UPK2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UPK2
Entrez Gene ID	7379
Full Name	uroplakin 2
Synonyms	UP2,UPII
General protein information	Preferred Names uroplakin 2 Names uroplakin-2 uroplakin II
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q23.3
Summary	This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009].
Disorder MIM:	611558

mRNA and Protein(s)

mRNA	Protein	Name
NM_006760.4	NP_006751.1	uroplakin-2 precursor
NM_006760.3	NP_006751.1	uroplakin-2 precursor

Pathways from BioSystems

Homologies

	UPK2	XP_001095616.1
Rattus norvegicus (Norway rat)	Upk2	NP_001102993.1
Homo sapiens (human)	UPK2	NP_006751.1
Canis lupus familiaris (dog)	UPK2	XP_853307.1
Mus musculus (house mouse)	Upk2	NP_033502.2
Bos taurus (cattle)	UPK2	NP_776639.1

Gene Ontology
Bibliography

Related articles in PubMed

A combination of p40, GATA-3 and uroplakin II shows utility in the diagnosis and prognosis of muscle-invasive urothelial carcinoma.
Leivo MZ, Elson PJ, Tacha DE, Delahunt B, Hansel DE
Pathology48(6)543-9(2016 Oct)

Uroplakin II (UPII), GATA3, and p40 are Highly Sensitive Markers for the Differential Diagnosis of Invasive Urothelial Carcinoma.
Hoang LL, Tacha D, Bremer RE, Haas TS, Cheng L
Applied immunohistochemistry & molecular morphology : AIMM23(10)711-6(2015 Nov-Dec)

Utility of uroplakin II expression as a marker of urothelial carcinoma.
Tian W, Guner G, Miyamoto H, Cimino-Mathews A, Gonzalez-Roibon N, Argani P, Li X, Sharma R, Subhawong AP, Rezaei K, Bivalacqua TJ, Epstein JI, Bishop JA, Netto GJ
Human pathology46(1)58-64(2015 Jan)

Uroplakin II is a more sensitive immunohistochemical marker than uroplakin III in urothelial carcinoma and its variants.
Li W, Liang Y, Deavers MT, Kamat AM, Matin SF, Dinney CP, Czerniak B, Guo CC
American journal of clinical pathology142(6)864-71(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that whereas GATA-3 and uroplakin II may be most useful in the diagnosis of urothelial carcinoma metastasis, p40 may be additionally suited as a prognostic marker.
Title: A combination of p40, GATA-3 and uroplakin II shows utility in the diagnosis and prognosis of muscle-invasive urothelial carcinoma.

UPII, GATA3, and p40, when used in combination, are highly sensitive in the differential diagnosis of invasive urothelial carcinoma.
Title: Uroplakin II (UPII), GATA3, and p40 are Highly Sensitive Markers for the Differential Diagnosis of Invasive Urothelial Carcinoma.

UPII was highly specific/moderately sensitive for urothelial carcinoma. May be a potentially useful marker to identify urothelial lineage and help distinguish UC from prostate cancer or, in conjunction with GATA3, from metastatic breast cancer.
Title: Utility of uroplakin II expression as a marker of urothelial carcinoma.

UPII demonstrates a significantly higher sensitivity than UPIII in conventional and variant urothelial carcinomas
Title: Uroplakin II is a more sensitive immunohistochemical marker than uroplakin III in urothelial carcinoma and its variants.

Uroplakin II antibody BC21 demonstrated superior sensitivity and specificity in urothelial carcinoma, compared with uroplakin III, suggesting an advantage in differential diagnosis of urothelial carcinoma and in the detection of tumors of unknown origin.
Title: A newly developed uroplakin II antibody with increased sensitivity in urothelial carcinoma of the bladder.

The following UPK2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UPK2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09458	NM_006760.4 Latest version!	Homo sapiens uroplakin 2 (UPK2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu09458	NM_006760.3	Homo sapiens uroplakin 2 (UPK2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UPK2 ( NM_006760.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006751.1 Homo sapiens uroplakin 2 (UPK2), mRNA.

