Gene Symbol | UNG |
Entrez Gene ID | 7374 |
Full Name | uracil DNA glycosylase |
Synonyms | DGU,HIGM4,HIGM5,UDG,UNG1,UNG15,UNG2 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]. |
Disorder MIM: | |
Disorder Html: | Immunodeficiency with hyper IgM, type 5, 608106 (3) |