VDAC3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	VDAC3
Entrez Gene ID	7419
Full Name	voltage dependent anion channel 3
Synonyms	HD-VDAC3,VDAC-3
General protein information	Preferred Names voltage dependent anion channel 3 Names voltage-dependent anion-selective channel protein 3 outer mitochondrial membrane protein porin 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p11.21
Summary	This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011].
Disorder MIM:	610029

mRNA and Protein(s)

mRNA	Protein	Name
XM_006716394.1	XP_006716457.1	voltage-dependent anion-selective channel protein 3 isoform X1
NM_005662.7	NP_005653.3	voltage-dependent anion-selective channel protein 3 isoform 1
NM_005662.6	NP_005653.3	voltage-dependent anion-selective channel protein 3 isoform 1
NM_001135694.2	NP_001129166.1	voltage-dependent anion-selective channel protein 3 isoform 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	VDAC3	NP_777154.1
Xenopus tropicalis (tropical clawed frog)	vdac3	NP_001011249.1
Mus musculus (house mouse)	Vdac3	NP_035826.1
Pan troglodytes (chimpanzee)	VDAC3	XP_001138480.2
Rattus norvegicus (Norway rat)	Vdac3	NP_112645.1
Gallus gallus (chicken)	VDAC3	XP_004947676.1
Homo sapiens (human)	VDAC3	NP_005653.3
Danio rerio (zebrafish)	vdac3	NP_998411.1
Canis lupus familiaris (dog)	VDAC3	NP_001238895.1
Danio rerio (zebrafish)	zgc:56235	NP_956511.1

Gene Ontology
Bibliography

Related articles in PubMed

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-?B Signaling.
Malty RH, Aoki H, Kumar A, Phanse S, Amin S, Zhang Q, Minic Z, Goebels F, Musso G, Wu Z, Abou-Tok H, Meyer M, Deineko V, Kassir S, Sidhu V, Jessulat M, Scott NE, Xiong X, Vlasblom J, Prasad B, Foster LJ, Alberio T, Garavaglia B, Yu H, Bader GD, Nakamura K, Parkinson J, Babu M
Cell systems5(6)564-577.e12(2017 Dec)

Analysis of blood-based gene expression in idiopathic Parkinson disease.
Shamir R, Klein C, Amar D, Vollstedt EJ, Bonin M, Usenovic M, Wong YC, Maver A, Poths S, Safer H, Corvol JC, Lesage S, Lavi O, Deuschl G, Kuhlenbaeumer G, Pawlack H, Ulitsky I, Kasten M, Riess O, Brice A, Peterlin B, Krainc D
Neurology89(16)1676-1683(2017 Oct)

Association of the VDAC3 gene polymorphism with sperm count in Han-Chinese population with idiopathic male infertility.
Pan L, Liu Q, Li J, Wu W, Wang X, Zhao D, Ma J
Oncotarget8(28)45242-45248(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This cohort study showed that the VDAC3 gene was down regulation between patients with idiopathic Parkinson disease and controls
Title: Analysis of blood-based gene expression in idiopathic Parkinson disease.

The works available on VDAC cysteines support the notion that VDAC1, VDAC2, and VDAC3 proteins are paralogs with a similar pore-function and slightly different, but important, ancillary biological functions. (Review)
Title: Role of cysteines in mammalian VDAC isoforms' function.

VDAC3 is able to modulate its pore size and current by exploiting the mobility of the N-terminal and forming, upon external stimuli, disulfide bridges with cysteine residues located on the barrel and exposed to the inter-membrane space.
Title: A computational study of ion current modulation in hVDAC3 induced by disulfide bonds.

channel gating of VDAC3 might be controlled by redox sensing under physiological conditions
Title: VDAC3 gating is activated by suppression of disulfide-bond formation between the N-terminal region and the bottom of the pore.

These data suggest that an interaction between Mcl-1 and VDAC promotes lung cancer cell migration by a mechanism that involves Ca(2+)-dependent reactive oxygen species production.
Title: Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation.

