LAT2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LAT2
Entrez Gene ID	7462
Full Name	linker for activation of T cells family member 2
Synonyms	HSPC046,LAB,NTAL,WBSCR15,WBSCR5,WSCR5
General protein information	Preferred Names linker for activation of T cells family member 2 Names linker for activation of T-cells family member 2 Williams-Beuren syndrome chromosomal region 15 protein Williams-Beuren syndrome chromosomal region 5 protein linker for activation of B-cells linker for activation of T cells, transmembrane adaptor 2 membrane-associated adapter molecule non-T-cell activation linker
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q11.23
Summary	This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008].
Disorder MIM:	605719

mRNA and Protein(s)

mRNA	Protein	Name
NM_032464.2	NP_115853.2	linker for activation of T-cells family member 2 precursor
NM_014146.3	NP_054865.2	linker for activation of T-cells family member 2 precursor
XM_011516558.1	XP_011514860.1	linker for activation of T-cells family member 2 isoform X1
NM_032464.3	NP_115853.2	linker for activation of T-cells family member 2 precursor
NM_032463.3	NP_115852.1	linker for activation of T-cells family member 2 precursor
NM_014146.4	NP_054865.2	linker for activation of T-cells family member 2 precursor
NM_032463.2	NP_115852.1	linker for activation of T-cells family member 2 precursor
XM_011516558.2	XP_011514860.1	linker for activation of T-cells family member 2 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	LAT2	NP_054865.2
	LAT2	XP_001082644.1
Bos taurus (cattle)	LAT2	NP_001068651.2
Mus musculus (house mouse)	Lat2	NP_064428.1
Rattus norvegicus (Norway rat)	Lat2	NP_776212.1
Gallus gallus (chicken)	LOC100857708	XP_003643276.2
Pan troglodytes (chimpanzee)	LAT2	XP_003318629.1
Canis lupus familiaris (dog)	LAT2	XP_005621012.1
Gallus gallus (chicken)	LOC100857800	XP_004950582.1
Gallus gallus (chicken)	LAT2	NP_001007483.1
Gallus gallus (chicken)	LOC100857709	XP_004950578.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of large neutral amino acid transporters LAT1 and LAT2 in medulloblastoma.
Cicone F, Minniti G, Oliva MA, Carideo L, Prior JO, Scopinaro F, Giangaspero F, Arcella A
Brain tumor pathology34(4)179-181(2017 Oct)

Overexpression of L-Type Amino Acid Transporter 1 (LAT1) and 2 (LAT2): Novel Markers of Neuroendocrine Tumors.
Barollo S, Bertazza L, Watutantrige-Fernando S, Censi S, Cavedon E, Galuppini F, Pennelli G, Fassina A, Citton M, Rubin B, Pezzani R, Benna C, Opocher G, Iacobone M, Mian C
PloS one11(5)e0156044(2016)

The AML1/ETO target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells.
Essig A, Duque-Afonso J, Schwemmers S, Pahl HL, L?bbert M
Leukemia research38(3)340-5(2014 Mar)

Detergent-induced stabilization and improved 3D map of the human heteromeric amino acid transporter 4F2hc-LAT2.
Meury M, Costa M, Harder D, Stauffer M, Jeckelmann JM, Br?hlmann B, Rosell A, Ilg? H, Kovar K, Palac?n M, Fotiadis D
PloS one9(10)e109882(2014)

Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity.
Thom? CH, dos Santos GA, Ferreira GA, Scheucher PS, Izumi C, Leopoldino AM, Sim?o AM, Ciancaglini P, de Oliveira KT, Chin A, Hanash SM, Falc?o RP, Rego EM, Greene LJ, Fa?a VM
Molecular & cellular proteomics : MCP11(12)1898-912(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LAT1 and LAT2 were overexpressed in both pheochromocytoma and medullary thyroid carcinoma by comparison with normal tissues.
Title: Overexpression of L-Type Amino Acid Transporter 1 (LAT1) and 2 (LAT2): Novel Markers of Neuroendocrine Tumors.

The AML1/ETO target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells.
Title: The AML1/ETO target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells.

The detergent-induced stabilization of the purified human 4F2hc-LAT2 complex presented here paves the way towards its crystallization and structure determination at high-resolution
Title: Detergent-induced stabilization and improved 3D map of the human heteromeric amino acid transporter 4F2hc-LAT2.

LAT2 is an early mediator of the anti-leukemic activity of alkylphospholipids and arsenic trioxide. Thus, LAT2 may be used as a target for the design of drugs for cancer therapy.
Title: Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity.

NTAL acts as a tumor suppressor that enhances the proximal signaling of leukemic blasts. The key downstream molecule responsible for the biological effect of TCR signaling is ERK.
Title: The adaptor protein NTAL enhances proximal signaling and potentiates corticosteroid-induced apoptosis in T-ALL.

