RNF113A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RNF113A
Entrez Gene ID	7737
Full Name	ring finger protein 113A
Synonyms	Cwc24,RNF113,TTD5,ZNF183
General protein information	Preferred Names ring finger protein 113A Names RING finger protein 113A zinc finger protein 183 (RING finger, C3HC4 type)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq24
Summary	This intronless gene encodes a protein which contains a C3H1-type zinc finger domain and a C3HC4 Ring-type (Really Interesting New Gene-type) zinc finger domain. The Ring-type zinc finger domain is identified in various tumor suppressors, DNA repair genes and cytokine receptor-associated molecules, and is probably involved in mediating protein-protein interactions. [provided by RefSeq, May 2010]. COMPLETENESS: complete on the 3' end.
Disorder MIM:	300951
Disorder Html:	?Trichothiodystrophy 5, nonphotosensitive, 300953 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_006978.2	NP_008909.1	E3 ubiquitin-protein ligase RNF113A
NM_006978.3	NP_008909.1	E3 ubiquitin-protein ligase RNF113A

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Rnf113a2	NP_001004445.1
Homo sapiens (human)	RNF113A	NP_008909.1
Pan troglodytes (chimpanzee)	RNF113A	XP_529135.1
Canis lupus familiaris (dog)	RNF113A	XP_003640277.1
Bos taurus (cattle)	RNF113A	NP_001007808.1
	RNF113A	XP_001083433.1
Mus musculus (house mouse)	Rnf113a2	NP_079801.2

Gene Ontology
Bibliography

Related articles in PubMed

Structure of the human activated spliceosome in three conformational states.
Zhang X, Yan C, Zhan X, Li L, Lei J, Shi Y
Cell research(2018 Jan)

RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling.
Lear T, Dunn SR, McKelvey AC, Mir A, Evankovich J, Chen BB, Liu Y
American journal of physiology. Cell physiology313(5)C584-C592(2017 Nov)

A novel X-linked trichothiodystrophy associated with a nonsense mutation in RNF113A.
Corbett MA, Dudding-Byth T, Crock PA, Botta E, Christie LM, Nardo T, Caligiuri G, Hobson L, Boyle J, Mansour A, Friend KL, Crawford J, Jackson G, Vandeleur L, Hackett A, Tarpey P, Stratton MR, Turner G, G?cz J, Field M
Journal of medical genetics52(4)269-74(2015 Apr)

Dynamic protein-protein interaction wiring of the human spliceosome.
Hegele A, Kamburov A, Grossmann A, Sourlis C, Wowro S, Weimann M, Will CL, Pena V, L?hrmann R, Stelzl U
Molecular cell45(4)567-80(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A mutation that resulted in significant reduction of RNF113A protein was implicated in a non-photosensitive form of trichothiodystrophy. Lymphoblastoid cell lines from patients with the mutation in RNF113A had normal DNA damage responses on exposure to mitomycin C, diepoxybutane (DEB), bromodeoxyuridine (BrdU) and irradiation with ultraviolet light.
Title: A novel X-linked trichothiodystrophy associated with a nonsense mutation in RNF113A.

The following RNF113A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RNF113A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17798	NM_006978.3 Latest version!	Homo sapiens ring finger protein 113A (RNF113A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu17798	NM_006978.2	Homo sapiens ring finger protein 113A (RNF113A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RNF113A ( NM_006978.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_008909.1 Homo sapiens ring finger protein 113A (RNF113A), mRNA.

Price & Availability↑

CloneID	OHu17798
Clone ID Related Accession (Same CDS sequence)	NM_006978.2 , NM_006978.3
Accession Version	NM_006978.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase RNF113A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AW001915.1 and BC020556.1. This sequence is a reference standard in the RefSeqGene project. On Dec 2, 2008 this sequence version replaced NM_006978.1. COMPLETENESS: complete on the 3' end.

