UMPS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UMPS
Entrez Gene ID	7372
Full Name	uridine monophosphate synthetase
Synonyms	OPRT
General protein information	Preferred Names uridine monophosphate synthetase Names uridine 5'-monophosphate synthase OMPdecase OPRTase UMP synthase orotate phosphoribosyltransferase orotidine 5'-phosphate decarboxylase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q21.2
Summary	This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
Disorder MIM:	613891
Disorder Html:	Orotic aciduria, 258900 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000373.3	NP_000364.1	uridine 5'-monophosphate synthase
NM_000373.4	NP_000364.1	uridine 5'-monophosphate synthase

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	umps	NP_956468.2
	UMPS	XP_001113783.1
Rattus norvegicus (Norway rat)	Umps	NP_001020573.1
Arabidopsis thaliana (thale cress)	AT3G54470	NP_680130.1
Pan troglodytes (chimpanzee)	UMPS	XP_001169083.1
Homo sapiens (human)	UMPS	NP_000364.1
Mus musculus (house mouse)	Umps	NP_033497.1
Drosophila melanogaster (fruit fly)	r-l	NP_524427.1
Oryza sativa (rice)	Os01g0951200	NP_001045412.1
Xenopus tropicalis (tropical clawed frog)	umps	XP_002944316.2
Canis lupus familiaris (dog)	UMPS	XP_535769.3
Bos taurus (cattle)	UMPS	NP_803474.1
Gallus gallus (chicken)	UMPS	NP_001026431.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004175	XP_313061.3

Gene Ontology
Bibliography

Related articles in PubMed

Mild orotic aciduria in UMPS heterozygotes: a metabolic finding without clinical consequences.
Wortmann SB, Chen MA, Colombo R, Pontoglio A, Alhaddad B, Botto LD, Yuzyuk T, Coughlin CR, Descartes M, Gr?newald S, Maranda B, Mills PB, Pitt J, Potente C, Rodenburg R, Kluijtmans LA, Sampath S, Pai EF, Wevers RA, Tiller GE,
Journal of inherited metabolic disease40(3)423-431(2017 May)

A phase II study of preoperative chemoradiation with tegafur-uracil plus leucovorin for locally advanced rectal cancer with pharmacogenetic analysis.
Kim SY, Baek JY, Oh JH, Park SC, Sohn DK, Kim MJ, Chang HJ, Kong SY, Kim DY
Radiation oncology (London, England)12(1)62(2017 Mar)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases.
Zhang Y, Evans GB, Clinch K, Crump DR, Harris LD, Fr?hlich RF, Tyler PC, Hazleton KZ, Cassera MB, Schramm VL
The Journal of biological chemistry288(48)34746-54(2013 Nov)

[Expressions of orotate phosphoribosyltransferase in colorectal carcinoma and its correlations with toxicities of chemotherapy].
Dong Q, Huang S, Li Y, Liu J
Nan fang yi ke da xue xue bao = Journal of Southern Medical University32(8)1179-81(2012 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Partial UMPS-deficiency should be included in the differential diagnosis of mild orotic aciduria.
Title: Mild orotic aciduria in UMPS heterozygotes: a metabolic finding without clinical consequences.

The UMPS 638 CC genotype might be a candidate biomarker predicting toxicity in patients receiving tegafur-uracil/leucovorin-based preoperative chemoradiation for locally advanced rectal cancer
Title: A phase II study of preoperative chemoradiation with tegafur-uracil plus leucovorin for locally advanced rectal cancer with pharmacogenetic analysis.

OPRT transition state analogues identify crucial components of potent inhibitors targeting OPRT enzymes.
Title: Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases.

OPRT expression in colorectal carcinoma tissues is not correlated with the toxicity of 5-FU, but OPRT expression in the normal tissues can help predict the toxicity associated with 5-FU.
Title: [Expressions of orotate phosphoribosyltransferase in colorectal carcinoma and its correlations with toxicities of chemotherapy].

High expression levels of orotate phosphoribosyl transferase and thymidylate synthase in colorectal cancer appear to be significantly involved in metastasis after curative surgery
Title: Expression of dihydropyrimidine dehydrogenase, orotate phosphoribosyl transferase and thymidylate synthase in patients with primary colorectal cancer, and associations with site of first metastasis.