The following LAT2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LAT2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17337	NM_032464.3 Latest version!	Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu17337	NM_032463.3 Latest version!	Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu17337	NM_014146.4 Latest version!	Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu17337	XM_011516558.2 Latest version!	Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17337	NM_032464.2	Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu17337	NM_014146.3	Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu17337	NM_032463.2	Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu17337	XM_011516558.1	Homo sapiens linker for activation of T cells family, member 2 (LAT2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LAT2 ( NM_032464.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_115853.2 Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17337
Clone ID Related Accession (Same CDS sequence)	NM_032464.2 , NM_014146.3 , XM_011516558.1 , NM_032464.3 , NM_032463.3 , NM_014146.4 , NM_032463.2 , XM_011516558.2
Accession Version	NM_032464.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 732bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-12
Organism	Homo sapiens(human)
Product	linker for activation of T-cells family member 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM468969.1, BC001609.1 and AI492348.1. This sequence is a reference standard in the RefSeqGene project. On or before Dec 4, 2006 this sequence version replaced NM_022040.3, NM_032464.1. Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein. CCDS Note: The coding region has been updated to represent an alternate splice pattern, resulting in an alternate and longer C-terminus that is better supported by available transcript and conservation data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.27842.1, BC001609.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCTCGG GGACTGAACT GCTGTGGCCC GGAGCAGCGC TGCTGGTGCT GTTGGGGGTG 
GCAGCCAGTC TGTGTGTGCG CTGCTCACGC CCAGGTGCAA AGAGGTCAGA GAAAATCTAC 
CAGCAGAGAA GTCTGCGTGA GGACCAACAG AGCTTTACGG GGTCCCGGAC CTACTCCTTG 
GTCGGGCAGG CATGGCCAGG ACCCCTGGCG GACATGGCAC CCACAAGGAA GGACAAGCTG 
TTGCAATTCT ACCCCAGCCT GGAGGATCCA GCATCTTCCA GGTACCAGAA CTTCAGCAAA 
GGAAGCAGAC ACGGGTCGGA GGAAGCCTAC ATAGACCCCA TTGCCATGGA GTATTACAAC 
TGGGGGCGGT TCTCGAAGCC CCCAGAAGAT GATGATGCCA ATTCCTACGA GAATGTGCTC 
ATTTGCAAGC AGAAAACCAC AGAGACAGGT GCCCAGCAGG AGGGCATAGG TGGCCTCTGC 
AGAGGGGACC TCAGCCTGTC ACTGGCCCTG AAGACTGGCC CCACTTCTGG TCTCTGTCCC 
TCTGCCTCCC CGGAAGAAGA TGAGGAATCT GAGGATTATC AGAACTCAGC ATCCATCCAT 
CAGTGGCGCG AGTCCAGGAA GGTCATGGGG CAACTCCAGA GAGAAGCATC CCCTGGCCCG 
GTGGGAAGCC CAGACGAGGA GGACGGGGAA CCGGATTACG TGAATGGGGA GGTGGCAGCC 
ACAGAAGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115853.2
CDS	551..1282
Translation	MSSGTELLWPGAALLVLLGVAASLCVRCSRPGAKRSEKIYQQRSLREDQQSFTGSRTYSLVGQAWPGPLADMAPTRKDKLLQFYPSLEDPASSRYQNFSKGSRHGSEEAYIDPIAMEYYNWGRFSKPPEDDDANSYENVLICKQKTTETGAQQEGIGGLCRGDLSLSLALKTGPTSGLCPSASPEEDEESEDYQNSASIHQWRESRKVMGQLQREASPGPVGSPDEEDGEPDYVNGEVAATEA

Target ORF information:

RefSeq Version	NM_032464.2
Organism	Homo sapiens(human)
Definition	Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032464.2

ORF Insert Sequence:

ATGAGCTCGG GGACTGAACT GCTGTGGCCC GGAGCAGCGC TGCTGGTGCT GTTGGGGGTG 
GCAGCCAGTC TGTGTGTGCG CTGCTCACGC CCAGGTGCAA AGAGGTCAGA GAAAATCTAC 
CAGCAGAGAA GTCTGCGTGA GGACCAACAG AGCTTTACGG GGTCCCGGAC CTACTCCTTG 
GTCGGGCAGG CATGGCCAGG ACCCCTGGCG GACATGGCAC CCACAAGGAA GGACAAGCTG 
TTGCAATTCT ACCCCAGCCT GGAGGATCCA GCATCTTCCA GGTACCAGAA CTTCAGCAAA 
GGAAGCAGAC ACGGGTCGGA GGAAGCCTAC ATAGACCCCA TTGCCATGGA GTATTACAAC 
TGGGGGCGGT TCTCGAAGCC CCCAGAAGAT GATGATGCCA ATTCCTACGA GAATGTGCTC 
ATTTGCAAGC AGAAAACCAC AGAGACAGGT GCCCAGCAGG AGGGCATAGG TGGCCTCTGC 
AGAGGGGACC TCAGCCTGTC ACTGGCCCTG AAGACTGGCC CCACTTCTGG TCTCTGTCCC 
TCTGCCTCCC CGGAAGAAGA TGAGGAATCT GAGGATTATC AGAACTCAGC ATCCATCCAT 
CAGTGGCGCG AGTCCAGGAA GGTCATGGGG CAACTCCAGA GAGAAGCATC CCCTGGCCCG 
GTGGGAAGCC CAGACGAGGA GGACGGGGAA CCGGATTACG TGAATGGGGA GGTGGCAGCC 
ACAGAAGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAT2 ( NM_014146.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_054865.2 Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu17337
Clone ID Related Accession (Same CDS sequence)	NM_032464.2 , NM_014146.3 , XM_011516558.1 , NM_032464.3 , NM_032463.3 , NM_014146.4 , NM_032463.2 , XM_011516558.2
Accession Version	NM_014146.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 732bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	linker for activation of T-cells family member 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM468969.1, AF252613.1 and AI492348.1. On Feb 28, 2006 this sequence version replaced NM_014146.2. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein. CCDS Note: The coding region has been updated to represent an alternate splice pattern, resulting in an alternate and longer C-terminus that is better supported by available transcript and conservation data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.124552.1, SRR1163658.403049.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCTCGG GGACTGAACT GCTGTGGCCC GGAGCAGCGC TGCTGGTGCT GTTGGGGGTG 
GCAGCCAGTC TGTGTGTGCG CTGCTCACGC CCAGGTGCAA AGAGGTCAGA GAAAATCTAC 
CAGCAGAGAA GTCTGCGTGA GGACCAACAG AGCTTTACGG GGTCCCGGAC CTACTCCTTG 
GTCGGGCAGG CATGGCCAGG ACCCCTGGCG GACATGGCAC CCACAAGGAA GGACAAGCTG 
TTGCAATTCT ACCCCAGCCT GGAGGATCCA GCATCTTCCA GGTACCAGAA CTTCAGCAAA 
GGAAGCAGAC ACGGGTCGGA GGAAGCCTAC ATAGACCCCA TTGCCATGGA GTATTACAAC 
TGGGGGCGGT TCTCGAAGCC CCCAGAAGAT GATGATGCCA ATTCCTACGA GAATGTGCTC 
ATTTGCAAGC AGAAAACCAC AGAGACAGGT GCCCAGCAGG AGGGCATAGG TGGCCTCTGC 
AGAGGGGACC TCAGCCTGTC ACTGGCCCTG AAGACTGGCC CCACTTCTGG TCTCTGTCCC 
TCTGCCTCCC CGGAAGAAGA TGAGGAATCT GAGGATTATC AGAACTCAGC ATCCATCCAT 
CAGTGGCGCG AGTCCAGGAA GGTCATGGGG CAACTCCAGA GAGAAGCATC CCCTGGCCCG 
GTGGGAAGCC CAGACGAGGA GGACGGGGAA CCGGATTACG TGAATGGGGA GGTGGCAGCC 
ACAGAAGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054865.2
CDS	362..1093
Translation	MSSGTELLWPGAALLVLLGVAASLCVRCSRPGAKRSEKIYQQRSLREDQQSFTGSRTYSLVGQAWPGPLADMAPTRKDKLLQFYPSLEDPASSRYQNFSKGSRHGSEEAYIDPIAMEYYNWGRFSKPPEDDDANSYENVLICKQKTTETGAQQEGIGGLCRGDLSLSLALKTGPTSGLCPSASPEEDEESEDYQNSASIHQWRESRKVMGQLQREASPGPVGSPDEEDGEPDYVNGEVAATEA

