MKRN3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MKRN3
Entrez Gene ID	7681
Full Name	makorin ring finger protein 3
Synonyms	CPPB2,D15S9,RNF63,ZFP127,ZNF127
General protein information	Preferred Names makorin ring finger protein 3 Names probable E3 ubiquitin-protein ligase makorin-3 RING finger protein 63 RING-type E3 ubiquitin transferase makorin-3 zinc finger protein 127
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q11.2
Summary	The protein encoded by this gene contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs. This gene is intronless and imprinted, with expression only from the paternal allele. Disruption of the imprinting at this locus may contribute to Prader-Willi syndrome. An antisense RNA of unknown function has been found overlapping this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	603856
Disorder Html:	Precocious puberty, central, 2, 615346 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005664.3	NP_005655.1	probable E3 ubiquitin-protein ligase makorin-3
NM_005664.4	NP_005655.1	probable E3 ubiquitin-protein ligase makorin-3

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MKRN3	XP_005221747.1
Pan troglodytes (chimpanzee)	MKRN3	XP_510258.2
Canis lupus familiaris (dog)	MKRN3	XP_005642528.1
	MKRN3	XP_001106523.1
Rattus norvegicus (Norway rat)	Mkrn3	XP_218735.6
Homo sapiens (human)	MKRN3	NP_005655.1
Mus musculus (house mouse)	Mkrn3	NP_035876.2

Gene Ontology
Bibliography

Related articles in PubMed

Makorin ring finger 3 gene analysis in Koreans with familial precocious puberty.
Jeong HR, Lee HS, Hwang JS
Journal of pediatric endocrinology & metabolism : JPEM30(11)1197-1201(2017 Oct)

Molecular Screening of MKRN3, DLK1, and KCNK9 Genes in Girls with Idiopathic Central Precocious Puberty.
Grandone A, Capristo C, Cirillo G, Sasso M, Umano GR, Mariani M, Miraglia Del Giudice E, Perrone L
Hormone research in paediatrics88(3-4)194-200(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MKRN3 is the most frequent genetic cause of familial Idiopathic Central Precocious Puberty, so it is wise to screen for MKRN3 mutations in all patients with familial Idiopathic Central Precocious Puberty and in patients with an unclear paternal pubertal history.
Title: Clinical Exome Sequencing Reveals MKRN3 Pathogenic Variants in Familial and Nonfamilial Idiopathic Central Precocious Puberty.

The genetic findings in our patients' cohort with central precocious puberty are in agreement with the hypothesis that the MKRN3 gene may act as an inhibitor of GnRH secretion during childhood. 13 It seems that MKRN3 gene alterations do not necessarily lead to early pubertal development in males, but paternally inherited MKRN3 mutations are responsible for central precocious puberty in females.
Title: Males with Paternally Inherited MKRN3 Mutations May Be Asymptomatic.

Peripheral MKRN3 levels in boys appear to serve as a readout of the diminishing central inhibition that controls the onset of puberty.
Title: Circulating makorin ring finger protein 3 levels decline in boys before the clinical onset of puberty.

Declining MKRN3 before pubertal onset support MKRN3 as an inhibitor of GnRH secretion during midchildhood.
Title: Circulating MKRN3 Levels Decline During Puberty in Healthy Boys.

The identification of carriers of MKRN3 mutations may contribute to early diagnosis of Central Precocious Puberty, facilitating treatment decisions and guiding genetic counseling and prompt intervention in familial cases.
Title: Time Course of Central Precocious Puberty Development Caused by an MKRN3 Gene Mutation: A Prismatic Case.

The following MKRN3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MKRN3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18283	NM_005664.4 Latest version!	Homo sapiens makorin ring finger protein 3 (MKRN3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
View Old Accession Versions >>
OHu18283	NM_005664.3	Homo sapiens makorin ring finger protein 3 (MKRN3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MKRN3 ( NM_005664.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005655.1 Homo sapiens makorin ring finger protein 3 (MKRN3), mRNA.

