VHL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	VHL
Entrez Gene ID	7428
Full Name	von Hippel-Lindau tumor suppressor
Synonyms	HRCA1,RCA1,VHL1,pVHL
General protein information	Preferred Names von Hippel-Lindau tumor suppressor Names von Hippel-Lindau disease tumor suppressor elongin binding protein protein G7 von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p25.3
Summary	Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
Disorder MIM:	608537
Disorder Html:	von Hippel-Lindau syndrome, 193300 (3); Renal cell carcinoma, somatic, 144700 (3); Pheochromocytoma, 171300 (3); Hemangioblastoma, cerebellar, somatic (3); Erythrocytosis, familial, 2, 263400 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001354723.2	NP_001341652.1	von Hippel-Lindau disease tumor suppressor isoform 3
NM_000551.3	NP_000542.1	von Hippel-Lindau disease tumor suppressor isoform 1
NM_000551.4	NP_000542.1	von Hippel-Lindau disease tumor suppressor isoform 1
NM_198156.3	NP_937799.1	von Hippel-Lindau disease tumor suppressor isoform 2
NM_001354723.1	NP_001341652.1	von Hippel-Lindau disease tumor suppressor isoform 3
NM_198156.2	NP_937799.1	von Hippel-Lindau disease tumor suppressor isoform 2

Pathways from BioSystems

Homologies

	LOC701870	XP_001090152.2
Bos taurus (cattle)	VHL	NP_001103489.1
Mus musculus (house mouse)	Vhl	NP_033533.1
Xenopus tropicalis (tropical clawed frog)	vhl	NP_001016367.1
Gallus gallus (chicken)	VHL	XP_414447.3
Homo sapiens (human)	VHL	NP_000542.1
Canis lupus familiaris (dog)	VHL	NP_001008552.1
Rattus norvegicus (Norway rat)	Vhl	NP_434688.1
Danio rerio (zebrafish)	vhl	NP_001074153.1

Gene Ontology

The following VHL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VHL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23297	NM_000551.4 Latest version!	Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu23524	NM_198156.3 Latest version!	Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu61302	NM_001354723.2 Latest version!	Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu23297	NM_000551.3	Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu61302	NM_001354723.1	Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu23524	NM_198156.2	Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

VHL ( NM_000551.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000542.1 Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.

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CloneID	OHu23297
Clone ID Related Accession (Same CDS sequence)	NM_000551.3 , NM_000551.4
Accession Version	NM_000551.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-04
Organism	Homo sapiens(human)
Product	von Hippel-Lindau disease tumor suppressor isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC034193.5, L15409.1, AK315799.1, BC058831.1 and D58014.1. This sequence is a reference standard in the RefSeqGene project. On Jan 19, 2011 this sequence version replaced NM_000551.2. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L15409.1, SRR1803611.148663.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCCCGGA GGGCGGAGAA CTGGGACGAG GCCGAGGTAG GCGCGGAGGA GGCAGGCGTC 
GAAGAGTACG GCCCTGAAGA AGACGGCGGG GAGGAGTCGG GCGCCGAGGA GTCCGGCCCG 
GAAGAGTCCG GCCCGGAGGA ACTGGGCGCC GAGGAGGAGA TGGAGGCCGG GCGGCCGCGG 
CCCGTGCTGC GCTCGGTGAA CTCGCGCGAG CCCTCCCAGG TCATCTTCTG CAATCGCAGT 
CCGCGCGTCG TGCTGCCCGT ATGGCTCAAC TTCGACGGCG AGCCGCAGCC CTACCCAACG 
CTGCCGCCTG GCACGGGCCG CCGCATCCAC AGCTACCGAG GTCACCTTTG GCTCTTCAGA 
GATGCAGGGA CACACGATGG GCTTCTGGTT AACCAAACTG AATTATTTGT GCCATCTCTC 
AATGTTGACG GACAGCCTAT TTTTGCCAAT ATCACACTGC CAGTGTATAC TCTGAAAGAG 
CGATGCCTCC AGGTTGTCCG GAGCCTAGTC AAGCCTGAGA ATTACAGGAG ACTGGACATC 
GTCAGGTCGC TCTACGAAGA TCTGGAAGAC CACCCAAATG TGCAGAAAGA CCTGGAGCGG 
CTGACACAGG AGCGCATTGC ACATCAACGG ATGGGAGATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000542.1
CDS	214..855
Translation	MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD

Target ORF information:

RefSeq Version	NM_000551.3
Organism	Homo sapiens(human)
Definition	Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000551.3

ORF Insert Sequence:

ATGCCCCGGA GGGCGGAGAA CTGGGACGAG GCCGAGGTAG GCGCGGAGGA GGCAGGCGTC 
GAAGAGTACG GCCCTGAAGA AGACGGCGGG GAGGAGTCGG GCGCCGAGGA GTCCGGCCCG 
GAAGAGTCCG GCCCGGAGGA ACTGGGCGCC GAGGAGGAGA TGGAGGCCGG GCGGCCGCGG 
CCCGTGCTGC GCTCGGTGAA CTCGCGCGAG CCCTCCCAGG TCATCTTCTG CAATCGCAGT 
CCGCGCGTCG TGCTGCCCGT ATGGCTCAAC TTCGACGGCG AGCCGCAGCC CTACCCAACG 
CTGCCGCCTG GCACGGGCCG CCGCATCCAC AGCTACCGAG GTCACCTTTG GCTCTTCAGA 
GATGCAGGGA CACACGATGG GCTTCTGGTT AACCAAACTG AATTATTTGT GCCATCTCTC 
AATGTTGACG GACAGCCTAT TTTTGCCAAT ATCACACTGC CAGTGTATAC TCTGAAAGAG 
CGATGCCTCC AGGTTGTCCG GAGCCTAGTC AAGCCTGAGA ATTACAGGAG ACTGGACATC 
GTCAGGTCGC TCTACGAAGA TCTGGAAGAC CACCCAAATG TGCAGAAAGA CCTGGAGCGG 
CTGACACAGG AGCGCATTGC ACATCAACGG ATGGGAGATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VHL ( NM_000551.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000542.1 Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23297
Clone ID Related Accession (Same CDS sequence)	NM_000551.3 , NM_000551.4
Accession Version	NM_000551.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	von Hippel-Lindau disease tumor suppressor isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC034193.5. On Nov 30, 2019 this sequence version replaced NM_000551.3. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.971511.1, L15409.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCCCGGA GGGCGGAGAA CTGGGACGAG GCCGAGGTAG GCGCGGAGGA GGCAGGCGTC 
GAAGAGTACG GCCCTGAAGA AGACGGCGGG GAGGAGTCGG GCGCCGAGGA GTCCGGCCCG 
GAAGAGTCCG GCCCGGAGGA ACTGGGCGCC GAGGAGGAGA TGGAGGCCGG GCGGCCGCGG 
CCCGTGCTGC GCTCGGTGAA CTCGCGCGAG CCCTCCCAGG TCATCTTCTG CAATCGCAGT 
CCGCGCGTCG TGCTGCCCGT ATGGCTCAAC TTCGACGGCG AGCCGCAGCC CTACCCAACG 
CTGCCGCCTG GCACGGGCCG CCGCATCCAC AGCTACCGAG GTCACCTTTG GCTCTTCAGA 
GATGCAGGGA CACACGATGG GCTTCTGGTT AACCAAACTG AATTATTTGT GCCATCTCTC 
AATGTTGACG GACAGCCTAT TTTTGCCAAT ATCACACTGC CAGTGTATAC TCTGAAAGAG 
CGATGCCTCC AGGTTGTCCG GAGCCTAGTC AAGCCTGAGA ATTACAGGAG ACTGGACATC 
GTCAGGTCGC TCTACGAAGA TCTGGAAGAC CACCCAAATG TGCAGAAAGA CCTGGAGCGG 
CTGACACAGG AGCGCATTGC ACATCAACGG ATGGGAGATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000542.1
CDS	71..712
Translation	MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD

Target ORF information:

RefSeq Version	NM_000551.4
Organism	Homo sapiens(human)
Definition	Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000551.4

ORF Insert Sequence:

ATGCCCCGGA GGGCGGAGAA CTGGGACGAG GCCGAGGTAG GCGCGGAGGA GGCAGGCGTC 
GAAGAGTACG GCCCTGAAGA AGACGGCGGG GAGGAGTCGG GCGCCGAGGA GTCCGGCCCG 
GAAGAGTCCG GCCCGGAGGA ACTGGGCGCC GAGGAGGAGA TGGAGGCCGG GCGGCCGCGG 
CCCGTGCTGC GCTCGGTGAA CTCGCGCGAG CCCTCCCAGG TCATCTTCTG CAATCGCAGT 
CCGCGCGTCG TGCTGCCCGT ATGGCTCAAC TTCGACGGCG AGCCGCAGCC CTACCCAACG 
CTGCCGCCTG GCACGGGCCG CCGCATCCAC AGCTACCGAG GTCACCTTTG GCTCTTCAGA 
GATGCAGGGA CACACGATGG GCTTCTGGTT AACCAAACTG AATTATTTGT GCCATCTCTC 
AATGTTGACG GACAGCCTAT TTTTGCCAAT ATCACACTGC CAGTGTATAC TCTGAAAGAG 
CGATGCCTCC AGGTTGTCCG GAGCCTAGTC AAGCCTGAGA ATTACAGGAG ACTGGACATC 
GTCAGGTCGC TCTACGAAGA TCTGGAAGAC CACCCAAATG TGCAGAAAGA CCTGGAGCGG 
CTGACACAGG AGCGCATTGC ACATCAACGG ATGGGAGATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VHL ( NM_198156.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_937799.1 Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu23524
Clone ID Related Accession (Same CDS sequence)	NM_198156.3 , NM_198156.2
Accession Version	NM_198156.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	von Hippel-Lindau disease tumor suppressor isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC034193.5. On Jun 2, 2019 this sequence version replaced NM_198156.2. Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. The resulting isoform (2) lacks an internal region, as compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.117813.1, SRR1803613.122864.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCCGGA GGGCGGAGAA CTGGGACGAG GCCGAGGTAG GCGCGGAGGA GGCAGGCGTC 
GAAGAGTACG GCCCTGAAGA AGACGGCGGG GAGGAGTCGG GCGCCGAGGA GTCCGGCCCG 
GAAGAGTCCG GCCCGGAGGA ACTGGGCGCC GAGGAGGAGA TGGAGGCCGG GCGGCCGCGG 
CCCGTGCTGC GCTCGGTGAA CTCGCGCGAG CCCTCCCAGG TCATCTTCTG CAATCGCAGT 
CCGCGCGTCG TGCTGCCCGT ATGGCTCAAC TTCGACGGCG AGCCGCAGCC CTACCCAACG 
CTGCCGCCTG GCACGGGCCG CCGCATCCAC AGCTACCGAG TGTATACTCT GAAAGAGCGA 
TGCCTCCAGG TTGTCCGGAG CCTAGTCAAG CCTGAGAATT ACAGGAGACT GGACATCGTC 
AGGTCGCTCT ACGAAGATCT GGAAGACCAC CCAAATGTGC AGAAAGACCT GGAGCGGCTG 
ACACAGGAGC GCATTGCACA TCAACGGATG GGAGATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_937799.1
CDS	71..589
Translation	MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD

Target ORF information:

RefSeq Version	NM_198156.3
Organism	Homo sapiens(human)
Definition	Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198156.3

ORF Insert Sequence:

ATGCCCCGGA GGGCGGAGAA CTGGGACGAG GCCGAGGTAG GCGCGGAGGA GGCAGGCGTC 
GAAGAGTACG GCCCTGAAGA AGACGGCGGG GAGGAGTCGG GCGCCGAGGA GTCCGGCCCG 
GAAGAGTCCG GCCCGGAGGA ACTGGGCGCC GAGGAGGAGA TGGAGGCCGG GCGGCCGCGG 
CCCGTGCTGC GCTCGGTGAA CTCGCGCGAG CCCTCCCAGG TCATCTTCTG CAATCGCAGT 
CCGCGCGTCG TGCTGCCCGT ATGGCTCAAC TTCGACGGCG AGCCGCAGCC CTACCCAACG 
CTGCCGCCTG GCACGGGCCG CCGCATCCAC AGCTACCGAG TGTATACTCT GAAAGAGCGA 
TGCCTCCAGG TTGTCCGGAG CCTAGTCAAG CCTGAGAATT ACAGGAGACT GGACATCGTC 
AGGTCGCTCT ACGAAGATCT GGAAGACCAC CCAAATGTGC AGAAAGACCT GGAGCGGCTG 
ACACAGGAGC GCATTGCACA TCAACGGATG GGAGATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VHL ( NM_198156.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_937799.1 Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu23524
Clone ID Related Accession (Same CDS sequence)	NM_198156.3 , NM_198156.2
Accession Version	NM_198156.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-11
Organism	Homo sapiens(human)
Product	von Hippel-Lindau disease tumor suppressor isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC034193.5, L15409.1, AK315799.1, BC058831.1 and D58014.1. On Jan 19, 2011 this sequence version replaced NM_198156.1. Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. The resulting isoform (2) lacks an internal region, as compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.411260.1, BC058831.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCCGGA GGGCGGAGAA CTGGGACGAG GCCGAGGTAG GCGCGGAGGA GGCAGGCGTC 
GAAGAGTACG GCCCTGAAGA AGACGGCGGG GAGGAGTCGG GCGCCGAGGA GTCCGGCCCG 
GAAGAGTCCG GCCCGGAGGA ACTGGGCGCC GAGGAGGAGA TGGAGGCCGG GCGGCCGCGG 
CCCGTGCTGC GCTCGGTGAA CTCGCGCGAG CCCTCCCAGG TCATCTTCTG CAATCGCAGT 
CCGCGCGTCG TGCTGCCCGT ATGGCTCAAC TTCGACGGCG AGCCGCAGCC CTACCCAACG 
CTGCCGCCTG GCACGGGCCG CCGCATCCAC AGCTACCGAG TGTATACTCT GAAAGAGCGA 
TGCCTCCAGG TTGTCCGGAG CCTAGTCAAG CCTGAGAATT ACAGGAGACT GGACATCGTC 
AGGTCGCTCT ACGAAGATCT GGAAGACCAC CCAAATGTGC AGAAAGACCT GGAGCGGCTG 
ACACAGGAGC GCATTGCACA TCAACGGATG GGAGATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_937799.1
CDS	214..732
Translation	MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD

Target ORF information:

RefSeq Version	NM_198156.2
Organism	Homo sapiens(human)
Definition	Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198156.2

ORF Insert Sequence:

ATGCCCCGGA GGGCGGAGAA CTGGGACGAG GCCGAGGTAG GCGCGGAGGA GGCAGGCGTC 
GAAGAGTACG GCCCTGAAGA AGACGGCGGG GAGGAGTCGG GCGCCGAGGA GTCCGGCCCG 
GAAGAGTCCG GCCCGGAGGA ACTGGGCGCC GAGGAGGAGA TGGAGGCCGG GCGGCCGCGG 
CCCGTGCTGC GCTCGGTGAA CTCGCGCGAG CCCTCCCAGG TCATCTTCTG CAATCGCAGT 
CCGCGCGTCG TGCTGCCCGT ATGGCTCAAC TTCGACGGCG AGCCGCAGCC CTACCCAACG 
CTGCCGCCTG GCACGGGCCG CCGCATCCAC AGCTACCGAG TGTATACTCT GAAAGAGCGA 
TGCCTCCAGG TTGTCCGGAG CCTAGTCAAG CCTGAGAATT ACAGGAGACT GGACATCGTC 
AGGTCGCTCT ACGAAGATCT GGAAGACCAC CCAAATGTGC AGAAAGACCT GGAGCGGCTG 
ACACAGGAGC GCATTGCACA TCAACGGATG GGAGATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VHL ( NM_001354723.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001341652.1 Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu61302
Clone ID Related Accession (Same CDS sequence)	NM_001354723.2 , NM_001354723.1
Accession Version	NM_001354723.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	von Hippel-Lindau disease tumor suppressor isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC034193.5. On Jun 2, 2019 this sequence version replaced NM_001354723.1. Transcript Variant: This variant (3) lacks an alternate in-frame exon and contains another alternate exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to variant 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.136882.1, SRR1163658.455261.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCCGGA GGGCGGAGAA CTGGGACGAG GCCGAGGTAG GCGCGGAGGA GGCAGGCGTC 
GAAGAGTACG GCCCTGAAGA AGACGGCGGG GAGGAGTCGG GCGCCGAGGA GTCCGGCCCG 
GAAGAGTCCG GCCCGGAGGA ACTGGGCGCC GAGGAGGAGA TGGAGGCCGG GCGGCCGCGG 
CCCGTGCTGC GCTCGGTGAA CTCGCGCGAG CCCTCCCAGG TCATCTTCTG CAATCGCAGT 
CCGCGCGTCG TGCTGCCCGT ATGGCTCAAC TTCGACGGCG AGCCGCAGCC CTACCCAACG 
CTGCCGCCTG GCACGGGCCG CCGCATCCAC AGCTACCGAG TCCTCATGAC TCCAGTGGGC 
CAGTTCTGCG TAGTCCCTGC CCTCGTGGAG AACACATTCC TCCTGGGGAG ACTGACAGAT 
GCAAAGACAG GAACAAGCCA GGGTCATGTT GGCGCCGGAA GAGCCGACCG TGTGTGGCGT 
GGGAAATTGA CTTACCTGCC TGCTGGGAGA TGGAGGGGTT GCGGTTGTGT GGTTTCAGTT 
AAGGAGCACT TCCCGGAGAA GGAAGAGAGC AGGATGGAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001341652.1
CDS	71..652
Translation	MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRVLMTPVGQFCVVPALVENTFLLGRLTDAKTGTSQGHVGAGRADRVWRGKLTYLPAGRWRGCGCVVSVKEHFPEKEESRME

Target ORF information:

RefSeq Version	NM_001354723.2
Organism	Homo sapiens(human)
Definition	Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001354723.2

ORF Insert Sequence:

ATGCCCCGGA GGGCGGAGAA CTGGGACGAG GCCGAGGTAG GCGCGGAGGA GGCAGGCGTC 
GAAGAGTACG GCCCTGAAGA AGACGGCGGG GAGGAGTCGG GCGCCGAGGA GTCCGGCCCG 
GAAGAGTCCG GCCCGGAGGA ACTGGGCGCC GAGGAGGAGA TGGAGGCCGG GCGGCCGCGG 
CCCGTGCTGC GCTCGGTGAA CTCGCGCGAG CCCTCCCAGG TCATCTTCTG CAATCGCAGT 
CCGCGCGTCG TGCTGCCCGT ATGGCTCAAC TTCGACGGCG AGCCGCAGCC CTACCCAACG 
CTGCCGCCTG GCACGGGCCG CCGCATCCAC AGCTACCGAG TCCTCATGAC TCCAGTGGGC 
CAGTTCTGCG TAGTCCCTGC CCTCGTGGAG AACACATTCC TCCTGGGGAG ACTGACAGAT 
GCAAAGACAG GAACAAGCCA GGGTCATGTT GGCGCCGGAA GAGCCGACCG TGTGTGGCGT 
GGGAAATTGA CTTACCTGCC TGCTGGGAGA TGGAGGGGTT GCGGTTGTGT GGTTTCAGTT 
AAGGAGCACT TCCCGGAGAA GGAAGAGAGC AGGATGGAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VHL ( NM_001354723.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001341652.1 Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 3, mRNA.