Target ORF information:

RefSeq Version	NM_014146.3
Organism	Homo sapiens(human)
Definition	Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014146.3

ORF Insert Sequence:

ATGAGCTCGG GGACTGAACT GCTGTGGCCC GGAGCAGCGC TGCTGGTGCT GTTGGGGGTG 
GCAGCCAGTC TGTGTGTGCG CTGCTCACGC CCAGGTGCAA AGAGGTCAGA GAAAATCTAC 
CAGCAGAGAA GTCTGCGTGA GGACCAACAG AGCTTTACGG GGTCCCGGAC CTACTCCTTG 
GTCGGGCAGG CATGGCCAGG ACCCCTGGCG GACATGGCAC CCACAAGGAA GGACAAGCTG 
TTGCAATTCT ACCCCAGCCT GGAGGATCCA GCATCTTCCA GGTACCAGAA CTTCAGCAAA 
GGAAGCAGAC ACGGGTCGGA GGAAGCCTAC ATAGACCCCA TTGCCATGGA GTATTACAAC 
TGGGGGCGGT TCTCGAAGCC CCCAGAAGAT GATGATGCCA ATTCCTACGA GAATGTGCTC 
ATTTGCAAGC AGAAAACCAC AGAGACAGGT GCCCAGCAGG AGGGCATAGG TGGCCTCTGC 
AGAGGGGACC TCAGCCTGTC ACTGGCCCTG AAGACTGGCC CCACTTCTGG TCTCTGTCCC 
TCTGCCTCCC CGGAAGAAGA TGAGGAATCT GAGGATTATC AGAACTCAGC ATCCATCCAT 
CAGTGGCGCG AGTCCAGGAA GGTCATGGGG CAACTCCAGA GAGAAGCATC CCCTGGCCCG 
GTGGGAAGCC CAGACGAGGA GGACGGGGAA CCGGATTACG TGAATGGGGA GGTGGCAGCC 
ACAGAAGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAT2 ( NM_032464.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_115853.2 Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17337
Clone ID Related Accession (Same CDS sequence)	NM_032464.2 , NM_014146.3 , XM_011516558.1 , NM_032464.3 , NM_032463.3 , NM_014146.4 , NM_032463.2 , XM_011516558.2
Accession Version	NM_032464.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 732bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	linker for activation of T-cells family member 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM468969.1, BC001609.1 and AI492348.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_032464.2. Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein. CCDS Note: The coding region has been updated to represent an alternate splice pattern, resulting in an alternate and longer C-terminus that is better supported by available transcript and conservation data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF252611.1, SRR3476690.44670.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000460943.6/ ENSP00000420494.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCTCGG GGACTGAACT GCTGTGGCCC GGAGCAGCGC TGCTGGTGCT GTTGGGGGTG 
GCAGCCAGTC TGTGTGTGCG CTGCTCACGC CCAGGTGCAA AGAGGTCAGA GAAAATCTAC 
CAGCAGAGAA GTCTGCGTGA GGACCAACAG AGCTTTACGG GGTCCCGGAC CTACTCCTTG 
GTCGGGCAGG CATGGCCAGG ACCCCTGGCG GACATGGCAC CCACAAGGAA GGACAAGCTG 
TTGCAATTCT ACCCCAGCCT GGAGGATCCA GCATCTTCCA GGTACCAGAA CTTCAGCAAA 
GGAAGCAGAC ACGGGTCGGA GGAAGCCTAC ATAGACCCCA TTGCCATGGA GTATTACAAC 
TGGGGGCGGT TCTCGAAGCC CCCAGAAGAT GATGATGCCA ATTCCTACGA GAATGTGCTC 
ATTTGCAAGC AGAAAACCAC AGAGACAGGT GCCCAGCAGG AGGGCATAGG TGGCCTCTGC 
AGAGGGGACC TCAGCCTGTC ACTGGCCCTG AAGACTGGCC CCACTTCTGG TCTCTGTCCC 
TCTGCCTCCC CGGAAGAAGA TGAGGAATCT GAGGATTATC AGAACTCAGC ATCCATCCAT 
CAGTGGCGCG AGTCCAGGAA GGTCATGGGG CAACTCCAGA GAGAAGCATC CCCTGGCCCG 
GTGGGAAGCC CAGACGAGGA GGACGGGGAA CCGGATTACG TGAATGGGGA GGTGGCAGCC 
ACAGAAGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115853.2
CDS	302..1033
Translation	MSSGTELLWPGAALLVLLGVAASLCVRCSRPGAKRSEKIYQQRSLREDQQSFTGSRTYSLVGQAWPGPLADMAPTRKDKLLQFYPSLEDPASSRYQNFSKGSRHGSEEAYIDPIAMEYYNWGRFSKPPEDDDANSYENVLICKQKTTETGAQQEGIGGLCRGDLSLSLALKTGPTSGLCPSASPEEDEESEDYQNSASIHQWRESRKVMGQLQREASPGPVGSPDEEDGEPDYVNGEVAATEA