Price & Availability↑

CloneID	OHu18283
Clone ID Related Accession (Same CDS sequence)	NM_005664.3 , NM_005664.4
Accession Version	NM_005664.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1524bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-03
Organism	Homo sapiens(human)
Product	probable E3 ubiquitin-protein ligase makorin-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI939624.1, DA495139.1 and BC044639.1. This sequence is a reference standard in the RefSeqGene project. On May 30, 2008 this sequence version replaced NM_005664.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## imprinted gene :: PMID: 10196367 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAAGAGC CTGCAGCTCC CTCAGAAGCC CACGAGGCAG CCGGGGCCCA GGCAGGTGCT 
GAGGCAGCAA GGGAGGGTGT GTCTGGGCCG GACCTTCCCG TCTGTGAGCC CTCCGGGGAA 
TCTGCTGCTC CAGATTCAGC CCTGCCACAT GCGGCAAGGG GCTGGGCCCC CTTCCCTGTA 
GCTCCAGTCC CTGCCCACCT CCGCAGAGGA GGCCTGAGGC CTGCCCCAGC CTCAGGAGGA 
GGAGCCTGGC CCAGTCCGTT GCCAAGCCGA AGCAGCGGCA TTTGGACAAA GCAGATCATC 
TGCAGGTATT ATATACATGG GCAGTGCAAG GAGGGGGAGA ACTGTCGCTA TTCGCACGAC 
CTTTCTGGTC GGAAGATGGC CACTGAGGGT GGCGTTTCGC CGCCTGGGGC CTCTGCAGGT 
GGAGGCCCTA GCACGGCTGC GCACATCGAG CCCCCGACTC AGGAAGTGGC GGAAGCCCCC 
CCGGCTGCAT CCTCCCTTTC CTTGCCTGTG ATTGGCTCGG CTGCTGAAAG GGGTTTCTTT 
GAAGCCGAGA GAGACAATGC AGACCGTGGA GCTGCTGGAG GAGCAGGTGT AGAAAGCTGG 
GCGGATGCCA TTGAGTTTGT TCCAGGGCAG CCCTACCGGG GCCGCTGGGT TGCATCTGCC 
CCCGAGGCTC CTCTACAGAG CTCAGAGACT GAGAGGAAGC AGATGGCTGT GGGCAGTGGG 
TTGCGGTTTT GCTATTATGC TTCCAGGGGA GTTTGCTTTC GTGGGGAGAG CTGTATGTAC 
CTCCATGGAG ACATATGCGA CATGTGTGGG CTGCAGACCT TGCACCCCAT GGATGCTGCC 
CAGAGGGAAG AACATATGAG GGCCTGCATT GAAGCACACG AGAAAGATAT GGAACTCTCG 
TTTGCTGTGC AGCGTGGTAT GGACAAGGTG TGTGGCATCT GCATGGAGGT TGTCTATGAG 
AAGGCCAACC CCAATGACCG CCGCTTTGGC ATTCTTTCCA ATTGCAACCA TTCCTTCTGT 
ATTAGGTGTA TCCGCAGGTG GAGAAGTGCC AGACAGTTTG AGAACAGGAT CGTCAAGTCT 
TGCCCACAGT GCAGGGTCAC CTCTGAATTG GTCATTCCCA GTGAGTTCTG GGTGGAGGAG 
GAGGAAGAGA AGCAGAAACT TATTCAGCAA TACAAGGAGG CAATGAGCAA CAAGGCCTGC 
AGGTATTTTG CGGAAGGCAG GGGTAACTGC CCATTTGGAG ACACATGCTT TTACAAGCAT 
GAATACCCTG AGGGCTGGGG AGATGAGCCT CCTGGGCCAG GTGGTGGGTC ATTCAGCGCA 
TACTGGCATC AACTTGTGGA GCCTGTGCGA ATGGGAGAGG GCAACATGCT CTATAAAAGC 
ATTAAGAAGG AGCTTGTCGT GCTTCGGCTG GCCAGTCTGT TGTTTAAGCG GTTTCTTTCA 
CTGAGAGATG AGTTACCCTT CTCTGAGGAC CAGTGGGACT TGCTTCATTA TGAGCTGGAA 
GAATATTTCA ATTTGATTCT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005655.1
CDS	477..2000
Translation	MEEPAAPSEAHEAAGAQAGAEAAREGVSGPDLPVCEPSGESAAPDSALPHAARGWAPFPVAPVPAHLRRGGLRPAPASGGGAWPSPLPSRSSGIWTKQIICRYYIHGQCKEGENCRYSHDLSGRKMATEGGVSPPGASAGGGPSTAAHIEPPTQEVAEAPPAASSLSLPVIGSAAERGFFEAERDNADRGAAGGAGVESWADAIEFVPGQPYRGRWVASAPEAPLQSSETERKQMAVGSGLRFCYYASRGVCFRGESCMYLHGDICDMCGLQTLHPMDAAQREEHMRACIEAHEKDMELSFAVQRGMDKVCGICMEVVYEKANPNDRRFGILSNCNHSFCIRCIRRWRSARQFENRIVKSCPQCRVTSELVIPSEFWVEEEEEKQKLIQQYKEAMSNKACRYFAEGRGNCPFGDTCFYKHEYPEGWGDEPPGPGGGSFSAYWHQLVEPVRMGEGNMLYKSIKKELVVLRLASLLFKRFLSLRDELPFSEDQWDLLHYELEEYFNLIL

