UGT2B4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UGT2B4
Entrez Gene ID	7363
Full Name	UDP glucuronosyltransferase family 2 member B4
Synonyms	HLUG25,UDPGT2B4,UDPGTH1,UDPGTh-1,UGT2B11
General protein information	Preferred Names UDP glucuronosyltransferase family 2 member B4 Names UDP-glucuronosyltransferase 2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 UDP-glucuronyltransferase, family 2, beta-4 UDPGT 2B4 hyodeoxycholic acid hyodeoxycholic acid-specific UDPGT
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q13.3
Disorder MIM:	600067

mRNA and Protein(s)

mRNA	Protein	Name
NM_021139.2	NP_066962.2	UDP-glucuronosyltransferase 2B4 isoform 1 precursor
NM_001297615.1	NP_001284544.1	UDP-glucuronosyltransferase 2B4 isoform 2 precursor
NM_001297615.2	NP_001284544.1	UDP-glucuronosyltransferase 2B4 isoform 2 precursor
NM_021139.3	NP_066962.2	UDP-glucuronosyltransferase 2B4 isoform 1 precursor
NM_001297616.1	NP_001284545.1	UDP-glucuronosyltransferase 2B4 isoform 3

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Ugt2b7	NP_775445.1
	UGT2B4	XP_001107708.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007374	XP_308459.4
Homo sapiens (human)	UGT2B4	NP_066962.2
Pan troglodytes (chimpanzee)	UGT2B4	XP_001161846.1

Gene Ontology
Bibliography

Related articles in PubMed

Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions
Kahma H, Filppula AM, Neuvonen M, Tarkiainen EK, Tornio A, Holmberg MT, Itkonen MK, Finel M, Neuvonen PJ, Niemi M, Backman JT
Drug metabolism and disposition: the biological fate of chemicals46(2)141-150(2018 Feb)

UGT2B4 previously implicated in the risk of breast cancer is associated with menarche timing in Ukrainian females.
Yermachenko A, Dvornyk V
Gene590(1)85-9(2016 Sep)

Upregulation of UGT2B4 Expression by 3'-Phosphoadenosine-5'-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation.
Barrett KG, Fang H, Cukovic D, Dombkowski AA, Kocarek TA, Runge-Morris M
Drug metabolism and disposition: the biological fate of chemicals43(7)1061-70(2015 Jul)

High enzyme activity UGT1A1 or low activity UGT1A8 and UGT2B4 genotypes increase esophageal cancer risk.
Dura P, Salomon J, Te Morsche RH, Roelofs HM, Kristinsson JO, Wobbes T, Witteman BJ, Tan AC, Drenth JP, Peters WH
International journal of oncology40(6)1789-96(2012 Jun)

Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects.
Gelston EA, Coller JK, Lopatko OV, James HM, Schmidt H, White JM, Somogyi AA
British journal of clinical pharmacology73(5)786-94(2012 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

UGT2B4 previously implicated in the risk of breast cancer is associated with menarche timing in Ukrainian females.
Title: UGT2B4 previously implicated in the risk of breast cancer is associated with menarche timing in Ukrainian females.

These data indicate that knocking down PAPSS increases UGT2B4 transcription and mRNA stability as a compensatory response to the loss of SULT2A1 activity
Title: Upregulation of UGT2B4 Expression by 3'-Phosphoadenosine-5'-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation.

The UGT1A8 and UGT2B4 genotypes associated with decreased predicted enzyme activities, were significantly associated with an increased risk of esophageal squamous cell carcinoma.
Title: High enzyme activity UGT1A1 or low activity UGT1A8 and UGT2B4 genotypes increase esophageal cancer risk.

Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo
Title: Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects.

The variation pattern upstream UGT2B4 is highly unusual and may be the result of balancing selection.
Title: A signature of balancing selection in the region upstream to the human UGT2B4 gene and implications for breast cancer risk.

