STEAP4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	STEAP4
Entrez Gene ID	79689
Full Name	STEAP4 metalloreductase
Synonyms	STAMP2,SchLAH,TIARP,TNFAIP9
General protein information	Preferred Names STEAP4 metalloreductase Names metalloreductase STEAP4 STEAP family member 4 seven chromosome locus associated with HCC six transmembrane prostate protein 2 six-transmembrane epithelial antigen of prostate 4 sixTransMembrane protein of prostate 2 tumor necrosis factor, alpha-induced protein 9 tumor necrosis-alpha-induced adipose-related protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q21.12
Summary	The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011].
Disorder MIM:	611098

mRNA and Protein(s)

mRNA	Protein	Name
NM_024636.3	NP_078912.2	metalloreductase STEAP4 isoform 1
NM_001205316.1	NP_001192245.1	metalloreductase STEAP4 isoform 2
NM_001205316.2	NP_001192245.1	metalloreductase STEAP4 isoform 2
NM_001205315.2	NP_001192244.1	metalloreductase STEAP4 isoform 1
NM_001205315.1	NP_001192244.1	metalloreductase STEAP4 isoform 1
NM_024636.4	NP_078912.2	metalloreductase STEAP4 isoform 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	STEAP4	XP_002686905.1
Danio rerio (zebrafish)	steap4	XP_005158128.1
Rattus norvegicus (Norway rat)	Steap4	NP_001037730.1
Pan troglodytes (chimpanzee)	STEAP4	XP_001164605.1
	STEAP4	XP_001104041.1
Xenopus tropicalis (tropical clawed frog)	LOC100145516	NP_001120430.1
Mus musculus (house mouse)	Steap4	NP_473439.2
Homo sapiens (human)	STEAP4	NP_001192244.1
Canis lupus familiaris (dog)	STEAP4	XP_005628536.1
Gallus gallus (chicken)	STEAP4	XP_001235257.3
Xenopus tropicalis (tropical clawed frog)	steap4	NP_001015852.1

Gene Ontology
Bibliography

Related articles in PubMed

Clinical and functional significance of STEAP4-splice variant in CD14
Ebe H, Matsumoto I, Kawaguchi H, Kurata I, Tanaka Y, Inoue A, Kondo Y, Tsuboi H, Sumida T
Clinical and experimental immunology(2017 Oct)

STEAP4: its emerging role in metabolism and homeostasis of cellular iron and copper.
Scarl RT, Lawrence CM, Gordon HM, Nunemaker CS
The Journal of endocrinology234(3)R123-R134(2017 Sep)

STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation.
Gordon HM, Majithia N, MacDonald PE, Fox JEM, Sharma PR, Byrne FL, Hoehn KL, Evans-Molina C, Langman L, Brayman KL, Nunemaker CS
Endocrine56(3)528-537(2017 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

STEAP4 plays role in metal homeostasis is critical to the maintenance of cellular homeostasis , and in preventing the onset of metabolic disease. [review]
Title: STEAP4: its emerging role in metabolism and homeostasis of cellular iron and copper.

the expression of STEAP4 was significantly downregulated in the adipose tissue of obese children.
Title: Expression and clinical significance of obesity-associated gene STEAP4 in obese children.

The expression of TNFAIP9 significantly decreased in the adipose tissue of obese children, and its levels are closely related to blood lipid level, insulin resistance, and obesity.
Title: Expression and clinical significance of the obesity-related gene TNFAIP9 in obese children.

a down regulation of STEAP4 and up-regulation of HIF-1alpha are observed in morbidly obese patients
Title: STEAP4 and HIF-1? gene expressions in visceral and subcutaneous adipose tissue of the morbidly obese patients.

Some SNPs of the STEAP4 gene altered the risk of developing a metabolic syndrome in the Han Chinese population.
Title: Genetic Variants in Six-Transmembrane Epithelial Antigen of Prostate 4 Increase Risk of Developing Metabolic Syndrome in a Han Chinese Population.

The following STEAP4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the STEAP4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17449	NM_001205315.2 Latest version!	Homo sapiens STEAP4 metalloreductase (STEAP4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu17449	NM_024636.4 Latest version!	Homo sapiens STEAP4 metalloreductase (STEAP4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu17593	NM_001205316.2 Latest version!	Homo sapiens STEAP4 metalloreductase (STEAP4), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu17593	NM_001205316.1	Homo sapiens STEAP4 metalloreductase (STEAP4), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu17449	NM_001205315.1	Homo sapiens STEAP4 metalloreductase (STEAP4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu17449	NM_024636.3	Homo sapiens STEAP4 metalloreductase (STEAP4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