Target ORF information:

RefSeq Version	NM_005664.3
Organism	Homo sapiens(human)
Definition	Homo sapiens makorin ring finger protein 3 (MKRN3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005664.3

ORF Insert Sequence:

ATGGAAGAGC CTGCAGCTCC CTCAGAAGCC CACGAGGCAG CCGGGGCCCA GGCAGGTGCT 
GAGGCAGCAA GGGAGGGTGT GTCTGGGCCG GACCTTCCCG TCTGTGAGCC CTCCGGGGAA 
TCTGCTGCTC CAGATTCAGC CCTGCCACAT GCGGCAAGGG GCTGGGCCCC CTTCCCTGTA 
GCTCCAGTCC CTGCCCACCT CCGCAGAGGA GGCCTGAGGC CTGCCCCAGC CTCAGGAGGA 
GGAGCCTGGC CCAGTCCGTT GCCAAGCCGA AGCAGCGGCA TTTGGACAAA GCAGATCATC 
TGCAGGTATT ATATACATGG GCAGTGCAAG GAGGGGGAGA ACTGTCGCTA TTCGCACGAC 
CTTTCTGGTC GGAAGATGGC CACTGAGGGT GGCGTTTCGC CGCCTGGGGC CTCTGCAGGT 
GGAGGCCCTA GCACGGCTGC GCACATCGAG CCCCCGACTC AGGAAGTGGC GGAAGCCCCC 
CCGGCTGCAT CCTCCCTTTC CTTGCCTGTG ATTGGCTCGG CTGCTGAAAG GGGTTTCTTT 
GAAGCCGAGA GAGACAATGC AGACCGTGGA GCTGCTGGAG GAGCAGGTGT AGAAAGCTGG 
GCGGATGCCA TTGAGTTTGT TCCAGGGCAG CCCTACCGGG GCCGCTGGGT TGCATCTGCC 
CCCGAGGCTC CTCTACAGAG CTCAGAGACT GAGAGGAAGC AGATGGCTGT GGGCAGTGGG 
TTGCGGTTTT GCTATTATGC TTCCAGGGGA GTTTGCTTTC GTGGGGAGAG CTGTATGTAC 
CTCCATGGAG ACATATGCGA CATGTGTGGG CTGCAGACCT TGCACCCCAT GGATGCTGCC 
CAGAGGGAAG AACATATGAG GGCCTGCATT GAAGCACACG AGAAAGATAT GGAACTCTCG 
TTTGCTGTGC AGCGTGGTAT GGACAAGGTG TGTGGCATCT GCATGGAGGT TGTCTATGAG 
AAGGCCAACC CCAATGACCG CCGCTTTGGC ATTCTTTCCA ATTGCAACCA TTCCTTCTGT 
ATTAGGTGTA TCCGCAGGTG GAGAAGTGCC AGACAGTTTG AGAACAGGAT CGTCAAGTCT 
TGCCCACAGT GCAGGGTCAC CTCTGAATTG GTCATTCCCA GTGAGTTCTG GGTGGAGGAG 
GAGGAAGAGA AGCAGAAACT TATTCAGCAA TACAAGGAGG CAATGAGCAA CAAGGCCTGC 
AGGTATTTTG CGGAAGGCAG GGGTAACTGC CCATTTGGAG ACACATGCTT TTACAAGCAT 
GAATACCCTG AGGGCTGGGG AGATGAGCCT CCTGGGCCAG GTGGTGGGTC ATTCAGCGCA 
TACTGGCATC AACTTGTGGA GCCTGTGCGA ATGGGAGAGG GCAACATGCT CTATAAAAGC 
ATTAAGAAGG AGCTTGTCGT GCTTCGGCTG GCCAGTCTGT TGTTTAAGCG GTTTCTTTCA 
CTGAGAGATG AGTTACCCTT CTCTGAGGAC CAGTGGGACT TGCTTCATTA TGAGCTGGAA 
GAATATTTCA ATTTGATTCT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MKRN3 ( NM_005664.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005655.1 Homo sapiens makorin ring finger protein 3 (MKRN3), mRNA.