The following UMPS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UMPS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20635	NM_000373.4 Latest version!	Homo sapiens uridine monophosphate synthetase (UMPS), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu20635	NM_000373.3	Homo sapiens uridine monophosphate synthetase (UMPS), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UMPS ( NM_000373.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000364.1 Homo sapiens uridine monophosphate synthetase (UMPS), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20635
Clone ID Related Accession (Same CDS sequence)	NM_000373.3 , NM_000373.4
Accession Version	NM_000373.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	uridine 5'-monophosphate synthase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC022336.12 and BC007511.2. This sequence is a reference standard in the RefSeqGene project. On Apr 1, 2010 this sequence version replaced NM_000373.2. Transcript Variant: This variant (1) encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: J03626.1, SRR1660807.20671.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGTCG CTCGTGCAGC TTTGGGGCCA TTGGTGACGG GTCTGTACGA CGTGCAGGCT 
TTCAAGTTTG GGGACTTCGT GCTGAAGAGC GGGCTTTCCT CCCCCATCTA CATCGATCTG 
CGGGGCATCG TGTCTCGACC GCGTCTTCTG AGTCAGGTTG CAGATATTTT ATTCCAAACT 
GCCCAAAATG CAGGCATCAG TTTTGACACC GTGTGTGGAG TGCCTTATAC AGCTTTGCCA 
TTGGCTACAG TTATCTGTTC AACCAATCAA ATTCCAATGC TTATTAGAAG GAAAGAAACA 
AAGGATTATG GAACTAAGCG TCTTGTAGAA GGAACTATTA ATCCAGGAGA AACCTGTTTA 
ATCATTGAAG ATGTTGTCAC CAGTGGATCT AGTGTTTTGG AAACTGTTGA GGTTCTTCAG 
AAGGAGGGCT TGAAGGTCAC TGATGCCATA GTGCTGTTGG ACAGAGAGCA GGGAGGCAAG 
GACAAGTTGC AGGCGCACGG GATCCGCCTC CACTCAGTGT GTACATTGTC CAAAATGCTG 
GAGATTCTCG AGCAGCAGAA AAAAGTTGAT GCTGAGACAG TTGGGAGAGT GAAGAGGTTT 
ATTCAGGAGA ATGTCTTTGT GGCAGCGAAT CATAATGGTT CTCCCCTTTC TATAAAGGAA 
GCACCCAAAG AACTCAGCTT CGGTGCACGT GCAGAGCTGC CCAGGATCCA CCCAGTTGCA 
TCGAAGCTTC TCAGGCTTAT GCAAAAGAAG GAGACCAATC TGTGTCTATC TGCTGATGTT 
TCACTGGCCA GAGAGCTGTT GCAGCTAGCA GATGCTTTAG GACCTAGTAT CTGCATGCTG 
AAGACTCATG TAGATATTTT GAATGATTTT ACTCTGGATG TGATGAAGGA GTTGATAACT 
CTGGCAAAAT GCCATGAGTT CTTGATATTT GAAGACCGGA AGTTTGCAGA TATAGGAAAC 
ACAGTGAAAA AGCAGTATGA AGGAGGTATC TTTAAAATAG CTTCCTGGGC AGATCTAGTA 
AATGCTCACG TGGTGCCAGG CTCAGGAGTT GTGAAAGGCC TGCAAGAAGT GGGCCTGCCT 
TTGCATCGGG GGTGCCTCCT TATTGCGGAA ATGAGCTCCA CCGGCTCCCT GGCCACTGGG 
GACTACACTA GAGCAGCGGT TAGAATGGCT GAGGAGCACT CTGAATTTGT TGTTGGTTTT 
ATTTCTGGCT CCCGAGTAAG CATGAAACCA GAATTTCTTC ACTTGACTCC AGGAGTTCAG 
TTGGAAGCAG GAGGAGATAA TCTTGGCCAA CAGTACAATA GCCCACAAGA AGTTATTGGC 
AAACGAGGTT CCGATATCAT CATTGTAGGT CGTGGCATAA TCTCAGCAGC TGATCGTCTG 
GAAGCAGCAG AGATGTACAG AAAAGCTGCT TGGGAAGCGT ATTTGAGTAG ACTTGGTGTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000364.1
CDS	107..1549
Translation	MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQTAQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCLIIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKMLEILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV

Target ORF information:

RefSeq Version	NM_000373.3
Organism	Homo sapiens(human)
Definition	Homo sapiens uridine monophosphate synthetase (UMPS), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000373.3

ORF Insert Sequence:

ATGGCGGTCG CTCGTGCAGC TTTGGGGCCA TTGGTGACGG GTCTGTACGA CGTGCAGGCT 
TTCAAGTTTG GGGACTTCGT GCTGAAGAGC GGGCTTTCCT CCCCCATCTA CATCGATCTG 
CGGGGCATCG TGTCTCGACC GCGTCTTCTG AGTCAGGTTG CAGATATTTT ATTCCAAACT 
GCCCAAAATG CAGGCATCAG TTTTGACACC GTGTGTGGAG TGCCTTATAC AGCTTTGCCA 
TTGGCTACAG TTATCTGTTC AACCAATCAA ATTCCAATGC TTATTAGAAG GAAAGAAACA 
AAGGATTATG GAACTAAGCG TCTTGTAGAA GGAACTATTA ATCCAGGAGA AACCTGTTTA 
ATCATTGAAG ATGTTGTCAC CAGTGGATCT AGTGTTTTGG AAACTGTTGA GGTTCTTCAG 
AAGGAGGGCT TGAAGGTCAC TGATGCCATA GTGCTGTTGG ACAGAGAGCA GGGAGGCAAG 
GACAAGTTGC AGGCGCACGG GATCCGCCTC CACTCAGTGT GTACATTGTC CAAAATGCTG 
GAGATTCTCG AGCAGCAGAA AAAAGTTGAT GCTGAGACAG TTGGGAGAGT GAAGAGGTTT 
ATTCAGGAGA ATGTCTTTGT GGCAGCGAAT CATAATGGTT CTCCCCTTTC TATAAAGGAA 
GCACCCAAAG AACTCAGCTT CGGTGCACGT GCAGAGCTGC CCAGGATCCA CCCAGTTGCA 
TCGAAGCTTC TCAGGCTTAT GCAAAAGAAG GAGACCAATC TGTGTCTATC TGCTGATGTT 
TCACTGGCCA GAGAGCTGTT GCAGCTAGCA GATGCTTTAG GACCTAGTAT CTGCATGCTG 
AAGACTCATG TAGATATTTT GAATGATTTT ACTCTGGATG TGATGAAGGA GTTGATAACT 
CTGGCAAAAT GCCATGAGTT CTTGATATTT GAAGACCGGA AGTTTGCAGA TATAGGAAAC 
ACAGTGAAAA AGCAGTATGA AGGAGGTATC TTTAAAATAG CTTCCTGGGC AGATCTAGTA 
AATGCTCACG TGGTGCCAGG CTCAGGAGTT GTGAAAGGCC TGCAAGAAGT GGGCCTGCCT 
TTGCATCGGG GGTGCCTCCT TATTGCGGAA ATGAGCTCCA CCGGCTCCCT GGCCACTGGG 
GACTACACTA GAGCAGCGGT TAGAATGGCT GAGGAGCACT CTGAATTTGT TGTTGGTTTT 
ATTTCTGGCT CCCGAGTAAG CATGAAACCA GAATTTCTTC ACTTGACTCC AGGAGTTCAG 
TTGGAAGCAG GAGGAGATAA TCTTGGCCAA CAGTACAATA GCCCACAAGA AGTTATTGGC 
AAACGAGGTT CCGATATCAT CATTGTAGGT CGTGGCATAA TCTCAGCAGC TGATCGTCTG 
GAAGCAGCAG AGATGTACAG AAAAGCTGCT TGGGAAGCGT ATTTGAGTAG ACTTGGTGTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UMPS ( NM_000373.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000364.1 Homo sapiens uridine monophosphate synthetase (UMPS), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20635
Clone ID Related Accession (Same CDS sequence)	NM_000373.3 , NM_000373.4
