IPO4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IPO4
Entrez Gene ID	79711
Full Name	importin 4
Synonyms	Imp4
General protein information	Preferred Names importin 4 Names importin-4 imp4b importin-4b ran-binding protein 4 ranBP4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q12

mRNA and Protein(s)

mRNA	Protein	Name
NM_024658.4	NP_078934.3	importin-4
NM_024658.3	NP_078934.3	importin-4

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	IPO4	XP_001168091.1
Bos taurus (cattle)	IPO4	NP_001077130.1
Danio rerio (zebrafish)	ipo4	XP_684163.4
Drosophila melanogaster (fruit fly)	CG32165	NP_730182.1
Saccharomyces cerevisiae (baker's yeast)	KAP123	NP_011035.1
Eremothecium gossypii	AGOS_AGL298C	NP_986369.2
Homo sapiens (human)	IPO4	NP_078934.3
Mus musculus (house mouse)	Ipo4	NP_077229.4
Schizosaccharomyces pombe (fission yeast)	kap123	NP_596729.1
	IPO4	XP_002808502.1
Canis lupus familiaris (dog)	IPO4	XP_537384.3
Drosophila melanogaster (fruit fly)	CG32164	NP_001261957.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006942	XP_308814.4
Kluyveromyces lactis	KLLA0E20769g	XP_454889.1
Magnaporthe oryzae (rice blast fungus)	MGG_16711	XP_003711698.1
Arabidopsis thaliana (thale cress)	AT4G27640	NP_194494.2
Xenopus tropicalis (tropical clawed frog)	ipo4	NP_001008011.2
Rattus norvegicus (Norway rat)	Ipo4	NP_001099508.1
Neurospora crassa	NCU05650	XP_960211.2

Gene Ontology
Bibliography

Related articles in PubMed

Competitive regulation of IPO4 transcription by ELK1 and GABP.
Xu P, Lin W, Liu F, Tartakoff A, Tao T
Gene61330-38(2017 May)

Recognition Elements in the Histone H3 and H4 Tails for Seven Different Importins.
Soniat M, Ca?atay T, Chook YM
The Journal of biological chemistry291(40)21171-21183(2016 Sep)

An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine.
Echeverr?a PC, Bernthaler A, Dupuis P, Mayer B, Picard D
PloS one6(10)e26044(2011)

CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage.
Wang J, Sarkar TR, Zhou M, Sharan S, Ritt DA, Veenstra TD, Morrison DK, Huang AM, Sterneck E
Proceedings of the National Academy of Sciences of the United States of America107(37)16131-6(2010 Sep)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study identified a core region encompassing nt - 118 to + 108 of IPO4 gene that is necessary for its promoter activity. Transcription factors binding to this region were screened, resulting in the identification of two members of the Ets family, Ets-like transcription factor-1 and GA binding protein, which repress or activate its promoter activity, respectively.
Title: Competitive regulation of IPO4 transcription by ELK1 and GABP.

Importins, Impbeta, Kapbeta2, Imp4, Imp5, Imp7, Imp9, and Impalpha, show the H3 tail binding more tightly than the H4 tail. The H3 tail binds Kapbeta2 and Imp5 with KD values of 77 and 57 nm, respectively, and binds the other five Importins more weakly.
Title: Recognition Elements in the Histone H3 and H4 Tails for Seven Different Importins.

report a function of IPO4 and nuclear import in the Fanconi anemia pathway of DNA repair
Title: CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage.

importins 4 and 7 accomplish nuclear import of HIF-1alpha more efficiently than the classical importin alpha/beta NLS receptor.
Title: Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7.

demonstrated that vitamin D receptor (VDR) has two nuclear import systems: ligand-dependent & ligand-independent pathways, & that importin 4 fulfills the ligand-independent nuclear transport through the interaction with the amino terminus of VDR
Title: Importin 4 is responsible for ligand-independent nuclear translocation of vitamin D receptor.