STEAP4 ( NM_024636.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_078912.2 Homo sapiens STEAP4 metalloreductase (STEAP4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17449
Clone ID Related Accession (Same CDS sequence)	NM_024636.3 , NM_001205315.2 , NM_001205315.1 , NM_024636.4
Accession Version	NM_024636.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1380bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-09
Organism	Homo sapiens(human)
Product	metalloreductase STEAP4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC333286.1, AK307644.1, AF423422.1 and AL833671.1. On Apr 14, 2011 this sequence version replaced NM_024636.2. Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.121056.1, SRR1803616.213191.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAAAA CTTGTATAGA TGCACTTCCT CTTACTATGA ATTCTTCAGA AAAGCAAGAG 
ACTGTATGTA TTTTTGGAAC TGGTGATTTT GGAAGATCAC TGGGATTGAA AATGCTCCAG 
TGTGGTTATT CTGTTGTTTT TGGAAGTCGA AACCCCCAGA AGACCACCCT ACTGCCCAGT 
GGTGCAGAAG TCTTGAGCTA TTCAGAAGCA GCCAAGAAGT CTGGCATCAT AATCATAGCA 
ATCCACAGAG AGCATTATGA TTTTCTCACA GAATTAACTG AGGTTCTCAA TGGAAAAATA 
TTGGTAGACA TCAGCAACAA CCTCAAAATC AATCAATATC CAGAATCTAA TGCAGAGTAC 
CTTGCTCATT TGGTGCCAGG AGCCCACGTG GTAAAAGCAT TTAACACCAT CTCAGCCTGG 
GCTCTCCAGT CAGGAGCACT GGATGCAAGT CGGCAGGTGT TTGTGTGTGG AAATGACAGC 
AAAGCCAAGC AAAGAGTGAT GGATATTGTT CGTAATCTTG GACTTACTCC AATGGATCAA 
GGATCACTCA TGGCAGCCAA AGAAATTGAA AAGTACCCCC TGCAGCTATT TCCAATGTGG 
AGGTTCCCCT TCTATTTGTC TGCTGTGCTG TGTGTCTTCT TGTTTTTCTA TTGTGTTATA 
AGAGACGTAA TCTACCCTTA TGTTTATGAA AAGAAAGATA ATACATTTCG TATGGCTATT 
TCCATTCCAA ATCGTATCTT TCCAATAACA GCACTTACAC TGCTTGCTTT GGTTTACCTC 
CCTGGTGTTA TTGCTGCCAT TCTACAACTG TACCGAGGCA CAAAATACCG TCGATTCCCA 
GACTGGCTTG ACCACTGGAT GCTTTGCCGA AAGCAGCTTG GCTTGGTAGC TCTGGGATTT 
GCCTTCCTTC ATGTCCTCTA CACACTTGTG ATTCCTATTC GATATTATGT ACGATGGAGA 
TTGGGAAACT TAACCGTTAC CCAGGCAATA CTCAAGAAGG AGAATCCATT TAGCACCTCC 
TCAGCCTGGC TCAGTGATTC ATATGTGGCT TTGGGAATAC TTGGGTTTTT TCTGTTTGTA 
CTCTTGGGAA TCACTTCTTT GCCATCTGTT AGCAATGCAG TCAACTGGAG AGAGTTCCGA 
TTTGTCCAGT CCAAACTGGG TTATTTGACC CTGATCTTGT GTACAGCCCA CACCCTGGTG 
TACGGTGGGA AGAGATTCCT CAGCCCTTCA AATCTCAGAT GGTATCTTCC TGCAGCCTAC 
GTGTTAGGGC TTATCATTCC TTGCACTGTG CTGGTGATCA AGTTTGTCCT AATCATGCCA 
TGTGTAGACA ACACCCTTAC AAGGATCCGC CAGGGCTGGG AAAGGAACTC AAAACACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_078912.2
CDS	125..1504
Translation	MEKTCIDALPLTMNSSEKQETVCIFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLPSGAEVLSYSEAAKKSGIIIIAIHREHYDFLTELTEVLNGKILVDISNNLKINQYPESNAEYLAHLVPGAHVVKAFNTISAWALQSGALDASRQVFVCGNDSKAKQRVMDIVRNLGLTPMDQGSLMAAKEIEKYPLQLFPMWRFPFYLSAVLCVFLFFYCVIRDVIYPYVYEKKDNTFRMAISIPNRIFPITALTLLALVYLPGVIAAILQLYRGTKYRRFPDWLDHWMLCRKQLGLVALGFAFLHVLYTLVIPIRYYVRWRLGNLTVTQAILKKENPFSTSSAWLSDSYVALGILGFFLFVLLGITSLPSVSNAVNWREFRFVQSKLGYLTLILCTAHTLVYGGKRFLSPSNLRWYLPAAYVLGLIIPCTVLVIKFVLIMPCVDNTLTRIRQGWERNSKH

Target ORF information:

RefSeq Version	NM_024636.3
Organism	Homo sapiens(human)
Definition	Homo sapiens STEAP4 metalloreductase (STEAP4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024636.3

ORF Insert Sequence:

ATGGAGAAAA CTTGTATAGA TGCACTTCCT CTTACTATGA ATTCTTCAGA AAAGCAAGAG 
ACTGTATGTA TTTTTGGAAC TGGTGATTTT GGAAGATCAC TGGGATTGAA AATGCTCCAG 
TGTGGTTATT CTGTTGTTTT TGGAAGTCGA AACCCCCAGA AGACCACCCT ACTGCCCAGT 
GGTGCAGAAG TCTTGAGCTA TTCAGAAGCA GCCAAGAAGT CTGGCATCAT AATCATAGCA 
ATCCACAGAG AGCATTATGA TTTTCTCACA GAATTAACTG AGGTTCTCAA TGGAAAAATA 
TTGGTAGACA TCAGCAACAA CCTCAAAATC AATCAATATC CAGAATCTAA TGCAGAGTAC 
CTTGCTCATT TGGTGCCAGG AGCCCACGTG GTAAAAGCAT TTAACACCAT CTCAGCCTGG 
GCTCTCCAGT CAGGAGCACT GGATGCAAGT CGGCAGGTGT TTGTGTGTGG AAATGACAGC 
AAAGCCAAGC AAAGAGTGAT GGATATTGTT CGTAATCTTG GACTTACTCC AATGGATCAA 
GGATCACTCA TGGCAGCCAA AGAAATTGAA AAGTACCCCC TGCAGCTATT TCCAATGTGG 
AGGTTCCCCT TCTATTTGTC TGCTGTGCTG TGTGTCTTCT TGTTTTTCTA TTGTGTTATA 
AGAGACGTAA TCTACCCTTA TGTTTATGAA AAGAAAGATA ATACATTTCG TATGGCTATT 
TCCATTCCAA ATCGTATCTT TCCAATAACA GCACTTACAC TGCTTGCTTT GGTTTACCTC 
CCTGGTGTTA TTGCTGCCAT TCTACAACTG TACCGAGGCA CAAAATACCG TCGATTCCCA 
GACTGGCTTG ACCACTGGAT GCTTTGCCGA AAGCAGCTTG GCTTGGTAGC TCTGGGATTT 
GCCTTCCTTC ATGTCCTCTA CACACTTGTG ATTCCTATTC GATATTATGT ACGATGGAGA 
TTGGGAAACT TAACCGTTAC CCAGGCAATA CTCAAGAAGG AGAATCCATT TAGCACCTCC 
TCAGCCTGGC TCAGTGATTC ATATGTGGCT TTGGGAATAC TTGGGTTTTT TCTGTTTGTA 
CTCTTGGGAA TCACTTCTTT GCCATCTGTT AGCAATGCAG TCAACTGGAG AGAGTTCCGA 
TTTGTCCAGT CCAAACTGGG TTATTTGACC CTGATCTTGT GTACAGCCCA CACCCTGGTG 
TACGGTGGGA AGAGATTCCT CAGCCCTTCA AATCTCAGAT GGTATCTTCC TGCAGCCTAC 
GTGTTAGGGC TTATCATTCC TTGCACTGTG CTGGTGATCA AGTTTGTCCT AATCATGCCA 
TGTGTAGACA ACACCCTTAC AAGGATCCGC CAGGGCTGGG AAAGGAACTC AAAACACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