ATGGCAGAGC AGCTTTCTCC AGGAAAGGCG GTGGATCAGG TGTGCACCTT CCTTTTCAAA 
AAGCCTGGGC GGAAAGGGGC TGCTGGACGC AGAAAGCGCC CGGCCTGCGA CCCAGAGCCC 
GGAGAAAGCG GCAGCAGTAG CGACGAAGGC TGCACTGTGG TTCGACCGGA AAAGAAGCGG 
GTGACCCACA ATCCAATGAT ACAGAAGACC CGTGACAGTG GTAAACAGAA GGCGGCTTAC 
GGCGACTTGA GCAGCGAAGA GGAAGAGGAA AATGAGCCCG AGAGTCTCGG CGTGGTTTAT 
AAATCCACCC GTTCGGCGAA ACCCGTGGGA CCAGAGGATA TGGGAGCGAC AGCTGTCTAT 
GAGCTGGACA CAGAGAAAGA GCGCGATGCA CAAGCCATCT TTGAGCGCAG CCAGAAGATC 
CAGGAGGAGC TGAGGGGCAA GGAGGATGAC AAGATCTATC GGGGAATCAA CAATTATCAG 
AAATACATGA AGCCCAAGGA TACGTCTATG GGCAATGCCT CTTCCGGGAT GGTGAGGAAG 
GGCCCCATCC GAGCGCCCGA GCATCTACGT GCCACCGTGC GCTGGGATTA CCAGCCCGAC 
ATCTGTAAGG ACTACAAAGA GACTGGCTTC TGCGGCTTCG GAGACAGCTG CAAATTCCTC 
CATGACCGTT CAGATTACAA GCATGGGTGG CAGATCGAAC GTGAGCTTGA TGAGGGTCGC 
TATGGTGTCT ATGAGGATGA AAACTATGAA GTGGGAAGCG ATGATGAGGA AATACCATTC 
AAGTGTTTCA TCTGTCGCCA GAGCTTCCAA AACCCAGTTG TCACCAAGTG CAGGCATTAT 
TTCTGCGAGA GCTGTGCACT GCAGCATTTC CGCACCACCC CGCGCTGCTA TGTCTGTGAC 
CAGCAGACCA ATGGCGTCTT CAATCCAGCG AAAGAATTGA TTGCTAAACT AGAGAAGCAT 
CGAGCTACAG GAGAGGGTGG TGCTTCCGAC TTGCCAGAAG ACCCCGATGA GGATGCAATT 
CCCATTACTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008909.1
CDS	216..1247
Translation	MAEQLSPGKAVDQVCTFLFKKPGRKGAAGRRKRPACDPEPGESGSSSDEGCTVVRPEKKRVTHNPMIQKTRDSGKQKAAYGDLSSEEEEENEPESLGVVYKSTRSAKPVGPEDMGATAVYELDTEKERDAQAIFERSQKIQEELRGKEDDKIYRGINNYQKYMKPKDTSMGNASSGMVRKGPIRAPEHLRATVRWDYQPDICKDYKETGFCGFGDSCKFLHDRSDYKHGWQIERELDEGRYGVYEDENYEVGSDDEEIPFKCFICRQSFQNPVVTKCRHYFCESCALQHFRTTPRCYVCDQQTNGVFNPAKELIAKLEKHRATGEGGASDLPEDPDEDAIPIT

Target ORF information:

RefSeq Version	NM_006978.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 113A (RNF113A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006978.2

ORF Insert Sequence:

ATGGCAGAGC AGCTTTCTCC AGGAAAGGCG GTGGATCAGG TGTGCACCTT CCTTTTCAAA 
AAGCCTGGGC GGAAAGGGGC TGCTGGACGC AGAAAGCGCC CGGCCTGCGA CCCAGAGCCC 
GGAGAAAGCG GCAGCAGTAG CGACGAAGGC TGCACTGTGG TTCGACCGGA AAAGAAGCGG 
GTGACCCACA ATCCAATGAT ACAGAAGACC CGTGACAGTG GTAAACAGAA GGCGGCTTAC 
GGCGACTTGA GCAGCGAAGA GGAAGAGGAA AATGAGCCCG AGAGTCTCGG CGTGGTTTAT 
AAATCCACCC GTTCGGCGAA ACCCGTGGGA CCAGAGGATA TGGGAGCGAC AGCTGTCTAT 
GAGCTGGACA CAGAGAAAGA GCGCGATGCA CAAGCCATCT TTGAGCGCAG CCAGAAGATC 
CAGGAGGAGC TGAGGGGCAA GGAGGATGAC AAGATCTATC GGGGAATCAA CAATTATCAG 
AAATACATGA AGCCCAAGGA TACGTCTATG GGCAATGCCT CTTCCGGGAT GGTGAGGAAG 
GGCCCCATCC GAGCGCCCGA GCATCTACGT GCCACCGTGC GCTGGGATTA CCAGCCCGAC 
ATCTGTAAGG ACTACAAAGA GACTGGCTTC TGCGGCTTCG GAGACAGCTG CAAATTCCTC 
CATGACCGTT CAGATTACAA GCATGGGTGG CAGATCGAAC GTGAGCTTGA TGAGGGTCGC 
TATGGTGTCT ATGAGGATGA AAACTATGAA GTGGGAAGCG ATGATGAGGA AATACCATTC 
AAGTGTTTCA TCTGTCGCCA GAGCTTCCAA AACCCAGTTG TCACCAAGTG CAGGCATTAT 
TTCTGCGAGA GCTGTGCACT GCAGCATTTC CGCACCACCC CGCGCTGCTA TGTCTGTGAC 
CAGCAGACCA ATGGCGTCTT CAATCCAGCG AAAGAATTGA TTGCTAAACT AGAGAAGCAT 
CGAGCTACAG GAGAGGGTGG TGCTTCCGAC TTGCCAGAAG ACCCCGATGA GGATGCAATT 
CCCATTACTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNF113A ( NM_006978.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_008909.1 Homo sapiens ring finger protein 113A (RNF113A), mRNA.