The following UGT2B4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UGT2B4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28802	NM_001297616.1 Latest version!	Homo sapiens UDP glucuronosyltransferase family 2 member B4 (UGT2B4), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu28805	NM_001297615.2 Latest version!	Homo sapiens UDP glucuronosyltransferase family 2 member B4 (UGT2B4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu28815	NM_021139.3 Latest version!	Homo sapiens UDP glucuronosyltransferase family 2 member B4 (UGT2B4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
View Old Accession Versions >>
OHu28805	NM_001297615.1	Homo sapiens UDP glucuronosyltransferase family 2 member B4 (UGT2B4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu28815	NM_021139.2	Homo sapiens UDP glucuronosyltransferase family 2 member B4 (UGT2B4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UGT2B4 ( NM_001297616.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001284545.1 Homo sapiens UDP glucuronosyltransferase family 2 member B4 (UGT2B4), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu28802
Clone ID Related Accession (Same CDS sequence)	NM_001297616.1
Accession Version	NM_001297616.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1179bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	UDP-glucuronosyltransferase 2B4 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK300084.1 and AF064200.1. Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK300084.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTTTTTG CTCTCTTACA TGTCTCATCA ACGAATGGAT TAGATGCTGT TTTCCCCTTT 
GGTGAGCTGC TGGCCGAGTT ACTTAAAATA CCCTTTGTCT ACAGCCTCCG CTTCTCTCCT 
GGCTACGCAA TTGAAAAGCA TAGTGGAGGA CTTCTGTTCC CTCCTTCCTA TGTGCCTGTT 
GTTATGTCAG AACTAAGTGA CCAAATGACT TTCATAGAGA GGGTAAAAAA TATGATCTAT 
GTGCTTTATT TTGAATTTTG GTTCCAAATA TTTGACATGA AGAAGTGGGA TCAGTTCTAC 
AGTGAAGTTC TAGGAAGACC CACTACGTTA TCTGAGACAA TGGCAAAAGC TGACATATGG 
CTTATTCGAA ACTACTGGGA TTTTCAATTT CCTCACCCAC TCTTACCAAA TGTTGAGTTC 
GTTGGAGGAC TCCACTGCAA ACCTGCCAAA CCCCTACCGA AGGAAATGGA AGAGTTTGTC 
CAGAGCTCTG GAGAAAATGG TGTTGTGGTG TTTTCTCTGG GGTCGATGGT CAGTAACACG 
TCAGAAGAAA GGGCCAATGT AATTGCATCA GCCCTTGCCA AGATCCCACA AAAGGTTCTG 
TGGAGATTTG ATGGGAATAA ACCAGATACT TTAGGACTCA ATACTCGGCT GTACAAGTGG 
ATACCCCAGA ATGATCTTCT TGGTCACCCA AAAACCAGAG CTTTTATAAC TCATGGTGGA 
GCCAATGGCA TCTATGAGGC AATCTACCAT GGAATCCCTA TGGTGGGCGT TCCATTGTTT 
GCAGATCAAC CTGATAACAT TGCACACATG AAGGCCAAGG GAGCAGCTGT TAGTTTGGAC 
TTCCACACAA TGTCGAGTAC AGACTTACTC AATGCACTGA AGACAGTAAT TAATGATCCT 
TTATATAAAG AGAATGCTAT GAAATTATCA AGAATTCATC ATGATCAACC AGTGAAGCCC 
CTTGATCGAG CAGTCTTCTG GATTGAATTT GTCATGCGCC ATAAAGGAGC CAAGCACCTT 
CGGGTTGCAG CCCACGACCT CACCTGGTTC CAGTACCACT CTTTGGATGT GACTGGGTTC 
CTGCTGGCCT GTGTGGCAAC TGTGATATTC ATCATCACAA AATGTCTGTT TTGTGTCTGG 
AAGTTTGTTA GAACAGGAAA GAAGGGGAAA AGAGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001284545.1
CDS	286..1464
Translation	MFFALLHVSSTNGLDAVFPFGELLAELLKIPFVYSLRFSPGYAIEKHSGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEVLGRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSMVSNTSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTMSSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVTGFLLACVATVIFIITKCLFCVWKFVRTGKKGKRD

Target ORF information:

RefSeq Version	NM_001297616.1
Organism	Homo sapiens(human)
Definition	Homo sapiens UDP glucuronosyltransferase family 2 member B4 (UGT2B4), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001297616.1

ORF Insert Sequence:

ATGTTTTTTG CTCTCTTACA TGTCTCATCA ACGAATGGAT TAGATGCTGT TTTCCCCTTT 
GGTGAGCTGC TGGCCGAGTT ACTTAAAATA CCCTTTGTCT ACAGCCTCCG CTTCTCTCCT 
GGCTACGCAA TTGAAAAGCA TAGTGGAGGA CTTCTGTTCC CTCCTTCCTA TGTGCCTGTT 
GTTATGTCAG AACTAAGTGA CCAAATGACT TTCATAGAGA GGGTAAAAAA TATGATCTAT 
GTGCTTTATT TTGAATTTTG GTTCCAAATA TTTGACATGA AGAAGTGGGA TCAGTTCTAC 
AGTGAAGTTC TAGGAAGACC CACTACGTTA TCTGAGACAA TGGCAAAAGC TGACATATGG 
CTTATTCGAA ACTACTGGGA TTTTCAATTT CCTCACCCAC TCTTACCAAA TGTTGAGTTC 
GTTGGAGGAC TCCACTGCAA ACCTGCCAAA CCCCTACCGA AGGAAATGGA AGAGTTTGTC 
CAGAGCTCTG GAGAAAATGG TGTTGTGGTG TTTTCTCTGG GGTCGATGGT CAGTAACACG 
TCAGAAGAAA GGGCCAATGT AATTGCATCA GCCCTTGCCA AGATCCCACA AAAGGTTCTG 
TGGAGATTTG ATGGGAATAA ACCAGATACT TTAGGACTCA ATACTCGGCT GTACAAGTGG 
ATACCCCAGA ATGATCTTCT TGGTCACCCA AAAACCAGAG CTTTTATAAC TCATGGTGGA 
GCCAATGGCA TCTATGAGGC AATCTACCAT GGAATCCCTA TGGTGGGCGT TCCATTGTTT 
GCAGATCAAC CTGATAACAT TGCACACATG AAGGCCAAGG GAGCAGCTGT TAGTTTGGAC 
TTCCACACAA TGTCGAGTAC AGACTTACTC AATGCACTGA AGACAGTAAT TAATGATCCT 
TTATATAAAG AGAATGCTAT GAAATTATCA AGAATTCATC ATGATCAACC AGTGAAGCCC 
CTTGATCGAG CAGTCTTCTG GATTGAATTT GTCATGCGCC ATAAAGGAGC CAAGCACCTT 
CGGGTTGCAG CCCACGACCT CACCTGGTTC CAGTACCACT CTTTGGATGT GACTGGGTTC 
CTGCTGGCCT GTGTGGCAAC TGTGATATTC ATCATCACAA AATGTCTGTT TTGTGTCTGG 
AAGTTTGTTA GAACAGGAAA GAAGGGGAAA AGAGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UGT2B4 ( NM_001297615.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001284544.1 Homo sapiens UDP glucuronosyltransferase family 2 member B4 (UGT2B4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28805
Clone ID Related Accession (Same CDS sequence)	NM_001297615.1 , NM_001297615.2
Accession Version	NM_001297615.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1110bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	UDP-glucuronosyltransferase 2B4 isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX494777.1, AY529122.1, AJ005162.1 and AF064200.1. On Jul 4, 2014 this sequence version replaced XM_005265700.2. Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD013997.1, AY529122.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04284274 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTATGA AATGGACTTC AGCTCTTCTG CTGATACAGC TGAGCTGTTA CTTTAGCTCT 
GGGAGTTGTG GAAAGGTGCT GGTGTGGCCC ACAGAATTCA GCCACTGGAT GAATATAAAG 
ACAATCCTGG ATGAACTTGT CCAGAGAGGT CATGAGGTGA CTGTATTGGC ATCTTCAGCT 
TCCATTTCTT TCGATCCCAA CAGCCCATCT ACTCTTAAAT TTGAAGTTTA TCCTGTATCT 
TTAACTAAAA CTGAGTTTGA GGATATTATC AAGCAGCTGG TTAAGAGATG GGCAGAACTT 
CCAAAAGACA CATTTTGGTC ATATTTTTCA CAAGTACAAG AAATCATGTG GACATTTAAT 
GACATACTTA GAAAGTTCTG TAAGGATATA GTTTCAAATA AGAAACTTAT GAAGAAACTA 
CAGGAGTCAA GATTTGATGT TGTTCTTGCA GATGCTGTTT TCCCCTTTGG TGAGCTGCTG 
GCCGAGTTAC TTAAAATACC CTTTGTCTAC AGCCTCCGCT TCTCTCCTGG CTACGCAATT 
GAAAAGCATA GTGGAGGACT TCTGTTCCCT CCTTCCTATG TGCCTGTTGT TATGTCAGAA 
CTAAGTGACC AAATGACTTT CATAGAGAGG GTAAAAAATA TGATCTATGT GCTTTATTTT 
GAATTTTGGT TCCAAATATT TGACATGAAG AAGTGGGATC AGTTCTACAG TGAAGTTCTA 
GGAAGACCCA CTACGTTATC TGAGACAATG GCAAAAGCTG ACATATGGCT TATTCGAAAC 
TACTGGGATT TTCAATTTCC TCACCCACTC TTACCAAATG TTGAGTTCGT TGGAGGACTC 
CACTGCAAAC CTGCCAAACC CCTACCGAAG GAAATGGAAG AGTTTGTCCA GAGCTCTGGA 
GAAAATGGTG TTGTGGTGTT TTCTCTGGGG TCGATGGTCA GTAACACGTC AGAAGAAAGG 
GCCAATGTAA TTGCATCAGC CCTTGCCAAG ATCCCACAAA AGGTTCTGTG GAGATTTGAT 
GGGAATAAAC CAGATACTTT AGGACTCAAT ACTCGGCTGT ACAAGTGGAT ACCCCAGAAT 
GATCTTCTTG ATATAAAGAG AATGCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001284544.1
CDS	48..1157
Translation	MSMKWTSALLLIQLSCYFSSGSCGKVLVWPTEFSHWMNIKTILDELVQRGHEVTVLASSASISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFNDILRKFCKDIVSNKKLMKKLQESRFDVVLADAVFPFGELLAELLKIPFVYSLRFSPGYAIEKHSGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEVLGRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSMVSNTSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLDIKRML

Target ORF information:

RefSeq Version	NM_001297615.1
Organism	Homo sapiens(human)
Definition	Homo sapiens UDP glucuronosyltransferase family 2 member B4 (UGT2B4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001297615.1

ORF Insert Sequence:

ATGTCTATGA AATGGACTTC AGCTCTTCTG CTGATACAGC TGAGCTGTTA CTTTAGCTCT 
GGGAGTTGTG GAAAGGTGCT GGTGTGGCCC ACAGAATTCA GCCACTGGAT GAATATAAAG 
ACAATCCTGG ATGAACTTGT CCAGAGAGGT CATGAGGTGA CTGTATTGGC ATCTTCAGCT 
TCCATTTCTT TCGATCCCAA CAGCCCATCT ACTCTTAAAT TTGAAGTTTA TCCTGTATCT 
TTAACTAAAA CTGAGTTTGA GGATATTATC AAGCAGCTGG TTAAGAGATG GGCAGAACTT 
CCAAAAGACA CATTTTGGTC ATATTTTTCA CAAGTACAAG AAATCATGTG GACATTTAAT 
GACATACTTA GAAAGTTCTG TAAGGATATA GTTTCAAATA AGAAACTTAT GAAGAAACTA 
CAGGAGTCAA GATTTGATGT TGTTCTTGCA GATGCTGTTT TCCCCTTTGG TGAGCTGCTG 
GCCGAGTTAC TTAAAATACC CTTTGTCTAC AGCCTCCGCT TCTCTCCTGG CTACGCAATT 
GAAAAGCATA GTGGAGGACT TCTGTTCCCT CCTTCCTATG TGCCTGTTGT TATGTCAGAA 
CTAAGTGACC AAATGACTTT CATAGAGAGG GTAAAAAATA TGATCTATGT GCTTTATTTT 
GAATTTTGGT TCCAAATATT TGACATGAAG AAGTGGGATC AGTTCTACAG TGAAGTTCTA 
GGAAGACCCA CTACGTTATC TGAGACAATG GCAAAAGCTG ACATATGGCT TATTCGAAAC 
TACTGGGATT TTCAATTTCC TCACCCACTC TTACCAAATG TTGAGTTCGT TGGAGGACTC 
CACTGCAAAC CTGCCAAACC CCTACCGAAG GAAATGGAAG AGTTTGTCCA GAGCTCTGGA 
GAAAATGGTG TTGTGGTGTT TTCTCTGGGG TCGATGGTCA GTAACACGTC AGAAGAAAGG 
GCCAATGTAA TTGCATCAGC CCTTGCCAAG ATCCCACAAA AGGTTCTGTG GAGATTTGAT 
GGGAATAAAC CAGATACTTT AGGACTCAAT ACTCGGCTGT ACAAGTGGAT ACCCCAGAAT 
GATCTTCTTG ATATAAAGAG AATGCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UGT2B4 ( NM_001297615.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001284544.1 Homo sapiens UDP glucuronosyltransferase family 2 member B4 (UGT2B4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28805
Clone ID Related Accession (Same CDS sequence)	NM_001297615.1 , NM_001297615.2
Accession Version	NM_001297615.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1110bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	UDP-glucuronosyltransferase 2B4 isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX494777.1, AY529122.1, AJ005162.1 and AF064200.1. On May 31, 2019 this sequence version replaced NM_001297615.1. Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD013997.1, AY529122.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04284274 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTATGA AATGGACTTC AGCTCTTCTG CTGATACAGC TGAGCTGTTA CTTTAGCTCT 
GGGAGTTGTG GAAAGGTGCT GGTGTGGCCC ACAGAATTCA GCCACTGGAT GAATATAAAG 
ACAATCCTGG ATGAACTTGT CCAGAGAGGT CATGAGGTGA CTGTATTGGC ATCTTCAGCT 
TCCATTTCTT TCGATCCCAA CAGCCCATCT ACTCTTAAAT TTGAAGTTTA TCCTGTATCT 
TTAACTAAAA CTGAGTTTGA GGATATTATC AAGCAGCTGG TTAAGAGATG GGCAGAACTT 
CCAAAAGACA CATTTTGGTC ATATTTTTCA CAAGTACAAG AAATCATGTG GACATTTAAT 
GACATACTTA GAAAGTTCTG TAAGGATATA GTTTCAAATA AGAAACTTAT GAAGAAACTA 
CAGGAGTCAA GATTTGATGT TGTTCTTGCA GATGCTGTTT TCCCCTTTGG TGAGCTGCTG 
GCCGAGTTAC TTAAAATACC CTTTGTCTAC AGCCTCCGCT TCTCTCCTGG CTACGCAATT 
GAAAAGCATA GTGGAGGACT TCTGTTCCCT CCTTCCTATG TGCCTGTTGT TATGTCAGAA 
CTAAGTGACC AAATGACTTT CATAGAGAGG GTAAAAAATA TGATCTATGT GCTTTATTTT 
GAATTTTGGT TCCAAATATT TGACATGAAG AAGTGGGATC AGTTCTACAG TGAAGTTCTA 
GGAAGACCCA CTACGTTATC TGAGACAATG GCAAAAGCTG ACATATGGCT TATTCGAAAC 
TACTGGGATT TTCAATTTCC TCACCCACTC TTACCAAATG TTGAGTTCGT TGGAGGACTC 
CACTGCAAAC CTGCCAAACC CCTACCGAAG GAAATGGAAG AGTTTGTCCA GAGCTCTGGA 
GAAAATGGTG TTGTGGTGTT TTCTCTGGGG TCGATGGTCA GTAACACGTC AGAAGAAAGG 
GCCAATGTAA TTGCATCAGC CCTTGCCAAG ATCCCACAAA AGGTTCTGTG GAGATTTGAT 
GGGAATAAAC CAGATACTTT AGGACTCAAT ACTCGGCTGT ACAAGTGGAT ACCCCAGAAT 
GATCTTCTTG ATATAAAGAG AATGCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001284544.1
CDS	45..1154
Translation	MSMKWTSALLLIQLSCYFSSGSCGKVLVWPTEFSHWMNIKTILDELVQRGHEVTVLASSASISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFNDILRKFCKDIVSNKKLMKKLQESRFDVVLADAVFPFGELLAELLKIPFVYSLRFSPGYAIEKHSGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEVLGRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSMVSNTSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLDIKRML

Target ORF information:

RefSeq Version	NM_001297615.2
Organism	Homo sapiens(human)
Definition	Homo sapiens UDP glucuronosyltransferase family 2 member B4 (UGT2B4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001297615.2

ORF Insert Sequence:

ATGTCTATGA AATGGACTTC AGCTCTTCTG CTGATACAGC TGAGCTGTTA CTTTAGCTCT 
GGGAGTTGTG GAAAGGTGCT GGTGTGGCCC ACAGAATTCA GCCACTGGAT GAATATAAAG 
ACAATCCTGG ATGAACTTGT CCAGAGAGGT CATGAGGTGA CTGTATTGGC ATCTTCAGCT 
TCCATTTCTT TCGATCCCAA CAGCCCATCT ACTCTTAAAT TTGAAGTTTA TCCTGTATCT 
TTAACTAAAA CTGAGTTTGA GGATATTATC AAGCAGCTGG TTAAGAGATG GGCAGAACTT 
CCAAAAGACA CATTTTGGTC ATATTTTTCA CAAGTACAAG AAATCATGTG GACATTTAAT 
GACATACTTA GAAAGTTCTG TAAGGATATA GTTTCAAATA AGAAACTTAT GAAGAAACTA 
CAGGAGTCAA GATTTGATGT TGTTCTTGCA GATGCTGTTT TCCCCTTTGG TGAGCTGCTG 
GCCGAGTTAC TTAAAATACC CTTTGTCTAC AGCCTCCGCT TCTCTCCTGG CTACGCAATT 
GAAAAGCATA GTGGAGGACT TCTGTTCCCT CCTTCCTATG TGCCTGTTGT TATGTCAGAA 
CTAAGTGACC AAATGACTTT CATAGAGAGG GTAAAAAATA TGATCTATGT GCTTTATTTT 
GAATTTTGGT TCCAAATATT TGACATGAAG AAGTGGGATC AGTTCTACAG TGAAGTTCTA 
GGAAGACCCA CTACGTTATC TGAGACAATG GCAAAAGCTG ACATATGGCT TATTCGAAAC 
TACTGGGATT TTCAATTTCC TCACCCACTC TTACCAAATG TTGAGTTCGT TGGAGGACTC 
CACTGCAAAC CTGCCAAACC CCTACCGAAG GAAATGGAAG AGTTTGTCCA GAGCTCTGGA 
GAAAATGGTG TTGTGGTGTT TTCTCTGGGG TCGATGGTCA GTAACACGTC AGAAGAAAGG 
GCCAATGTAA TTGCATCAGC CCTTGCCAAG ATCCCACAAA AGGTTCTGTG GAGATTTGAT 
GGGAATAAAC CAGATACTTT AGGACTCAAT ACTCGGCTGT ACAAGTGGAT ACCCCAGAAT 
GATCTTCTTG ATATAAAGAG AATGCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UGT2B4 ( NM_021139.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_066962.2 Homo sapiens UDP glucuronosyltransferase family 2 member B4 (UGT2B4), transcript variant 1, mRNA.

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CloneID	OHu28815
Clone ID Related Accession (Same CDS sequence)	NM_021139.2 , NM_021139.3
Accession Version	NM_021139.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1587bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-06-24
Organism	Homo sapiens(human)
Product	UDP-glucuronosyltransferase 2B4 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB185148.1, BC026264.1, Y00317.1 and AF064200.1. On Jun 28, 2007 this sequence version replaced NM_021139.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF064200.1, BC026264.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTATGA AATGGACTTC AGCTCTTCTG CTGATACAGC TGAGCTGTTA CTTTAGCTCT 
GGGAGTTGTG GAAAGGTGCT GGTGTGGCCC ACAGAATTCA GCCACTGGAT GAATATAAAG 
ACAATCCTGG ATGAACTTGT CCAGAGAGGT CATGAGGTGA CTGTATTGGC ATCTTCAGCT 
TCCATTTCTT TCGATCCCAA CAGCCCATCT ACTCTTAAAT TTGAAGTTTA TCCTGTATCT 
TTAACTAAAA CTGAGTTTGA GGATATTATC AAGCAGCTGG TTAAGAGATG GGCAGAACTT 
CCAAAAGACA CATTTTGGTC ATATTTTTCA CAAGTACAAG AAATCATGTG GACATTTAAT 
GACATACTTA GAAAGTTCTG TAAGGATATA GTTTCAAATA AGAAACTTAT GAAGAAACTA 
CAGGAGTCAA GATTTGATGT TGTTCTTGCA GATGCTGTTT TCCCCTTTGG TGAGCTGCTG 
GCCGAGTTAC TTAAAATACC CTTTGTCTAC AGCCTCCGCT TCTCTCCTGG CTACGCAATT 
GAAAAGCATA GTGGAGGACT TCTGTTCCCT CCTTCCTATG TGCCTGTTGT TATGTCAGAA 
CTAAGTGACC AAATGACTTT CATAGAGAGG GTAAAAAATA TGATCTATGT GCTTTATTTT 
GAATTTTGGT TCCAAATATT TGACATGAAG AAGTGGGATC AGTTCTACAG TGAAGTTCTA 
GGAAGACCCA CTACGTTATC TGAGACAATG GCAAAAGCTG ACATATGGCT TATTCGAAAC 
TACTGGGATT TTCAATTTCC TCACCCACTC TTACCAAATG TTGAGTTCGT TGGAGGACTC 
CACTGCAAAC CTGCCAAACC CCTACCGAAG GAAATGGAAG AGTTTGTCCA GAGCTCTGGA 
GAAAATGGTG TTGTGGTGTT TTCTCTGGGG TCGATGGTCA GTAACACGTC AGAAGAAAGG 
GCCAATGTAA TTGCATCAGC CCTTGCCAAG ATCCCACAAA AGGTTCTGTG GAGATTTGAT 
GGGAATAAAC CAGATACTTT AGGACTCAAT ACTCGGCTGT ACAAGTGGAT ACCCCAGAAT 
GATCTTCTTG GTCACCCAAA AACCAGAGCT TTTATAACTC ATGGTGGAGC CAATGGCATC 
TATGAGGCAA TCTACCATGG AATCCCTATG GTGGGCGTTC CATTGTTTGC AGATCAACCT 
GATAACATTG CACACATGAA GGCCAAGGGA GCAGCTGTTA GTTTGGACTT CCACACAATG 
TCGAGTACAG ACTTACTCAA TGCACTGAAG ACAGTAATTA ATGATCCTTT ATATAAAGAG 
AATGCTATGA AATTATCAAG AATTCATCAT GATCAACCAG TGAAGCCCCT TGATCGAGCA 
GTCTTCTGGA TTGAATTTGT CATGCGCCAT AAAGGAGCCA AGCACCTTCG GGTTGCAGCC 
CACGACCTCA CCTGGTTCCA GTACCACTCT TTGGATGTGA CTGGGTTCCT GCTGGCCTGT 
GTGGCAACTG TGATATTCAT CATCACAAAA TGTCTGTTTT GTGTCTGGAA GTTTGTTAGA 
ACAGGAAAGA AGGGGAAAAG AGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066962.2
CDS	48..1634
Translation	MSMKWTSALLLIQLSCYFSSGSCGKVLVWPTEFSHWMNIKTILDELVQRGHEVTVLASSASISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFNDILRKFCKDIVSNKKLMKKLQESRFDVVLADAVFPFGELLAELLKIPFVYSLRFSPGYAIEKHSGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEVLGRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSMVSNTSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTMSSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVTGFLLACVATVIFIITKCLFCVWKFVRTGKKGKRD