STEAP4 ( NM_001205315.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001192244.1 Homo sapiens STEAP4 metalloreductase (STEAP4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu17449
Clone ID Related Accession (Same CDS sequence)	NM_024636.3 , NM_001205315.2 , NM_001205315.1 , NM_024636.4
Accession Version	NM_001205315.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1380bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	metalloreductase STEAP4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC333286.1, DB162772.1, AF423422.1, AL833671.1 and AC003991.1. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_001205315.1. Transcript Variant: This variant (2) contains an additional 5' non-coding exon, and has a longer 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.23149.1, SRR1803615.267144.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGAAAA CTTGTATAGA TGCACTTCCT CTTACTATGA ATTCTTCAGA AAAGCAAGAG 
ACTGTATGTA TTTTTGGAAC TGGTGATTTT GGAAGATCAC TGGGATTGAA AATGCTCCAG 
TGTGGTTATT CTGTTGTTTT TGGAAGTCGA AACCCCCAGA AGACCACCCT ACTGCCCAGT 
GGTGCAGAAG TCTTGAGCTA TTCAGAAGCA GCCAAGAAGT CTGGCATCAT AATCATAGCA 
ATCCACAGAG AGCATTATGA TTTTCTCACA GAATTAACTG AGGTTCTCAA TGGAAAAATA 
TTGGTAGACA TCAGCAACAA CCTCAAAATC AATCAATATC CAGAATCTAA TGCAGAGTAC 
CTTGCTCATT TGGTGCCAGG AGCCCACGTG GTAAAAGCAT TTAACACCAT CTCAGCCTGG 
GCTCTCCAGT CAGGAGCACT GGATGCAAGT CGGCAGGTGT TTGTGTGTGG AAATGACAGC 
AAAGCCAAGC AAAGAGTGAT GGATATTGTT CGTAATCTTG GACTTACTCC AATGGATCAA 
GGATCACTCA TGGCAGCCAA AGAAATTGAA AAGTACCCCC TGCAGCTATT TCCAATGTGG 
AGGTTCCCCT TCTATTTGTC TGCTGTGCTG TGTGTCTTCT TGTTTTTCTA TTGTGTTATA 
AGAGACGTAA TCTACCCTTA TGTTTATGAA AAGAAAGATA ATACATTTCG TATGGCTATT 
TCCATTCCAA ATCGTATCTT TCCAATAACA GCACTTACAC TGCTTGCTTT GGTTTACCTC 
CCTGGTGTTA TTGCTGCCAT TCTACAACTG TACCGAGGCA CAAAATACCG TCGATTCCCA 
GACTGGCTTG ACCACTGGAT GCTTTGCCGA AAGCAGCTTG GCTTGGTAGC TCTGGGATTT 
GCCTTCCTTC ATGTCCTCTA CACACTTGTG ATTCCTATTC GATATTATGT ACGATGGAGA 
TTGGGAAACT TAACCGTTAC CCAGGCAATA CTCAAGAAGG AGAATCCATT TAGCACCTCC 
TCAGCCTGGC TCAGTGATTC ATATGTGGCT TTGGGAATAC TTGGGTTTTT TCTGTTTGTA 
CTCTTGGGAA TCACTTCTTT GCCATCTGTT AGCAATGCAG TCAACTGGAG AGAGTTCCGA 
TTTGTCCAGT CCAAACTGGG TTATTTGACC CTGATCTTGT GTACAGCCCA CACCCTGGTG 
TACGGTGGGA AGAGATTCCT CAGCCCTTCA AATCTCAGAT GGTATCTTCC TGCAGCCTAC 
GTGTTAGGGC TTATCATTCC TTGCACTGTG CTGGTGATCA AGTTTGTCCT AATCATGCCA 
TGTGTAGACA ACACCCTTAC AAGGATCCGC CAGGGCTGGG AAAGGAACTC AAAACACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001192244.1
CDS	205..1584
Translation	MEKTCIDALPLTMNSSEKQETVCIFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLPSGAEVLSYSEAAKKSGIIIIAIHREHYDFLTELTEVLNGKILVDISNNLKINQYPESNAEYLAHLVPGAHVVKAFNTISAWALQSGALDASRQVFVCGNDSKAKQRVMDIVRNLGLTPMDQGSLMAAKEIEKYPLQLFPMWRFPFYLSAVLCVFLFFYCVIRDVIYPYVYEKKDNTFRMAISIPNRIFPITALTLLALVYLPGVIAAILQLYRGTKYRRFPDWLDHWMLCRKQLGLVALGFAFLHVLYTLVIPIRYYVRWRLGNLTVTQAILKKENPFSTSSAWLSDSYVALGILGFFLFVLLGITSLPSVSNAVNWREFRFVQSKLGYLTLILCTAHTLVYGGKRFLSPSNLRWYLPAAYVLGLIIPCTVLVIKFVLIMPCVDNTLTRIRQGWERNSKH

Target ORF information:

RefSeq Version	NM_001205315.2
Organism	Homo sapiens(human)
Definition	Homo sapiens STEAP4 metalloreductase (STEAP4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001205315.2

ORF Insert Sequence:

ATGGAGAAAA CTTGTATAGA TGCACTTCCT CTTACTATGA ATTCTTCAGA AAAGCAAGAG 
ACTGTATGTA TTTTTGGAAC TGGTGATTTT GGAAGATCAC TGGGATTGAA AATGCTCCAG 
TGTGGTTATT CTGTTGTTTT TGGAAGTCGA AACCCCCAGA AGACCACCCT ACTGCCCAGT 
GGTGCAGAAG TCTTGAGCTA TTCAGAAGCA GCCAAGAAGT CTGGCATCAT AATCATAGCA 
ATCCACAGAG AGCATTATGA TTTTCTCACA GAATTAACTG AGGTTCTCAA TGGAAAAATA 
TTGGTAGACA TCAGCAACAA CCTCAAAATC AATCAATATC CAGAATCTAA TGCAGAGTAC 
CTTGCTCATT TGGTGCCAGG AGCCCACGTG GTAAAAGCAT TTAACACCAT CTCAGCCTGG 
GCTCTCCAGT CAGGAGCACT GGATGCAAGT CGGCAGGTGT TTGTGTGTGG AAATGACAGC 
AAAGCCAAGC AAAGAGTGAT GGATATTGTT CGTAATCTTG GACTTACTCC AATGGATCAA 
GGATCACTCA TGGCAGCCAA AGAAATTGAA AAGTACCCCC TGCAGCTATT TCCAATGTGG 
AGGTTCCCCT TCTATTTGTC TGCTGTGCTG TGTGTCTTCT TGTTTTTCTA TTGTGTTATA 
AGAGACGTAA TCTACCCTTA TGTTTATGAA AAGAAAGATA ATACATTTCG TATGGCTATT 
TCCATTCCAA ATCGTATCTT TCCAATAACA GCACTTACAC TGCTTGCTTT GGTTTACCTC 
CCTGGTGTTA TTGCTGCCAT TCTACAACTG TACCGAGGCA CAAAATACCG TCGATTCCCA 
GACTGGCTTG ACCACTGGAT GCTTTGCCGA AAGCAGCTTG GCTTGGTAGC TCTGGGATTT 
GCCTTCCTTC ATGTCCTCTA CACACTTGTG ATTCCTATTC GATATTATGT ACGATGGAGA 
TTGGGAAACT TAACCGTTAC CCAGGCAATA CTCAAGAAGG AGAATCCATT TAGCACCTCC 
TCAGCCTGGC TCAGTGATTC ATATGTGGCT TTGGGAATAC TTGGGTTTTT TCTGTTTGTA 
CTCTTGGGAA TCACTTCTTT GCCATCTGTT AGCAATGCAG TCAACTGGAG AGAGTTCCGA 
TTTGTCCAGT CCAAACTGGG TTATTTGACC CTGATCTTGT GTACAGCCCA CACCCTGGTG 
TACGGTGGGA AGAGATTCCT CAGCCCTTCA AATCTCAGAT GGTATCTTCC TGCAGCCTAC 
GTGTTAGGGC TTATCATTCC TTGCACTGTG CTGGTGATCA AGTTTGTCCT AATCATGCCA 
TGTGTAGACA ACACCCTTAC AAGGATCCGC CAGGGCTGGG AAAGGAACTC AAAACACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

STEAP4 ( NM_001205315.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001192244.1 Homo sapiens STEAP4 metalloreductase (STEAP4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu17449
Clone ID Related Accession (Same CDS sequence)	NM_024636.3 , NM_001205315.2 , NM_001205315.1 , NM_024636.4
Accession Version	NM_001205315.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1380bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-09
Organism	Homo sapiens(human)
Product	metalloreductase STEAP4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC333286.1, DB162772.1, AF423422.1 and AL833671.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (2) contains an additional 5' non-coding exon, and has a longer 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.267144.1, SRR1660809.75557.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAAAA CTTGTATAGA TGCACTTCCT CTTACTATGA ATTCTTCAGA AAAGCAAGAG 
ACTGTATGTA TTTTTGGAAC TGGTGATTTT GGAAGATCAC TGGGATTGAA AATGCTCCAG 
TGTGGTTATT CTGTTGTTTT TGGAAGTCGA AACCCCCAGA AGACCACCCT ACTGCCCAGT 
GGTGCAGAAG TCTTGAGCTA TTCAGAAGCA GCCAAGAAGT CTGGCATCAT AATCATAGCA 
ATCCACAGAG AGCATTATGA TTTTCTCACA GAATTAACTG AGGTTCTCAA TGGAAAAATA 
TTGGTAGACA TCAGCAACAA CCTCAAAATC AATCAATATC CAGAATCTAA TGCAGAGTAC 
CTTGCTCATT TGGTGCCAGG AGCCCACGTG GTAAAAGCAT TTAACACCAT CTCAGCCTGG 
GCTCTCCAGT CAGGAGCACT GGATGCAAGT CGGCAGGTGT TTGTGTGTGG AAATGACAGC 
AAAGCCAAGC AAAGAGTGAT GGATATTGTT CGTAATCTTG GACTTACTCC AATGGATCAA 
GGATCACTCA TGGCAGCCAA AGAAATTGAA AAGTACCCCC TGCAGCTATT TCCAATGTGG 
AGGTTCCCCT TCTATTTGTC TGCTGTGCTG TGTGTCTTCT TGTTTTTCTA TTGTGTTATA 
AGAGACGTAA TCTACCCTTA TGTTTATGAA AAGAAAGATA ATACATTTCG TATGGCTATT 
TCCATTCCAA ATCGTATCTT TCCAATAACA GCACTTACAC TGCTTGCTTT GGTTTACCTC 
CCTGGTGTTA TTGCTGCCAT TCTACAACTG TACCGAGGCA CAAAATACCG TCGATTCCCA 
GACTGGCTTG ACCACTGGAT GCTTTGCCGA AAGCAGCTTG GCTTGGTAGC TCTGGGATTT 
GCCTTCCTTC ATGTCCTCTA CACACTTGTG ATTCCTATTC GATATTATGT ACGATGGAGA 
TTGGGAAACT TAACCGTTAC CCAGGCAATA CTCAAGAAGG AGAATCCATT TAGCACCTCC 
TCAGCCTGGC TCAGTGATTC ATATGTGGCT TTGGGAATAC TTGGGTTTTT TCTGTTTGTA 
CTCTTGGGAA TCACTTCTTT GCCATCTGTT AGCAATGCAG TCAACTGGAG AGAGTTCCGA 
TTTGTCCAGT CCAAACTGGG TTATTTGACC CTGATCTTGT GTACAGCCCA CACCCTGGTG 
TACGGTGGGA AGAGATTCCT CAGCCCTTCA AATCTCAGAT GGTATCTTCC TGCAGCCTAC 
GTGTTAGGGC TTATCATTCC TTGCACTGTG CTGGTGATCA AGTTTGTCCT AATCATGCCA 
TGTGTAGACA ACACCCTTAC AAGGATCCGC CAGGGCTGGG AAAGGAACTC AAAACACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001192244.1
CDS	224..1603
Translation	MEKTCIDALPLTMNSSEKQETVCIFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLPSGAEVLSYSEAAKKSGIIIIAIHREHYDFLTELTEVLNGKILVDISNNLKINQYPESNAEYLAHLVPGAHVVKAFNTISAWALQSGALDASRQVFVCGNDSKAKQRVMDIVRNLGLTPMDQGSLMAAKEIEKYPLQLFPMWRFPFYLSAVLCVFLFFYCVIRDVIYPYVYEKKDNTFRMAISIPNRIFPITALTLLALVYLPGVIAAILQLYRGTKYRRFPDWLDHWMLCRKQLGLVALGFAFLHVLYTLVIPIRYYVRWRLGNLTVTQAILKKENPFSTSSAWLSDSYVALGILGFFLFVLLGITSLPSVSNAVNWREFRFVQSKLGYLTLILCTAHTLVYGGKRFLSPSNLRWYLPAAYVLGLIIPCTVLVIKFVLIMPCVDNTLTRIRQGWERNSKH