The following IPO4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IPO4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16284	NM_024658.4 Latest version!	Homo sapiens importin 4 (IPO4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$399.50-$559.30 $799.00
View Old Accession Versions >>
OHu16284	NM_024658.3	Homo sapiens importin 4 (IPO4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$399.50-$559.30 $799.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IPO4 ( NM_024658.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_078934.3 Homo sapiens importin 4 (IPO4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16284
Clone ID Related Accession (Same CDS sequence)	NM_024658.4 , NM_024658.3
Accession Version	NM_024658.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3246bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	importin-4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK056527.1, BC003690.1 and AK094897.1. On Nov 22, 2018 this sequence version replaced NM_024658.3. Transcript Variant: This variant (1) represents the shorter transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC110804.1, AK057277.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000354464.11/ ENSP00000346453.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGTCAG CCGGGCTAGA GCAGCTCCTA CGGGAGCTGC TGCTACCGGA CACCGAGCGC 
ATCCGTCGGG CCACGGAACA GCTCCAGATC GTTCTTCGGG CCCCCGCCGC TTTGCCGGCT 
CTCTGCGACC TGCTAGCCTC GGCGGCCGAC CCCCAGATCC GCCAGTTTGC GGCCGTGCTG 
ACCCGCAGAC GACTGAACAC CCGCTGGCGA CGGCTGGCGG CGGAGCAACG GGAGAGCCTC 
AAGTCCCTGA TCCTGACGGC CCTGCAGAGA GAAACAGAGC ACTGTGTGAG CCTCAGCCTG 
GCCCAGCTCT CAGCCACCAT TTTTCGAAAG GAAGGCTTGG AGGCCTGGCC ACAGCTTTTG 
CAGCTGCTTC AGCACAGTAC CCACAGCCCC CACAGCCCAG AGAGAGAGAT GGGGCTTTTG 
CTGCTAAGTG TGGTGGTGAC CTCCCGGCCC GAGGCCTTCC AACCCCACCA CCGGGAGCTT 
CTTCGGCTTC TGAATGAGAC TCTTGGTGAG GTGGGCTCTC CTGGGCTGCT CTTCTACTCC 
CTGCGCACTC TGACCACCAT GGCTCCCTAC CTCAGCACTG AAGATGTGCC TCTCGCTCGG 
ATGTTGGTGC CCAAGCTGAT CATGGCCATG CAGACTCTGA TCCCCATAGA TGAGGCAAAG 
GCCTGTGAGG CCCTTGAGGC TTTGGATGAA CTGTTGGAGT CAGAGGTGCC GGTCATCACC 
CCCTACCTCT CTGAAGTCCT CACATTCTGC CTGGAGGTAG CTAGAAATGT GGCCCTGGGC 
AATGCGATAC GCATACGTAT TCTCTGCTGC CTCACTTTCT TGGTCAAAGT CAAGAGCAAG 
GCCTTACTGA AGAATCGTCT CCTGCCACCC TTGCTGCACA CCCTTTTCCC CATTGTGGCT 
GCTGAGCCCC CACCAGGCCA GTTGGATCCC GAGGACCAGG ATTCAGAAGA GGAAGAGTTG 
GAGATTGAGC TGATGGGGGA GACTCCCAAG CATTTCGCTG TACAAGTTGT GGACATGCTG 
GCACTACACC TGCCCCCCGA GAAGCTCTGT CCCCAGCTGA TGCCCATGTT GGAAGAGGCT 
TTGCGGAGCG AGAGCCCATA CCAGCGCAAA GCTGGACTCC TGGTGCTGGC CGTGCTGTCT 
GACGGAGCTG GCGACCACAT CAGGCAGAGA CTGCTGCCCC CACTGCTGCA GATTGTGTGC 
AAGGGCCTGG AGGACCCCTC GCAAGTTGTA CGCAATGCTG CGCTGTTTGC CCTGGGCCAG 
TTCTCAGAAA ACCTACAGCC CCATATCAGC AGCTATTCAA GGGAGGTAAT GCCACTGCTC 
CTCGCCTACT TGAAGTCGGT GCCTCTTGGA CACACACACC ACCTAGCCAA GGCCTGCTAT 
GCCCTGGAGA ATTTTGTGGA GAACCTAGGG CCCAAGGTGC AGCCCTACCT TCCGGAGCTT 
ATGGAATGCA TGCTGCAGCT TCTGAGGAAC CCCAGCAGTC CCCGGGCCAA GGAGCTGGCT 
GTGAGCGCCC TGGGAGCCAT TGCTACGGCT GCCCAGGCCT CGCTGCTGCC CTACTTCCCT 