Target ORF information:

RefSeq Version	NM_032464.3
Organism	Homo sapiens(human)
Definition	Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032464.3

ORF Insert Sequence:

ATGAGCTCGG GGACTGAACT GCTGTGGCCC GGAGCAGCGC TGCTGGTGCT GTTGGGGGTG 
GCAGCCAGTC TGTGTGTGCG CTGCTCACGC CCAGGTGCAA AGAGGTCAGA GAAAATCTAC 
CAGCAGAGAA GTCTGCGTGA GGACCAACAG AGCTTTACGG GGTCCCGGAC CTACTCCTTG 
GTCGGGCAGG CATGGCCAGG ACCCCTGGCG GACATGGCAC CCACAAGGAA GGACAAGCTG 
TTGCAATTCT ACCCCAGCCT GGAGGATCCA GCATCTTCCA GGTACCAGAA CTTCAGCAAA 
GGAAGCAGAC ACGGGTCGGA GGAAGCCTAC ATAGACCCCA TTGCCATGGA GTATTACAAC 
TGGGGGCGGT TCTCGAAGCC CCCAGAAGAT GATGATGCCA ATTCCTACGA GAATGTGCTC 
ATTTGCAAGC AGAAAACCAC AGAGACAGGT GCCCAGCAGG AGGGCATAGG TGGCCTCTGC 
AGAGGGGACC TCAGCCTGTC ACTGGCCCTG AAGACTGGCC CCACTTCTGG TCTCTGTCCC 
TCTGCCTCCC CGGAAGAAGA TGAGGAATCT GAGGATTATC AGAACTCAGC ATCCATCCAT 
CAGTGGCGCG AGTCCAGGAA GGTCATGGGG CAACTCCAGA GAGAAGCATC CCCTGGCCCG 
GTGGGAAGCC CAGACGAGGA GGACGGGGAA CCGGATTACG TGAATGGGGA GGTGGCAGCC 
ACAGAAGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAT2 ( NM_032463.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_115852.1 Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu17337
Clone ID Related Accession (Same CDS sequence)	NM_032464.2 , NM_014146.3 , XM_011516558.1 , NM_032464.3 , NM_032463.3 , NM_014146.4 , NM_032463.2 , XM_011516558.2
Accession Version	NM_032463.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 732bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	linker for activation of T-cells family member 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM468969.1, AF252614.1 and AI492348.1. On May 31, 2019 this sequence version replaced NM_032463.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein. CCDS Note: The coding region has been updated to represent an alternate splice pattern, resulting in an alternate and longer C-terminus that is better supported by available transcript and conservation data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF252614.1, SRR1660807.54582.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCTCGG GGACTGAACT GCTGTGGCCC GGAGCAGCGC TGCTGGTGCT GTTGGGGGTG 
GCAGCCAGTC TGTGTGTGCG CTGCTCACGC CCAGGTGCAA AGAGGTCAGA GAAAATCTAC 
CAGCAGAGAA GTCTGCGTGA GGACCAACAG AGCTTTACGG GGTCCCGGAC CTACTCCTTG 
GTCGGGCAGG CATGGCCAGG ACCCCTGGCG GACATGGCAC CCACAAGGAA GGACAAGCTG 
TTGCAATTCT ACCCCAGCCT GGAGGATCCA GCATCTTCCA GGTACCAGAA CTTCAGCAAA 
GGAAGCAGAC ACGGGTCGGA GGAAGCCTAC ATAGACCCCA TTGCCATGGA GTATTACAAC 
TGGGGGCGGT TCTCGAAGCC CCCAGAAGAT GATGATGCCA ATTCCTACGA GAATGTGCTC 
ATTTGCAAGC AGAAAACCAC AGAGACAGGT GCCCAGCAGG AGGGCATAGG TGGCCTCTGC 
AGAGGGGACC TCAGCCTGTC ACTGGCCCTG AAGACTGGCC CCACTTCTGG TCTCTGTCCC 
TCTGCCTCCC CGGAAGAAGA TGAGGAATCT GAGGATTATC AGAACTCAGC ATCCATCCAT 
CAGTGGCGCG AGTCCAGGAA GGTCATGGGG CAACTCCAGA GAGAAGCATC CCCTGGCCCG 
GTGGGAAGCC CAGACGAGGA GGACGGGGAA CCGGATTACG TGAATGGGGA GGTGGCAGCC 
ACAGAAGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115852.1
CDS	232..963
Translation	MSSGTELLWPGAALLVLLGVAASLCVRCSRPGAKRSEKIYQQRSLREDQQSFTGSRTYSLVGQAWPGPLADMAPTRKDKLLQFYPSLEDPASSRYQNFSKGSRHGSEEAYIDPIAMEYYNWGRFSKPPEDDDANSYENVLICKQKTTETGAQQEGIGGLCRGDLSLSLALKTGPTSGLCPSASPEEDEESEDYQNSASIHQWRESRKVMGQLQREASPGPVGSPDEEDGEPDYVNGEVAATEA