Target ORF information:

RefSeq Version	NM_001205315.1
Organism	Homo sapiens(human)
Definition	Homo sapiens STEAP4 metalloreductase (STEAP4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001205315.1

ORF Insert Sequence:

ATGGAGAAAA CTTGTATAGA TGCACTTCCT CTTACTATGA ATTCTTCAGA AAAGCAAGAG 
ACTGTATGTA TTTTTGGAAC TGGTGATTTT GGAAGATCAC TGGGATTGAA AATGCTCCAG 
TGTGGTTATT CTGTTGTTTT TGGAAGTCGA AACCCCCAGA AGACCACCCT ACTGCCCAGT 
GGTGCAGAAG TCTTGAGCTA TTCAGAAGCA GCCAAGAAGT CTGGCATCAT AATCATAGCA 
ATCCACAGAG AGCATTATGA TTTTCTCACA GAATTAACTG AGGTTCTCAA TGGAAAAATA 
TTGGTAGACA TCAGCAACAA CCTCAAAATC AATCAATATC CAGAATCTAA TGCAGAGTAC 
CTTGCTCATT TGGTGCCAGG AGCCCACGTG GTAAAAGCAT TTAACACCAT CTCAGCCTGG 
GCTCTCCAGT CAGGAGCACT GGATGCAAGT CGGCAGGTGT TTGTGTGTGG AAATGACAGC 
AAAGCCAAGC AAAGAGTGAT GGATATTGTT CGTAATCTTG GACTTACTCC AATGGATCAA 
GGATCACTCA TGGCAGCCAA AGAAATTGAA AAGTACCCCC TGCAGCTATT TCCAATGTGG 
AGGTTCCCCT TCTATTTGTC TGCTGTGCTG TGTGTCTTCT TGTTTTTCTA TTGTGTTATA 
AGAGACGTAA TCTACCCTTA TGTTTATGAA AAGAAAGATA ATACATTTCG TATGGCTATT 
TCCATTCCAA ATCGTATCTT TCCAATAACA GCACTTACAC TGCTTGCTTT GGTTTACCTC 
CCTGGTGTTA TTGCTGCCAT TCTACAACTG TACCGAGGCA CAAAATACCG TCGATTCCCA 
GACTGGCTTG ACCACTGGAT GCTTTGCCGA AAGCAGCTTG GCTTGGTAGC TCTGGGATTT 
GCCTTCCTTC ATGTCCTCTA CACACTTGTG ATTCCTATTC GATATTATGT ACGATGGAGA 
TTGGGAAACT TAACCGTTAC CCAGGCAATA CTCAAGAAGG AGAATCCATT TAGCACCTCC 
TCAGCCTGGC TCAGTGATTC ATATGTGGCT TTGGGAATAC TTGGGTTTTT TCTGTTTGTA 
CTCTTGGGAA TCACTTCTTT GCCATCTGTT AGCAATGCAG TCAACTGGAG AGAGTTCCGA 
TTTGTCCAGT CCAAACTGGG TTATTTGACC CTGATCTTGT GTACAGCCCA CACCCTGGTG 
TACGGTGGGA AGAGATTCCT CAGCCCTTCA AATCTCAGAT GGTATCTTCC TGCAGCCTAC 
GTGTTAGGGC TTATCATTCC TTGCACTGTG CTGGTGATCA AGTTTGTCCT AATCATGCCA 
TGTGTAGACA ACACCCTTAC AAGGATCCGC CAGGGCTGGG AAAGGAACTC AAAACACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

STEAP4 ( NM_024636.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_078912.2 Homo sapiens STEAP4 metalloreductase (STEAP4), transcript variant 1, mRNA.