GCCATCATGG AGCACCTGCG GGAATTCCTG TTAACAGGCC GTGAGGACCT TCAGCCTGTG 
CAGATCCAGA GCCTGGAGAC ACTGGGGGTG CTGGCACGAG CAGTGGGGGA GCCCATGAGG 
CCGCTGGCTG AGGAATGCTG CCAGCTGGGT CTGGGCCTCT GCGACCAGGT AGACGACCCT 
GACTTGCGGC GCTGCACGTA CAGCCTATTT GCAGCCTTAT CGGGTCTGAT GGGTGAGGGC 
CTGGCGCCCC ACTTGGAACA GATCACCACG CTCATGCTGC TGTCACTGCG TTCCACCGAG 
GGCATTGTGC CTCAGTATGA CGGGAGCAGC TCCTTCCTTC TGTTTGACGA TGAGAGTGAT 
GGGGAAGAAG AGGAGGAGCT CATGGATGAG GATGTGGAAG AAGAGGATGA CTCAGAGATC 
TCAGGGTACA GCGTGGAGAA TGCCTTCTTC GATGAGAAGG AAGACACCTG TGCTGCCGTG 
GGGGAGATCT CTGTGAACAC CAGTGTGGCC TTCCTTCCAT ACATGGAAAG TGTCTTTGAA 
GAAGTATTTA AACTGCTGGA GTGCCCTCAC CTGAATGTGC GGAAGGCAGC CCATGAGGCT 
CTGGGTCAGT TTTGCTGTGC ACTGCACAAG GCCTGTCAAA GCTGCCCCTC GGAACCCAAC 
ACTGCTGCTT TGCAGGCTGC CCTGGCCCGA GTCGTGCCAT CCTACATGCA GGCAGTGAAC 
AGGGAGCGGG AACGCCAGGT GGTGATGGCC GTGCTGGAGG CCCTGACAGG GGTGCTCCGC 
AGCTGTGGGA CCCTCACACT GAAGCCCCCT GGGCGCCTCG CTGAGCTCTG TGGCGTGCTC 
AAGGCTGTGC TGCAGAGGAA GACAGCCTGT CAGGATACTG ACGAGGAGGA GGAAGAGGAA 
GATGATGATC AGGCTGAATA CGACGCCATG TTGCTGGAGC ACGCTGGAGA GGCCATCCCT 
GCCCTGGCAG CCGCGGCTGG GGGAGACTCC TTTGCCCCAT TCTTTGCCGG TTTCCTGCCA 
TTATTGGTGT GCAAGACAAA ACAGGGCTGC ACAGTGGCAG AGAAGTCCTT TGCAGTGGGG 
ACCTTGGCAG AGACTATTCA GGGCCTGGGT GCTGCCTCAG CCCAGTTTGT GTCTCGGCTG 
CTCCCTGTGC TGTTGAGCAC CGCCCAAGAG GCAGACCCCG AGGTGCGAAG CAATGCCATC 
TTCGGGATGG GCGTGCTGGC AGAGCATGGG GGCCACCCTG CCCAGGAACA CTTCCCCAAG 
CTGCTGGGGC TCCTTTTTCC CCTCCTGGCG CGGGAGCGAC ATGATCGTGT CCGTGACAAC 
ATCTGTGGGG CACTTGCCCG CCTGTTGATG GCCAGTCCCA CCAGGAAACC AGAGCCCCAG 
GTGCTGGCTG CCCTACTGCA TGCCCTGCCA CTGAAGGAGG ACTTGGAGGA GTGGGTCACC 
ATTGGGCGCC TCTTCAGCTT CCTGTACCAG AGCAGCCCTG ACCAGGTTAT AGATGTGGCT 
CCCGAGCTTC TGCGTATCTG CAGCCTCATT CTGGCTGACA ACAAGATCCC ACCAGACACC 
AAGGCCGCAC TGTTGCTGCT CCTGACGTTC CTGGCCAAAC AGCACACCGA CAGCTTTCAA 
GCAGCTCTGG GCTCACTGCC TGTTGACAAG GCTCAGGAGC TCCAGGCTGT ACTGGGCCTC 
TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_078934.3
CDS	30..3275
Translation	MESAGLEQLLRELLLPDTERIRRATEQLQIVLRAPAALPALCDLLASAADPQIRQFAAVLTRRRLNTRWRRLAAEQRESLKSLILTALQRETEHCVSLSLAQLSATIFRKEGLEAWPQLLQLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPHHRELLRLLNETLGEVGSPGLLFYSLRTLTTMAPYLSTEDVPLARMLVPKLIMAMQTLIPIDEAKACEALEALDELLESEVPVITPYLSEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKALLKNRLLPPLLHTLFPIVAAEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQFSENLQPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYFPAIMEHLREFLLTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEECCQLGLGLCDQVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTEGIVPQYDGSSSFLLFDDESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDTCAAVGEISVNTSVAFLPYMESVFEEVFKLLECPHLNVRKAAHEALGQFCCALHKACQSCPSEPNTAALQAALARVVPSYMQAVNRERERQVVMAVLEALTGVLRSCGTLTLKPPGRLAELCGVLKAVLQRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIPALAAAAGGDSFAPFFAGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRLLPVLLSTAQEADPEVRSNAIFGMGVLAEHGGHPAQEHFPKLLGLLFPLLARERHDRVRDNICGALARLLMASPTRKPEPQVLAALLHALPLKEDLEEWVTIGRLFSFLYQSSPDQVIDVAPELLRICSLILADNKIPPDTKAALLLLLTFLAKQHTDSFQAALGSLPVDKAQELQAVLGLS

