PANK3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PANK3
Entrez Gene ID	79646
Full Name	pantothenate kinase 3
General protein information	Preferred Names pantothenate kinase 3 Names pantothenate kinase 3 hPanK3 pantothenic acid kinase 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q34
Summary	This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver. [provided by RefSeq, Jul 2008].
Disorder MIM:	606161

mRNA and Protein(s)

mRNA	Protein	Name
NM_024594.4	NP_078870.1	pantothenate kinase 3
NM_024594.3	NP_078870.1	pantothenate kinase 3

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Pank3	NP_001101742.1
Gallus gallus (chicken)	PANK3	XP_414502.3
Xenopus tropicalis (tropical clawed frog)	pank3	NP_001107378.1
Homo sapiens (human)	PANK3	NP_078870.1
	PANK3	XP_002804670.1
Mus musculus (house mouse)	Pank3	NP_666074.1
Pan troglodytes (chimpanzee)	PANK3	XP_518087.3
Canis lupus familiaris (dog)	PANK3	XP_546251.2
Bos taurus (cattle)	PANK3	NP_001068931.1

Gene Ontology
Bibliography

Related articles in PubMed

Allosteric Regulation of Mammalian Pantothenate Kinase.
Subramanian C, Yun MK, Yao J, Sharma LK, Lee RE, White SW, Jackowski S, Rock CO
The Journal of biological chemistry291(42)22302-22314(2016 Oct)

Compartmentalization of mammalian pantothenate kinases.
Alfonso-Pecchio A, Garcia M, Leonardi R, Jackowski S
PloS one7(11)e49509(2012)

Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain.
Leonardi R, Zhang YM, Yun MK, Zhou R, Zeng FY, Lin W, Cui J, Chen T, Rock CO, White SW, Jackowski S
Chemistry & biology17(8)892-902(2010 Aug)

Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.
Hong BS, Senisterra G, Rabeh WM, Vedadi M, Leonardi R, Zhang YM, Rock CO, Jackowski S, Park HW
The Journal of biological chemistry282(38)27984-93(2007 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Biochemical analyses showed that the transition between the inactive and active conformations, as assessed by the binding of either ATP.Mg(2+) or acyl-CoA to PANK3, is highly cooperative indicating that both protomers move in concert.
Title: Allosteric Regulation of Mammalian Pantothenate Kinase.

analysis of the homodimeric structures of the catalytic cores of PanK1alpha and PanK3 in complex with acetyl-CoA and the the structural effects of the PanK2 mutations that have been implicated in neurodegeneration
Title: Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.

The following PANK3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PANK3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00352	NM_024594.4 Latest version!	Homo sapiens pantothenate kinase 3 (PANK3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu00352	NM_024594.3	Homo sapiens pantothenate kinase 3 (PANK3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PANK3 ( NM_024594.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_078870.1 Homo sapiens pantothenate kinase 3 (PANK3), mRNA.