The following VDAC3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VDAC3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09523	NM_005662.7 Latest version!	Homo sapiens voltage dependent anion channel 3 (VDAC3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu09820	NM_001135694.2 Latest version!	Homo sapiens voltage dependent anion channel 3 (VDAC3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu42157	XM_006716394.1 Latest version!	Homo sapiens voltage dependent anion channel 3 (VDAC3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu09523	NM_005662.6	Homo sapiens voltage dependent anion channel 3 (VDAC3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

VDAC3 ( NM_005662.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_005653.3 Homo sapiens voltage dependent anion channel 3 (VDAC3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09523
Clone ID Related Accession (Same CDS sequence)	NM_005662.7 , NM_005662.6
Accession Version	NM_005662.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 852bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Homo sapiens(human)
Product	voltage-dependent anion-selective channel protein 3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA930673.1, BC056870.1 and BQ001504.1. On Nov 22, 2018 this sequence version replaced NM_005662.6. Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.105874.1, SRR3476690.998046.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000022615.9/ ENSP00000022615.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTGTAACA CACCAACGTA CTGTGACCTA GGAAAGGCTG CTAAGGATGT CTTCAACAAA 
GGATATGGCT TTGGCATGGT CAAGATAGAC CTGAAAACCA AGTCTTGTAG TGGAGTGGAA 
TTTTCTACTT CTGGTCATGC TTACACTGAT ACAGGGAAAG CATCAGGCAA CCTAGAAACC 
AAATATAAGG TCTGTAACTA TGGACTTACC TTCACCCAGA AATGGAACAC AGACAATACT 
CTAGGGACAG AAATCTCTTG GGAGAATAAG TTGGCTGAAG GGTTGAAACT GACTCTTGAT 
ACCATATTTG TACCGAACAC AGGAAAGAAG AGTGGGAAAT TGAAGGCCTC CTATAAACGG 
GATTGTTTTA GTGTTGGCAG TAATGTTGAT ATAGATTTTT CTGGACCAAC CATCTATGGC 
TGGGCTGTGT TGGCCTTCGA AGGGTGGCTT GCTGGCTATC AGATGAGTTT TGACACAGCC 
AAATCCAAAC TGTCACAGAA TAATTTCGCC CTGGGTTACA AGGCTGCGGA CTTCCAGCTG 
CACACACATG TGAACGATGG CACTGAATTT GGAGGTTCTA TCTACCAGAA GGTGAATGAG 
AAGATTGAAA CATCCATAAA CCTTGCTTGG ACAGCTGGGA GTAACAACAC CCGTTTTGGC 
ATTGCTGCTA AGTACATGCT GGATTGTAGA ACTTCTCTCT CTGCTAAAGT AAATAATGCC 
AGCCTGATTG GACTGGGTTA TACTCAGACC CTTCGACCAG GAGTCAAATT GACTTTATCA 
GCTTTAATCG ATGGGAAGAA CTTCAGTGCA GGAGGTCACA AGGTTGGCTT GGGATTTGAA 
CTGGAAGCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005653.3
CDS	92..943
Translation	MCNTPTYCDLGKAAKDVFNKGYGFGMVKIDLKTKSCSGVEFSTSGHAYTDTGKASGNLETKYKVCNYGLTFTQKWNTDNTLGTEISWENKLAEGLKLTLDTIFVPNTGKKSGKLKASYKRDCFSVGSNVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLSQNNFALGYKAADFQLHTHVNDGTEFGGSIYQKVNEKIETSINLAWTAGSNNTRFGIAAKYMLDCRTSLSAKVNNASLIGLGYTQTLRPGVKLTLSALIDGKNFSAGGHKVGLGFELEA

Target ORF information:

RefSeq Version	NM_005662.7
Organism	Homo sapiens(human)
Definition	Homo sapiens voltage dependent anion channel 3 (VDAC3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005662.7

ORF Insert Sequence:

ATGTGTAACA CACCAACGTA CTGTGACCTA GGAAAGGCTG CTAAGGATGT CTTCAACAAA 
GGATATGGCT TTGGCATGGT CAAGATAGAC CTGAAAACCA AGTCTTGTAG TGGAGTGGAA 
TTTTCTACTT CTGGTCATGC TTACACTGAT ACAGGGAAAG CATCAGGCAA CCTAGAAACC 
AAATATAAGG TCTGTAACTA TGGACTTACC TTCACCCAGA AATGGAACAC AGACAATACT 
CTAGGGACAG AAATCTCTTG GGAGAATAAG TTGGCTGAAG GGTTGAAACT GACTCTTGAT 
ACCATATTTG TACCGAACAC AGGAAAGAAG AGTGGGAAAT TGAAGGCCTC CTATAAACGG 
GATTGTTTTA GTGTTGGCAG TAATGTTGAT ATAGATTTTT CTGGACCAAC CATCTATGGC 
TGGGCTGTGT TGGCCTTCGA AGGGTGGCTT GCTGGCTATC AGATGAGTTT TGACACAGCC 
AAATCCAAAC TGTCACAGAA TAATTTCGCC CTGGGTTACA AGGCTGCGGA CTTCCAGCTG 
CACACACATG TGAACGATGG CACTGAATTT GGAGGTTCTA TCTACCAGAA GGTGAATGAG 
AAGATTGAAA CATCCATAAA CCTTGCTTGG ACAGCTGGGA GTAACAACAC CCGTTTTGGC 
ATTGCTGCTA AGTACATGCT GGATTGTAGA ACTTCTCTCT CTGCTAAAGT AAATAATGCC 
AGCCTGATTG GACTGGGTTA TACTCAGACC CTTCGACCAG GAGTCAAATT GACTTTATCA 
GCTTTAATCG ATGGGAAGAA CTTCAGTGCA GGAGGTCACA AGGTTGGCTT GGGATTTGAA 
CTGGAAGCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VDAC3 ( NM_005662.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_005653.3 Homo sapiens voltage dependent anion channel 3 (VDAC3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09523
Clone ID Related Accession (Same CDS sequence)	NM_005662.7 , NM_005662.6
Accession Version	NM_005662.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 852bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-01
Organism	Homo sapiens(human)
Product	voltage-dependent anion-selective channel protein 3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA930673.1, BC056870.1 and BQ001504.1. On Oct 21, 2011 this sequence version replaced NM_005662.5. Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.551258.1, SRR1163658.288235.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGTAACA CACCAACGTA CTGTGACCTA GGAAAGGCTG CTAAGGATGT CTTCAACAAA 
GGATATGGCT TTGGCATGGT CAAGATAGAC CTGAAAACCA AGTCTTGTAG TGGAGTGGAA 
TTTTCTACTT CTGGTCATGC TTACACTGAT ACAGGGAAAG CATCAGGCAA CCTAGAAACC 
AAATATAAGG TCTGTAACTA TGGACTTACC TTCACCCAGA AATGGAACAC AGACAATACT 
CTAGGGACAG AAATCTCTTG GGAGAATAAG TTGGCTGAAG GGTTGAAACT GACTCTTGAT 
ACCATATTTG TACCGAACAC AGGAAAGAAG AGTGGGAAAT TGAAGGCCTC CTATAAACGG 
GATTGTTTTA GTGTTGGCAG TAATGTTGAT ATAGATTTTT CTGGACCAAC CATCTATGGC 
TGGGCTGTGT TGGCCTTCGA AGGGTGGCTT GCTGGCTATC AGATGAGTTT TGACACAGCC 
AAATCCAAAC TGTCACAGAA TAATTTCGCC CTGGGTTACA AGGCTGCGGA CTTCCAGCTG 
CACACACATG TGAACGATGG CACTGAATTT GGAGGTTCTA TCTACCAGAA GGTGAATGAG 
AAGATTGAAA CATCCATAAA CCTTGCTTGG ACAGCTGGGA GTAACAACAC CCGTTTTGGC 
ATTGCTGCTA AGTACATGCT GGATTGTAGA ACTTCTCTCT CTGCTAAAGT AAATAATGCC 
AGCCTGATTG GACTGGGTTA TACTCAGACC CTTCGACCAG GAGTCAAATT GACTTTATCA 
GCTTTAATCG ATGGGAAGAA CTTCAGTGCA GGAGGTCACA AGGTTGGCTT GGGATTTGAA 
CTGGAAGCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005653.3
CDS	211..1062
Translation	MCNTPTYCDLGKAAKDVFNKGYGFGMVKIDLKTKSCSGVEFSTSGHAYTDTGKASGNLETKYKVCNYGLTFTQKWNTDNTLGTEISWENKLAEGLKLTLDTIFVPNTGKKSGKLKASYKRDCFSVGSNVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLSQNNFALGYKAADFQLHTHVNDGTEFGGSIYQKVNEKIETSINLAWTAGSNNTRFGIAAKYMLDCRTSLSAKVNNASLIGLGYTQTLRPGVKLTLSALIDGKNFSAGGHKVGLGFELEA

Target ORF information:

RefSeq Version	NM_005662.6
Organism	Homo sapiens(human)
Definition	Homo sapiens voltage dependent anion channel 3 (VDAC3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005662.6

ORF Insert Sequence:

ATGTGTAACA CACCAACGTA CTGTGACCTA GGAAAGGCTG CTAAGGATGT CTTCAACAAA 
GGATATGGCT TTGGCATGGT CAAGATAGAC CTGAAAACCA AGTCTTGTAG TGGAGTGGAA 
TTTTCTACTT CTGGTCATGC TTACACTGAT ACAGGGAAAG CATCAGGCAA CCTAGAAACC 
AAATATAAGG TCTGTAACTA TGGACTTACC TTCACCCAGA AATGGAACAC AGACAATACT 
CTAGGGACAG AAATCTCTTG GGAGAATAAG TTGGCTGAAG GGTTGAAACT GACTCTTGAT 
ACCATATTTG TACCGAACAC AGGAAAGAAG AGTGGGAAAT TGAAGGCCTC CTATAAACGG 
GATTGTTTTA GTGTTGGCAG TAATGTTGAT ATAGATTTTT CTGGACCAAC CATCTATGGC 
TGGGCTGTGT TGGCCTTCGA AGGGTGGCTT GCTGGCTATC AGATGAGTTT TGACACAGCC 
AAATCCAAAC TGTCACAGAA TAATTTCGCC CTGGGTTACA AGGCTGCGGA CTTCCAGCTG 
CACACACATG TGAACGATGG CACTGAATTT GGAGGTTCTA TCTACCAGAA GGTGAATGAG 
AAGATTGAAA CATCCATAAA CCTTGCTTGG ACAGCTGGGA GTAACAACAC CCGTTTTGGC 
ATTGCTGCTA AGTACATGCT GGATTGTAGA ACTTCTCTCT CTGCTAAAGT AAATAATGCC 
AGCCTGATTG GACTGGGTTA TACTCAGACC CTTCGACCAG GAGTCAAATT GACTTTATCA 
GCTTTAATCG ATGGGAAGAA CTTCAGTGCA GGAGGTCACA AGGTTGGCTT GGGATTTGAA 
CTGGAAGCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VDAC3 ( NM_001135694.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001129166.1 Homo sapiens voltage dependent anion channel 3 (VDAC3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09820
Clone ID Related Accession (Same CDS sequence)	NM_001135694.2
Accession Version	NM_001135694.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Homo sapiens(human)
Product	voltage-dependent anion-selective channel protein 3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA930673.1, BC056870.1, AK308760.1 and BQ001504.1. On Oct 21, 2011 this sequence version replaced NM_001135694.1. Transcript Variant: This variant (2) contains an additional, in-frame 3 nt coding exon compared to variant 1. This results in an isoform (2) that is 1 aa longer than isoform 1. The short exon is supported by PMID:10833333, and orthologs in mouse, rat and bovine. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.285484.1, SRR1803613.89492.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGTAACA CACCAACGTA CTGTGACCTA GGAAAGGCTG CTAAGGATGT CTTCAACAAA 
GGATATGGCT TTGGCATGGT CAAGATAGAC CTGAAAACCA AGTCTTGTAG TGGAGTGATG 
GAATTTTCTA CTTCTGGTCA TGCTTACACT GATACAGGGA AAGCATCAGG CAACCTAGAA 
ACCAAATATA AGGTCTGTAA CTATGGACTT ACCTTCACCC AGAAATGGAA CACAGACAAT 
ACTCTAGGGA CAGAAATCTC TTGGGAGAAT AAGTTGGCTG AAGGGTTGAA ACTGACTCTT 
GATACCATAT TTGTACCGAA CACAGGAAAG AAGAGTGGGA AATTGAAGGC CTCCTATAAA 
CGGGATTGTT TTAGTGTTGG CAGTAATGTT GATATAGATT TTTCTGGACC AACCATCTAT 
GGCTGGGCTG TGTTGGCCTT CGAAGGGTGG CTTGCTGGCT ATCAGATGAG TTTTGACACA 
GCCAAATCCA AACTGTCACA GAATAATTTC GCCCTGGGTT ACAAGGCTGC GGACTTCCAG 
CTGCACACAC ATGTGAACGA TGGCACTGAA TTTGGAGGTT CTATCTACCA GAAGGTGAAT 
GAGAAGATTG AAACATCCAT AAACCTTGCT TGGACAGCTG GGAGTAACAA CACCCGTTTT 
GGCATTGCTG CTAAGTACAT GCTGGATTGT AGAACTTCTC TCTCTGCTAA AGTAAATAAT 
GCCAGCCTGA TTGGACTGGG TTATACTCAG ACCCTTCGAC CAGGAGTCAA ATTGACTTTA 
TCAGCTTTAA TCGATGGGAA GAACTTCAGT GCAGGAGGTC ACAAGGTTGG CTTGGGATTT 
GAACTGGAAG CTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001129166.1
CDS	211..1065
Translation	MCNTPTYCDLGKAAKDVFNKGYGFGMVKIDLKTKSCSGVMEFSTSGHAYTDTGKASGNLETKYKVCNYGLTFTQKWNTDNTLGTEISWENKLAEGLKLTLDTIFVPNTGKKSGKLKASYKRDCFSVGSNVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLSQNNFALGYKAADFQLHTHVNDGTEFGGSIYQKVNEKIETSINLAWTAGSNNTRFGIAAKYMLDCRTSLSAKVNNASLIGLGYTQTLRPGVKLTLSALIDGKNFSAGGHKVGLGFELEA