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CloneID	OHu17449
Clone ID Related Accession (Same CDS sequence)	NM_024636.3 , NM_001205315.2 , NM_001205315.1 , NM_024636.4
Accession Version	NM_024636.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1380bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-01
Organism	Homo sapiens(human)
Product	metalloreductase STEAP4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC333286.1, AK307644.1, AF423422.1, AL833671.1 and AC003991.1. On Jun 2, 2019 this sequence version replaced NM_024636.3. Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.213191.1, SRR1803611.54527.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAAAA CTTGTATAGA TGCACTTCCT CTTACTATGA ATTCTTCAGA AAAGCAAGAG 
ACTGTATGTA TTTTTGGAAC TGGTGATTTT GGAAGATCAC TGGGATTGAA AATGCTCCAG 
TGTGGTTATT CTGTTGTTTT TGGAAGTCGA AACCCCCAGA AGACCACCCT ACTGCCCAGT 
GGTGCAGAAG TCTTGAGCTA TTCAGAAGCA GCCAAGAAGT CTGGCATCAT AATCATAGCA 
ATCCACAGAG AGCATTATGA TTTTCTCACA GAATTAACTG AGGTTCTCAA TGGAAAAATA 
TTGGTAGACA TCAGCAACAA CCTCAAAATC AATCAATATC CAGAATCTAA TGCAGAGTAC 
CTTGCTCATT TGGTGCCAGG AGCCCACGTG GTAAAAGCAT TTAACACCAT CTCAGCCTGG 
GCTCTCCAGT CAGGAGCACT GGATGCAAGT CGGCAGGTGT TTGTGTGTGG AAATGACAGC 
AAAGCCAAGC AAAGAGTGAT GGATATTGTT CGTAATCTTG GACTTACTCC AATGGATCAA 
GGATCACTCA TGGCAGCCAA AGAAATTGAA AAGTACCCCC TGCAGCTATT TCCAATGTGG 
AGGTTCCCCT TCTATTTGTC TGCTGTGCTG TGTGTCTTCT TGTTTTTCTA TTGTGTTATA 
AGAGACGTAA TCTACCCTTA TGTTTATGAA AAGAAAGATA ATACATTTCG TATGGCTATT 
TCCATTCCAA ATCGTATCTT TCCAATAACA GCACTTACAC TGCTTGCTTT GGTTTACCTC 
CCTGGTGTTA TTGCTGCCAT TCTACAACTG TACCGAGGCA CAAAATACCG TCGATTCCCA 
GACTGGCTTG ACCACTGGAT GCTTTGCCGA AAGCAGCTTG GCTTGGTAGC TCTGGGATTT 
GCCTTCCTTC ATGTCCTCTA CACACTTGTG ATTCCTATTC GATATTATGT ACGATGGAGA 
TTGGGAAACT TAACCGTTAC CCAGGCAATA CTCAAGAAGG AGAATCCATT TAGCACCTCC 
TCAGCCTGGC TCAGTGATTC ATATGTGGCT TTGGGAATAC TTGGGTTTTT TCTGTTTGTA 
CTCTTGGGAA TCACTTCTTT GCCATCTGTT AGCAATGCAG TCAACTGGAG AGAGTTCCGA 
TTTGTCCAGT CCAAACTGGG TTATTTGACC CTGATCTTGT GTACAGCCCA CACCCTGGTG 
TACGGTGGGA AGAGATTCCT CAGCCCTTCA AATCTCAGAT GGTATCTTCC TGCAGCCTAC 
GTGTTAGGGC TTATCATTCC TTGCACTGTG CTGGTGATCA AGTTTGTCCT AATCATGCCA 
TGTGTAGACA ACACCCTTAC AAGGATCCGC CAGGGCTGGG AAAGGAACTC AAAACACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_078912.2
CDS	106..1485
Translation	MEKTCIDALPLTMNSSEKQETVCIFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLPSGAEVLSYSEAAKKSGIIIIAIHREHYDFLTELTEVLNGKILVDISNNLKINQYPESNAEYLAHLVPGAHVVKAFNTISAWALQSGALDASRQVFVCGNDSKAKQRVMDIVRNLGLTPMDQGSLMAAKEIEKYPLQLFPMWRFPFYLSAVLCVFLFFYCVIRDVIYPYVYEKKDNTFRMAISIPNRIFPITALTLLALVYLPGVIAAILQLYRGTKYRRFPDWLDHWMLCRKQLGLVALGFAFLHVLYTLVIPIRYYVRWRLGNLTVTQAILKKENPFSTSSAWLSDSYVALGILGFFLFVLLGITSLPSVSNAVNWREFRFVQSKLGYLTLILCTAHTLVYGGKRFLSPSNLRWYLPAAYVLGLIIPCTVLVIKFVLIMPCVDNTLTRIRQGWERNSKH

Target ORF information:

RefSeq Version	NM_024636.4
Organism	Homo sapiens(human)
Definition	Homo sapiens STEAP4 metalloreductase (STEAP4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024636.4

ORF Insert Sequence:

ATGGAGAAAA CTTGTATAGA TGCACTTCCT CTTACTATGA ATTCTTCAGA AAAGCAAGAG 
ACTGTATGTA TTTTTGGAAC TGGTGATTTT GGAAGATCAC TGGGATTGAA AATGCTCCAG 
TGTGGTTATT CTGTTGTTTT TGGAAGTCGA AACCCCCAGA AGACCACCCT ACTGCCCAGT 
GGTGCAGAAG TCTTGAGCTA TTCAGAAGCA GCCAAGAAGT CTGGCATCAT AATCATAGCA 
ATCCACAGAG AGCATTATGA TTTTCTCACA GAATTAACTG AGGTTCTCAA TGGAAAAATA 
TTGGTAGACA TCAGCAACAA CCTCAAAATC AATCAATATC CAGAATCTAA TGCAGAGTAC 
CTTGCTCATT TGGTGCCAGG AGCCCACGTG GTAAAAGCAT TTAACACCAT CTCAGCCTGG 
GCTCTCCAGT CAGGAGCACT GGATGCAAGT CGGCAGGTGT TTGTGTGTGG AAATGACAGC 
AAAGCCAAGC AAAGAGTGAT GGATATTGTT CGTAATCTTG GACTTACTCC AATGGATCAA 
GGATCACTCA TGGCAGCCAA AGAAATTGAA AAGTACCCCC TGCAGCTATT TCCAATGTGG 
AGGTTCCCCT TCTATTTGTC TGCTGTGCTG TGTGTCTTCT TGTTTTTCTA TTGTGTTATA 
AGAGACGTAA TCTACCCTTA TGTTTATGAA AAGAAAGATA ATACATTTCG TATGGCTATT 
TCCATTCCAA ATCGTATCTT TCCAATAACA GCACTTACAC TGCTTGCTTT GGTTTACCTC 
CCTGGTGTTA TTGCTGCCAT TCTACAACTG TACCGAGGCA CAAAATACCG TCGATTCCCA 
GACTGGCTTG ACCACTGGAT GCTTTGCCGA AAGCAGCTTG GCTTGGTAGC TCTGGGATTT 
GCCTTCCTTC ATGTCCTCTA CACACTTGTG ATTCCTATTC GATATTATGT ACGATGGAGA 
TTGGGAAACT TAACCGTTAC CCAGGCAATA CTCAAGAAGG AGAATCCATT TAGCACCTCC 
TCAGCCTGGC TCAGTGATTC ATATGTGGCT TTGGGAATAC TTGGGTTTTT TCTGTTTGTA 
CTCTTGGGAA TCACTTCTTT GCCATCTGTT AGCAATGCAG TCAACTGGAG AGAGTTCCGA 
TTTGTCCAGT CCAAACTGGG TTATTTGACC CTGATCTTGT GTACAGCCCA CACCCTGGTG 
TACGGTGGGA AGAGATTCCT CAGCCCTTCA AATCTCAGAT GGTATCTTCC TGCAGCCTAC 
GTGTTAGGGC TTATCATTCC TTGCACTGTG CTGGTGATCA AGTTTGTCCT AATCATGCCA 
TGTGTAGACA ACACCCTTAC AAGGATCCGC CAGGGCTGGG AAAGGAACTC AAAACACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

STEAP4 ( NM_001205316.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001192245.1 Homo sapiens STEAP4 metalloreductase (STEAP4), transcript variant 3, mRNA.