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CloneID	OHu61302
Clone ID Related Accession (Same CDS sequence)	NM_001354723.2 , NM_001354723.1
Accession Version	NM_001354723.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-11
Organism	Homo sapiens(human)
Product	von Hippel-Lindau disease tumor suppressor isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC034193.5 and HY256093.1. Transcript Variant: This variant (3) lacks an alternate in-frame exon and contains another alternate exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to variant 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.455261.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCCGGA GGGCGGAGAA CTGGGACGAG GCCGAGGTAG GCGCGGAGGA GGCAGGCGTC 
GAAGAGTACG GCCCTGAAGA AGACGGCGGG GAGGAGTCGG GCGCCGAGGA GTCCGGCCCG 
GAAGAGTCCG GCCCGGAGGA ACTGGGCGCC GAGGAGGAGA TGGAGGCCGG GCGGCCGCGG 
CCCGTGCTGC GCTCGGTGAA CTCGCGCGAG CCCTCCCAGG TCATCTTCTG CAATCGCAGT 
CCGCGCGTCG TGCTGCCCGT ATGGCTCAAC TTCGACGGCG AGCCGCAGCC CTACCCAACG 
CTGCCGCCTG GCACGGGCCG CCGCATCCAC AGCTACCGAG TCCTCATGAC TCCAGTGGGC 
CAGTTCTGCG TAGTCCCTGC CCTCGTGGAG AACACATTCC TCCTGGGGAG ACTGACAGAT 
GCAAAGACAG GAACAAGCCA GGGTCATGTT GGCGCCGGAA GAGCCGACCG TGTGTGGCGT 
GGGAAATTGA CTTACCTGCC TGCTGGGAGA TGGAGGGGTT GCGGTTGTGT GGTTTCAGTT 
AAGGAGCACT TCCCGGAGAA GGAAGAGAGC AGGATGGAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001341652.1
CDS	214..795
Translation	MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRVLMTPVGQFCVVPALVENTFLLGRLTDAKTGTSQGHVGAGRADRVWRGKLTYLPAGRWRGCGCVVSVKEHFPEKEESRME

Target ORF information:

RefSeq Version	NM_001354723.1
Organism	Homo sapiens(human)
Definition	Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001354723.1

ORF Insert Sequence:

ATGCCCCGGA GGGCGGAGAA CTGGGACGAG GCCGAGGTAG GCGCGGAGGA GGCAGGCGTC 
GAAGAGTACG GCCCTGAAGA AGACGGCGGG GAGGAGTCGG GCGCCGAGGA GTCCGGCCCG 
GAAGAGTCCG GCCCGGAGGA ACTGGGCGCC GAGGAGGAGA TGGAGGCCGG GCGGCCGCGG 
CCCGTGCTGC GCTCGGTGAA CTCGCGCGAG CCCTCCCAGG TCATCTTCTG CAATCGCAGT 
CCGCGCGTCG TGCTGCCCGT ATGGCTCAAC TTCGACGGCG AGCCGCAGCC CTACCCAACG 
CTGCCGCCTG GCACGGGCCG CCGCATCCAC AGCTACCGAG TCCTCATGAC TCCAGTGGGC 
CAGTTCTGCG TAGTCCCTGC CCTCGTGGAG AACACATTCC TCCTGGGGAG ACTGACAGAT 
GCAAAGACAG GAACAAGCCA GGGTCATGTT GGCGCCGGAA GAGCCGACCG TGTGTGGCGT 
GGGAAATTGA CTTACCTGCC TGCTGGGAGA TGGAGGGGTT GCGGTTGTGT GGTTTCAGTT 
AAGGAGCACT TCCCGGAGAA GGAAGAGAGC AGGATGGAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

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VHL cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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