Target ORF information:

RefSeq Version	NM_021139.2
Organism	Homo sapiens(human)
Definition	Homo sapiens UDP glucuronosyltransferase family 2 member B4 (UGT2B4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021139.2

ORF Insert Sequence:

ATGTCTATGA AATGGACTTC AGCTCTTCTG CTGATACAGC TGAGCTGTTA CTTTAGCTCT 
GGGAGTTGTG GAAAGGTGCT GGTGTGGCCC ACAGAATTCA GCCACTGGAT GAATATAAAG 
ACAATCCTGG ATGAACTTGT CCAGAGAGGT CATGAGGTGA CTGTATTGGC ATCTTCAGCT 
TCCATTTCTT TCGATCCCAA CAGCCCATCT ACTCTTAAAT TTGAAGTTTA TCCTGTATCT 
TTAACTAAAA CTGAGTTTGA GGATATTATC AAGCAGCTGG TTAAGAGATG GGCAGAACTT 
CCAAAAGACA CATTTTGGTC ATATTTTTCA CAAGTACAAG AAATCATGTG GACATTTAAT 
GACATACTTA GAAAGTTCTG TAAGGATATA GTTTCAAATA AGAAACTTAT GAAGAAACTA 
CAGGAGTCAA GATTTGATGT TGTTCTTGCA GATGCTGTTT TCCCCTTTGG TGAGCTGCTG 
GCCGAGTTAC TTAAAATACC CTTTGTCTAC AGCCTCCGCT TCTCTCCTGG CTACGCAATT 
GAAAAGCATA GTGGAGGACT TCTGTTCCCT CCTTCCTATG TGCCTGTTGT TATGTCAGAA 
CTAAGTGACC AAATGACTTT CATAGAGAGG GTAAAAAATA TGATCTATGT GCTTTATTTT 
GAATTTTGGT TCCAAATATT TGACATGAAG AAGTGGGATC AGTTCTACAG TGAAGTTCTA 
GGAAGACCCA CTACGTTATC TGAGACAATG GCAAAAGCTG ACATATGGCT TATTCGAAAC 
TACTGGGATT TTCAATTTCC TCACCCACTC TTACCAAATG TTGAGTTCGT TGGAGGACTC 
CACTGCAAAC CTGCCAAACC CCTACCGAAG GAAATGGAAG AGTTTGTCCA GAGCTCTGGA 
GAAAATGGTG TTGTGGTGTT TTCTCTGGGG TCGATGGTCA GTAACACGTC AGAAGAAAGG 
GCCAATGTAA TTGCATCAGC CCTTGCCAAG ATCCCACAAA AGGTTCTGTG GAGATTTGAT 
GGGAATAAAC CAGATACTTT AGGACTCAAT ACTCGGCTGT ACAAGTGGAT ACCCCAGAAT 
GATCTTCTTG GTCACCCAAA AACCAGAGCT TTTATAACTC ATGGTGGAGC CAATGGCATC 
TATGAGGCAA TCTACCATGG AATCCCTATG GTGGGCGTTC CATTGTTTGC AGATCAACCT 
GATAACATTG CACACATGAA GGCCAAGGGA GCAGCTGTTA GTTTGGACTT CCACACAATG 
TCGAGTACAG ACTTACTCAA TGCACTGAAG ACAGTAATTA ATGATCCTTT ATATAAAGAG 
AATGCTATGA AATTATCAAG AATTCATCAT GATCAACCAG TGAAGCCCCT TGATCGAGCA 
GTCTTCTGGA TTGAATTTGT CATGCGCCAT AAAGGAGCCA AGCACCTTCG GGTTGCAGCC 
CACGACCTCA CCTGGTTCCA GTACCACTCT TTGGATGTGA CTGGGTTCCT GCTGGCCTGT 
GTGGCAACTG TGATATTCAT CATCACAAAA TGTCTGTTTT GTGTCTGGAA GTTTGTTAGA 
ACAGGAAAGA AGGGGAAAAG AGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UGT2B4 ( NM_021139.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_066962.2 Homo sapiens UDP glucuronosyltransferase family 2 member B4 (UGT2B4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu28815
Clone ID Related Accession (Same CDS sequence)	NM_021139.2 , NM_021139.3
