BTG2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BTG2
Entrez Gene ID	7832
Full Name	BTG anti-proliferation factor 2
Synonyms	APRO1,PC3,TIS21
General protein information	Preferred Names BTG anti-proliferation factor 2 Names protein BTG2 B-cell translocation gene 2 BTG family member 2 NGF-inducible anti-proliferative protein PC3 nerve growth factor-inducible anti-proliferative pheochromacytoma cell-3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q32.1
Summary	The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq, Jul 2008].
Disorder MIM:	601597

mRNA and Protein(s)

mRNA	Protein	Name
NM_006763.2	NP_006754.1	protein BTG2
NM_006763.3	NP_006754.1	protein BTG2

Pathways from BioSystems

Homologies

Homo sapiens (human)	BTG2	NP_006754.1
Gallus gallus (chicken)	BTG2	XP_418053.3
Xenopus tropicalis (tropical clawed frog)	btg2	NP_001011013.1
Canis lupus familiaris (dog)	BTG2	XP_545676.3
Bos taurus (cattle)	BTG2	XP_002693925.2
Danio rerio (zebrafish)	btg2	NP_570997.1
Pan troglodytes (chimpanzee)	BTG2	XP_001155267.1
	BTG2	XP_001102745.1
Rattus norvegicus (Norway rat)	Btg2	NP_058955.1
Mus musculus (house mouse)	Btg2	NP_031596.1

Gene Ontology
Bibliography

Related articles in PubMed

miR-663 sustains NSCLC by inhibiting mitochondrial outer membrane permeabilization (MOMP) through PUMA/BBC3 and BTG2.
Fiori ME, Villanova L, Barbini C, De Angelis ML, De Maria R
Cell death & disease9(2)49(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

decreases tumorigenesis of hepatocellular carcinoma cell line side population cells
Title: BTG2 Is Down-Regulated and Inhibits Cancer Stem Cell-Like Features of Side Population Cells in Hepatocellular Carcinoma.

TIS21 attenuated Doxorubicin-induced cancer cell senescence by inhibiting linear actin nucleation via Nox4-ROS-ABI2-DRF signal cascade
Title: TIS21

The results indicated that BTG2 expression was downregulated in skin cancer cell lines. Overexpression of BTG2 significantly inhibited cell proliferation, cell cycle progression, and the invasion and migration of skin cancer cells.
Title: Inhibitory effects of B?cell translocation gene?2 on skin cancer cells via the Wnt/??catenin signaling pathway.

Data indicate that BTG2, MAP3K11, RPS6KA1 and PRDM1 as putative targets of microRNA miR-125b.
Title: Identification of miR-125b targets involved in acute promyelocytic leukemia cell proliferation.

we found that miR-27-3p was overexpressed in gastric cancer tissues and cell lines and that BTG2 was a direct and functional target of miR-27a-3p in gastric cancer
Title: MiR-27a-3p functions as an oncogene in gastric cancer by targeting BTG2.

The following BTG2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BTG2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15195	NM_006763.3 Latest version!	Homo sapiens BTG anti-proliferation factor 2 (BTG2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu15195	NM_006763.2	Homo sapiens BTG anti-proliferation factor 2 (BTG2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BTG2 ( NM_006763.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006754.1 Homo sapiens BTG anti-proliferation factor 2 (BTG2), mRNA.

Price & Availability↑

CloneID	OHu15195
Clone ID Related Accession (Same CDS sequence)	NM_006763.2 , NM_006763.3
Accession Version	NM_006763.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 477bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	protein BTG2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U72649.1. This sequence is a reference standard in the RefSeqGene project. On Mar 6, 2003 this sequence version replaced NM_006763.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U72649.1, SRR1660805.237860.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCCACG GGAAGGGAAC CGACATGCTC CCGGAGATCG CCGCCGCCGT GGGCTTCCTC 
TCCAGCCTCC TGAGGACCCG GGGCTGCGTG AGCGAGCAGA GGCTTAAGGT CTTCAGCGGG 
GCGCTCCAGG AGGCACTCAC AGAGCACTAC AAACACCACT GGTTTCCCGA AAAGCCGTCC 
AAGGGCTCCG GCTACCGCTG CATTCGCATC AACCACAAGA TGGACCCCAT CATCAGCAGG 
GTGGCCAGCC AGATCGGACT CAGCCAGCCC CAGCTGCACC AGCTGCTGCC CAGCGAGCTG 
ACCCTGTGGG TGGACCCCTA TGAGGTGTCC TACCGCATTG GGGAGGACGG CTCCATCTGC 
GTCTTGTACG AGGAGGCCCC ACTGGCCGCC TCCTGTGGGC TCCTCACCTG CAAGAACCAA 
GTGCTGCTGG GCCGGAGCAG CCCCTCCAAG AACTACGTGA TGGCAGTCTC CAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006754.1
CDS	72..548
Translation	MSHGKGTDMLPEIAAAVGFLSSLLRTRGCVSEQRLKVFSGALQEALTEHYKHHWFPEKPSKGSGYRCIRINHKMDPIISRVASQIGLSQPQLHQLLPSELTLWVDPYEVSYRIGEDGSICVLYEEAPLAASCGLLTCKNQVLLGRSSPSKNYVMAVSS