Target ORF information:

RefSeq Version	NM_032463.3
Organism	Homo sapiens(human)
Definition	Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032463.3

ORF Insert Sequence:

ATGAGCTCGG GGACTGAACT GCTGTGGCCC GGAGCAGCGC TGCTGGTGCT GTTGGGGGTG 
GCAGCCAGTC TGTGTGTGCG CTGCTCACGC CCAGGTGCAA AGAGGTCAGA GAAAATCTAC 
CAGCAGAGAA GTCTGCGTGA GGACCAACAG AGCTTTACGG GGTCCCGGAC CTACTCCTTG 
GTCGGGCAGG CATGGCCAGG ACCCCTGGCG GACATGGCAC CCACAAGGAA GGACAAGCTG 
TTGCAATTCT ACCCCAGCCT GGAGGATCCA GCATCTTCCA GGTACCAGAA CTTCAGCAAA 
GGAAGCAGAC ACGGGTCGGA GGAAGCCTAC ATAGACCCCA TTGCCATGGA GTATTACAAC 
TGGGGGCGGT TCTCGAAGCC CCCAGAAGAT GATGATGCCA ATTCCTACGA GAATGTGCTC 
ATTTGCAAGC AGAAAACCAC AGAGACAGGT GCCCAGCAGG AGGGCATAGG TGGCCTCTGC 
AGAGGGGACC TCAGCCTGTC ACTGGCCCTG AAGACTGGCC CCACTTCTGG TCTCTGTCCC 
TCTGCCTCCC CGGAAGAAGA TGAGGAATCT GAGGATTATC AGAACTCAGC ATCCATCCAT 
CAGTGGCGCG AGTCCAGGAA GGTCATGGGG CAACTCCAGA GAGAAGCATC CCCTGGCCCG 
GTGGGAAGCC CAGACGAGGA GGACGGGGAA CCGGATTACG TGAATGGGGA GGTGGCAGCC 
ACAGAAGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAT2 ( NM_014146.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_054865.2 Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu17337
Clone ID Related Accession (Same CDS sequence)	NM_032464.2 , NM_014146.3 , XM_011516558.1 , NM_032464.3 , NM_032463.3 , NM_014146.4 , NM_032463.2 , XM_011516558.2
Accession Version	NM_014146.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 732bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	linker for activation of T-cells family member 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM468969.1, AF252613.1 and AI492348.1. On May 31, 2019 this sequence version replaced NM_014146.3. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein. CCDS Note: The coding region has been updated to represent an alternate splice pattern, resulting in an alternate and longer C-terminus that is better supported by available transcript and conservation data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.124552.1, SRR1163655.343384.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCTCGG GGACTGAACT GCTGTGGCCC GGAGCAGCGC TGCTGGTGCT GTTGGGGGTG 
GCAGCCAGTC TGTGTGTGCG CTGCTCACGC CCAGGTGCAA AGAGGTCAGA GAAAATCTAC 
CAGCAGAGAA GTCTGCGTGA GGACCAACAG AGCTTTACGG GGTCCCGGAC CTACTCCTTG 
GTCGGGCAGG CATGGCCAGG ACCCCTGGCG GACATGGCAC CCACAAGGAA GGACAAGCTG 
TTGCAATTCT ACCCCAGCCT GGAGGATCCA GCATCTTCCA GGTACCAGAA CTTCAGCAAA 
GGAAGCAGAC ACGGGTCGGA GGAAGCCTAC ATAGACCCCA TTGCCATGGA GTATTACAAC 
TGGGGGCGGT TCTCGAAGCC CCCAGAAGAT GATGATGCCA ATTCCTACGA GAATGTGCTC 
ATTTGCAAGC AGAAAACCAC AGAGACAGGT GCCCAGCAGG AGGGCATAGG TGGCCTCTGC 
AGAGGGGACC TCAGCCTGTC ACTGGCCCTG AAGACTGGCC CCACTTCTGG TCTCTGTCCC 
TCTGCCTCCC CGGAAGAAGA TGAGGAATCT GAGGATTATC AGAACTCAGC ATCCATCCAT 
CAGTGGCGCG AGTCCAGGAA GGTCATGGGG CAACTCCAGA GAGAAGCATC CCCTGGCCCG 
GTGGGAAGCC CAGACGAGGA GGACGGGGAA CCGGATTACG TGAATGGGGA GGTGGCAGCC 
ACAGAAGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054865.2
CDS	113..844
Translation	MSSGTELLWPGAALLVLLGVAASLCVRCSRPGAKRSEKIYQQRSLREDQQSFTGSRTYSLVGQAWPGPLADMAPTRKDKLLQFYPSLEDPASSRYQNFSKGSRHGSEEAYIDPIAMEYYNWGRFSKPPEDDDANSYENVLICKQKTTETGAQQEGIGGLCRGDLSLSLALKTGPTSGLCPSASPEEDEESEDYQNSASIHQWRESRKVMGQLQREASPGPVGSPDEEDGEPDYVNGEVAATEA

Target ORF information:

RefSeq Version	NM_014146.4
Organism	Homo sapiens(human)
Definition	Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014146.4

ORF Insert Sequence:

ATGAGCTCGG GGACTGAACT GCTGTGGCCC GGAGCAGCGC TGCTGGTGCT GTTGGGGGTG 
GCAGCCAGTC TGTGTGTGCG CTGCTCACGC CCAGGTGCAA AGAGGTCAGA GAAAATCTAC 
CAGCAGAGAA GTCTGCGTGA GGACCAACAG AGCTTTACGG GGTCCCGGAC CTACTCCTTG 
GTCGGGCAGG CATGGCCAGG ACCCCTGGCG GACATGGCAC CCACAAGGAA GGACAAGCTG 
TTGCAATTCT ACCCCAGCCT GGAGGATCCA GCATCTTCCA GGTACCAGAA CTTCAGCAAA 
GGAAGCAGAC ACGGGTCGGA GGAAGCCTAC ATAGACCCCA TTGCCATGGA GTATTACAAC 
TGGGGGCGGT TCTCGAAGCC CCCAGAAGAT GATGATGCCA ATTCCTACGA GAATGTGCTC 
ATTTGCAAGC AGAAAACCAC AGAGACAGGT GCCCAGCAGG AGGGCATAGG TGGCCTCTGC 
AGAGGGGACC TCAGCCTGTC ACTGGCCCTG AAGACTGGCC CCACTTCTGG TCTCTGTCCC 
TCTGCCTCCC CGGAAGAAGA TGAGGAATCT GAGGATTATC AGAACTCAGC ATCCATCCAT 
CAGTGGCGCG AGTCCAGGAA GGTCATGGGG CAACTCCAGA GAGAAGCATC CCCTGGCCCG 
GTGGGAAGCC CAGACGAGGA GGACGGGGAA CCGGATTACG TGAATGGGGA GGTGGCAGCC 
ACAGAAGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAT2 ( NM_032463.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_115852.1 Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu17337
Clone ID Related Accession (Same CDS sequence)	NM_032464.2 , NM_014146.3 , XM_011516558.1 , NM_032464.3 , NM_032463.3 , NM_014146.4 , NM_032463.2 , XM_011516558.2
Accession Version	NM_032463.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 732bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	linker for activation of T-cells family member 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM468969.1, AF252614.1 and AI492348.1. On Feb 28, 2006 this sequence version replaced NM_032463.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein. CCDS Note: The coding region has been updated to represent an alternate splice pattern, resulting in an alternate and longer C-terminus that is better supported by available transcript and conservation data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.373986.1, SRR1163655.142961.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCTCGG GGACTGAACT GCTGTGGCCC GGAGCAGCGC TGCTGGTGCT GTTGGGGGTG 
GCAGCCAGTC TGTGTGTGCG CTGCTCACGC CCAGGTGCAA AGAGGTCAGA GAAAATCTAC 
CAGCAGAGAA GTCTGCGTGA GGACCAACAG AGCTTTACGG GGTCCCGGAC CTACTCCTTG 
GTCGGGCAGG CATGGCCAGG ACCCCTGGCG GACATGGCAC CCACAAGGAA GGACAAGCTG 
TTGCAATTCT ACCCCAGCCT GGAGGATCCA GCATCTTCCA GGTACCAGAA CTTCAGCAAA 
GGAAGCAGAC ACGGGTCGGA GGAAGCCTAC ATAGACCCCA TTGCCATGGA GTATTACAAC 
TGGGGGCGGT TCTCGAAGCC CCCAGAAGAT GATGATGCCA ATTCCTACGA GAATGTGCTC 
ATTTGCAAGC AGAAAACCAC AGAGACAGGT GCCCAGCAGG AGGGCATAGG TGGCCTCTGC 
AGAGGGGACC TCAGCCTGTC ACTGGCCCTG AAGACTGGCC CCACTTCTGG TCTCTGTCCC 
TCTGCCTCCC CGGAAGAAGA TGAGGAATCT GAGGATTATC AGAACTCAGC ATCCATCCAT 
CAGTGGCGCG AGTCCAGGAA GGTCATGGGG CAACTCCAGA GAGAAGCATC CCCTGGCCCG 
GTGGGAAGCC CAGACGAGGA GGACGGGGAA CCGGATTACG TGAATGGGGA GGTGGCAGCC 
ACAGAAGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115852.1
CDS	481..1212
Translation	MSSGTELLWPGAALLVLLGVAASLCVRCSRPGAKRSEKIYQQRSLREDQQSFTGSRTYSLVGQAWPGPLADMAPTRKDKLLQFYPSLEDPASSRYQNFSKGSRHGSEEAYIDPIAMEYYNWGRFSKPPEDDDANSYENVLICKQKTTETGAQQEGIGGLCRGDLSLSLALKTGPTSGLCPSASPEEDEESEDYQNSASIHQWRESRKVMGQLQREASPGPVGSPDEEDGEPDYVNGEVAATEA

Target ORF information:

RefSeq Version	NM_032463.2
Organism	Homo sapiens(human)
Definition	Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032463.2

ORF Insert Sequence:

ATGAGCTCGG GGACTGAACT GCTGTGGCCC GGAGCAGCGC TGCTGGTGCT GTTGGGGGTG 
GCAGCCAGTC TGTGTGTGCG CTGCTCACGC CCAGGTGCAA AGAGGTCAGA GAAAATCTAC 
CAGCAGAGAA GTCTGCGTGA GGACCAACAG AGCTTTACGG GGTCCCGGAC CTACTCCTTG 
GTCGGGCAGG CATGGCCAGG ACCCCTGGCG GACATGGCAC CCACAAGGAA GGACAAGCTG 
TTGCAATTCT ACCCCAGCCT GGAGGATCCA GCATCTTCCA GGTACCAGAA CTTCAGCAAA 
GGAAGCAGAC ACGGGTCGGA GGAAGCCTAC ATAGACCCCA TTGCCATGGA GTATTACAAC 
TGGGGGCGGT TCTCGAAGCC CCCAGAAGAT GATGATGCCA ATTCCTACGA GAATGTGCTC 
ATTTGCAAGC AGAAAACCAC AGAGACAGGT GCCCAGCAGG AGGGCATAGG TGGCCTCTGC 
AGAGGGGACC TCAGCCTGTC ACTGGCCCTG AAGACTGGCC CCACTTCTGG TCTCTGTCCC 
TCTGCCTCCC CGGAAGAAGA TGAGGAATCT GAGGATTATC AGAACTCAGC ATCCATCCAT 
CAGTGGCGCG AGTCCAGGAA GGTCATGGGG CAACTCCAGA GAGAAGCATC CCCTGGCCCG 
GTGGGAAGCC CAGACGAGGA GGACGGGGAA CCGGATTACG TGAATGGGGA GGTGGCAGCC 
ACAGAAGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAT2 ( XM_011516558.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011514860.1 Homo sapiens linker for activation of T cells family, member 2 (LAT2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu17337
Clone ID Related Accession (Same CDS sequence)	NM_032464.2 , NM_014146.3 , XM_011516558.1 , NM_032464.3 , NM_032463.3 , NM_014146.4 , NM_032463.2 , XM_011516558.2
Accession Version	XM_011516558.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 732bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	linker for activation of T-cells family member 2 isoform X1
Comment