Price & Availability↑

CloneID	OHu17798
Clone ID Related Accession (Same CDS sequence)	NM_006978.2 , NM_006978.3
Accession Version	NM_006978.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase RNF113A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AW001915.1, BC020556.1 and AC002477.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_006978.2. ##Evidence-Data-START## Transcript is intronless :: X98253.1, BC020556.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000371442.4/ ENSP00000360497.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAGC AGCTTTCTCC AGGAAAGGCG GTGGATCAGG TGTGCACCTT CCTTTTCAAA 
AAGCCTGGGC GGAAAGGGGC TGCTGGACGC AGAAAGCGCC CGGCCTGCGA CCCAGAGCCC 
GGAGAAAGCG GCAGCAGTAG CGACGAAGGC TGCACTGTGG TTCGACCGGA AAAGAAGCGG 
GTGACCCACA ATCCAATGAT ACAGAAGACC CGTGACAGTG GTAAACAGAA GGCGGCTTAC 
GGCGACTTGA GCAGCGAAGA GGAAGAGGAA AATGAGCCCG AGAGTCTCGG CGTGGTTTAT 
AAATCCACCC GTTCGGCGAA ACCCGTGGGA CCAGAGGATA TGGGAGCGAC AGCTGTCTAT 
GAGCTGGACA CAGAGAAAGA GCGCGATGCA CAAGCCATCT TTGAGCGCAG CCAGAAGATC 
CAGGAGGAGC TGAGGGGCAA GGAGGATGAC AAGATCTATC GGGGAATCAA CAATTATCAG 
AAATACATGA AGCCCAAGGA TACGTCTATG GGCAATGCCT CTTCCGGGAT GGTGAGGAAG 
GGCCCCATCC GAGCGCCCGA GCATCTACGT GCCACCGTGC GCTGGGATTA CCAGCCCGAC 
ATCTGTAAGG ACTACAAAGA GACTGGCTTC TGCGGCTTCG GAGACAGCTG CAAATTCCTC 
CATGACCGTT CAGATTACAA GCATGGGTGG CAGATCGAAC GTGAGCTTGA TGAGGGTCGC 
TATGGTGTCT ATGAGGATGA AAACTATGAA GTGGGAAGCG ATGATGAGGA AATACCATTC 
AAGTGTTTCA TCTGTCGCCA GAGCTTCCAA AACCCAGTTG TCACCAAGTG CAGGCATTAT 
TTCTGCGAGA GCTGTGCACT GCAGCATTTC CGCACCACCC CGCGCTGCTA TGTCTGTGAC 
CAGCAGACCA ATGGCGTCTT CAATCCAGCG AAAGAATTGA TTGCTAAACT AGAGAAGCAT 
CGAGCTACAG GAGAGGGTGG TGCTTCCGAC TTGCCAGAAG ACCCCGATGA GGATGCAATT 
CCCATTACTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008909.1
CDS	121..1152
Translation	MAEQLSPGKAVDQVCTFLFKKPGRKGAAGRRKRPACDPEPGESGSSSDEGCTVVRPEKKRVTHNPMIQKTRDSGKQKAAYGDLSSEEEEENEPESLGVVYKSTRSAKPVGPEDMGATAVYELDTEKERDAQAIFERSQKIQEELRGKEDDKIYRGINNYQKYMKPKDTSMGNASSGMVRKGPIRAPEHLRATVRWDYQPDICKDYKETGFCGFGDSCKFLHDRSDYKHGWQIERELDEGRYGVYEDENYEVGSDDEEIPFKCFICRQSFQNPVVTKCRHYFCESCALQHFRTTPRCYVCDQQTNGVFNPAKELIAKLEKHRATGEGGASDLPEDPDEDAIPIT