Price & Availability↑

CloneID	OHu00352
Clone ID Related Accession (Same CDS sequence)	NM_024594.4 , NM_024594.3
Accession Version	NM_024594.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1113bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	pantothenate kinase 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB045475.1, BC013705.1, AC020894.5 and AA831520.1. On Nov 23, 2018 this sequence version replaced NM_024594.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.11331.1, SRR3476690.841492.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000239231.7/ ENSP00000239231.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGATCA AAGATGCCAA GAAACCCTCT TTCCCATGGT TTGGCATGGA CATTGGGGGA 
ACTCTAGTAA AGCTCTCGTA CTTTGAACCT ATTGATATCA CAGCAGAGGA AGAGCAAGAA 
GAAGTTGAGA GTTTAAAAAG TATTCGGAAA TATTTGACTT CTAACGTGGC ATATGGATCC 
ACCGGCATTC GGGATGTACA CCTTGAACTG AAAGATTTAA CACTTTTTGG CCGAAGAGGG 
AACTTGCACT TTATCAGGTT TCCAACCCAG GACCTGCCTA CTTTTATCCA AATGGGAAGA 
GATAAAAACT TCTCAACATT GCAGACGGTG CTATGTGCTA CAGGAGGTGG TGCTTACAAG 
TTTGAAAAAG ATTTTCGCAC AATTGGAAAC CTCCACCTGC ACAAACTGGA TGAACTTGAC 
TGCCTTGTAA AGGGCTTGCT GTATATAGAC TCTGTCAGTT TCAATGGACA AGCCGAGTGC 
TATTATTTTG CTAATGCCTC AGAACCTGAG CGATGCCAAA AGATGCCTTT TAACCTGGAT 
GATCCCTATC CACTGCTTGT AGTGAACATT GGCTCAGGAG TCAGTATTTT AGCAGTCCAT 
TCCAAAGACA ACTATAAACG AGTGACTGGG ACAAGCCTTG GAGGGGGTAC CTTTCTGGGT 
TTATGCAGTT TATTGACTGG CTGTGAAAGT TTTGAAGAGG CTCTTGAAAT GGCATCCAAA 
GGTGATAGCA CACAAGCTGA CAAGCTGGTC CGTGATATTT ATGGAGGAGA TTATGAAAGA 
TTTGGTTTGC CAGGTTGGGC TGTAGCATCT AGTTTTGGGA ATATGATTTA TAAGGAGAAG 
CGAGAATCTG TTAGTAAAGA AGATCTGGCA AGAGCTACTT TAGTTACTAT CACCAATAAC 
ATTGGTTCTG TGGCACGAAT GTGTGCTGTT AATGAGAAAA TAAACAGAGT TGTCTTTGTT 
GGAAACTTTT TACGTGTCAA TACCCTCTCA ATGAAACTTT TGGCATATGC ACTGGATTAC 
TGGTCAAAAG GTCAACTAAA AGCATTGTTT CTAGAACATG AGGGTTACTT TGGAGCAGTT 
GGTGCACTTC TTGGGCTGCC AAATTTCAGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_078870.1
CDS	86..1198
Translation	MKIKDAKKPSFPWFGMDIGGTLVKLSYFEPIDITAEEEQEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDKNFSTLQTVLCATGGGAYKFEKDFRTIGNLHLHKLDELDCLVKGLLYIDSVSFNGQAECYYFANASEPERCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTQADKLVRDIYGGDYERFGLPGWAVASSFGNMIYKEKRESVSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTLSMKLLAYALDYWSKGQLKALFLEHEGYFGAVGALLGLPNFS

Target ORF information:

RefSeq Version	NM_024594.4
Organism	Homo sapiens(human)
Definition	Homo sapiens pantothenate kinase 3 (PANK3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024594.4

ORF Insert Sequence:

ATGAAGATCA AAGATGCCAA GAAACCCTCT TTCCCATGGT TTGGCATGGA CATTGGGGGA 
ACTCTAGTAA AGCTCTCGTA CTTTGAACCT ATTGATATCA CAGCAGAGGA AGAGCAAGAA 
GAAGTTGAGA GTTTAAAAAG TATTCGGAAA TATTTGACTT CTAACGTGGC ATATGGATCC 
ACCGGCATTC GGGATGTACA CCTTGAACTG AAAGATTTAA CACTTTTTGG CCGAAGAGGG 
AACTTGCACT TTATCAGGTT TCCAACCCAG GACCTGCCTA CTTTTATCCA AATGGGAAGA 
GATAAAAACT TCTCAACATT GCAGACGGTG CTATGTGCTA CAGGAGGTGG TGCTTACAAG 
TTTGAAAAAG ATTTTCGCAC AATTGGAAAC CTCCACCTGC ACAAACTGGA TGAACTTGAC 
TGCCTTGTAA AGGGCTTGCT GTATATAGAC TCTGTCAGTT TCAATGGACA AGCCGAGTGC 
TATTATTTTG CTAATGCCTC AGAACCTGAG CGATGCCAAA AGATGCCTTT TAACCTGGAT 
GATCCCTATC CACTGCTTGT AGTGAACATT GGCTCAGGAG TCAGTATTTT AGCAGTCCAT 
TCCAAAGACA ACTATAAACG AGTGACTGGG ACAAGCCTTG GAGGGGGTAC CTTTCTGGGT 
TTATGCAGTT TATTGACTGG CTGTGAAAGT TTTGAAGAGG CTCTTGAAAT GGCATCCAAA 
GGTGATAGCA CACAAGCTGA CAAGCTGGTC CGTGATATTT ATGGAGGAGA TTATGAAAGA 
TTTGGTTTGC CAGGTTGGGC TGTAGCATCT AGTTTTGGGA ATATGATTTA TAAGGAGAAG 
CGAGAATCTG TTAGTAAAGA AGATCTGGCA AGAGCTACTT TAGTTACTAT CACCAATAAC 
ATTGGTTCTG TGGCACGAAT GTGTGCTGTT AATGAGAAAA TAAACAGAGT TGTCTTTGTT 
GGAAACTTTT TACGTGTCAA TACCCTCTCA ATGAAACTTT TGGCATATGC ACTGGATTAC 
TGGTCAAAAG GTCAACTAAA AGCATTGTTT CTAGAACATG AGGGTTACTT TGGAGCAGTT 
GGTGCACTTC TTGGGCTGCC AAATTTCAGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PANK3 ( NM_024594.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_078870.1 Homo sapiens pantothenate kinase 3 (PANK3), mRNA.

