCAA GTCTTTTTAT TTATAAGAAC AGTGGAGAAA GTTATCAAGC ACCAGATCCT 
GGTAATGGCT CAATACAAAG GCCTTATCAG GACACAGTTG CAGAGAACAA AGATGCATTG 
GAAAAAACTC AAACATATTT AAAAGTACAT TCTAATTTGG TAATTCCAGA TGTAGAATTA 
GAAACATATA TTCCGTATTC AACCCCCACA CTGACACCAA CAGATACATT CCAAACAGTT 
GAAACGCTGA CATGTTTGTC TTTGGAAAGA AACAGGCTAA CTGATTATTA TGAACCATTA 
CTCAAGAACA ATTCCACTGC TTATTCAACA AGGGGAAATA GAATAGAAAT TTCTTACGAA 
AATTTACAGG TCACAAATAT TACTAGAAAG GGAAGCATGT TACCAGTGAG CTGTAAGTTA 
CCGAATATGG GTACTTCCCA GAGTTACCTT TCCTCATCTA TGCCAGCTGG TTGTGTTTTG 
CCAGTAGGTG GTAATTTTGA GATCTTGTTA CATTACTATC TTCTCAATTA TGCCAAAAAA 
TGCCATCAAT CAGAAGAAAC CATGGTTAGT ATGATAATAG CTAATGCACT TTTAGGCATT 
CCCAAAGTCC TTTATAAATC TAAAACAGGA AAGTACAGCT TTCCACATAC ATATATAAGA 
GCTGTCCATG CACTGCAAAC CAATCAACCC TTGGTAAGCA GTCAGACAGG TTTGGAATCA 
GTAATGGGTA AATACCAGCT ACTAACTTCA GTTCTTCAGT GTTTGACAAA AATATTAACC 
ATTGACATGG TAATCACTGT TAAGAGACAC CCTCAGAAAG TTCACAATCA AGATTCAGAA 
GATGAACTAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sequence variants in four genes underlying Bardet-Biedl syndrome in consanguineous families.
Molecular vision23482-494(2017)
Ullah A,Umair M,Yousaf M,Khan SA,Nazim-Ud-Din M,Shah K,Ahmad F,Azeem Z,Ali G,Alhaddad B,Rafique A,Jan A,Haack TB,Strom TM,Meitinger T,Ghous T,Ahmad W

A novel test for recessive contributions to complex diseases implicates Bardet-Biedl syndrome gene BBS10 in idiopathic type 2 diabetes and obesity.
American journal of human genetics95(5)509-20(2014 Nov)
Lim ET,Liu YP,Chan Y,Tiinamaija T,K?r?j?m?ki A,Madsen E,,Altshuler DM,Raychaudhuri S,Groop L,Flannick J,Hirschhorn JN,Katsanis N,Daly MJ

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BBS10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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