Target ORF information:

RefSeq Version	NM_006978.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 113A (RNF113A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006978.3

ORF Insert Sequence:

ATGGCAGAGC AGCTTTCTCC AGGAAAGGCG GTGGATCAGG TGTGCACCTT CCTTTTCAAA 
AAGCCTGGGC GGAAAGGGGC TGCTGGACGC AGAAAGCGCC CGGCCTGCGA CCCAGAGCCC 
GGAGAAAGCG GCAGCAGTAG CGACGAAGGC TGCACTGTGG TTCGACCGGA AAAGAAGCGG 
GTGACCCACA ATCCAATGAT ACAGAAGACC CGTGACAGTG GTAAACAGAA GGCGGCTTAC 
GGCGACTTGA GCAGCGAAGA GGAAGAGGAA AATGAGCCCG AGAGTCTCGG CGTGGTTTAT 
AAATCCACCC GTTCGGCGAA ACCCGTGGGA CCAGAGGATA TGGGAGCGAC AGCTGTCTAT 
GAGCTGGACA CAGAGAAAGA GCGCGATGCA CAAGCCATCT TTGAGCGCAG CCAGAAGATC 
CAGGAGGAGC TGAGGGGCAA GGAGGATGAC AAGATCTATC GGGGAATCAA CAATTATCAG 
AAATACATGA AGCCCAAGGA TACGTCTATG GGCAATGCCT CTTCCGGGAT GGTGAGGAAG 
GGCCCCATCC GAGCGCCCGA GCATCTACGT GCCACCGTGC GCTGGGATTA CCAGCCCGAC 
ATCTGTAAGG ACTACAAAGA GACTGGCTTC TGCGGCTTCG GAGACAGCTG CAAATTCCTC 
CATGACCGTT CAGATTACAA GCATGGGTGG CAGATCGAAC GTGAGCTTGA TGAGGGTCGC 
TATGGTGTCT ATGAGGATGA AAACTATGAA GTGGGAAGCG ATGATGAGGA AATACCATTC 
AAGTGTTTCA TCTGTCGCCA GAGCTTCCAA AACCCAGTTG TCACCAAGTG CAGGCATTAT 
TTCTGCGAGA GCTGTGCACT GCAGCATTTC CGCACCACCC CGCGCTGCTA TGTCTGTGAC 
CAGCAGACCA ATGGCGTCTT CAATCCAGCG AAAGAATTGA TTGCTAAACT AGAGAAGCAT 
CGAGCTACAG GAGAGGGTGG TGCTTCCGAC TTGCCAGAAG ACCCCGATGA GGATGCAATT 
CCCATTACTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structure of the human activated spliceosome in three conformational states.
Cell research(2018 Jan)
Zhang X,Yan C,Zhan X,Li L,Lei J,Shi Y

RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling.
American journal of physiology. Cell physiology313(5)C584-C592(2017 Nov)
Lear T,Dunn SR,McKelvey AC,Mir A,Evankovich J,Chen BB,Liu Y

A novel X-linked trichothiodystrophy associated with a nonsense mutation in RNF113A.
Journal of medical genetics52(4)269-74(2015 Apr)
Corbett MA,Dudding-Byth T,Crock PA,Botta E,Christie LM,Nardo T,Caligiuri G,Hobson L,Boyle J,Mansour A,Friend KL,Crawford J,Jackson G,Vandeleur L,Hackett A,Tarpey P,Stratton MR,Turner G,G?cz J,Field M

Dynamic protein-protein interaction wiring of the human spliceosome.
Molecular cell45(4)567-80(2012 Feb)
Hegele A,Kamburov A,Grossmann A,Sourlis C,Wowro S,Weimann M,Will CL,Pena V,L?hrmann R,Stelzl U

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RNF113A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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