Price & Availability↑

CloneID	OHu00352
Clone ID Related Accession (Same CDS sequence)	NM_024594.4 , NM_024594.3
Accession Version	NM_024594.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1113bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	pantothenate kinase 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC020894.5, CB045475.1, BC013705.1 and AA831520.1. On Jan 5, 2011 this sequence version replaced NM_024594.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.11331.1, SRR1803614.197740.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGATCA AAGATGCCAA GAAACCCTCT TTCCCATGGT TTGGCATGGA CATTGGGGGA 
ACTCTAGTAA AGCTCTCGTA CTTTGAACCT ATTGATATCA CAGCAGAGGA AGAGCAAGAA 
GAAGTTGAGA GTTTAAAAAG TATTCGGAAA TATTTGACTT CTAACGTGGC ATATGGATCC 
ACCGGCATTC GGGATGTACA CCTTGAACTG AAAGATTTAA CACTTTTTGG CCGAAGAGGG 
AACTTGCACT TTATCAGGTT TCCAACCCAG GACCTGCCTA CTTTTATCCA AATGGGAAGA 
GATAAAAACT TCTCAACATT GCAGACGGTG CTATGTGCTA CAGGAGGTGG TGCTTACAAG 
TTTGAAAAAG ATTTTCGCAC AATTGGAAAC CTCCACCTGC ACAAACTGGA TGAACTTGAC 
TGCCTTGTAA AGGGCTTGCT GTATATAGAC TCTGTCAGTT TCAATGGACA AGCCGAGTGC 
TATTATTTTG CTAATGCCTC AGAACCTGAG CGATGCCAAA AGATGCCTTT TAACCTGGAT 
GATCCCTATC CACTGCTTGT AGTGAACATT GGCTCAGGAG TCAGTATTTT AGCAGTCCAT 
TCCAAAGACA ACTATAAACG AGTGACTGGG ACAAGCCTTG GAGGGGGTAC CTTTCTGGGT 
TTATGCAGTT TATTGACTGG CTGTGAAAGT TTTGAAGAGG CTCTTGAAAT GGCATCCAAA 
GGTGATAGCA CACAAGCTGA CAAGCTGGTC CGTGATATTT ATGGAGGAGA TTATGAAAGA 
TTTGGTTTGC CAGGTTGGGC TGTAGCATCT AGTTTTGGGA ATATGATTTA TAAGGAGAAG 
CGAGAATCTG TTAGTAAAGA AGATCTGGCA AGAGCTACTT TAGTTACTAT CACCAATAAC 
ATTGGTTCTG TGGCACGAAT GTGTGCTGTT AATGAGAAAA TAAACAGAGT TGTCTTTGTT 
GGAAACTTTT TACGTGTCAA TACCCTCTCA ATGAAACTTT TGGCATATGC ACTGGATTAC 
TGGTCAAAAG GTCAACTAAA AGCATTGTTT CTAGAACATG AGGGTTACTT TGGAGCAGTT 
GGTGCACTTC TTGGGCTGCC AAATTTCAGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_078870.1
CDS	327..1439
Translation	MKIKDAKKPSFPWFGMDIGGTLVKLSYFEPIDITAEEEQEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDKNFSTLQTVLCATGGGAYKFEKDFRTIGNLHLHKLDELDCLVKGLLYIDSVSFNGQAECYYFANASEPERCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTQADKLVRDIYGGDYERFGLPGWAVASSFGNMIYKEKRESVSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTLSMKLLAYALDYWSKGQLKALFLEHEGYFGAVGALLGLPNFS