Target ORF information:

RefSeq Version	NM_001135694.2
Organism	Homo sapiens(human)
Definition	Homo sapiens voltage dependent anion channel 3 (VDAC3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001135694.2

ORF Insert Sequence:

ATGTGTAACA CACCAACGTA CTGTGACCTA GGAAAGGCTG CTAAGGATGT CTTCAACAAA 
GGATATGGCT TTGGCATGGT CAAGATAGAC CTGAAAACCA AGTCTTGTAG TGGAGTGATG 
GAATTTTCTA CTTCTGGTCA TGCTTACACT GATACAGGGA AAGCATCAGG CAACCTAGAA 
ACCAAATATA AGGTCTGTAA CTATGGACTT ACCTTCACCC AGAAATGGAA CACAGACAAT 
ACTCTAGGGA CAGAAATCTC TTGGGAGAAT AAGTTGGCTG AAGGGTTGAA ACTGACTCTT 
GATACCATAT TTGTACCGAA CACAGGAAAG AAGAGTGGGA AATTGAAGGC CTCCTATAAA 
CGGGATTGTT TTAGTGTTGG CAGTAATGTT GATATAGATT TTTCTGGACC AACCATCTAT 
GGCTGGGCTG TGTTGGCCTT CGAAGGGTGG CTTGCTGGCT ATCAGATGAG TTTTGACACA 
GCCAAATCCA AACTGTCACA GAATAATTTC GCCCTGGGTT ACAAGGCTGC GGACTTCCAG 
CTGCACACAC ATGTGAACGA TGGCACTGAA TTTGGAGGTT CTATCTACCA GAAGGTGAAT 
GAGAAGATTG AAACATCCAT AAACCTTGCT TGGACAGCTG GGAGTAACAA CACCCGTTTT 
GGCATTGCTG CTAAGTACAT GCTGGATTGT AGAACTTCTC TCTCTGCTAA AGTAAATAAT 
GCCAGCCTGA TTGGACTGGG TTATACTCAG ACCCTTCGAC CAGGAGTCAA ATTGACTTTA 
TCAGCTTTAA TCGATGGGAA GAACTTCAGT GCAGGAGGTC ACAAGGTTGG CTTGGGATTT 
GAACTGGAAG CTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VDAC3 ( XM_006716394.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_006716457.1 Homo sapiens voltage dependent anion channel 3 (VDAC3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu42157
Clone ID Related Accession (Same CDS sequence)	XM_006716394.1
Accession Version	XM_006716394.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 756bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	voltage-dependent anion-selective channel protein 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTTCAA CAAAGGATAT GGAATTTTCT ACTTCTGGTC ATGCTTACAC TGATACAGGG 
AAAGCATCAG GCAACCTAGA AACCAAATAT AAGGTCTGTA ACTATGGACT TACCTTCACC 
CAGAAATGGA ACACAGACAA TACTCTAGGG ACAGAAATCT CTTGGGAGAA TAAGTTGGCT 
GAAGGGTTGA AACTGACTCT TGATACCATA TTTGTACCGA ACACAGGAAA GAAGAGTGGG 
AAATTGAAGG CCTCCTATAA ACGGGATTGT TTTAGTGTTG GCAGTAATGT TGATATAGAT 
TTTTCTGGAC CAACCATCTA TGGCTGGGCT GTGTTGGCCT TCGAAGGGTG GCTTGCTGGC 
TATCAGATGA GTTTTGACAC AGCCAAATCC AAACTGTCAC AGAATAATTT CGCCCTGGGT 
TACAAGGCTG CGGACTTCCA GCTGCACACA CATGTGAACG ATGGCACTGA ATTTGGAGGT 
TCTATCTACC AGAAGGTGAA TGAGAAGATT GAAACATCCA TAAACCTTGC TTGGACAGCT 
GGGAGTAACA ACACCCGTTT TGGCATTGCT GCTAAGTACA TGCTGGATTG TAGAACTTCT 
CTCTCTGCTA AAGTAAATAA TGCCAGCCTG ATTGGACTGG GTTATACTCA GACCCTTCGA 
CCAGGAGTCA AATTGACTTT ATCAGCTTTA ATCGATGGGA AGAACTTCAG TGCAGGAGGT 
CACAAGGTTG GCTTGGGATT TGAACTGGAA GCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006716457.1
CDS	394..1149
Translation	MSSTKDMEFSTSGHAYTDTGKASGNLETKYKVCNYGLTFTQKWNTDNTLGTEISWENKLAEGLKLTLDTIFVPNTGKKSGKLKASYKRDCFSVGSNVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLSQNNFALGYKAADFQLHTHVNDGTEFGGSIYQKVNEKIETSINLAWTAGSNNTRFGIAAKYMLDCRTSLSAKVNNASLIGLGYTQTLRPGVKLTLSALIDGKNFSAGGHKVGLGFELEA