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CloneID	OHu17593
Clone ID Related Accession (Same CDS sequence)	NM_001205316.1 , NM_001205316.2
Accession Version	NM_001205316.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 852bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-09
Organism	Homo sapiens(human)
Product	metalloreductase STEAP4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC333286.1, AK307644.1, BC020600.1 and AL833671.1. Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) missing an internal protein segment compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC020600.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142680, SAMEA2145240 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAAAA CTTGTATAGA TGCACTTCCT CTTACTATGA ATTCTTCAGA AAAGCAAGAG 
ACTGTATGTA TTTTTGGAAC TGGTGATTTT GGAAGATCAC TGGGATTGAA AATGCTCCAG 
TGTGGTTATT CTGTTGTTTT TGGAAGTCGA AACCCCCAGA AGACCACCCT ACTGCCCAGT 
GGTGCAGAAG TCTTGAGCTA TTCAGAAGCA GCCAAGAAGT CTGGCATCAT AATCATAGCA 
ATCCACAGAG AGCATTATGA TTTTCTCACA GAATTAACTG AGGTTCTCAA TGGAAAAATA 
TTGGTAGACA TCAGCAACAA CCTCAAAATC AATCAATATC CAGAATCTAA TGCAGAGTAC 
CTTGCTCATT TGGTGCCAGG AGCCCACGTG GTAAAAGCAT TTAACACCAT CTCAGCCTGG 
GCTCTCCAGT CAGGAGCACT GGATGCAAGT CGGCAGGCAA TACTCAAGAA GGAGAATCCA 
TTTAGCACCT CCTCAGCCTG GCTCAGTGAT TCATATGTGG CTTTGGGAAT ACTTGGGTTT 
TTTCTGTTTG TACTCTTGGG AATCACTTCT TTGCCATCTG TTAGCAATGC AGTCAACTGG 
AGAGAGTTCC GATTTGTCCA GTCCAAACTG GGTTATTTGA CCCTGATCTT GTGTACAGCC 
CACACCCTGG TGTACGGTGG GAAGAGATTC CTCAGCCCTT CAAATCTCAG ATGGTATCTT 
CCTGCAGCCT ACGTGTTAGG GCTTATCATT CCTTGCACTG TGCTGGTGAT CAAGTTTGTC 
CTAATCATGC CATGTGTAGA CAACACCCTT ACAAGGATCC GCCAGGGCTG GGAAAGGAAC 
TCAAAACACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001192245.1
CDS	125..976
Translation	MEKTCIDALPLTMNSSEKQETVCIFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLPSGAEVLSYSEAAKKSGIIIIAIHREHYDFLTELTEVLNGKILVDISNNLKINQYPESNAEYLAHLVPGAHVVKAFNTISAWALQSGALDASRQAILKKENPFSTSSAWLSDSYVALGILGFFLFVLLGITSLPSVSNAVNWREFRFVQSKLGYLTLILCTAHTLVYGGKRFLSPSNLRWYLPAAYVLGLIIPCTVLVIKFVLIMPCVDNTLTRIRQGWERNSKH

Target ORF information:

RefSeq Version	NM_001205316.1
Organism	Homo sapiens(human)
Definition	Homo sapiens STEAP4 metalloreductase (STEAP4), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001205316.1

ORF Insert Sequence:

ATGGAGAAAA CTTGTATAGA TGCACTTCCT CTTACTATGA ATTCTTCAGA AAAGCAAGAG 
ACTGTATGTA TTTTTGGAAC TGGTGATTTT GGAAGATCAC TGGGATTGAA AATGCTCCAG 
TGTGGTTATT CTGTTGTTTT TGGAAGTCGA AACCCCCAGA AGACCACCCT ACTGCCCAGT 
GGTGCAGAAG TCTTGAGCTA TTCAGAAGCA GCCAAGAAGT CTGGCATCAT AATCATAGCA 
ATCCACAGAG AGCATTATGA TTTTCTCACA GAATTAACTG AGGTTCTCAA TGGAAAAATA 
TTGGTAGACA TCAGCAACAA CCTCAAAATC AATCAATATC CAGAATCTAA TGCAGAGTAC 
CTTGCTCATT TGGTGCCAGG AGCCCACGTG GTAAAAGCAT TTAACACCAT CTCAGCCTGG 
GCTCTCCAGT CAGGAGCACT GGATGCAAGT CGGCAGGCAA TACTCAAGAA GGAGAATCCA 
TTTAGCACCT CCTCAGCCTG GCTCAGTGAT TCATATGTGG CTTTGGGAAT ACTTGGGTTT 
TTTCTGTTTG TACTCTTGGG AATCACTTCT TTGCCATCTG TTAGCAATGC AGTCAACTGG 
AGAGAGTTCC GATTTGTCCA GTCCAAACTG GGTTATTTGA CCCTGATCTT GTGTACAGCC 
CACACCCTGG TGTACGGTGG GAAGAGATTC CTCAGCCCTT CAAATCTCAG ATGGTATCTT 
CCTGCAGCCT ACGTGTTAGG GCTTATCATT CCTTGCACTG TGCTGGTGAT CAAGTTTGTC 
CTAATCATGC CATGTGTAGA CAACACCCTT ACAAGGATCC GCCAGGGCTG GGAAAGGAAC 
TCAAAACACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

STEAP4 ( NM_001205316.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001192245.1 Homo sapiens STEAP4 metalloreductase (STEAP4), transcript variant 3, mRNA.