Target ORF information:

RefSeq Version	NM_024658.4
Organism	Homo sapiens(human)
Definition	Homo sapiens importin 4 (IPO4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024658.4

ORF Insert Sequence:

ATGGAGTCAG CCGGGCTAGA GCAGCTCCTA CGGGAGCTGC TGCTACCGGA CACCGAGCGC 
ATCCGTCGGG CCACGGAACA GCTCCAGATC GTTCTTCGGG CCCCCGCCGC TTTGCCGGCT 
CTCTGCGACC TGCTAGCCTC GGCGGCCGAC CCCCAGATCC GCCAGTTTGC GGCCGTGCTG 
ACCCGCAGAC GACTGAACAC CCGCTGGCGA CGGCTGGCGG CGGAGCAACG GGAGAGCCTC 
AAGTCCCTGA TCCTGACGGC CCTGCAGAGA GAAACAGAGC ACTGTGTGAG CCTCAGCCTG 
GCCCAGCTCT CAGCCACCAT TTTTCGAAAG GAAGGCTTGG AGGCCTGGCC ACAGCTTTTG 
CAGCTGCTTC AGCACAGTAC CCACAGCCCC CACAGCCCAG AGAGAGAGAT GGGGCTTTTG 
CTGCTAAGTG TGGTGGTGAC CTCCCGGCCC GAGGCCTTCC AACCCCACCA CCGGGAGCTT 
CTTCGGCTTC TGAATGAGAC TCTTGGTGAG GTGGGCTCTC CTGGGCTGCT CTTCTACTCC 
CTGCGCACTC TGACCACCAT GGCTCCCTAC CTCAGCACTG AAGATGTGCC TCTCGCTCGG 
ATGTTGGTGC CCAAGCTGAT CATGGCCATG CAGACTCTGA TCCCCATAGA TGAGGCAAAG 
GCCTGTGAGG CCCTTGAGGC TTTGGATGAA CTGTTGGAGT CAGAGGTGCC GGTCATCACC 
CCCTACCTCT CTGAAGTCCT CACATTCTGC CTGGAGGTAG CTAGAAATGT GGCCCTGGGC 
AATGCGATAC GCATACGTAT TCTCTGCTGC CTCACTTTCT TGGTCAAAGT CAAGAGCAAG 
GCCTTACTGA AGAATCGTCT CCTGCCACCC TTGCTGCACA CCCTTTTCCC CATTGTGGCT 
GCTGAGCCCC CACCAGGCCA GTTGGATCCC GAGGACCAGG ATTCAGAAGA GGAAGAGTTG 
GAGATTGAGC TGATGGGGGA GACTCCCAAG CATTTCGCTG TACAAGTTGT GGACATGCTG 
GCACTACACC TGCCCCCCGA GAAGCTCTGT CCCCAGCTGA TGCCCATGTT GGAAGAGGCT 
TTGCGGAGCG AGAGCCCATA CCAGCGCAAA GCTGGACTCC TGGTGCTGGC CGTGCTGTCT 
GACGGAGCTG GCGACCACAT CAGGCAGAGA CTGCTGCCCC CACTGCTGCA GATTGTGTGC 
AAGGGCCTGG AGGACCCCTC GCAAGTTGTA CGCAATGCTG CGCTGTTTGC CCTGGGCCAG 
TTCTCAGAAA ACCTACAGCC CCATATCAGC AGCTATTCAA GGGAGGTAAT GCCACTGCTC 
CTCGCCTACT TGAAGTCGGT GCCTCTTGGA CACACACACC ACCTAGCCAA GGCCTGCTAT 
GCCCTGGAGA ATTTTGTGGA GAACCTAGGG CCCAAGGTGC AGCCCTACCT TCCGGAGCTT 
ATGGAATGCA TGCTGCAGCT TCTGAGGAAC CCCAGCAGTC CCCGGGCCAA GGAGCTGGCT 
GTGAGCGCCC TGGGAGCCAT TGCTACGGCT GCCCAGGCCT CGCTGCTGCC CTACTTCCCT 
GCCATCATGG AGCACCTGCG GGAATTCCTG TTAACAGGCC GTGAGGACCT TCAGCCTGTG 
CAGATCCAGA GCCTGGAGAC ACTGGGGGTG CTGGCACGAG CAGTGGGGGA GCCCATGAGG 
CCGCTGGCTG AGGAATGCTG CCAGCTGGGT CTGGGCCTCT GCGACCAGGT AGACGACCCT 
GACTTGCGGC GCTGCACGTA CAGCCTATTT GCAGCCTTAT CGGGTCTGAT GGGTGAGGGC 
CTGGCGCCCC ACTTGGAACA GATCACCACG CTCATGCTGC TGTCACTGCG TTCCACCGAG 
GGCATTGTGC CTCAGTATGA CGGGAGCAGC TCCTTCCTTC TGTTTGACGA TGAGAGTGAT 
GGGGAAGAAG AGGAGGAGCT CATGGATGAG GATGTGGAAG AAGAGGATGA CTCAGAGATC 
TCAGGGTACA GCGTGGAGAA TGCCTTCTTC GATGAGAAGG AAGACACCTG TGCTGCCGTG 
GGGGAGATCT CTGTGAACAC CAGTGTGGCC TTCCTTCCAT ACATGGAAAG TGTCTTTGAA 
GAAGTATTTA AACTGCTGGA GTGCCCTCAC CTGAATGTGC GGAAGGCAGC CCATGAGGCT 
CTGGGTCAGT TTTGCTGTGC ACTGCACAAG GCCTGTCAAA GCTGCCCCTC GGAACCCAAC 
ACTGCTGCTT TGCAGGCTGC CCTGGCCCGA GTCGTGCCAT CCTACATGCA GGCAGTGAAC 
AGGGAGCGGG AACGCCAGGT GGTGATGGCC GTGCTGGAGG CCCTGACAGG GGTGCTCCGC 
AGCTGTGGGA CCCTCACACT GAAGCCCCCT GGGCGCCTCG CTGAGCTCTG TGGCGTGCTC 
AAGGCTGTGC TGCAGAGGAA GACAGCCTGT CAGGATACTG ACGAGGAGGA GGAAGAGGAA 
GATGATGATC AGGCTGAATA CGACGCCATG TTGCTGGAGC ACGCTGGAGA GGCCATCCCT 
GCCCTGGCAG CCGCGGCTGG GGGAGACTCC TTTGCCCCAT TCTTTGCCGG TTTCCTGCCA 
TTATTGGTGT GCAAGACAAA ACAGGGCTGC ACAGTGGCAG AGAAGTCCTT TGCAGTGGGG 