Target ORF information:

RefSeq Version	XM_006716394.1
Organism	Homo sapiens(human)
Definition	Homo sapiens voltage dependent anion channel 3 (VDAC3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006716394.1

ORF Insert Sequence:

ATGTCTTCAA CAAAGGATAT GGAATTTTCT ACTTCTGGTC ATGCTTACAC TGATACAGGG 
AAAGCATCAG GCAACCTAGA AACCAAATAT AAGGTCTGTA ACTATGGACT TACCTTCACC 
CAGAAATGGA ACACAGACAA TACTCTAGGG ACAGAAATCT CTTGGGAGAA TAAGTTGGCT 
GAAGGGTTGA AACTGACTCT TGATACCATA TTTGTACCGA ACACAGGAAA GAAGAGTGGG 
AAATTGAAGG CCTCCTATAA ACGGGATTGT TTTAGTGTTG GCAGTAATGT TGATATAGAT 
TTTTCTGGAC CAACCATCTA TGGCTGGGCT GTGTTGGCCT TCGAAGGGTG GCTTGCTGGC 
TATCAGATGA GTTTTGACAC AGCCAAATCC AAACTGTCAC AGAATAATTT CGCCCTGGGT 
TACAAGGCTG CGGACTTCCA GCTGCACACA CATGTGAACG ATGGCACTGA ATTTGGAGGT 
TCTATCTACC AGAAGGTGAA TGAGAAGATT GAAACATCCA TAAACCTTGC TTGGACAGCT 
GGGAGTAACA ACACCCGTTT TGGCATTGCT GCTAAGTACA TGCTGGATTG TAGAACTTCT 
CTCTCTGCTA AAGTAAATAA TGCCAGCCTG ATTGGACTGG GTTATACTCA GACCCTTCGA 
CCAGGAGTCA AATTGACTTT ATCAGCTTTA ATCGATGGGA AGAACTTCAG TGCAGGAGGT 
CACAAGGTTG GCTTGGGATT TGAACTGGAA GCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-?B Signaling.
Cell systems5(6)564-577.e12(2017 Dec)
Malty RH,Aoki H,Kumar A,Phanse S,Amin S,Zhang Q,Minic Z,Goebels F,Musso G,Wu Z,Abou-Tok H,Meyer M,Deineko V,Kassir S,Sidhu V,Jessulat M,Scott NE,Xiong X,Vlasblom J,Prasad B,Foster LJ,Alberio T,Garavaglia B,Yu H,Bader GD,Nakamura K,Parkinson J,Babu M

Analysis of blood-based gene expression in idiopathic Parkinson disease.
Neurology89(16)1676-1683(2017 Oct)
Shamir R,Klein C,Amar D,Vollstedt EJ,Bonin M,Usenovic M,Wong YC,Maver A,Poths S,Safer H,Corvol JC,Lesage S,Lavi O,Deuschl G,Kuhlenbaeumer G,Pawlack H,Ulitsky I,Kasten M,Riess O,Brice A,Peterlin B,Krainc D

Association of the VDAC3 gene polymorphism with sperm count in Han-Chinese population with idiopathic male infertility.
Oncotarget8(28)45242-45248(2017 Jul)
Pan L,Liu Q,Li J,Wu W,Wang X,Zhao D,Ma J

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VDAC3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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