Target ORF information:

RefSeq Version	NM_006763.2
Organism	Homo sapiens(human)
Definition	Homo sapiens BTG anti-proliferation factor 2 (BTG2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006763.2

ORF Insert Sequence:

ATGAGCCACG GGAAGGGAAC CGACATGCTC CCGGAGATCG CCGCCGCCGT GGGCTTCCTC 
TCCAGCCTCC TGAGGACCCG GGGCTGCGTG AGCGAGCAGA GGCTTAAGGT CTTCAGCGGG 
GCGCTCCAGG AGGCACTCAC AGAGCACTAC AAACACCACT GGTTTCCCGA AAAGCCGTCC 
AAGGGCTCCG GCTACCGCTG CATTCGCATC AACCACAAGA TGGACCCCAT CATCAGCAGG 
GTGGCCAGCC AGATCGGACT CAGCCAGCCC CAGCTGCACC AGCTGCTGCC CAGCGAGCTG 
ACCCTGTGGG TGGACCCCTA TGAGGTGTCC TACCGCATTG GGGAGGACGG CTCCATCTGC 
GTCTTGTACG AGGAGGCCCC ACTGGCCGCC TCCTGTGGGC TCCTCACCTG CAAGAACCAA 
GTGCTGCTGG GCCGGAGCAG CCCCTCCAAG AACTACGTGA TGGCAGTCTC CAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BTG2 ( NM_006763.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006754.1 Homo sapiens BTG anti-proliferation factor 2 (BTG2), mRNA.

Price & Availability↑

CloneID	OHu15195
Clone ID Related Accession (Same CDS sequence)	NM_006763.2 , NM_006763.3
Accession Version	NM_006763.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 477bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	protein BTG2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL513326.19. This sequence is a reference standard in the RefSeqGene project. On Nov 26, 2018 this sequence version replaced NM_006763.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.11497.1, SRR1660805.237860.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000290551.5/ ENSP00000290551.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCCACG GGAAGGGAAC CGACATGCTC CCGGAGATCG CCGCCGCCGT GGGCTTCCTC 
TCCAGCCTCC TGAGGACCCG GGGCTGCGTG AGCGAGCAGA GGCTTAAGGT CTTCAGCGGG 
GCGCTCCAGG AGGCACTCAC AGAGCACTAC AAACACCACT GGTTTCCCGA AAAGCCGTCC 
AAGGGCTCCG GCTACCGCTG CATTCGCATC AACCACAAGA TGGACCCCAT CATCAGCAGG 
GTGGCCAGCC AGATCGGACT CAGCCAGCCC CAGCTGCACC AGCTGCTGCC CAGCGAGCTG 
ACCCTGTGGG TGGACCCCTA TGAGGTGTCC TACCGCATTG GGGAGGACGG CTCCATCTGC 
GTCTTGTACG AGGAGGCCCC ACTGGCCGCC TCCTGTGGGC TCCTCACCTG CAAGAACCAA 
GTGCTGCTGG GCCGGAGCAG CCCCTCCAAG AACTACGTGA TGGCAGTCTC CAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006754.1
CDS	89..565
Translation	MSHGKGTDMLPEIAAAVGFLSSLLRTRGCVSEQRLKVFSGALQEALTEHYKHHWFPEKPSKGSGYRCIRINHKMDPIISRVASQIGLSQPQLHQLLPSELTLWVDPYEVSYRIGEDGSICVLYEEAPLAASCGLLTCKNQVLLGRSSPSKNYVMAVSS

Target ORF information:

RefSeq Version	NM_006763.3
Organism	Homo sapiens(human)
Definition	Homo sapiens BTG anti-proliferation factor 2 (BTG2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006763.3

ORF Insert Sequence:

ATGAGCCACG GGAAGGGAAC CGACATGCTC CCGGAGATCG CCGCCGCCGT GGGCTTCCTC 
TCCAGCCTCC TGAGGACCCG GGGCTGCGTG AGCGAGCAGA GGCTTAAGGT CTTCAGCGGG 
GCGCTCCAGG AGGCACTCAC AGAGCACTAC AAACACCACT GGTTTCCCGA AAAGCCGTCC 
AAGGGCTCCG GCTACCGCTG CATTCGCATC AACCACAAGA TGGACCCCAT CATCAGCAGG 
GTGGCCAGCC AGATCGGACT CAGCCAGCCC CAGCTGCACC AGCTGCTGCC CAGCGAGCTG 
ACCCTGTGGG TGGACCCCTA TGAGGTGTCC TACCGCATTG GGGAGGACGG CTCCATCTGC 
GTCTTGTACG AGGAGGCCCC ACTGGCCGCC TCCTGTGGGC TCCTCACCTG CAAGAACCAA 
GTGCTGCTGG GCCGGAGCAG CCCCTCCAAG AACTACGTGA TGGCAGTCTC CAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

miR-663 sustains NSCLC by inhibiting mitochondrial outer membrane permeabilization (MOMP) through PUMA/BBC3 and BTG2.
Cell death & disease9(2)49(2018 Jan)
Fiori ME,Villanova L,Barbini C,De Angelis ML,De Maria R

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BTG2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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