Accession Version	NM_021139.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1587bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	UDP-glucuronosyltransferase 2B4 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC026264.1, Y00317.1 and AF064200.1. On Nov 23, 2018 this sequence version replaced NM_021139.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC026264.1, SRR5189664.92344.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000305107.7/ ENSP00000305221.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTATGA AATGGACTTC AGCTCTTCTG CTGATACAGC TGAGCTGTTA CTTTAGCTCT 
GGGAGTTGTG GAAAGGTGCT GGTGTGGCCC ACAGAATTCA GCCACTGGAT GAATATAAAG 
ACAATCCTGG ATGAACTTGT CCAGAGAGGT CATGAGGTGA CTGTATTGGC ATCTTCAGCT 
TCCATTTCTT TCGATCCCAA CAGCCCATCT ACTCTTAAAT TTGAAGTTTA TCCTGTATCT 
TTAACTAAAA CTGAGTTTGA GGATATTATC AAGCAGCTGG TTAAGAGATG GGCAGAACTT 
CCAAAAGACA CATTTTGGTC ATATTTTTCA CAAGTACAAG AAATCATGTG GACATTTAAT 
GACATACTTA GAAAGTTCTG TAAGGATATA GTTTCAAATA AGAAACTTAT GAAGAAACTA 
CAGGAGTCAA GATTTGATGT TGTTCTTGCA GATGCTGTTT TCCCCTTTGG TGAGCTGCTG 
GCCGAGTTAC TTAAAATACC CTTTGTCTAC AGCCTCCGCT TCTCTCCTGG CTACGCAATT 
GAAAAGCATA GTGGAGGACT TCTGTTCCCT CCTTCCTATG TGCCTGTTGT TATGTCAGAA 
CTAAGTGACC AAATGACTTT CATAGAGAGG GTAAAAAATA TGATCTATGT GCTTTATTTT 
GAATTTTGGT TCCAAATATT TGACATGAAG AAGTGGGATC AGTTCTACAG TGAAGTTCTA 
GGAAGACCCA CTACGTTATC TGAGACAATG GCAAAAGCTG ACATATGGCT TATTCGAAAC 
TACTGGGATT TTCAATTTCC TCACCCACTC TTACCAAATG TTGAGTTCGT TGGAGGACTC 
CACTGCAAAC CTGCCAAACC CCTACCGAAG GAAATGGAAG AGTTTGTCCA GAGCTCTGGA 
GAAAATGGTG TTGTGGTGTT TTCTCTGGGG TCGATGGTCA GTAACACGTC AGAAGAAAGG 
GCCAATGTAA TTGCATCAGC CCTTGCCAAG ATCCCACAAA AGGTTCTGTG GAGATTTGAT 
GGGAATAAAC CAGATACTTT AGGACTCAAT ACTCGGCTGT ACAAGTGGAT ACCCCAGAAT 
GATCTTCTTG GTCACCCAAA AACCAGAGCT TTTATAACTC ATGGTGGAGC CAATGGCATC 
TATGAGGCAA TCTACCATGG AATCCCTATG GTGGGCGTTC CATTGTTTGC AGATCAACCT 
GATAACATTG CACACATGAA GGCCAAGGGA GCAGCTGTTA GTTTGGACTT CCACACAATG 
TCGAGTACAG ACTTACTCAA TGCACTGAAG ACAGTAATTA ATGATCCTTT ATATAAAGAG 
AATGCTATGA AATTATCAAG AATTCATCAT GATCAACCAG TGAAGCCCCT TGATCGAGCA 
GTCTTCTGGA TTGAATTTGT CATGCGCCAT AAAGGAGCCA AGCACCTTCG GGTTGCAGCC 
CACGACCTCA CCTGGTTCCA GTACCACTCT TTGGATGTGA CTGGGTTCCT GCTGGCCTGT 
GTGGCAACTG TGATATTCAT CATCACAAAA TGTCTGTTTT GTGTCTGGAA GTTTGTTAGA 
ACAGGAAAGA AGGGGAAAAG AGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066962.2
CDS	45..1631
Translation	MSMKWTSALLLIQLSCYFSSGSCGKVLVWPTEFSHWMNIKTILDELVQRGHEVTVLASSASISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFNDILRKFCKDIVSNKKLMKKLQESRFDVVLADAVFPFGELLAELLKIPFVYSLRFSPGYAIEKHSGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEVLGRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSMVSNTSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTMSSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVTGFLLACVATVIFIITKCLFCVWKFVRTGKKGKRD