Price & Availability↑

CloneID	OHu18283
Clone ID Related Accession (Same CDS sequence)	NM_005664.3 , NM_005664.4
Accession Version	NM_005664.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1524bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	probable E3 ubiquitin-protein ligase makorin-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA495139.1, BC044639.1 and AC126407.6. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_005664.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: SRR1803616.86777.1, SRR1803611.109736.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 10196367 MANE Ensembl match :: ENST00000314520.6/ ENSP00000313881.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAAGAGC CTGCAGCTCC CTCAGAAGCC CACGAGGCAG CCGGGGCCCA GGCAGGTGCT 
GAGGCAGCAA GGGAGGGTGT GTCTGGGCCG GACCTTCCCG TCTGTGAGCC CTCCGGGGAA 
TCTGCTGCTC CAGATTCAGC CCTGCCACAT GCGGCAAGGG GCTGGGCCCC CTTCCCTGTA 
GCTCCAGTCC CTGCCCACCT CCGCAGAGGA GGCCTGAGGC CTGCCCCAGC CTCAGGAGGA 
GGAGCCTGGC CCAGTCCGTT GCCAAGCCGA AGCAGCGGCA TTTGGACAAA GCAGATCATC 
TGCAGGTATT ATATACATGG GCAGTGCAAG GAGGGGGAGA ACTGTCGCTA TTCGCACGAC 
CTTTCTGGTC GGAAGATGGC CACTGAGGGT GGCGTTTCGC CGCCTGGGGC CTCTGCAGGT 
GGAGGCCCTA GCACGGCTGC GCACATCGAG CCCCCGACTC AGGAAGTGGC GGAAGCCCCC 
CCGGCTGCAT CCTCCCTTTC CTTGCCTGTG ATTGGCTCGG CTGCTGAAAG GGGTTTCTTT 
GAAGCCGAGA GAGACAATGC AGACCGTGGA GCTGCTGGAG GAGCAGGTGT AGAAAGCTGG 
GCGGATGCCA TTGAGTTTGT TCCAGGGCAG CCCTACCGGG GCCGCTGGGT TGCATCTGCC 
CCCGAGGCTC CTCTACAGAG CTCAGAGACT GAGAGGAAGC AGATGGCTGT GGGCAGTGGG 
TTGCGGTTTT GCTATTATGC TTCCAGGGGA GTTTGCTTTC GTGGGGAGAG CTGTATGTAC 