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CloneID	OHu17593
Clone ID Related Accession (Same CDS sequence)	NM_001205316.1 , NM_001205316.2
Accession Version	NM_001205316.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 852bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-01
Organism	Homo sapiens(human)
Product	metalloreductase STEAP4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC333286.1, AK307644.1, BC020600.1, AL833671.1 and AC003991.1. On Jun 2, 2019 this sequence version replaced NM_001205316.1. Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) missing an internal protein segment compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.1835622.1, BC020600.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142680, SAMEA2145240 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAAAA CTTGTATAGA TGCACTTCCT CTTACTATGA ATTCTTCAGA AAAGCAAGAG 
ACTGTATGTA TTTTTGGAAC TGGTGATTTT GGAAGATCAC TGGGATTGAA AATGCTCCAG 
TGTGGTTATT CTGTTGTTTT TGGAAGTCGA AACCCCCAGA AGACCACCCT ACTGCCCAGT 
GGTGCAGAAG TCTTGAGCTA TTCAGAAGCA GCCAAGAAGT CTGGCATCAT AATCATAGCA 
ATCCACAGAG AGCATTATGA TTTTCTCACA GAATTAACTG AGGTTCTCAA TGGAAAAATA 
TTGGTAGACA TCAGCAACAA CCTCAAAATC AATCAATATC CAGAATCTAA TGCAGAGTAC 
CTTGCTCATT TGGTGCCAGG AGCCCACGTG GTAAAAGCAT TTAACACCAT CTCAGCCTGG 
GCTCTCCAGT CAGGAGCACT GGATGCAAGT CGGCAGGCAA TACTCAAGAA GGAGAATCCA 
TTTAGCACCT CCTCAGCCTG GCTCAGTGAT TCATATGTGG CTTTGGGAAT ACTTGGGTTT 
TTTCTGTTTG TACTCTTGGG AATCACTTCT TTGCCATCTG TTAGCAATGC AGTCAACTGG 
AGAGAGTTCC GATTTGTCCA GTCCAAACTG GGTTATTTGA CCCTGATCTT GTGTACAGCC 
CACACCCTGG TGTACGGTGG GAAGAGATTC CTCAGCCCTT CAAATCTCAG ATGGTATCTT 
CCTGCAGCCT ACGTGTTAGG GCTTATCATT CCTTGCACTG TGCTGGTGAT CAAGTTTGTC 
CTAATCATGC CATGTGTAGA CAACACCCTT ACAAGGATCC GCCAGGGCTG GGAAAGGAAC 
TCAAAACACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001192245.1
CDS	106..957
Translation	MEKTCIDALPLTMNSSEKQETVCIFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLPSGAEVLSYSEAAKKSGIIIIAIHREHYDFLTELTEVLNGKILVDISNNLKINQYPESNAEYLAHLVPGAHVVKAFNTISAWALQSGALDASRQAILKKENPFSTSSAWLSDSYVALGILGFFLFVLLGITSLPSVSNAVNWREFRFVQSKLGYLTLILCTAHTLVYGGKRFLSPSNLRWYLPAAYVLGLIIPCTVLVIKFVLIMPCVDNTLTRIRQGWERNSKH

Target ORF information:

RefSeq Version	NM_001205316.2
Organism	Homo sapiens(human)
Definition	Homo sapiens STEAP4 metalloreductase (STEAP4), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001205316.2

ORF Insert Sequence:

ATGGAGAAAA CTTGTATAGA TGCACTTCCT CTTACTATGA ATTCTTCAGA AAAGCAAGAG 
ACTGTATGTA TTTTTGGAAC TGGTGATTTT GGAAGATCAC TGGGATTGAA AATGCTCCAG 
TGTGGTTATT CTGTTGTTTT TGGAAGTCGA AACCCCCAGA AGACCACCCT ACTGCCCAGT 
GGTGCAGAAG TCTTGAGCTA TTCAGAAGCA GCCAAGAAGT CTGGCATCAT AATCATAGCA 
ATCCACAGAG AGCATTATGA TTTTCTCACA GAATTAACTG AGGTTCTCAA TGGAAAAATA 
TTGGTAGACA TCAGCAACAA CCTCAAAATC AATCAATATC CAGAATCTAA TGCAGAGTAC 
CTTGCTCATT TGGTGCCAGG AGCCCACGTG GTAAAAGCAT TTAACACCAT CTCAGCCTGG 
GCTCTCCAGT CAGGAGCACT GGATGCAAGT CGGCAGGCAA TACTCAAGAA GGAGAATCCA 
TTTAGCACCT CCTCAGCCTG GCTCAGTGAT TCATATGTGG CTTTGGGAAT ACTTGGGTTT 
TTTCTGTTTG TACTCTTGGG AATCACTTCT TTGCCATCTG TTAGCAATGC AGTCAACTGG 
AGAGAGTTCC GATTTGTCCA GTCCAAACTG GGTTATTTGA CCCTGATCTT GTGTACAGCC 
CACACCCTGG TGTACGGTGG GAAGAGATTC CTCAGCCCTT CAAATCTCAG ATGGTATCTT 
CCTGCAGCCT ACGTGTTAGG GCTTATCATT CCTTGCACTG TGCTGGTGAT CAAGTTTGTC 
CTAATCATGC CATGTGTAGA CAACACCCTT ACAAGGATCC GCCAGGGCTG GGAAAGGAAC 
TCAAAACACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Clinical and functional significance of STEAP4-splice variant in CD14
Clinical and experimental immunology(2017 Oct)
Ebe H,Matsumoto I,Kawaguchi H,Kurata I,Tanaka Y,Inoue A,Kondo Y,Tsuboi H,Sumida T

STEAP4: its emerging role in metabolism and homeostasis of cellular iron and copper.
The Journal of endocrinology234(3)R123-R134(2017 Sep)
Scarl RT,Lawrence CM,Gordon HM,Nunemaker CS

STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation.
Endocrine56(3)528-537(2017 Jun)
Gordon HM,Majithia N,MacDonald PE,Fox JEM,Sharma PR,Byrne FL,Hoehn KL,Evans-Molina C,Langman L,Brayman KL,Nunemaker CS

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STEAP4 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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