Target ORF information:

RefSeq Version	NM_024594.3
Organism	Homo sapiens(human)
Definition	Homo sapiens pantothenate kinase 3 (PANK3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024594.3

ORF Insert Sequence:

ATGAAGATCA AAGATGCCAA GAAACCCTCT TTCCCATGGT TTGGCATGGA CATTGGGGGA 
ACTCTAGTAA AGCTCTCGTA CTTTGAACCT ATTGATATCA CAGCAGAGGA AGAGCAAGAA 
GAAGTTGAGA GTTTAAAAAG TATTCGGAAA TATTTGACTT CTAACGTGGC ATATGGATCC 
ACCGGCATTC GGGATGTACA CCTTGAACTG AAAGATTTAA CACTTTTTGG CCGAAGAGGG 
AACTTGCACT TTATCAGGTT TCCAACCCAG GACCTGCCTA CTTTTATCCA AATGGGAAGA 
GATAAAAACT TCTCAACATT GCAGACGGTG CTATGTGCTA CAGGAGGTGG TGCTTACAAG 
TTTGAAAAAG ATTTTCGCAC AATTGGAAAC CTCCACCTGC ACAAACTGGA TGAACTTGAC 
TGCCTTGTAA AGGGCTTGCT GTATATAGAC TCTGTCAGTT TCAATGGACA AGCCGAGTGC 
TATTATTTTG CTAATGCCTC AGAACCTGAG CGATGCCAAA AGATGCCTTT TAACCTGGAT 
GATCCCTATC CACTGCTTGT AGTGAACATT GGCTCAGGAG TCAGTATTTT AGCAGTCCAT 
TCCAAAGACA ACTATAAACG AGTGACTGGG ACAAGCCTTG GAGGGGGTAC CTTTCTGGGT 
TTATGCAGTT TATTGACTGG CTGTGAAAGT TTTGAAGAGG CTCTTGAAAT GGCATCCAAA 
GGTGATAGCA CACAAGCTGA CAAGCTGGTC CGTGATATTT ATGGAGGAGA TTATGAAAGA 
TTTGGTTTGC CAGGTTGGGC TGTAGCATCT AGTTTTGGGA ATATGATTTA TAAGGAGAAG 
CGAGAATCTG TTAGTAAAGA AGATCTGGCA AGAGCTACTT TAGTTACTAT CACCAATAAC 
ATTGGTTCTG TGGCACGAAT GTGTGCTGTT AATGAGAAAA TAAACAGAGT TGTCTTTGTT 
GGAAACTTTT TACGTGTCAA TACCCTCTCA ATGAAACTTT TGGCATATGC ACTGGATTAC 
TGGTCAAAAG GTCAACTAAA AGCATTGTTT CTAGAACATG AGGGTTACTT TGGAGCAGTT 
GGTGCACTTC TTGGGCTGCC AAATTTCAGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Allosteric Regulation of Mammalian Pantothenate Kinase.
The Journal of biological chemistry291(42)22302-22314(2016 Oct)
Subramanian C,Yun MK,Yao J,Sharma LK,Lee RE,White SW,Jackowski S,Rock CO

Compartmentalization of mammalian pantothenate kinases.
PloS one7(11)e49509(2012)
Alfonso-Pecchio A,Garcia M,Leonardi R,Jackowski S

Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain.
Chemistry & biology17(8)892-902(2010 Aug)
Leonardi R,Zhang YM,Yun MK,Zhou R,Zeng FY,Lin W,Cui J,Chen T,Rock CO,White SW,Jackowski S

Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.
The Journal of biological chemistry282(38)27984-93(2007 Sep)
Hong BS,Senisterra G,Rabeh WM,Vedadi M,Leonardi R,Zhang YM,Rock CO,Jackowski S,Park HW

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PANK3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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