Accession Version	NM_000373.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	uridine 5'-monophosphate synthase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC007511.2 and AC022336.12. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_000373.3. Transcript Variant: This variant (1) encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU921886.1, SRR1660807.20671.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000232607.7/ ENSP00000232607.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGTCG CTCGTGCAGC TTTGGGGCCA TTGGTGACGG GTCTGTACGA CGTGCAGGCT 
TTCAAGTTTG GGGACTTCGT GCTGAAGAGC GGGCTTTCCT CCCCCATCTA CATCGATCTG 
CGGGGCATCG TGTCTCGACC GCGTCTTCTG AGTCAGGTTG CAGATATTTT ATTCCAAACT 
GCCCAAAATG CAGGCATCAG TTTTGACACC GTGTGTGGAG TGCCTTATAC AGCTTTGCCA 
TTGGCTACAG TTATCTGTTC AACCAATCAA ATTCCAATGC TTATTAGAAG GAAAGAAACA 
AAGGATTATG GAACTAAGCG TCTTGTAGAA GGAACTATTA ATCCAGGAGA AACCTGTTTA 
ATCATTGAAG ATGTTGTCAC CAGTGGATCT AGTGTTTTGG AAACTGTTGA GGTTCTTCAG 
AAGGAGGGCT TGAAGGTCAC TGATGCCATA GTGCTGTTGG ACAGAGAGCA GGGAGGCAAG 
GACAAGTTGC AGGCGCACGG GATCCGCCTC CACTCAGTGT GTACATTGTC CAAAATGCTG 
GAGATTCTCG AGCAGCAGAA AAAAGTTGAT GCTGAGACAG TTGGGAGAGT GAAGAGGTTT 
ATTCAGGAGA ATGTCTTTGT GGCAGCGAAT CATAATGGTT CTCCCCTTTC TATAAAGGAA 
GCACCCAAAG AACTCAGCTT CGGTGCACGT GCAGAGCTGC CCAGGATCCA CCCAGTTGCA 
TCGAAGCTTC TCAGGCTTAT GCAAAAGAAG GAGACCAATC TGTGTCTATC TGCTGATGTT 
TCACTGGCCA GAGAGCTGTT GCAGCTAGCA GATGCTTTAG GACCTAGTAT CTGCATGCTG 
AAGACTCATG TAGATATTTT GAATGATTTT ACTCTGGATG TGATGAAGGA GTTGATAACT 
CTGGCAAAAT GCCATGAGTT CTTGATATTT GAAGACCGGA AGTTTGCAGA TATAGGAAAC 
ACAGTGAAAA AGCAGTATGA AGGAGGTATC TTTAAAATAG CTTCCTGGGC AGATCTAGTA 
AATGCTCACG TGGTGCCAGG CTCAGGAGTT GTGAAAGGCC TGCAAGAAGT GGGCCTGCCT 
TTGCATCGGG GGTGCCTCCT TATTGCGGAA ATGAGCTCCA CCGGCTCCCT GGCCACTGGG 
GACTACACTA GAGCAGCGGT TAGAATGGCT GAGGAGCACT CTGAATTTGT TGTTGGTTTT 
ATTTCTGGCT CCCGAGTAAG CATGAAACCA GAATTTCTTC ACTTGACTCC AGGAGTTCAG 
TTGGAAGCAG GAGGAGATAA TCTTGGCCAA CAGTACAATA GCCCACAAGA AGTTATTGGC 
AAACGAGGTT CCGATATCAT CATTGTAGGT CGTGGCATAA TCTCAGCAGC TGATCGTCTG 
GAAGCAGCAG AGATGTACAG AAAAGCTGCT TGGGAAGCGT ATTTGAGTAG ACTTGGTGTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000364.1
CDS	21..1463
Translation	MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQTAQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCLIIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKMLEILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV

Target ORF information:

RefSeq Version	NM_000373.4
Organism	Homo sapiens(human)
Definition	Homo sapiens uridine monophosphate synthetase (UMPS), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000373.4

ORF Insert Sequence:

ATGGCGGTCG CTCGTGCAGC TTTGGGGCCA TTGGTGACGG GTCTGTACGA CGTGCAGGCT 
TTCAAGTTTG GGGACTTCGT GCTGAAGAGC GGGCTTTCCT CCCCCATCTA CATCGATCTG 
CGGGGCATCG TGTCTCGACC GCGTCTTCTG AGTCAGGTTG CAGATATTTT ATTCCAAACT 
GCCCAAAATG CAGGCATCAG TTTTGACACC GTGTGTGGAG TGCCTTATAC AGCTTTGCCA 
TTGGCTACAG TTATCTGTTC AACCAATCAA ATTCCAATGC TTATTAGAAG GAAAGAAACA 
AAGGATTATG GAACTAAGCG TCTTGTAGAA GGAACTATTA ATCCAGGAGA AACCTGTTTA 
ATCATTGAAG ATGTTGTCAC CAGTGGATCT AGTGTTTTGG AAACTGTTGA GGTTCTTCAG 
AAGGAGGGCT TGAAGGTCAC TGATGCCATA GTGCTGTTGG ACAGAGAGCA GGGAGGCAAG 
GACAAGTTGC AGGCGCACGG GATCCGCCTC CACTCAGTGT GTACATTGTC CAAAATGCTG 
GAGATTCTCG AGCAGCAGAA AAAAGTTGAT GCTGAGACAG TTGGGAGAGT GAAGAGGTTT 
ATTCAGGAGA ATGTCTTTGT GGCAGCGAAT CATAATGGTT CTCCCCTTTC TATAAAGGAA 
GCACCCAAAG AACTCAGCTT CGGTGCACGT GCAGAGCTGC CCAGGATCCA CCCAGTTGCA 
TCGAAGCTTC TCAGGCTTAT GCAAAAGAAG GAGACCAATC TGTGTCTATC TGCTGATGTT 
TCACTGGCCA GAGAGCTGTT GCAGCTAGCA GATGCTTTAG GACCTAGTAT CTGCATGCTG 
AAGACTCATG TAGATATTTT GAATGATTTT ACTCTGGATG TGATGAAGGA GTTGATAACT 
CTGGCAAAAT GCCATGAGTT CTTGATATTT GAAGACCGGA AGTTTGCAGA TATAGGAAAC 
ACAGTGAAAA AGCAGTATGA AGGAGGTATC TTTAAAATAG CTTCCTGGGC AGATCTAGTA 
AATGCTCACG TGGTGCCAGG CTCAGGAGTT GTGAAAGGCC TGCAAGAAGT GGGCCTGCCT 
TTGCATCGGG GGTGCCTCCT TATTGCGGAA ATGAGCTCCA CCGGCTCCCT GGCCACTGGG 
GACTACACTA GAGCAGCGGT TAGAATGGCT GAGGAGCACT CTGAATTTGT TGTTGGTTTT 
ATTTCTGGCT CCCGAGTAAG CATGAAACCA GAATTTCTTC ACTTGACTCC AGGAGTTCAG 
TTGGAAGCAG GAGGAGATAA TCTTGGCCAA CAGTACAATA GCCCACAAGA AGTTATTGGC 
AAACGAGGTT CCGATATCAT CATTGTAGGT CGTGGCATAA TCTCAGCAGC TGATCGTCTG 
GAAGCAGCAG AGATGTACAG AAAAGCTGCT TGGGAAGCGT ATTTGAGTAG ACTTGGTGTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mild orotic aciduria in UMPS heterozygotes: a metabolic finding without clinical consequences.
Journal of inherited metabolic disease40(3)423-431(2017 May)
Wortmann SB,Chen MA,Colombo R,Pontoglio A,Alhaddad B,Botto LD,Yuzyuk T,Coughlin CR,Descartes M,Gr?newald S,Maranda B,Mills PB,Pitt J,Potente C,Rodenburg R,Kluijtmans LA,Sampath S,Pai EF,Wevers RA,Tiller GE,

A phase II study of preoperative chemoradiation with tegafur-uracil plus leucovorin for locally advanced rectal cancer with pharmacogenetic analysis.
Radiation oncology (London, England)12(1)62(2017 Mar)
Kim SY,Baek JY,Oh JH,Park SC,Sohn DK,Kim MJ,Chang HJ,Kong SY,Kim DY

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases.
The Journal of biological chemistry288(48)34746-54(2013 Nov)
Zhang Y,Evans GB,Clinch K,Crump DR,Harris LD,Fr?hlich RF,Tyler PC,Hazleton KZ,Cassera MB,Schramm VL

[Expressions of orotate phosphoribosyltransferase in colorectal carcinoma and its correlations with toxicities of chemotherapy].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University32(8)1179-81(2012 Aug)
Dong Q,Huang S,Li Y,Liu J

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UMPS cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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