VKORC1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	VKORC1
Entrez Gene ID	79001
Full Name	vitamin K epoxide reductase complex subunit 1
Synonyms	EDTP308,MST134,MST576,VKCFD2,VKOR
General protein information	Preferred Names vitamin K epoxide reductase complex subunit 1 Names vitamin K epoxide reductase complex subunit 1 phylloquinone epoxide reductase vitamin K dependent clotting factors deficiency 2 vitamin K1 2,3-epoxide reductase subunit 1 vitamin K1 epoxide reductase (warfarin-sensitive)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p11.2
Summary	This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
Disorder MIM:	608547
Disorder Html:	Vitamin K-dependent clotting factors, combined deficiency of, 2, 607473 (3); Warfarin resistance, 122700 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011545944.1	XP_011544246.1	vitamin K epoxide reductase complex subunit 1 isoform X1
NM_206824.2	NP_996560.1	vitamin K epoxide reductase complex subunit 1 isoform 2 precursor
NM_024006.6	NP_076869.1	vitamin K epoxide reductase complex subunit 1 isoform 1 precursor
NM_001311311.1	NP_001298240.1	vitamin K epoxide reductase complex subunit 1 isoform 3 precursor
NM_024006.5	NP_076869.1	vitamin K epoxide reductase complex subunit 1 isoform 1 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Vkorc1	NP_976080.1
Canis lupus familiaris (dog)	VKORC1	XP_005621301.1
Bos taurus (cattle)	VKORC1	NP_001003903.1
Drosophila melanogaster (fruit fly)	Vkor	NP_001014533.1
Pan troglodytes (chimpanzee)	VKORC1	NP_001238859.1
Homo sapiens (human)	VKORC1	NP_076869.1
Mus musculus (house mouse)	Vkorc1	NP_848715.1
Danio rerio (zebrafish)	vkorc1	XP_001336460.1

Gene Ontology
Bibliography

Related articles in PubMed

Human Herpesvirus 8 Interleukin-6 Interacts with Calnexin Cycle Components and Promotes Protein Folding.
Chen D, Xiang Q, Nicholas J
Journal of virology91(22)(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

VKORC1 genotype influenced the likelihood of INR lability during warfarin maintenance in atrial fibrillation patients.
Title: Genetic and Non-Genetic Factors Affecting the Quality of Anticoagulation Control and Vascular Events in Atrial Fibrillation.

results suggest that the VKORC1 gene rs7294 polymorphism is important for the development of essential hypertension
Title: Susceptiveness of Vitamin K epOxide Reductase Complex Subunit 1 Gene Polymorphism in Essential Hypertension.

Three SNPs (CYP2C9 *2, *3 and VKORC1 c.-1639G > A) were genotyped by electrochemical detection using a sandwich-type format that included a 3' short thiol capture probe and a 5' ferrocene-labeled signal probe.
Title: DNA sensors to assess the effect of VKORC1 and CYP2C9 gene polymorphisms on warfarin dose requirement in Chinese patients with atrial fibrillation.

Possession of CYP2C9*2 and/or CYP2C9*3 allele variants is associated with lower time of international normalized ratio (INR) in the therapeutic range (TTR) values and warfarin dose variations in aortic valve replacement patients, the latter affected also by VKORC1 c.-1693G>A polymorphism
Title: Factors influencing quality of anticoagulation control and warfarin dosage in patients after aortic valve replacement within the 3 months of follow up.

ESR1 and VKORC1 single nucleotide polymorphisms were used to determine the vitamin K dosage in patients with ulcer-related hemorrhage.
Title: [HORMONALLY-GENETICALLY DEPENDENT THERAPY, USING VITAMIN K IN PATIENTS, SUFFERING THE ULCER HEMORRHAGE].

