TMEM258 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TMEM258
Entrez Gene ID	746
Full Name	transmembrane protein 258
Synonyms	C11orf10
General protein information	Preferred Names transmembrane protein 258 Names transmembrane protein 258 UPF0197 transmembrane protein C11orf10
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q12.2
Disorder MIM:	617615

mRNA and Protein(s)

mRNA	Protein	Name
NM_014206.4	NP_055021.1	transmembrane protein 258
NM_014206.3	NP_055021.1	transmembrane protein 258

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	CG9669	NP_001246807.1
Xenopus tropicalis (tropical clawed frog)	tmem258	NP_001005138.1
Danio rerio (zebrafish)	tmem258	NP_957063.1
Canis lupus familiaris (dog)	TMEM258	XP_003432393.1
Pan troglodytes (chimpanzee)	C11H11orf10	XP_003951958.1
	LOC696112	XP_001088161.1
Mus musculus (house mouse)	Tmem258	NP_081195.1
Gallus gallus (chicken)	C5H11ORF10	NP_001006464.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005935	XP_315965.2
Homo sapiens (human)	TMEM258	NP_055021.1
Bos taurus (cattle)	TMEM258	NP_001181992.1

Gene Ontology
Bibliography

Related articles in PubMed

Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture.
Ding ZY, Wang YH, Huang YC, Lee MC, Tseng MJ, Chi YH, Huang ML
The Journal of cell biology216(9)2827-2841(2017 Sep)

TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation.
Graham DB, Lefkovith A, Deelen P, de Klein N, Varma M, Boroughs A, Desch AN, Ng ACY, Guzman G, Schenone M, Petersen CP, Bhan AK, Rivas MA, Daly MJ, Carr SA, Wijmenga C, Xavier RJ
Cell reports17(11)2955-2965(2016 12)

Gene essentiality and synthetic lethality in haploid human cells.
Blomen VA, M?jek P, Jae LT, Bigenzahn JW, Nieuwenhuis J, Staring J, Sacco R, van Diemen FR, Olk N, Stukalov A, Marceau C, Janssen H, Carette JE, Bennett KL, Colinge J, Superti-Furga G, Brummelkamp TR
Science (New York, N.Y.)350(6264)1092-6(2015 Nov)

Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
Guan W, Steffen BT, Lemaitre RN, Wu JHY, Tanaka T, Manichaikul A, Foy M, Rich SS, Wang L, Nettleton JA, Tang W, Gu X, Bandinelli S, King IB, McKnight B, Psaty BM, Siscovick D, Djousse L, Chen YI, Ferrucci L, Fornage M, Mozafarrian D, Tsai MY, Steffen LM
Circulation. Cardiovascular genetics7(3)321-331(2014 Jun)

An atlas of genetic influences on human blood metabolites.
Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L, Vasquez L, Valdes AM, Hyde CL, Wang V, Ziemek D, Roberts P, Xi L, Grundberg E, , Waldenberger M, Richards JB, Mohney RP, Milburn MV, John SL, Trimmer J, Theis FJ, Overington JP, Suhre K, Brosnan MJ, Gieger C, Kastenm?ller G, Spector TD, Soranzo N
Nature genetics46(6)543-550(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Genome-wide expression profiling identified the transcription of ADIPOR1, VAMP3 and C11ORF10 to be correlated with decreased ANRIL expression in a time-dependent manner.
Title: The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following TMEM258 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMEM258 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26341	NM_014206.4 Latest version!	Homo sapiens transmembrane protein 258 (TMEM258), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu26341	NM_014206.3	Homo sapiens transmembrane protein 258 (TMEM258), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TMEM258 ( NM_014206.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055021.1 Homo sapiens transmembrane protein 258 (TMEM258), mRNA.

Price & Availability↑

CloneID	OHu26341
Clone ID Related Accession (Same CDS sequence)	NM_014206.4 , NM_014206.3
Accession Version	NM_014206.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 240bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	transmembrane protein 258
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC015968.1, AF085986.1 and AP002380.3. On May 17, 2019 this sequence version replaced NM_014206.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD177046.1, CD174634.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000537328.6/ ENSP00000443216.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGAGCTCG AGGCCATGAG CAGATATACC AGCCCAGTGA ACCCAGCTGT CTTCCCCCAT 
CTGACCGTGG TGCTTTTGGC CATTGGCATG TTCTTCACCG CCTGGTTCTT CGTTTACGAG 
GTCACCTCTA CCAAGTACAC TCGTGATATC TATAAAGAGC TCCTCATCTC CTTAGTGGCC 
TCACTCTTCA TGGGCTTTGG AGTCCTCTTC CTGCTGCTCT GGGTTGGCAT CTACGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055021.1
CDS	42..281
Translation	MELEAMSRYTSPVNPAVFPHLTVVLLAIGMFFTAWFFVYEVTSTKYTRDIYKELLISLVASLFMGFGVLFLLLWVGIYV