ATGAGCTCGG GGACTGAACT GCTGTGGCCC GGAGCAGCGC TGCTGGTGCT GTTGGGGGTG 
GCAGCCAGTC TGTGTGTGCG CTGCTCACGC CCAGGTGCAA AGAGGTCAGA GAAAATCTAC 
CAGCAGAGAA GTCTGCGTGA GGACCAACAG AGCTTTACGG GGTCCCGGAC CTACTCCTTG 
GTCGGGCAGG CATGGCCAGG ACCCCTGGCG GACATGGCAC CCACAAGGAA GGACAAGCTG 
TTGCAATTCT ACCCCAGCCT GGAGGATCCA GCATCTTCCA GGTACCAGAA CTTCAGCAAA 
GGAAGCAGAC ACGGGTCGGA GGAAGCCTAC ATAGACCCCA TTGCCATGGA GTATTACAAC 
TGGGGGCGGT TCTCGAAGCC CCCAGAAGAT GATGATGCCA ATTCCTACGA GAATGTGCTC 
ATTTGCAAGC AGAAAACCAC AGAGACAGGT GCCCAGCAGG AGGGCATAGG TGGCCTCTGC 
AGAGGGGACC TCAGCCTGTC ACTGGCCCTG AAGACTGGCC CCACTTCTGG TCTCTGTCCC 
TCTGCCTCCC CGGAAGAAGA TGAGGAATCT GAGGATTATC AGAACTCAGC ATCCATCCAT 
CAGTGGCGCG AGTCCAGGAA GGTCATGGGG CAACTCCAGA GAGAAGCATC CCCTGGCCCG 
GTGGGAAGCC CAGACGAGGA GGACGGGGAA CCGGATTACG TGAATGGGGA GGTGGCAGCC 
ACAGAAGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011514860.1
Translation	MSSGTELLWPGAALLVLLGVAASLCVRCSRPGAKRSEKIYQQRSLREDQQSFTGSRTYSLVGQAWPGPLADMAPTRKDKLLQFYPSLEDPASSRYQNFSKGSRHGSEEAYIDPIAMEYYNWGRFSKPPEDDDANSYENVLICKQKTTETGAQQEGIGGLCRGDLSLSLALKTGPTSGLCPSASPEEDEESEDYQNSASIHQWRESRKVMGQLQREASPGPVGSPDEEDGEPDYVNGEVAATEA

Target ORF information:

RefSeq Version	XM_011516558.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens linker for activation of T cells family, member 2 (LAT2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011516558.1

ORF Insert Sequence:

ATGAGCTCGG GGACTGAACT GCTGTGGCCC GGAGCAGCGC TGCTGGTGCT GTTGGGGGTG 
GCAGCCAGTC TGTGTGTGCG CTGCTCACGC CCAGGTGCAA AGAGGTCAGA GAAAATCTAC 
CAGCAGAGAA GTCTGCGTGA GGACCAACAG AGCTTTACGG GGTCCCGGAC CTACTCCTTG 
GTCGGGCAGG CATGGCCAGG ACCCCTGGCG GACATGGCAC CCACAAGGAA GGACAAGCTG 
TTGCAATTCT ACCCCAGCCT GGAGGATCCA GCATCTTCCA GGTACCAGAA CTTCAGCAAA 
GGAAGCAGAC ACGGGTCGGA GGAAGCCTAC ATAGACCCCA TTGCCATGGA GTATTACAAC 
TGGGGGCGGT TCTCGAAGCC CCCAGAAGAT GATGATGCCA ATTCCTACGA GAATGTGCTC 
ATTTGCAAGC AGAAAACCAC AGAGACAGGT GCCCAGCAGG AGGGCATAGG TGGCCTCTGC 
AGAGGGGACC TCAGCCTGTC ACTGGCCCTG AAGACTGGCC CCACTTCTGG TCTCTGTCCC 
TCTGCCTCCC CGGAAGAAGA TGAGGAATCT GAGGATTATC AGAACTCAGC ATCCATCCAT 
CAGTGGCGCG AGTCCAGGAA GGTCATGGGG CAACTCCAGA GAGAAGCATC CCCTGGCCCG 
GTGGGAAGCC CAGACGAGGA GGACGGGGAA CCGGATTACG TGAATGGGGA GGTGGCAGCC 
ACAGAAGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAT2 ( XM_011516558.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011514860.1 Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu17337
Clone ID Related Accession (Same CDS sequence)	NM_032464.2 , NM_014146.3 , XM_011516558.1 , NM_032464.3 , NM_032463.3 , NM_014146.4 , NM_032463.2 , XM_011516558.2
Accession Version	XM_011516558.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 732bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	linker for activation of T-cells family member 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011516558.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCTCGG GGACTGAACT GCTGTGGCCC GGAGCAGCGC TGCTGGTGCT GTTGGGGGTG 
GCAGCCAGTC TGTGTGTGCG CTGCTCACGC CCAGGTGCAA AGAGGTCAGA GAAAATCTAC 
CAGCAGAGAA GTCTGCGTGA GGACCAACAG AGCTTTACGG GGTCCCGGAC CTACTCCTTG 
GTCGGGCAGG CATGGCCAGG ACCCCTGGCG GACATGGCAC CCACAAGGAA GGACAAGCTG 
TTGCAATTCT ACCCCAGCCT GGAGGATCCA GCATCTTCCA GGTACCAGAA CTTCAGCAAA 
GGAAGCAGAC ACGGGTCGGA GGAAGCCTAC ATAGACCCCA TTGCCATGGA GTATTACAAC 
TGGGGGCGGT TCTCGAAGCC CCCAGAAGAT GATGATGCCA ATTCCTACGA GAATGTGCTC 
ATTTGCAAGC AGAAAACCAC AGAGACAGGT GCCCAGCAGG AGGGCATAGG TGGCCTCTGC 
AGAGGGGACC TCAGCCTGTC ACTGGCCCTG AAGACTGGCC CCACTTCTGG TCTCTGTCCC 
TCTGCCTCCC CGGAAGAAGA TGAGGAATCT GAGGATTATC AGAACTCAGC ATCCATCCAT 
CAGTGGCGCG AGTCCAGGAA GGTCATGGGG CAACTCCAGA GAGAAGCATC CCCTGGCCCG 
GTGGGAAGCC CAGACGAGGA GGACGGGGAA CCGGATTACG TGAATGGGGA GGTGGCAGCC 
ACAGAAGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011514860.1
CDS	391..1122
Translation	MSSGTELLWPGAALLVLLGVAASLCVRCSRPGAKRSEKIYQQRSLREDQQSFTGSRTYSLVGQAWPGPLADMAPTRKDKLLQFYPSLEDPASSRYQNFSKGSRHGSEEAYIDPIAMEYYNWGRFSKPPEDDDANSYENVLICKQKTTETGAQQEGIGGLCRGDLSLSLALKTGPTSGLCPSASPEEDEESEDYQNSASIHQWRESRKVMGQLQREASPGPVGSPDEEDGEPDYVNGEVAATEA

