PTTG1IP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PTTG1IP
Entrez Gene ID	754
Full Name	PTTG1 interacting protein
Synonyms	C21orf1,C21orf3,PBF
General protein information	Preferred Names PTTG1 interacting protein Names pituitary tumor-transforming gene 1 protein-interacting protein PTTG-binding factor pituitary tumor-transforming 1 interacting protein pituitary tumor-transforming gene protein-binding factor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 21 Map Location: 21q22.3
Summary	This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic fibroblast growth factor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013].
Disorder MIM:	603784

mRNA and Protein(s)

mRNA	Protein	Name
NM_004339.4	NP_004330.1	pituitary tumor-transforming gene 1 protein-interacting protein isoform 1 precursor
NM_001286822.1	NP_001273751.1	pituitary tumor-transforming gene 1 protein-interacting protein isoform 2 precursor
NM_004339.3	NP_004330.1	pituitary tumor-transforming gene 1 protein-interacting protein isoform 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	PTTG1IP	NP_004330.1
Bos taurus (cattle)	PTTG1IP	NP_001040059.1
Danio rerio (zebrafish)	LOC101886260	XP_005173603.1
	LOC722061	XP_002803151.1
Canis lupus familiaris (dog)	PTTG1IP	XP_003640139.1
Mus musculus (house mouse)	Pttg1ip	NP_666037.1
Gallus gallus (chicken)	PTTG1IP	XP_418646.2
Pan troglodytes (chimpanzee)	PTTG1IP	XP_001155420.1
Canis lupus familiaris (dog)	LOC100855485	XP_005642370.1
Rattus norvegicus (Norway rat)	Pttg1ip	NP_001013256.1
Xenopus tropicalis (tropical clawed frog)	pttg1ip.2	NP_001011400.1

Gene Ontology
Bibliography

Related articles in PubMed

PTTG1-interacting protein (PTTG1IP/PBF) predicts breast cancer survival.
Repo H, Gurvits N, L?yttyniemi E, Nyk?nen M, Lintunen M, Karra H, Kurki S, Kuopio T, Talvinen K, S?derstr?m M, Kronqvist P
BMC cancer17(1)705(2017 Oct)

Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer.
Read ML, Fong JC, Modasia B, Fletcher A, Imruetaicharoenchoke W, Thompson RJ, Nieto H, Reynolds JJ, Bacon A, Mallick U, Hackshaw A, Watkinson JC, Boelaert K, Turnell AS, Smith VE, McCabe CJ
Oncogene36(37)5296-5308(2017 Sep)

Functional consequences of the first reported mutations of the proto-oncogene PTTG1IP/PBF.
Imruetaicharoenchoke W, Fletcher A, Lu W, Watkins RJ, Modasia B, Poole VL, Nieto HR, Thompson RJ, Boelaert K, Read ML, Smith VE, McCabe CJ
Endocrine-related cancer24(9)459-474(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings indicate that PBF and PTTG have a critical role in promoting thyroid cancer that is predictive of poorer patient outcome.
Title: Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer.

PTTG1IP and MAML3 are associated with BHR severity in adult asthma. The relevance of these genes is supported by the eQTL analyses and co-expression of PTTG1lP with vimentin and E-cadherin1, and MAML3 with MAML2.
Title: PTTG1IP and MAML3, novel genomewide association study genes for severity of hyperresponsiveness in adult asthma.

Unique role for PBF in regulating CTTN function to promote endocrine cell invasion and migration.
Title: Pro-invasive Effect of Proto-oncogene PBF Is Modulated by an Interaction with Cortactin.

these results demonstrate an emerging role for PBF in colorectal tumorigenesis through regulating p53 activity, with implications for PBF as a prognostic indicator for invasive tumors.
Title: The proto-oncogene PBF binds p53 and is associated with prognostic features in colorectal cancer.

These findings indicate that miR-584 suppresses glioma cell growth by negatively regulating the expression of PTTG1IP, suggesting that miR-584 has a tumor suppressive role in human glioma pathogenesis.
Title: MicroRNA-584 functions as a tumor suppressor and targets PTTG1IP in glioma.