Target ORF information:

RefSeq Version	NM_021139.3
Organism	Homo sapiens(human)
Definition	Homo sapiens UDP glucuronosyltransferase family 2 member B4 (UGT2B4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021139.3

ORF Insert Sequence:

ATGTCTATGA AATGGACTTC AGCTCTTCTG CTGATACAGC TGAGCTGTTA CTTTAGCTCT 
GGGAGTTGTG GAAAGGTGCT GGTGTGGCCC ACAGAATTCA GCCACTGGAT GAATATAAAG 
ACAATCCTGG ATGAACTTGT CCAGAGAGGT CATGAGGTGA CTGTATTGGC ATCTTCAGCT 
TCCATTTCTT TCGATCCCAA CAGCCCATCT ACTCTTAAAT TTGAAGTTTA TCCTGTATCT 
TTAACTAAAA CTGAGTTTGA GGATATTATC AAGCAGCTGG TTAAGAGATG GGCAGAACTT 
CCAAAAGACA CATTTTGGTC ATATTTTTCA CAAGTACAAG AAATCATGTG GACATTTAAT 
GACATACTTA GAAAGTTCTG TAAGGATATA GTTTCAAATA AGAAACTTAT GAAGAAACTA 
CAGGAGTCAA GATTTGATGT TGTTCTTGCA GATGCTGTTT TCCCCTTTGG TGAGCTGCTG 
GCCGAGTTAC TTAAAATACC CTTTGTCTAC AGCCTCCGCT TCTCTCCTGG CTACGCAATT 
GAAAAGCATA GTGGAGGACT TCTGTTCCCT CCTTCCTATG TGCCTGTTGT TATGTCAGAA 
CTAAGTGACC AAATGACTTT CATAGAGAGG GTAAAAAATA TGATCTATGT GCTTTATTTT 
GAATTTTGGT TCCAAATATT TGACATGAAG AAGTGGGATC AGTTCTACAG TGAAGTTCTA 
GGAAGACCCA CTACGTTATC TGAGACAATG GCAAAAGCTG ACATATGGCT TATTCGAAAC 
TACTGGGATT TTCAATTTCC TCACCCACTC TTACCAAATG TTGAGTTCGT TGGAGGACTC 
CACTGCAAAC CTGCCAAACC CCTACCGAAG GAAATGGAAG AGTTTGTCCA GAGCTCTGGA 
GAAAATGGTG TTGTGGTGTT TTCTCTGGGG TCGATGGTCA GTAACACGTC AGAAGAAAGG 
GCCAATGTAA TTGCATCAGC CCTTGCCAAG ATCCCACAAA AGGTTCTGTG GAGATTTGAT 
GGGAATAAAC CAGATACTTT AGGACTCAAT ACTCGGCTGT ACAAGTGGAT ACCCCAGAAT 
GATCTTCTTG GTCACCCAAA AACCAGAGCT TTTATAACTC ATGGTGGAGC CAATGGCATC 
TATGAGGCAA TCTACCATGG AATCCCTATG GTGGGCGTTC CATTGTTTGC AGATCAACCT 
GATAACATTG CACACATGAA GGCCAAGGGA GCAGCTGTTA GTTTGGACTT CCACACAATG 
TCGAGTACAG ACTTACTCAA TGCACTGAAG ACAGTAATTA ATGATCCTTT ATATAAAGAG 
AATGCTATGA AATTATCAAG AATTCATCAT GATCAACCAG TGAAGCCCCT TGATCGAGCA 
GTCTTCTGGA TTGAATTTGT CATGCGCCAT AAAGGAGCCA AGCACCTTCG GGTTGCAGCC 
CACGACCTCA CCTGGTTCCA GTACCACTCT TTGGATGTGA CTGGGTTCCT GCTGGCCTGT 
GTGGCAACTG TGATATTCAT CATCACAAAA TGTCTGTTTT GTGTCTGGAA GTTTGTTAGA 
ACAGGAAAGA AGGGGAAAAG AGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions
Drug metabolism and disposition: the biological fate of chemicals46(2)141-150(2018 Feb)
Kahma H,Filppula AM,Neuvonen M,Tarkiainen EK,Tornio A,Holmberg MT,Itkonen MK,Finel M,Neuvonen PJ,Niemi M,Backman JT

UGT2B4 previously implicated in the risk of breast cancer is associated with menarche timing in Ukrainian females.
Gene590(1)85-9(2016 Sep)
Yermachenko A,Dvornyk V

Upregulation of UGT2B4 Expression by 3'-Phosphoadenosine-5'-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation.
Drug metabolism and disposition: the biological fate of chemicals43(7)1061-70(2015 Jul)
Barrett KG,Fang H,Cukovic D,Dombkowski AA,Kocarek TA,Runge-Morris M

High enzyme activity UGT1A1 or low activity UGT1A8 and UGT2B4 genotypes increase esophageal cancer risk.
International journal of oncology40(6)1789-96(2012 Jun)
Dura P,Salomon J,Te Morsche RH,Roelofs HM,Kristinsson JO,Wobbes T,Witteman BJ,Tan AC,Drenth JP,Peters WH

Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects.
British journal of clinical pharmacology73(5)786-94(2012 May)
Gelston EA,Coller JK,Lopatko OV,James HM,Schmidt H,White JM,Somogyi AA

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UGT2B4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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