Price & Availability↑

CloneID	OHu09458
Clone ID Related Accession (Same CDS sequence)	NM_006760.4 , NM_006760.3
Accession Version	NM_006760.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	uroplakin-2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD556028.1 and Y13645.1. On Nov 23, 2018 this sequence version replaced NM_006760.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y13645.1, ERR279850.3032.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000264031.3/ ENSP00000264031.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCACCCC TGCTGCCCAT CCGGACCTTG CCCTTGATCC TGATTCTGCT GGCTCTGCTG 
TCCCCAGGGG CTGCAGACTT CAACATCTCA AGCCTCTCTG GTCTGCTGTC CCCGGCGCTA 
ACGGAGAGCC TGCTGGTTGC CTTGCCCCCC TGTCACCTCA CAGGAGGCAA TGCCACACTG 
ATGGTCCGGA GAGCCAATGA CAGCAAAGTG GTGACGTCCA GCTTTGTGGT GCCTCCGTGC 
CGTGGGCGCA GGGAACTGGT GAGTGTGGTG GACAGTGGTG CTGGCTTCAC AGTCACTCGG 
CTCAGTGCAT ACCAGGTGAC AAACCTCGTG CCAGGAACCA AATTCTACAT TTCCTACCTA 
GTGAAGAAGG GGACAGCCAC TGAGTCCAGC AGAGAGATCC CAATGTCCAC ACTCCCTCGA 
AGGAACATGG AATCCATTGG GCTGGGTATG GCCCGCACAG GGGGCATGGT GGTCATCACG 
GTGCTGCTCT CTGTCGCCAT GTTCCTGCTG GTGCTGGGCT TCATCATTGC CCTGGCACTG 
GGCTCCCGCA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006751.1
CDS	54..608
Translation	MAPLLPIRTLPLILILLALLSPGAADFNISSLSGLLSPALTESLLVALPPCHLTGGNATLMVRRANDSKVVTSSFVVPPCRGRRELVSVVDSGAGFTVTRLSAYQVTNLVPGTKFYISYLVKKGTATESSREIPMSTLPRRNMESIGLGMARTGGMVVITVLLSVAMFLLVLGFIIALALGSRK

Target ORF information:

RefSeq Version	NM_006760.4
Organism	Homo sapiens(human)
Definition	Homo sapiens uroplakin 2 (UPK2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006760.4

ORF Insert Sequence:

ATGGCACCCC TGCTGCCCAT CCGGACCTTG CCCTTGATCC TGATTCTGCT GGCTCTGCTG 
TCCCCAGGGG CTGCAGACTT CAACATCTCA AGCCTCTCTG GTCTGCTGTC CCCGGCGCTA 
ACGGAGAGCC TGCTGGTTGC CTTGCCCCCC TGTCACCTCA CAGGAGGCAA TGCCACACTG 
ATGGTCCGGA GAGCCAATGA CAGCAAAGTG GTGACGTCCA GCTTTGTGGT GCCTCCGTGC 
CGTGGGCGCA GGGAACTGGT GAGTGTGGTG GACAGTGGTG CTGGCTTCAC AGTCACTCGG 
CTCAGTGCAT ACCAGGTGAC AAACCTCGTG CCAGGAACCA AATTCTACAT TTCCTACCTA 
GTGAAGAAGG GGACAGCCAC TGAGTCCAGC AGAGAGATCC CAATGTCCAC ACTCCCTCGA 
AGGAACATGG AATCCATTGG GCTGGGTATG GCCCGCACAG GGGGCATGGT GGTCATCACG 
GTGCTGCTCT CTGTCGCCAT GTTCCTGCTG GTGCTGGGCT TCATCATTGC CCTGGCACTG 
GGCTCCCGCA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UPK2 ( NM_006760.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006751.1 Homo sapiens uroplakin 2 (UPK2), mRNA.