Target ORF information:

RefSeq Version	XM_011516558.2
Organism	Homo sapiens(human)
Definition	Homo sapiens linker for activation of T cells family member 2 (LAT2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011516558.2

ORF Insert Sequence:

ATGAGCTCGG GGACTGAACT GCTGTGGCCC GGAGCAGCGC TGCTGGTGCT GTTGGGGGTG 
GCAGCCAGTC TGTGTGTGCG CTGCTCACGC CCAGGTGCAA AGAGGTCAGA GAAAATCTAC 
CAGCAGAGAA GTCTGCGTGA GGACCAACAG AGCTTTACGG GGTCCCGGAC CTACTCCTTG 
GTCGGGCAGG CATGGCCAGG ACCCCTGGCG GACATGGCAC CCACAAGGAA GGACAAGCTG 
TTGCAATTCT ACCCCAGCCT GGAGGATCCA GCATCTTCCA GGTACCAGAA CTTCAGCAAA 
GGAAGCAGAC ACGGGTCGGA GGAAGCCTAC ATAGACCCCA TTGCCATGGA GTATTACAAC 
TGGGGGCGGT TCTCGAAGCC CCCAGAAGAT GATGATGCCA ATTCCTACGA GAATGTGCTC 
ATTTGCAAGC AGAAAACCAC AGAGACAGGT GCCCAGCAGG AGGGCATAGG TGGCCTCTGC 
AGAGGGGACC TCAGCCTGTC ACTGGCCCTG AAGACTGGCC CCACTTCTGG TCTCTGTCCC 
TCTGCCTCCC CGGAAGAAGA TGAGGAATCT GAGGATTATC AGAACTCAGC ATCCATCCAT 
CAGTGGCGCG AGTCCAGGAA GGTCATGGGG CAACTCCAGA GAGAAGCATC CCCTGGCCCG 
GTGGGAAGCC CAGACGAGGA GGACGGGGAA CCGGATTACG TGAATGGGGA GGTGGCAGCC 
ACAGAAGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of large neutral amino acid transporters LAT1 and LAT2 in medulloblastoma.
Brain tumor pathology34(4)179-181(2017 Oct)
Cicone F,Minniti G,Oliva MA,Carideo L,Prior JO,Scopinaro F,Giangaspero F,Arcella A

Overexpression of L-Type Amino Acid Transporter 1 (LAT1) and 2 (LAT2): Novel Markers of Neuroendocrine Tumors.
PloS one11(5)e0156044(2016)
Barollo S,Bertazza L,Watutantrige-Fernando S,Censi S,Cavedon E,Galuppini F,Pennelli G,Fassina A,Citton M,Rubin B,Pezzani R,Benna C,Opocher G,Iacobone M,Mian C

The AML1/ETO target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells.
Leukemia research38(3)340-5(2014 Mar)
Essig A,Duque-Afonso J,Schwemmers S,Pahl HL,L?bbert M

Detergent-induced stabilization and improved 3D map of the human heteromeric amino acid transporter 4F2hc-LAT2.
PloS one9(10)e109882(2014)
Meury M,Costa M,Harder D,Stauffer M,Jeckelmann JM,Br?hlmann B,Rosell A,Ilg? H,Kovar K,Palac?n M,Fotiadis D

Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity.
Molecular & cellular proteomics : MCP11(12)1898-912(2012 Dec)
Thom? CH,dos Santos GA,Ferreira GA,Scheucher PS,Izumi C,Leopoldino AM,Sim?o AM,Ciancaglini P,de Oliveira KT,Chin A,Hanash SM,Falc?o RP,Rego EM,Greene LJ,Fa?a VM

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LAT2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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