Target ORF information:

RefSeq Version	NM_014206.4
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 258 (TMEM258), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014206.4

ORF Insert Sequence:

ATGGAGCTCG AGGCCATGAG CAGATATACC AGCCCAGTGA ACCCAGCTGT CTTCCCCCAT 
CTGACCGTGG TGCTTTTGGC CATTGGCATG TTCTTCACCG CCTGGTTCTT CGTTTACGAG 
GTCACCTCTA CCAAGTACAC TCGTGATATC TATAAAGAGC TCCTCATCTC CTTAGTGGCC 
TCACTCTTCA TGGGCTTTGG AGTCCTCTTC CTGCTGCTCT GGGTTGGCAT CTACGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM258 ( NM_014206.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055021.1 Homo sapiens transmembrane protein 258 (TMEM258), mRNA.

Price & Availability↑

CloneID	OHu26341
Clone ID Related Accession (Same CDS sequence)	NM_014206.4 , NM_014206.3
Accession Version	NM_014206.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 240bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Homo sapiens(human)
Product	transmembrane protein 258
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF070661.1, BC015968.1 and AF085986.1. On Jul 10, 2008 this sequence version replaced NM_014206.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD246924.1, BC015968.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCTCG AGGCCATGAG CAGATATACC AGCCCAGTGA ACCCAGCTGT CTTCCCCCAT 
CTGACCGTGG TGCTTTTGGC CATTGGCATG TTCTTCACCG CCTGGTTCTT CGTTTACGAG 
GTCACCTCTA CCAAGTACAC TCGTGATATC TATAAAGAGC TCCTCATCTC CTTAGTGGCC 
TCACTCTTCA TGGGCTTTGG AGTCCTCTTC CTGCTGCTCT GGGTTGGCAT CTACGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055021.1
CDS	56..295
Translation	MELEAMSRYTSPVNPAVFPHLTVVLLAIGMFFTAWFFVYEVTSTKYTRDIYKELLISLVASLFMGFGVLFLLLWVGIYV

Target ORF information:

RefSeq Version	NM_014206.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 258 (TMEM258), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014206.3

ORF Insert Sequence:

ATGGAGCTCG AGGCCATGAG CAGATATACC AGCCCAGTGA ACCCAGCTGT CTTCCCCCAT 
CTGACCGTGG TGCTTTTGGC CATTGGCATG TTCTTCACCG CCTGGTTCTT CGTTTACGAG 
GTCACCTCTA CCAAGTACAC TCGTGATATC TATAAAGAGC TCCTCATCTC CTTAGTGGCC 
TCACTCTTCA TGGGCTTTGG AGTCCTCTTC CTGCTGCTCT GGGTTGGCAT CTACGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture.
The Journal of cell biology216(9)2827-2841(2017 Sep)
Ding ZY,Wang YH,Huang YC,Lee MC,Tseng MJ,Chi YH,Huang ML

TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation.
Cell reports17(11)2955-2965(2016 12)
Graham DB,Lefkovith A,Deelen P,de Klein N,Varma M,Boroughs A,Desch AN,Ng ACY,Guzman G,Schenone M,Petersen CP,Bhan AK,Rivas MA,Daly MJ,Carr SA,Wijmenga C,Xavier RJ

Gene essentiality and synthetic lethality in haploid human cells.
Science (New York, N.Y.)350(6264)1092-6(2015 Nov)
Blomen VA,M?jek P,Jae LT,Bigenzahn JW,Nieuwenhuis J,Staring J,Sacco R,van Diemen FR,Olk N,Stukalov A,Marceau C,Janssen H,Carette JE,Bennett KL,Colinge J,Superti-Furga G,Brummelkamp TR

Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
Circulation. Cardiovascular genetics7(3)321-331(2014 Jun)
Guan W,Steffen BT,Lemaitre RN,Wu JHY,Tanaka T,Manichaikul A,Foy M,Rich SS,Wang L,Nettleton JA,Tang W,Gu X,Bandinelli S,King IB,McKnight B,Psaty BM,Siscovick D,Djousse L,Chen YI,Ferrucci L,Fornage M,Mozafarrian D,Tsai MY,Steffen LM

An atlas of genetic influences on human blood metabolites.
Nature genetics46(6)543-550(2014 Jun)
Shin SY,Fauman EB,Petersen AK,Krumsiek J,Santos R,Huang J,Arnold M,Erte I,Forgetta V,Yang TP,Walter K,Menni C,Chen L,Vasquez L,Valdes AM,Hyde CL,Wang V,Ziemek D,Roberts P,Xi L,Grundberg E,,Waldenberger M,Richards JB,Mohney RP,Milburn MV,John SL,Trimmer J,Theis FJ,Overington JP,Suhre K,Brosnan MJ,Gieger C,Kastenm?ller G,Spector TD,Soranzo N

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TMEM258 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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