ACCTTGGCAG AGACTATTCA GGGCCTGGGT GCTGCCTCAG CCCAGTTTGT GTCTCGGCTG 
CTCCCTGTGC TGTTGAGCAC CGCCCAAGAG GCAGACCCCG AGGTGCGAAG CAATGCCATC 
TTCGGGATGG GCGTGCTGGC AGAGCATGGG GGCCACCCTG CCCAGGAACA CTTCCCCAAG 
CTGCTGGGGC TCCTTTTTCC CCTCCTGGCG CGGGAGCGAC ATGATCGTGT CCGTGACAAC 
ATCTGTGGGG CACTTGCCCG CCTGTTGATG GCCAGTCCCA CCAGGAAACC AGAGCCCCAG 
GTGCTGGCTG CCCTACTGCA TGCCCTGCCA CTGAAGGAGG ACTTGGAGGA GTGGGTCACC 
ATTGGGCGCC TCTTCAGCTT CCTGTACCAG AGCAGCCCTG ACCAGGTTAT AGATGTGGCT 
CCCGAGCTTC TGCGTATCTG CAGCCTCATT CTGGCTGACA ACAAGATCCC ACCAGACACC 
AAGGCCGCAC TGTTGCTGCT CCTGACGTTC CTGGCCAAAC AGCACACCGA CAGCTTTCAA 
GCAGCTCTGG GCTCACTGCC TGTTGACAAG GCTCAGGAGC TCCAGGCTGT ACTGGGCCTC 
TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IPO4 ( NM_024658.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_078934.3 Homo sapiens importin 4 (IPO4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16284
Clone ID Related Accession (Same CDS sequence)	NM_024658.4 , NM_024658.3
Accession Version	NM_024658.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3246bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-28
Organism	Homo sapiens(human)
Product	importin-4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BF001674.1, AK056527.1, BC003690.1 and AK094897.1. On Apr 9, 2005 this sequence version replaced NM_024658.2. Transcript Variant: This variant (1) represents the shorter transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC110804.1, AK057277.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTCAG CCGGGCTAGA GCAGCTCCTA CGGGAGCTGC TGCTACCGGA CACCGAGCGC 
ATCCGTCGGG CCACGGAACA GCTCCAGATC GTTCTTCGGG CCCCCGCCGC TTTGCCGGCT 
CTCTGCGACC TGCTAGCCTC GGCGGCCGAC CCCCAGATCC GCCAGTTTGC GGCCGTGCTG 
ACCCGCAGAC GACTGAACAC CCGCTGGCGA CGGCTGGCGG CGGAGCAACG GGAGAGCCTC 
AAGTCCCTGA TCCTGACGGC CCTGCAGAGA GAAACAGAGC ACTGTGTGAG CCTCAGCCTG 
GCCCAGCTCT CAGCCACCAT TTTTCGAAAG GAAGGCTTGG AGGCCTGGCC ACAGCTTTTG 
CAGCTGCTTC AGCACAGTAC CCACAGCCCC CACAGCCCAG AGAGAGAGAT GGGGCTTTTG 
CTGCTAAGTG TGGTGGTGAC CTCCCGGCCC GAGGCCTTCC AACCCCACCA CCGGGAGCTT 
CTTCGGCTTC TGAATGAGAC TCTTGGTGAG GTGGGCTCTC CTGGGCTGCT CTTCTACTCC 
CTGCGCACTC TGACCACCAT GGCTCCCTAC CTCAGCACTG AAGATGTGCC TCTCGCTCGG 
ATGTTGGTGC CCAAGCTGAT CATGGCCATG CAGACTCTGA TCCCCATAGA TGAGGCAAAG 
GCCTGTGAGG CCCTTGAGGC TTTGGATGAA CTGTTGGAGT CAGAGGTGCC GGTCATCACC 
CCCTACCTCT CTGAAGTCCT CACATTCTGC CTGGAGGTAG CTAGAAATGT GGCCCTGGGC 
AATGCGATAC GCATACGTAT TCTCTGCTGC CTCACTTTCT TGGTCAAAGT CAAGAGCAAG 
GCCTTACTGA AGAATCGTCT CCTGCCACCC TTGCTGCACA CCCTTTTCCC CATTGTGGCT 
GCTGAGCCCC CACCAGGCCA GTTGGATCCC GAGGACCAGG ATTCAGAAGA GGAAGAGTTG 
GAGATTGAGC TGATGGGGGA GACTCCCAAG CATTTCGCTG TACAAGTTGT GGACATGCTG 
GCACTACACC TGCCCCCCGA GAAGCTCTGT CCCCAGCTGA TGCCCATGTT GGAAGAGGCT 
TTGCGGAGCG AGAGCCCATA CCAGCGCAAA GCTGGACTCC TGGTGCTGGC CGTGCTGTCT 
GACGGAGCTG GCGACCACAT CAGGCAGAGA CTGCTGCCCC CACTGCTGCA GATTGTGTGC 
AAGGGCCTGG AGGACCCCTC GCAAGTTGTA CGCAATGCTG CGCTGTTTGC CCTGGGCCAG 
TTCTCAGAAA ACCTACAGCC CCATATCAGC AGCTATTCAA GGGAGGTAAT GCCACTGCTC 
CTCGCCTACT TGAAGTCGGT GCCTCTTGGA CACACACACC ACCTAGCCAA GGCCTGCTAT 
GCCCTGGAGA ATTTTGTGGA GAACCTAGGG CCCAAGGTGC AGCCCTACCT TCCGGAGCTT 
ATGGAATGCA TGCTGCAGCT TCTGAGGAAC CCCAGCAGTC CCCGGGCCAA GGAGCTGGCT 
