Gene Symbol | LRP8 |
Entrez Gene ID | 7804 |
Full Name | LDL receptor related protein 8 |
Synonyms | APOER2,HSZ75190,LRP-8,MCI1 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]. |
Disorder MIM: | |
Disorder Html: | {Myocardial infarction, susceptibility to}, 608446 (3) |