Price & Availability↑

CloneID	OHu09458
Clone ID Related Accession (Same CDS sequence)	NM_006760.4 , NM_006760.3
Accession Version	NM_006760.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	uroplakin-2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD556028.1 and Y13645.1. On Oct 2, 2009 this sequence version replaced NM_006760.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y13645.1, ERR279850.3032.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCACCCC TGCTGCCCAT CCGGACCTTG CCCTTGATCC TGATTCTGCT GGCTCTGCTG 
TCCCCAGGGG CTGCAGACTT CAACATCTCA AGCCTCTCTG GTCTGCTGTC CCCGGCGCTA 
ACGGAGAGCC TGCTGGTTGC CTTGCCCCCC TGTCACCTCA CAGGAGGCAA TGCCACACTG 
ATGGTCCGGA GAGCCAATGA CAGCAAAGTG GTGACGTCCA GCTTTGTGGT GCCTCCGTGC 
CGTGGGCGCA GGGAACTGGT GAGTGTGGTG GACAGTGGTG CTGGCTTCAC AGTCACTCGG 
CTCAGTGCAT ACCAGGTGAC AAACCTCGTG CCAGGAACCA AATTCTACAT TTCCTACCTA 
GTGAAGAAGG GGACAGCCAC TGAGTCCAGC AGAGAGATCC CAATGTCCAC ACTCCCTCGA 
AGGAACATGG AATCCATTGG GCTGGGTATG GCCCGCACAG GGGGCATGGT GGTCATCACG 
GTGCTGCTCT CTGTCGCCAT GTTCCTGCTG GTGCTGGGCT TCATCATTGC CCTGGCACTG 
GGCTCCCGCA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006751.1
CDS	54..608
Translation	MAPLLPIRTLPLILILLALLSPGAADFNISSLSGLLSPALTESLLVALPPCHLTGGNATLMVRRANDSKVVTSSFVVPPCRGRRELVSVVDSGAGFTVTRLSAYQVTNLVPGTKFYISYLVKKGTATESSREIPMSTLPRRNMESIGLGMARTGGMVVITVLLSVAMFLLVLGFIIALALGSRK

Target ORF information:

RefSeq Version	NM_006760.3
Organism	Homo sapiens(human)
Definition	Homo sapiens uroplakin 2 (UPK2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006760.3

ORF Insert Sequence:

ATGGCACCCC TGCTGCCCAT CCGGACCTTG CCCTTGATCC TGATTCTGCT GGCTCTGCTG 
TCCCCAGGGG CTGCAGACTT CAACATCTCA AGCCTCTCTG GTCTGCTGTC CCCGGCGCTA 
ACGGAGAGCC TGCTGGTTGC CTTGCCCCCC TGTCACCTCA CAGGAGGCAA TGCCACACTG 
ATGGTCCGGA GAGCCAATGA CAGCAAAGTG GTGACGTCCA GCTTTGTGGT GCCTCCGTGC 
CGTGGGCGCA GGGAACTGGT GAGTGTGGTG GACAGTGGTG CTGGCTTCAC AGTCACTCGG 
CTCAGTGCAT ACCAGGTGAC AAACCTCGTG CCAGGAACCA AATTCTACAT TTCCTACCTA 
GTGAAGAAGG GGACAGCCAC TGAGTCCAGC AGAGAGATCC CAATGTCCAC ACTCCCTCGA 
AGGAACATGG AATCCATTGG GCTGGGTATG GCCCGCACAG GGGGCATGGT GGTCATCACG 
GTGCTGCTCT CTGTCGCCAT GTTCCTGCTG GTGCTGGGCT TCATCATTGC CCTGGCACTG 
GGCTCCCGCA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A combination of p40, GATA-3 and uroplakin II shows utility in the diagnosis and prognosis of muscle-invasive urothelial carcinoma.
Pathology48(6)543-9(2016 Oct)
Leivo MZ,Elson PJ,Tacha DE,Delahunt B,Hansel DE

Uroplakin II (UPII), GATA3, and p40 are Highly Sensitive Markers for the Differential Diagnosis of Invasive Urothelial Carcinoma.
Applied immunohistochemistry & molecular morphology : AIMM23(10)711-6(2015 Nov-Dec)
Hoang LL,Tacha D,Bremer RE,Haas TS,Cheng L

Utility of uroplakin II expression as a marker of urothelial carcinoma.
Human pathology46(1)58-64(2015 Jan)
Tian W,Guner G,Miyamoto H,Cimino-Mathews A,Gonzalez-Roibon N,Argani P,Li X,Sharma R,Subhawong AP,Rezaei K,Bivalacqua TJ,Epstein JI,Bishop JA,Netto GJ

Uroplakin II is a more sensitive immunohistochemical marker than uroplakin III in urothelial carcinoma and its variants.
American journal of clinical pathology142(6)864-71(2014 Dec)
Li W,Liang Y,Deavers MT,Kamat AM,Matin SF,Dinney CP,Czerniak B,Guo CC

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UPK2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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