GTGAGCGCCC TGGGAGCCAT TGCTACGGCT GCCCAGGCCT CGCTGCTGCC CTACTTCCCT 
GCCATCATGG AGCACCTGCG GGAATTCCTG TTAACAGGCC GTGAGGACCT TCAGCCTGTG 
CAGATCCAGA GCCTGGAGAC ACTGGGGGTG CTGGCACGAG CAGTGGGGGA GCCCATGAGG 
CCGCTGGCTG AGGAATGCTG CCAGCTGGGT CTGGGCCTCT GCGACCAGGT AGACGACCCT 
GACTTGCGGC GCTGCACGTA CAGCCTATTT GCAGCCTTAT CGGGTCTGAT GGGTGAGGGC 
CTGGCGCCCC ACTTGGAACA GATCACCACG CTCATGCTGC TGTCACTGCG TTCCACCGAG 
GGCATTGTGC CTCAGTATGA CGGGAGCAGC TCCTTCCTTC TGTTTGACGA TGAGAGTGAT 
GGGGAAGAAG AGGAGGAGCT CATGGATGAG GATGTGGAAG AAGAGGATGA CTCAGAGATC 
TCAGGGTACA GCGTGGAGAA TGCCTTCTTC GATGAGAAGG AAGACACCTG TGCTGCCGTG 
GGGGAGATCT CTGTGAACAC CAGTGTGGCC TTCCTTCCAT ACATGGAAAG TGTCTTTGAA 
GAAGTATTTA AACTGCTGGA GTGCCCTCAC CTGAATGTGC GGAAGGCAGC CCATGAGGCT 
CTGGGTCAGT TTTGCTGTGC ACTGCACAAG GCCTGTCAAA GCTGCCCCTC GGAACCCAAC 
ACTGCTGCTT TGCAGGCTGC CCTGGCCCGA GTCGTGCCAT CCTACATGCA GGCAGTGAAC 
AGGGAGCGGG AACGCCAGGT GGTGATGGCC GTGCTGGAGG CCCTGACAGG GGTGCTCCGC 
AGCTGTGGGA CCCTCACACT GAAGCCCCCT GGGCGCCTCG CTGAGCTCTG TGGCGTGCTC 
AAGGCTGTGC TGCAGAGGAA GACAGCCTGT CAGGATACTG ACGAGGAGGA GGAAGAGGAA 
GATGATGATC AGGCTGAATA CGACGCCATG TTGCTGGAGC ACGCTGGAGA GGCCATCCCT 
GCCCTGGCAG CCGCGGCTGG GGGAGACTCC TTTGCCCCAT TCTTTGCCGG TTTCCTGCCA 
TTATTGGTGT GCAAGACAAA ACAGGGCTGC ACAGTGGCAG AGAAGTCCTT TGCAGTGGGG 
ACCTTGGCAG AGACTATTCA GGGCCTGGGT GCTGCCTCAG CCCAGTTTGT GTCTCGGCTG 
CTCCCTGTGC TGTTGAGCAC CGCCCAAGAG GCAGACCCCG AGGTGCGAAG CAATGCCATC 
TTCGGGATGG GCGTGCTGGC AGAGCATGGG GGCCACCCTG CCCAGGAACA CTTCCCCAAG 
CTGCTGGGGC TCCTTTTTCC CCTCCTGGCG CGGGAGCGAC ATGATCGTGT CCGTGACAAC 
ATCTGTGGGG CACTTGCCCG CCTGTTGATG GCCAGTCCCA CCAGGAAACC AGAGCCCCAG 
GTGCTGGCTG CCCTACTGCA TGCCCTGCCA CTGAAGGAGG ACTTGGAGGA GTGGGTCACC 
ATTGGGCGCC TCTTCAGCTT CCTGTACCAG AGCAGCCCTG ACCAGGTTAT AGATGTGGCT 
CCCGAGCTTC TGCGTATCTG CAGCCTCATT CTGGCTGACA ACAAGATCCC ACCAGACACC 
AAGGCCGCAC TGTTGCTGCT CCTGACGTTC CTGGCCAAAC AGCACACCGA CAGCTTTCAA 
GCAGCTCTGG GCTCACTGCC TGTTGACAAG GCTCAGGAGC TCCAGGCTGT ACTGGGCCTC 
TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_078934.3
CDS	132..3377
Translation	MESAGLEQLLRELLLPDTERIRRATEQLQIVLRAPAALPALCDLLASAADPQIRQFAAVLTRRRLNTRWRRLAAEQRESLKSLILTALQRETEHCVSLSLAQLSATIFRKEGLEAWPQLLQLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPHHRELLRLLNETLGEVGSPGLLFYSLRTLTTMAPYLSTEDVPLARMLVPKLIMAMQTLIPIDEAKACEALEALDELLESEVPVITPYLSEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKALLKNRLLPPLLHTLFPIVAAEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQFSENLQPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYFPAIMEHLREFLLTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEECCQLGLGLCDQVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTEGIVPQYDGSSSFLLFDDESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDTCAAVGEISVNTSVAFLPYMESVFEEVFKLLECPHLNVRKAAHEALGQFCCALHKACQSCPSEPNTAALQAALARVVPSYMQAVNRERERQVVMAVLEALTGVLRSCGTLTLKPPGRLAELCGVLKAVLQRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIPALAAAAGGDSFAPFFAGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRLLPVLLSTAQEADPEVRSNAIFGMGVLAEHGGHPAQEHFPKLLGLLFPLLARERHDRVRDNICGALARLLMASPTRKPEPQVLAALLHALPLKEDLEEWVTIGRLFSFLYQSSPDQVIDVAPELLRICSLILADNKIPPDTKAALLLLLTFLAKQHTDSFQAALGSLPVDKAQELQAVLGLS