The following PTTG1IP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTTG1IP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27336	NM_004339.4 Latest version!	Homo sapiens PTTG1 interacting protein (PTTG1IP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu27564	NM_001286822.1 Latest version!	Homo sapiens PTTG1 interacting protein (PTTG1IP), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu27336	NM_004339.3	Homo sapiens PTTG1 interacting protein (PTTG1IP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PTTG1IP ( NM_004339.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004330.1 Homo sapiens PTTG1 interacting protein (PTTG1IP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu27336
Clone ID Related Accession (Same CDS sequence)	NM_004339.4 , NM_004339.3
Accession Version	NM_004339.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	pituitary tumor-transforming gene 1 protein-interacting protein isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG721942.1 and BC019295.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_004339.3. Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.172735.1, SRR1660807.105466.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162568 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000330938.8/ ENSP00000328325.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGCCCG GAGTGGCCCG CGGGCCGACG CCGTACTGGA GGTTGCGCCT CGGTGGCGCC 
GCGCTGCTCC TGCTGCTCAT CCCGGTGGCC GCCGCGCAGG AGCCTCCCGG AGCTGCTTGT 
TCTCAGAACA CAAACAAAAC CTGTGAAGAG TGCCTGAAGA ACGTCTCCTG TCTTTGGTGC 
AACACTAACA AGGCTTGTCT GGACTACCCA GTTACAAGCG TCTTGCCACC GGCTTCCCTT 
TGTAAATTGA GCTCTGCACG CTGGGGAGTT TGTTGGGTGA ACTTTGAGGC GCTGATCATC 
ACCATGTCGG TAGTCGGGGG AACCCTCCTC CTGGGCATTG CCATCTGCTG CTGCTGCTGC 
TGCAGGAGGA AGAGGAGCCG GAAGCCGGAC AGGAGTGAGG AGAAGGCCAT GCGTGAGCGG 
GAGGAGAGGC GGATACGGCA GGAGGAACGG AGAGCAGAGA TGAAGACAAG ACATGATGAA 
ATCAGAAAAA AATATGGCCT GTTTAAAGAA GAAAACCCGT ATGCTAGATT TGAAAACAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004330.1
CDS	75..617
Translation	MAPGVARGPTPYWRLRLGGAALLLLLIPVAAAQEPPGAACSQNTNKTCEECLKNVSCLWCNTNKACLDYPVTSVLPPASLCKLSSARWGVCWVNFEALIITMSVVGGTLLLGIAICCCCCCRRKRSRKPDRSEEKAMREREERRIRQEERRAEMKTRHDEIRKKYGLFKEENPYARFENN

Target ORF information:

RefSeq Version	NM_004339.4
Organism	Homo sapiens(human)
Definition	Homo sapiens PTTG1 interacting protein (PTTG1IP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004339.4

ORF Insert Sequence:

ATGGCGCCCG GAGTGGCCCG CGGGCCGACG CCGTACTGGA GGTTGCGCCT CGGTGGCGCC 
GCGCTGCTCC TGCTGCTCAT CCCGGTGGCC GCCGCGCAGG AGCCTCCCGG AGCTGCTTGT 
TCTCAGAACA CAAACAAAAC CTGTGAAGAG TGCCTGAAGA ACGTCTCCTG TCTTTGGTGC 
AACACTAACA AGGCTTGTCT GGACTACCCA GTTACAAGCG TCTTGCCACC GGCTTCCCTT 
TGTAAATTGA GCTCTGCACG CTGGGGAGTT TGTTGGGTGA ACTTTGAGGC GCTGATCATC 
ACCATGTCGG TAGTCGGGGG AACCCTCCTC CTGGGCATTG CCATCTGCTG CTGCTGCTGC 
TGCAGGAGGA AGAGGAGCCG GAAGCCGGAC AGGAGTGAGG AGAAGGCCAT GCGTGAGCGG 
GAGGAGAGGC GGATACGGCA GGAGGAACGG AGAGCAGAGA TGAAGACAAG ACATGATGAA 
ATCAGAAAAA AATATGGCCT GTTTAAAGAA GAAAACCCGT ATGCTAGATT TGAAAACAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTTG1IP ( NM_004339.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004330.1 Homo sapiens PTTG1 interacting protein (PTTG1IP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu27336
Clone ID Related Accession (Same CDS sequence)	NM_004339.4 , NM_004339.3
Accession Version	NM_004339.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	pituitary tumor-transforming gene 1 protein-interacting protein isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC396020.1, BG721942.1, BC019295.1 and CB109980.1. This sequence is a reference standard in the RefSeqGene project. On Dec 31, 2010 this sequence version replaced NM_004339.2. Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF149785.1, SRR1803615.61057.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162568 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCCCG GAGTGGCCCG CGGGCCGACG CCGTACTGGA GGTTGCGCCT CGGTGGCGCC 
GCGCTGCTCC TGCTGCTCAT CCCGGTGGCC GCCGCGCAGG AGCCTCCCGG AGCTGCTTGT 
TCTCAGAACA CAAACAAAAC CTGTGAAGAG TGCCTGAAGA ACGTCTCCTG TCTTTGGTGC 
AACACTAACA AGGCTTGTCT GGACTACCCA GTTACAAGCG TCTTGCCACC GGCTTCCCTT 
TGTAAATTGA GCTCTGCACG CTGGGGAGTT TGTTGGGTGA ACTTTGAGGC GCTGATCATC 
ACCATGTCGG TAGTCGGGGG AACCCTCCTC CTGGGCATTG CCATCTGCTG CTGCTGCTGC 
TGCAGGAGGA AGAGGAGCCG GAAGCCGGAC AGGAGTGAGG AGAAGGCCAT GCGTGAGCGG 
GAGGAGAGGC GGATACGGCA GGAGGAACGG AGAGCAGAGA TGAAGACAAG ACATGATGAA 
ATCAGAAAAA AATATGGCCT GTTTAAAGAA GAAAACCCGT ATGCTAGATT TGAAAACAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004330.1
CDS	288..830
Translation	MAPGVARGPTPYWRLRLGGAALLLLLIPVAAAQEPPGAACSQNTNKTCEECLKNVSCLWCNTNKACLDYPVTSVLPPASLCKLSSARWGVCWVNFEALIITMSVVGGTLLLGIAICCCCCCRRKRSRKPDRSEEKAMREREERRIRQEERRAEMKTRHDEIRKKYGLFKEENPYARFENN

Target ORF information:

RefSeq Version	NM_004339.3
Organism	Homo sapiens(human)
Definition	Homo sapiens PTTG1 interacting protein (PTTG1IP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004339.3

ORF Insert Sequence:

ATGGCGCCCG GAGTGGCCCG CGGGCCGACG CCGTACTGGA GGTTGCGCCT CGGTGGCGCC 
GCGCTGCTCC TGCTGCTCAT CCCGGTGGCC GCCGCGCAGG AGCCTCCCGG AGCTGCTTGT 
TCTCAGAACA CAAACAAAAC CTGTGAAGAG TGCCTGAAGA ACGTCTCCTG TCTTTGGTGC 
AACACTAACA AGGCTTGTCT GGACTACCCA GTTACAAGCG TCTTGCCACC GGCTTCCCTT 
TGTAAATTGA GCTCTGCACG CTGGGGAGTT TGTTGGGTGA ACTTTGAGGC GCTGATCATC 
ACCATGTCGG TAGTCGGGGG AACCCTCCTC CTGGGCATTG CCATCTGCTG CTGCTGCTGC 
TGCAGGAGGA AGAGGAGCCG GAAGCCGGAC AGGAGTGAGG AGAAGGCCAT GCGTGAGCGG 
GAGGAGAGGC GGATACGGCA GGAGGAACGG AGAGCAGAGA TGAAGACAAG ACATGATGAA 
ATCAGAAAAA AATATGGCCT GTTTAAAGAA GAAAACCCGT ATGCTAGATT TGAAAACAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTTG1IP ( NM_001286822.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001273751.1 Homo sapiens PTTG1 interacting protein (PTTG1IP), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu27564
Clone ID Related Accession (Same CDS sequence)	NM_001286822.1
Accession Version	NM_001286822.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	pituitary tumor-transforming gene 1 protein-interacting protein isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC396020.1, BG721942.1, AK298557.1, BC019295.1 and CB109980.1. On Nov 16, 2013 this sequence version replaced XM_005261176.1. Transcript Variant: This variant (2) lacks 3 consecutive exons, which cause a frame-shift compared to variant 1. The resulting shorter isoform (2) has a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.176245.1, AK298557.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCCCG GAGTGGCCCG CGGGCCGACG CCGTACTGGA GGTTGCGCCT CGGTGGCGCC 
GCGCTGCTCC TGCTGCTCAT CCCGGTGGCC GCCGCGCAGG AGCCTCCCGG AGCTGCTTGT 
TCTCAGAACA CAAACAAAAC CTGTGAAGAG TGCCTGAAGA ACGTCTCCGC CTGTTTAAAG 
AAGAAAACCC GTATGCTAGA TTTGAAAACA ACTAAAGCGC TCCAGCACAT CAGTCCCGAC 
GCTTCCTGTG AGGTGCACGC TCCGCAGCCC AGCCCAGCCG GGAGACCACG TGGCCATTGC 
GGTCTCCTGA CCTTGGCCAG TGAACCTGCC AGCCTTCCAG GACAGGCGGC CGGAGAGCTG 
CCCCTGAAGG ACAGTCCTCT CGTCTTGCAG ACTGGTGACC TTCTATTCCC TGTTCATCTC 
TGTTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001273751.1
CDS	288..716
Translation	MAPGVARGPTPYWRLRLGGAALLLLLIPVAAAQEPPGAACSQNTNKTCEECLKNVSACLKKKTRMLDLKTTKALQHISPDASCEVHAPQPSPAGRPRGHCGLLTLASEPASLPGQAAGELPLKDSPLVLQTGDLLFPVHLCF

Target ORF information:

RefSeq Version	NM_001286822.1
Organism	Homo sapiens(human)
Definition	Homo sapiens PTTG1 interacting protein (PTTG1IP), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001286822.1

ORF Insert Sequence:

ATGGCGCCCG GAGTGGCCCG CGGGCCGACG CCGTACTGGA GGTTGCGCCT CGGTGGCGCC 
GCGCTGCTCC TGCTGCTCAT CCCGGTGGCC GCCGCGCAGG AGCCTCCCGG AGCTGCTTGT 
TCTCAGAACA CAAACAAAAC CTGTGAAGAG TGCCTGAAGA ACGTCTCCGC CTGTTTAAAG 
AAGAAAACCC GTATGCTAGA TTTGAAAACA ACTAAAGCGC TCCAGCACAT CAGTCCCGAC 
GCTTCCTGTG AGGTGCACGC TCCGCAGCCC AGCCCAGCCG GGAGACCACG TGGCCATTGC 
GGTCTCCTGA CCTTGGCCAG TGAACCTGCC AGCCTTCCAG GACAGGCGGC CGGAGAGCTG 
CCCCTGAAGG ACAGTCCTCT CGTCTTGCAG ACTGGTGACC TTCTATTCCC TGTTCATCTC 
TGTTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PTTG1-interacting protein (PTTG1IP/PBF) predicts breast cancer survival.
BMC cancer17(1)705(2017 Oct)
Repo H,Gurvits N,L?yttyniemi E,Nyk?nen M,Lintunen M,Karra H,Kurki S,Kuopio T,Talvinen K,S?derstr?m M,Kronqvist P

Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer.
Oncogene36(37)5296-5308(2017 Sep)
Read ML,Fong JC,Modasia B,Fletcher A,Imruetaicharoenchoke W,Thompson RJ,Nieto H,Reynolds JJ,Bacon A,Mallick U,Hackshaw A,Watkinson JC,Boelaert K,Turnell AS,Smith VE,McCabe CJ

Functional consequences of the first reported mutations of the proto-oncogene PTTG1IP/PBF.
Endocrine-related cancer24(9)459-474(2017 Sep)
Imruetaicharoenchoke W,Fletcher A,Lu W,Watkins RJ,Modasia B,Poole VL,Nieto HR,Thompson RJ,Boelaert K,Read ML,Smith VE,McCabe CJ

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PTTG1IP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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