The following VKORC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VKORC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25428	NM_024006.6 Latest version!	Homo sapiens vitamin K epoxide reductase complex subunit 1 (VKORC1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu71714	NM_001311311.1 Latest version!	Homo sapiens vitamin K epoxide reductase complex subunit 1 (VKORC1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu25428	XM_011545944.1 Latest version!	Homo sapiens vitamin K epoxide reductase complex, subunit 1 (VKORC1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu11764	NM_206824.2 Latest version!	Homo sapiens vitamin K epoxide reductase complex subunit 1 (VKORC1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu25428	NM_024006.5	Homo sapiens vitamin K epoxide reductase complex subunit 1 (VKORC1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

VKORC1 ( NM_024006.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_076869.1 Homo sapiens vitamin K epoxide reductase complex subunit 1 (VKORC1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25428
Clone ID Related Accession (Same CDS sequence)	XM_011545944.1 , NM_024006.6 , NM_024006.5
Accession Version	NM_024006.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 492bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-25
Organism	Homo sapiens(human)
Product	vitamin K epoxide reductase complex subunit 1 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI822140.1, BC002911.2, AY423044.1 and AY358456.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_024006.5. Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. It encodes isoform 1, which is shorter than isoform 3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY466113.1, SRR1163655.424216.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000394975.3/ ENSP00000378426.2 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCAGCA CCTGGGGGAG CCCTGGCTGG GTGCGGCTCG CTCTTTGCCT GACGGGCTTA 
GTGCTCTCGC TCTACGCGCT GCACGTGAAG GCGGCGCGCG CCCGGGACCG GGATTACCGC 
GCGCTCTGCG ACGTGGGCAC CGCCATCAGC TGTTCGCGCG TCTTCTCCTC CAGGTGGGGC 
AGGGGTTTCG GGCTGGTGGA GCATGTGCTG GGACAGGACA GCATCCTCAA TCAATCCAAC 
AGCATATTCG GTTGCATCTT CTACACACTA CAGCTATTGT TAGGTTGCCT GCGGACACGC 
TGGGCCTCTG TCCTGATGCT GCTGAGCTCC CTGGTGTCTC TCGCTGGTTC TGTCTACCTG 
GCCTGGATCC TGTTCTTCGT GCTCTATGAT TTCTGCATTG TTTGTATCAC CACCTATGCT 
ATCAACGTGA GCCTGATGTG GCTCAGTTTC CGGAAGGTCC AAGAACCCCA GGGCAAGGCT 
AAGAGGCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076869.1
CDS	69..560
Translation	MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLVSLAGSVYLAWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQEPQGKAKRH

Target ORF information:

RefSeq Version	NM_024006.6
Organism	Homo sapiens(human)
Definition	Homo sapiens vitamin K epoxide reductase complex subunit 1 (VKORC1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024006.6

ORF Insert Sequence:

ATGGGCAGCA CCTGGGGGAG CCCTGGCTGG GTGCGGCTCG CTCTTTGCCT GACGGGCTTA 
GTGCTCTCGC TCTACGCGCT GCACGTGAAG GCGGCGCGCG CCCGGGACCG GGATTACCGC 
GCGCTCTGCG ACGTGGGCAC CGCCATCAGC TGTTCGCGCG TCTTCTCCTC CAGGTGGGGC 
AGGGGTTTCG GGCTGGTGGA GCATGTGCTG GGACAGGACA GCATCCTCAA TCAATCCAAC 
AGCATATTCG GTTGCATCTT CTACACACTA CAGCTATTGT TAGGTTGCCT GCGGACACGC 
TGGGCCTCTG TCCTGATGCT GCTGAGCTCC CTGGTGTCTC TCGCTGGTTC TGTCTACCTG 
GCCTGGATCC TGTTCTTCGT GCTCTATGAT TTCTGCATTG TTTGTATCAC CACCTATGCT 
ATCAACGTGA GCCTGATGTG GCTCAGTTTC CGGAAGGTCC AAGAACCCCA GGGCAAGGCT 
AAGAGGCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VKORC1 ( NM_024006.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_076869.1 Homo sapiens vitamin K epoxide reductase complex subunit 1 (VKORC1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25428
Clone ID Related Accession (Same CDS sequence)	XM_011545944.1 , NM_024006.6 , NM_024006.5
Accession Version	NM_024006.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 492bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	vitamin K epoxide reductase complex subunit 1 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB064454.1, BI822140.1, BC002911.2, AY423044.1, AY358456.1 and BM663008.1. This sequence is a reference standard in the RefSeqGene project. On Aug 8, 2015 this sequence version replaced NM_024006.4. Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. It encodes isoform 1, which is shorter than isoform 3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.27870.1, SRR1163655.424216.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAGCA CCTGGGGGAG CCCTGGCTGG GTGCGGCTCG CTCTTTGCCT GACGGGCTTA 
GTGCTCTCGC TCTACGCGCT GCACGTGAAG GCGGCGCGCG CCCGGGACCG GGATTACCGC 
GCGCTCTGCG ACGTGGGCAC CGCCATCAGC TGTTCGCGCG TCTTCTCCTC CAGGTGGGGC 
AGGGGTTTCG GGCTGGTGGA GCATGTGCTG GGACAGGACA GCATCCTCAA TCAATCCAAC 
AGCATATTCG GTTGCATCTT CTACACACTA CAGCTATTGT TAGGTTGCCT GCGGACACGC 
TGGGCCTCTG TCCTGATGCT GCTGAGCTCC CTGGTGTCTC TCGCTGGTTC TGTCTACCTG 
GCCTGGATCC TGTTCTTCGT GCTCTATGAT TTCTGCATTG TTTGTATCAC CACCTATGCT 
ATCAACGTGA GCCTGATGTG GCTCAGTTTC CGGAAGGTCC AAGAACCCCA GGGCAAGGCT 
AAGAGGCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076869.1
CDS	271..762
Translation	MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLVSLAGSVYLAWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQEPQGKAKRH

Target ORF information:

RefSeq Version	NM_024006.5
Organism	Homo sapiens(human)
Definition	Homo sapiens vitamin K epoxide reductase complex subunit 1 (VKORC1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024006.5

ORF Insert Sequence:

ATGGGCAGCA CCTGGGGGAG CCCTGGCTGG GTGCGGCTCG CTCTTTGCCT GACGGGCTTA 
GTGCTCTCGC TCTACGCGCT GCACGTGAAG GCGGCGCGCG CCCGGGACCG GGATTACCGC 
GCGCTCTGCG ACGTGGGCAC CGCCATCAGC TGTTCGCGCG TCTTCTCCTC CAGGTGGGGC 
AGGGGTTTCG GGCTGGTGGA GCATGTGCTG GGACAGGACA GCATCCTCAA TCAATCCAAC 
AGCATATTCG GTTGCATCTT CTACACACTA CAGCTATTGT TAGGTTGCCT GCGGACACGC 
TGGGCCTCTG TCCTGATGCT GCTGAGCTCC CTGGTGTCTC TCGCTGGTTC TGTCTACCTG 
GCCTGGATCC TGTTCTTCGT GCTCTATGAT TTCTGCATTG TTTGTATCAC CACCTATGCT 
ATCAACGTGA GCCTGATGTG GCTCAGTTTC CGGAAGGTCC AAGAACCCCA GGGCAAGGCT 
AAGAGGCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VKORC1 ( NM_001311311.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001298240.1 Homo sapiens vitamin K epoxide reductase complex subunit 1 (VKORC1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu71714
Clone ID Related Accession (Same CDS sequence)	NM_001311311.1
Accession Version	NM_001311311.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-30
Organism	Homo sapiens(human)
Product	vitamin K epoxide reductase complex subunit 1 isoform 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB064454.1, AK312005.1, CN484751.1 and BM663008.1. On Aug 6, 2015 this sequence version replaced XM_011545943.1. Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.25946.1, SRR1163655.260875.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAGCA CCTGGGGGAG CCCTGGCTGG GTGCGGCTCG CTCTTTGCCT GACGGGCTTA 
GTGCTCTCGC TCTACGCGCT GCACGTGAAG GCGGCGCGCG CCCGGGACCG GGATTACCGC 
GCGCTCTGCG ACGTGGGCAC CGCCATCAGC TGTTCGCGCG TCTTCTCCTC CAGGTGGGGC 
AGGGGTTTCG GGCTGGTGGA GCATGTGCTG GGACAGGACA GCATCCTCAA TCAATCCAAC 
AGCATATTCG GTTGCATCTT CTACACACTA CAGCTATTGT TAGAGATGGT GTCTCGCCAT 
GTTGCCCAGG CTGGTCTCAA GCAATCTGTC TGCCTCAGCC TCCCAAAGTG CTGGGGGGAT 
TACAGGCGTT GCCTGCGGAC ACGCTGGGCC TCTGTCCTGA TGCTGCTGAG CTCCCTGGTG 
TCTCTCGCTG GTTCTGTCTA CCTGGCCTGG ATCCTGTTCT TCGTGCTCTA TGATTTCTGC 
ATTGTTTGTA TCACCACCTA TGCTATCAAC GTGAGCCTGA TGTGGCTCAG TTTCCGGAAG 
GTCCAAGAAC CCCAGGGCAA GGCTAAGAGG CACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001298240.1
CDS	271..846
Translation	MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLEMVSRHVAQAGLKQSVCLSLPKCWGDYRRCLRTRWASVLMLLSSLVSLAGSVYLAWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQEPQGKAKRH

Target ORF information:

RefSeq Version	NM_001311311.1
Organism	Homo sapiens(human)
Definition	Homo sapiens vitamin K epoxide reductase complex subunit 1 (VKORC1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001311311.1

ORF Insert Sequence:

ATGGGCAGCA CCTGGGGGAG CCCTGGCTGG GTGCGGCTCG CTCTTTGCCT GACGGGCTTA 
GTGCTCTCGC TCTACGCGCT GCACGTGAAG GCGGCGCGCG CCCGGGACCG GGATTACCGC 
GCGCTCTGCG ACGTGGGCAC CGCCATCAGC TGTTCGCGCG TCTTCTCCTC CAGGTGGGGC 
AGGGGTTTCG GGCTGGTGGA GCATGTGCTG GGACAGGACA GCATCCTCAA TCAATCCAAC 
AGCATATTCG GTTGCATCTT CTACACACTA CAGCTATTGT TAGAGATGGT GTCTCGCCAT 
GTTGCCCAGG CTGGTCTCAA GCAATCTGTC TGCCTCAGCC TCCCAAAGTG CTGGGGGGAT 
TACAGGCGTT GCCTGCGGAC ACGCTGGGCC TCTGTCCTGA TGCTGCTGAG CTCCCTGGTG 
TCTCTCGCTG GTTCTGTCTA CCTGGCCTGG ATCCTGTTCT TCGTGCTCTA TGATTTCTGC 
ATTGTTTGTA TCACCACCTA TGCTATCAAC GTGAGCCTGA TGTGGCTCAG TTTCCGGAAG 
GTCCAAGAAC CCCAGGGCAA GGCTAAGAGG CACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VKORC1 ( XM_011545944.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011544246.1 Homo sapiens vitamin K epoxide reductase complex, subunit 1 (VKORC1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu25428
Clone ID Related Accession (Same CDS sequence)	XM_011545944.1 , NM_024006.6 , NM_024006.5
Accession Version	XM_011545944.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 492bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	vitamin K epoxide reductase complex subunit 1 isoform X1
Comment

ATGGGCAGCA CCTGGGGGAG CCCTGGCTGG GTGCGGCTCG CTCTTTGCCT GACGGGCTTA 
GTGCTCTCGC TCTACGCGCT GCACGTGAAG GCGGCGCGCG CCCGGGACCG GGATTACCGC 
GCGCTCTGCG ACGTGGGCAC CGCCATCAGC TGTTCGCGCG TCTTCTCCTC CAGGTGGGGC 
AGGGGTTTCG GGCTGGTGGA GCATGTGCTG GGACAGGACA GCATCCTCAA TCAATCCAAC 
AGCATATTCG GTTGCATCTT CTACACACTA CAGCTATTGT TAGGTTGCCT GCGGACACGC 
TGGGCCTCTG TCCTGATGCT GCTGAGCTCC CTGGTGTCTC TCGCTGGTTC TGTCTACCTG 
GCCTGGATCC TGTTCTTCGT GCTCTATGAT TTCTGCATTG TTTGTATCAC CACCTATGCT 
ATCAACGTGA GCCTGATGTG GCTCAGTTTC CGGAAGGTCC AAGAACCCCA GGGCAAGGCT 
AAGAGGCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011544246.1
Translation	MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLVSLAGSVYLAWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQEPQGKAKRH

Target ORF information:

RefSeq Version	XM_011545944.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens vitamin K epoxide reductase complex, subunit 1 (VKORC1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011545944.1

ORF Insert Sequence:

ATGGGCAGCA CCTGGGGGAG CCCTGGCTGG GTGCGGCTCG CTCTTTGCCT GACGGGCTTA 
GTGCTCTCGC TCTACGCGCT GCACGTGAAG GCGGCGCGCG CCCGGGACCG GGATTACCGC 
GCGCTCTGCG ACGTGGGCAC CGCCATCAGC TGTTCGCGCG TCTTCTCCTC CAGGTGGGGC 
AGGGGTTTCG GGCTGGTGGA GCATGTGCTG GGACAGGACA GCATCCTCAA TCAATCCAAC 
AGCATATTCG GTTGCATCTT CTACACACTA CAGCTATTGT TAGGTTGCCT GCGGACACGC 
TGGGCCTCTG TCCTGATGCT GCTGAGCTCC CTGGTGTCTC TCGCTGGTTC TGTCTACCTG 
GCCTGGATCC TGTTCTTCGT GCTCTATGAT TTCTGCATTG TTTGTATCAC CACCTATGCT 
ATCAACGTGA GCCTGATGTG GCTCAGTTTC CGGAAGGTCC AAGAACCCCA GGGCAAGGCT 
AAGAGGCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VKORC1 ( NM_206824.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_996560.1 Homo sapiens vitamin K epoxide reductase complex subunit 1 (VKORC1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu11764
Clone ID Related Accession (Same CDS sequence)	NM_206824.2
Accession Version	NM_206824.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-30
Organism	Homo sapiens(human)
Product	vitamin K epoxide reductase complex subunit 1 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB064454.1, BI822140.1, AK129513.1 and BM663008.1. On Aug 6, 2015 this sequence version replaced NM_206824.1. Transcript Variant: This variant (2) lacks two alternate internal exons, resulting in a frame-shift compared to variant 3. It encodes isoform 2, which is shorter than and has a distinct C-terminus compared to isoform 3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM737748.1, BM557143.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAGCA CCTGGGGGAG CCCTGGCTGG GTGCGGCTCG CTCTTTGCCT GACGGGCTTA 
GTGCTCTCGC TCTACGCGCT GCACGTGAAG GCGGCGCGCG CCCGGGACCG GGATTACCGC 
GCGCTCTGCG ACGTGGGCAC CGCCATCAGC TGTTCGCGCG TCTTCTCCTC CAGGTTGCCT 
GCGGACACGC TGGGCCTCTG TCCTGATGCT GCTGAGCTCC CTGGTGTCTC TCGCTGGTTC 
TGTCTACCTG GCCTGGATCC TGTTCTTCGT GCTCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_996560.1
CDS	271..549
Translation	MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRLPADTLGLCPDAAELPGVSRWFCLPGLDPVLRAL

Target ORF information:

RefSeq Version	NM_206824.2
Organism	Homo sapiens(human)
Definition	Homo sapiens vitamin K epoxide reductase complex subunit 1 (VKORC1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_206824.2

ORF Insert Sequence:

ATGGGCAGCA CCTGGGGGAG CCCTGGCTGG GTGCGGCTCG CTCTTTGCCT GACGGGCTTA 
GTGCTCTCGC TCTACGCGCT GCACGTGAAG GCGGCGCGCG CCCGGGACCG GGATTACCGC 
GCGCTCTGCG ACGTGGGCAC CGCCATCAGC TGTTCGCGCG TCTTCTCCTC CAGGTTGCCT 
GCGGACACGC TGGGCCTCTG TCCTGATGCT GCTGAGCTCC CTGGTGTCTC TCGCTGGTTC 
TGTCTACCTG GCCTGGATCC TGTTCTTCGT GCTCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human Herpesvirus 8 Interleukin-6 Interacts with Calnexin Cycle Components and Promotes Protein Folding.
Journal of virology91(22)(2017 Nov)
Chen D,Xiang Q,Nicholas J

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VKORC1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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