Target ORF information:

RefSeq Version	NM_024658.3
Organism	Homo sapiens(human)
Definition	Homo sapiens importin 4 (IPO4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024658.3

ORF Insert Sequence:

ATGGAGTCAG CCGGGCTAGA GCAGCTCCTA CGGGAGCTGC TGCTACCGGA CACCGAGCGC 
ATCCGTCGGG CCACGGAACA GCTCCAGATC GTTCTTCGGG CCCCCGCCGC TTTGCCGGCT 
CTCTGCGACC TGCTAGCCTC GGCGGCCGAC CCCCAGATCC GCCAGTTTGC GGCCGTGCTG 
ACCCGCAGAC GACTGAACAC CCGCTGGCGA CGGCTGGCGG CGGAGCAACG GGAGAGCCTC 
AAGTCCCTGA TCCTGACGGC CCTGCAGAGA GAAACAGAGC ACTGTGTGAG CCTCAGCCTG 
GCCCAGCTCT CAGCCACCAT TTTTCGAAAG GAAGGCTTGG AGGCCTGGCC ACAGCTTTTG 
CAGCTGCTTC AGCACAGTAC CCACAGCCCC CACAGCCCAG AGAGAGAGAT GGGGCTTTTG 
CTGCTAAGTG TGGTGGTGAC CTCCCGGCCC GAGGCCTTCC AACCCCACCA CCGGGAGCTT 
CTTCGGCTTC TGAATGAGAC TCTTGGTGAG GTGGGCTCTC CTGGGCTGCT CTTCTACTCC 
CTGCGCACTC TGACCACCAT GGCTCCCTAC CTCAGCACTG AAGATGTGCC TCTCGCTCGG 
ATGTTGGTGC CCAAGCTGAT CATGGCCATG CAGACTCTGA TCCCCATAGA TGAGGCAAAG 
GCCTGTGAGG CCCTTGAGGC TTTGGATGAA CTGTTGGAGT CAGAGGTGCC GGTCATCACC 
CCCTACCTCT CTGAAGTCCT CACATTCTGC CTGGAGGTAG CTAGAAATGT GGCCCTGGGC 
AATGCGATAC GCATACGTAT TCTCTGCTGC CTCACTTTCT TGGTCAAAGT CAAGAGCAAG 
GCCTTACTGA AGAATCGTCT CCTGCCACCC TTGCTGCACA CCCTTTTCCC CATTGTGGCT 
GCTGAGCCCC CACCAGGCCA GTTGGATCCC GAGGACCAGG ATTCAGAAGA GGAAGAGTTG 
GAGATTGAGC TGATGGGGGA GACTCCCAAG CATTTCGCTG TACAAGTTGT GGACATGCTG 
GCACTACACC TGCCCCCCGA GAAGCTCTGT CCCCAGCTGA TGCCCATGTT GGAAGAGGCT 
TTGCGGAGCG AGAGCCCATA CCAGCGCAAA GCTGGACTCC TGGTGCTGGC CGTGCTGTCT 
GACGGAGCTG GCGACCACAT CAGGCAGAGA CTGCTGCCCC CACTGCTGCA GATTGTGTGC 
AAGGGCCTGG AGGACCCCTC GCAAGTTGTA CGCAATGCTG CGCTGTTTGC CCTGGGCCAG 
TTCTCAGAAA ACCTACAGCC CCATATCAGC AGCTATTCAA GGGAGGTAAT GCCACTGCTC 
CTCGCCTACT TGAAGTCGGT GCCTCTTGGA CACACACACC ACCTAGCCAA GGCCTGCTAT 
GCCCTGGAGA ATTTTGTGGA GAACCTAGGG CCCAAGGTGC AGCCCTACCT TCCGGAGCTT 
ATGGAATGCA TGCTGCAGCT TCTGAGGAAC CCCAGCAGTC CCCGGGCCAA GGAGCTGGCT 
GTGAGCGCCC TGGGAGCCAT TGCTACGGCT GCCCAGGCCT CGCTGCTGCC CTACTTCCCT 
GCCATCATGG AGCACCTGCG GGAATTCCTG TTAACAGGCC GTGAGGACCT TCAGCCTGTG 
CAGATCCAGA GCCTGGAGAC ACTGGGGGTG CTGGCACGAG CAGTGGGGGA GCCCATGAGG 
CCGCTGGCTG AGGAATGCTG CCAGCTGGGT CTGGGCCTCT GCGACCAGGT AGACGACCCT 
GACTTGCGGC GCTGCACGTA CAGCCTATTT GCAGCCTTAT CGGGTCTGAT GGGTGAGGGC 
CTGGCGCCCC ACTTGGAACA GATCACCACG CTCATGCTGC TGTCACTGCG TTCCACCGAG 
GGCATTGTGC CTCAGTATGA CGGGAGCAGC TCCTTCCTTC TGTTTGACGA TGAGAGTGAT 
GGGGAAGAAG AGGAGGAGCT CATGGATGAG GATGTGGAAG AAGAGGATGA CTCAGAGATC 