CTCCATGGAG ACATATGCGA CATGTGTGGG CTGCAGACCT TGCACCCCAT GGATGCTGCC 
CAGAGGGAAG AACATATGAG GGCCTGCATT GAAGCACACG AGAAAGATAT GGAACTCTCG 
TTTGCTGTGC AGCGTGGTAT GGACAAGGTG TGTGGCATCT GCATGGAGGT TGTCTATGAG 
AAGGCCAACC CCAATGACCG CCGCTTTGGC ATTCTTTCCA ATTGCAACCA TTCCTTCTGT 
ATTAGGTGTA TCCGCAGGTG GAGAAGTGCC AGACAGTTTG AGAACAGGAT CGTCAAGTCT 
TGCCCACAGT GCAGGGTCAC CTCTGAATTG GTCATTCCCA GTGAGTTCTG GGTGGAGGAG 
GAGGAAGAGA AGCAGAAACT TATTCAGCAA TACAAGGAGG CAATGAGCAA CAAGGCCTGC 
AGGTATTTTG CGGAAGGCAG GGGTAACTGC CCATTTGGAG ACACATGCTT TTACAAGCAT 
GAATACCCTG AGGGCTGGGG AGATGAGCCT CCTGGGCCAG GTGGTGGGTC ATTCAGCGCA 
TACTGGCATC AACTTGTGGA GCCTGTGCGA ATGGGAGAGG GCAACATGCT CTATAAAAGC 
ATTAAGAAGG AGCTTGTCGT GCTTCGGCTG GCCAGTCTGT TGTTTAAGCG GTTTCTTTCA 
CTGAGAGATG AGTTACCCTT CTCTGAGGAC CAGTGGGACT TGCTTCATTA TGAGCTGGAA 
GAATATTTCA ATTTGATTCT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005655.1
CDS	110..1633
Translation	MEEPAAPSEAHEAAGAQAGAEAAREGVSGPDLPVCEPSGESAAPDSALPHAARGWAPFPVAPVPAHLRRGGLRPAPASGGGAWPSPLPSRSSGIWTKQIICRYYIHGQCKEGENCRYSHDLSGRKMATEGGVSPPGASAGGGPSTAAHIEPPTQEVAEAPPAASSLSLPVIGSAAERGFFEAERDNADRGAAGGAGVESWADAIEFVPGQPYRGRWVASAPEAPLQSSETERKQMAVGSGLRFCYYASRGVCFRGESCMYLHGDICDMCGLQTLHPMDAAQREEHMRACIEAHEKDMELSFAVQRGMDKVCGICMEVVYEKANPNDRRFGILSNCNHSFCIRCIRRWRSARQFENRIVKSCPQCRVTSELVIPSEFWVEEEEEKQKLIQQYKEAMSNKACRYFAEGRGNCPFGDTCFYKHEYPEGWGDEPPGPGGGSFSAYWHQLVEPVRMGEGNMLYKSIKKELVVLRLASLLFKRFLSLRDELPFSEDQWDLLHYELEEYFNLIL

Target ORF information:

RefSeq Version	NM_005664.4
Organism	Homo sapiens(human)
Definition	Homo sapiens makorin ring finger protein 3 (MKRN3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005664.4

ORF Insert Sequence:

ATGGAAGAGC CTGCAGCTCC CTCAGAAGCC CACGAGGCAG CCGGGGCCCA GGCAGGTGCT 
GAGGCAGCAA GGGAGGGTGT GTCTGGGCCG GACCTTCCCG TCTGTGAGCC CTCCGGGGAA 
TCTGCTGCTC CAGATTCAGC CCTGCCACAT GCGGCAAGGG GCTGGGCCCC CTTCCCTGTA 
GCTCCAGTCC CTGCCCACCT CCGCAGAGGA GGCCTGAGGC CTGCCCCAGC CTCAGGAGGA 
GGAGCCTGGC CCAGTCCGTT GCCAAGCCGA AGCAGCGGCA TTTGGACAAA GCAGATCATC 
TGCAGGTATT ATATACATGG GCAGTGCAAG GAGGGGGAGA ACTGTCGCTA TTCGCACGAC 
CTTTCTGGTC GGAAGATGGC CACTGAGGGT GGCGTTTCGC CGCCTGGGGC CTCTGCAGGT 
GGAGGCCCTA GCACGGCTGC GCACATCGAG CCCCCGACTC AGGAAGTGGC GGAAGCCCCC 
CCGGCTGCAT CCTCCCTTTC CTTGCCTGTG ATTGGCTCGG CTGCTGAAAG GGGTTTCTTT 
GAAGCCGAGA GAGACAATGC AGACCGTGGA GCTGCTGGAG GAGCAGGTGT AGAAAGCTGG 
GCGGATGCCA TTGAGTTTGT TCCAGGGCAG CCCTACCGGG GCCGCTGGGT TGCATCTGCC 
CCCGAGGCTC CTCTACAGAG CTCAGAGACT GAGAGGAAGC AGATGGCTGT GGGCAGTGGG 
TTGCGGTTTT GCTATTATGC TTCCAGGGGA GTTTGCTTTC GTGGGGAGAG CTGTATGTAC 
CTCCATGGAG ACATATGCGA CATGTGTGGG CTGCAGACCT TGCACCCCAT GGATGCTGCC 
CAGAGGGAAG AACATATGAG GGCCTGCATT GAAGCACACG AGAAAGATAT GGAACTCTCG 
TTTGCTGTGC AGCGTGGTAT GGACAAGGTG TGTGGCATCT GCATGGAGGT TGTCTATGAG 
AAGGCCAACC CCAATGACCG CCGCTTTGGC ATTCTTTCCA ATTGCAACCA TTCCTTCTGT 
ATTAGGTGTA TCCGCAGGTG GAGAAGTGCC AGACAGTTTG AGAACAGGAT CGTCAAGTCT 
TGCCCACAGT GCAGGGTCAC CTCTGAATTG GTCATTCCCA GTGAGTTCTG GGTGGAGGAG 
GAGGAAGAGA AGCAGAAACT TATTCAGCAA TACAAGGAGG CAATGAGCAA CAAGGCCTGC 
AGGTATTTTG CGGAAGGCAG GGGTAACTGC CCATTTGGAG ACACATGCTT TTACAAGCAT 
GAATACCCTG AGGGCTGGGG AGATGAGCCT CCTGGGCCAG GTGGTGGGTC ATTCAGCGCA 
TACTGGCATC AACTTGTGGA GCCTGTGCGA ATGGGAGAGG GCAACATGCT CTATAAAAGC 
ATTAAGAAGG AGCTTGTCGT GCTTCGGCTG GCCAGTCTGT TGTTTAAGCG GTTTCTTTCA 
CTGAGAGATG AGTTACCCTT CTCTGAGGAC CAGTGGGACT TGCTTCATTA TGAGCTGGAA 
GAATATTTCA ATTTGATTCT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Makorin ring finger 3 gene analysis in Koreans with familial precocious puberty.
Journal of pediatric endocrinology & metabolism : JPEM30(11)1197-1201(2017 Oct)
Jeong HR,Lee HS,Hwang JS

Molecular Screening of MKRN3, DLK1, and KCNK9 Genes in Girls with Idiopathic Central Precocious Puberty.
Hormone research in paediatrics88(3-4)194-200(2017)
Grandone A,Capristo C,Cirillo G,Sasso M,Umano GR,Mariani M,Miraglia Del Giudice E,Perrone L

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MKRN3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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