TCAGGGTACA GCGTGGAGAA TGCCTTCTTC GATGAGAAGG AAGACACCTG TGCTGCCGTG 
GGGGAGATCT CTGTGAACAC CAGTGTGGCC TTCCTTCCAT ACATGGAAAG TGTCTTTGAA 
GAAGTATTTA AACTGCTGGA GTGCCCTCAC CTGAATGTGC GGAAGGCAGC CCATGAGGCT 
CTGGGTCAGT TTTGCTGTGC ACTGCACAAG GCCTGTCAAA GCTGCCCCTC GGAACCCAAC 
ACTGCTGCTT TGCAGGCTGC CCTGGCCCGA GTCGTGCCAT CCTACATGCA GGCAGTGAAC 
AGGGAGCGGG AACGCCAGGT GGTGATGGCC GTGCTGGAGG CCCTGACAGG GGTGCTCCGC 
AGCTGTGGGA CCCTCACACT GAAGCCCCCT GGGCGCCTCG CTGAGCTCTG TGGCGTGCTC 
AAGGCTGTGC TGCAGAGGAA GACAGCCTGT CAGGATACTG ACGAGGAGGA GGAAGAGGAA 
GATGATGATC AGGCTGAATA CGACGCCATG TTGCTGGAGC ACGCTGGAGA GGCCATCCCT 
GCCCTGGCAG CCGCGGCTGG GGGAGACTCC TTTGCCCCAT TCTTTGCCGG TTTCCTGCCA 
TTATTGGTGT GCAAGACAAA ACAGGGCTGC ACAGTGGCAG AGAAGTCCTT TGCAGTGGGG 
ACCTTGGCAG AGACTATTCA GGGCCTGGGT GCTGCCTCAG CCCAGTTTGT GTCTCGGCTG 
CTCCCTGTGC TGTTGAGCAC CGCCCAAGAG GCAGACCCCG AGGTGCGAAG CAATGCCATC 
TTCGGGATGG GCGTGCTGGC AGAGCATGGG GGCCACCCTG CCCAGGAACA CTTCCCCAAG 
CTGCTGGGGC TCCTTTTTCC CCTCCTGGCG CGGGAGCGAC ATGATCGTGT CCGTGACAAC 
ATCTGTGGGG CACTTGCCCG CCTGTTGATG GCCAGTCCCA CCAGGAAACC AGAGCCCCAG 
GTGCTGGCTG CCCTACTGCA TGCCCTGCCA CTGAAGGAGG ACTTGGAGGA GTGGGTCACC 
ATTGGGCGCC TCTTCAGCTT CCTGTACCAG AGCAGCCCTG ACCAGGTTAT AGATGTGGCT 
CCCGAGCTTC TGCGTATCTG CAGCCTCATT CTGGCTGACA ACAAGATCCC ACCAGACACC 
AAGGCCGCAC TGTTGCTGCT CCTGACGTTC CTGGCCAAAC AGCACACCGA CAGCTTTCAA 
GCAGCTCTGG GCTCACTGCC TGTTGACAAG GCTCAGGAGC TCCAGGCTGT ACTGGGCCTC 
TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Competitive regulation of IPO4 transcription by ELK1 and GABP.
Gene61330-38(2017 May)
Xu P,Lin W,Liu F,Tartakoff A,Tao T

Recognition Elements in the Histone H3 and H4 Tails for Seven Different Importins.
The Journal of biological chemistry291(40)21171-21183(2016 Sep)
Soniat M,Ca?atay T,Chook YM

An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine.
PloS one6(10)e26044(2011)
Echeverr?a PC,Bernthaler A,Dupuis P,Mayer B,Picard D

CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage.
Proceedings of the National Academy of Sciences of the United States of America107(37)16131-6(2010 Sep)
Wang J,Sarkar TR,Zhou M,Sharan S,Ritt DA,Veenstra TD,Morrison DK,Huang AM,Sterneck E

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

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IPO4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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