SCGB1A1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SCGB1A1
Entrez Gene ID	7356
Full Name	secretoglobin family 1A member 1
Synonyms	CC10,CC16,CCPBP,CCSP,UGB,UP-1,UP1
General protein information	Preferred Names secretoglobin family 1A member 1 Names uteroglobin blastokinin clara cell phospholipid-binding protein clara cells 10 kDa secretory protein secretoglobin, family 1A, member 1 (uteroglobin) urinary protein 1 urine protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q12.3
Summary	This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010].
Disorder MIM:	192020

mRNA and Protein(s)

mRNA	Protein	Name
NM_003357.4	NP_003348.1	uteroglobin precursor
NM_003357.5	NP_003348.1	uteroglobin precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Scgb1a1	NP_037183.1
Pan troglodytes (chimpanzee)	SCGB1A1	XP_001152343.1
Mus musculus (house mouse)	Scgb1a1	NP_035811.1
Homo sapiens (human)	SCGB1A1	NP_003348.1
	LOC718857	XP_001116505.1
Canis lupus familiaris (dog)	SCGB1A1	XP_005631683.1

Gene Ontology
Bibliography

Related articles in PubMed

Increased Expression of CC16 in Patients with Idiopathic Pulmonary Fibrosis.
Buend?a-Rold?n I, Ruiz V, Sierra P, Montes E, Ram?rez R, Vega A, Salgado A, Vargas MH, Mej?a M, Pardo A, Selman M
PloS one11(12)e0168552(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The G38A CCSP gene polymorphism may alter either the production of the protein and/or its activity in chronic obstructive pulmonary disease.
Title: CCSP G38A polymorphism environment interactions regulate CCSP levels differentially in COPD.

CC16 levels differed among idiopathic pulmonary fibrosis, pulmonary sarcoidosis and chronic pulmonary obstructive disease.
Title: Prognostic significance of surfactant protein A, surfactant protein D, Clara cell protein 16, S100 protein, trefoil factor 3, and prostatic secretory protein 94 in idiopathic pulmonary fibrosis, sarcoidosis, and chronic pulmonary obstructive disease.

There were associations between urinary CC16 and arsenic concentration in soil, water, house dust, and dust loading. In multiple analyses, only the concentration of arsenic in soil was associated with urinary CC16 levels after accounting for other factors.
Title: Association of Children's Urinary CC16 Levels with Arsenic Concentrations in Multiple Environmental Media.

Lung-specific (CC-16) and novel (RelB) biomarkers are associated with systemic cardiovascular changes over time. CC-16 can predict subsequent exacerbations in subjects with severe COPD and may be an important biomarker of pulmonary and systemic stress in COPD.
Title: Club Cell-16 and RelB as Novel Determinants of Arterial Stiffness in Exacerbating COPD Patients.

findings demonstrate that CC16 is upregulated in IPF patients suggesting that may participate in its pathogenesis.
Title: Increased Expression of CC16 in Patients with Idiopathic Pulmonary Fibrosis.

The following SCGB1A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SCGB1A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21907	NM_003357.5 Latest version!	Homo sapiens secretoglobin family 1A member 1 (SCGB1A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu21907	NM_003357.4	Homo sapiens secretoglobin family 1A member 1 (SCGB1A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SCGB1A1 ( NM_003357.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003348.1 Homo sapiens secretoglobin family 1A member 1 (SCGB1A1), mRNA.

Price & Availability↑

CloneID	OHu21907
Clone ID Related Accession (Same CDS sequence)	NM_003357.4 , NM_003357.5
Accession Version	NM_003357.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 276bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	uteroglobin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK312165.1, AP003064.2, BC004481.2 and DB196705.1. This sequence is a reference standard in the RefSeqGene project. On May 6, 2010 this sequence version replaced NM_003357.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DB196705.1, CD684434.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142363, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END##

ATGAAACTCG CTGTCACCCT CACCCTGGTC ACACTGGCTC TCTGCTGCAG CTCCGCTTCT 
GCAGAGATCT GCCCGAGCTT TCAGCGTGTC ATCGAAACCC TCCTCATGGA CACACCCTCC 
AGTTATGAGG CTGCCATGGA ACTTTTCAGC CCTGATCAAG ACATGAGGGA GGCAGGGGCT 
CAGCTGAAGA AGCTGGTGGA CACCCTCCCC CAAAAGCCCA GAGAAAGCAT CATTAAGCTC 
ATGGAAAAAA TAGCCCAAAG CTCACTGTGT AATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003348.1
CDS	62..337
Translation	MKLAVTLTLVTLALCCSSASAEICPSFQRVIETLLMDTPSSYEAAMELFSPDQDMREAGAQLKKLVDTLPQKPRESIIKLMEKIAQSSLCN

Target ORF information:

RefSeq Version	NM_003357.4
Organism	Homo sapiens(human)
Definition	Homo sapiens secretoglobin family 1A member 1 (SCGB1A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003357.4

ORF Insert Sequence:

ATGAAACTCG CTGTCACCCT CACCCTGGTC ACACTGGCTC TCTGCTGCAG CTCCGCTTCT 
GCAGAGATCT GCCCGAGCTT TCAGCGTGTC ATCGAAACCC TCCTCATGGA CACACCCTCC 
AGTTATGAGG CTGCCATGGA ACTTTTCAGC CCTGATCAAG ACATGAGGGA GGCAGGGGCT 
CAGCTGAAGA AGCTGGTGGA CACCCTCCCC CAAAAGCCCA GAGAAAGCAT CATTAAGCTC 
ATGGAAAAAA TAGCCCAAAG CTCACTGTGT AATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SCGB1A1 ( NM_003357.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_003348.1 Homo sapiens secretoglobin family 1A member 1 (SCGB1A1), mRNA.

Price & Availability↑

CloneID	OHu21907
Clone ID Related Accession (Same CDS sequence)	NM_003357.4 , NM_003357.5
Accession Version	NM_003357.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 276bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Homo sapiens(human)
Product	uteroglobin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP003064.2, AK312165.1 and BC004481.2. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_003357.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD684434.1, DB196705.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142363, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000278282.3/ ENSP00000278282.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAACTCG CTGTCACCCT CACCCTGGTC ACACTGGCTC TCTGCTGCAG CTCCGCTTCT 
GCAGAGATCT GCCCGAGCTT TCAGCGTGTC ATCGAAACCC TCCTCATGGA CACACCCTCC 
AGTTATGAGG CTGCCATGGA ACTTTTCAGC CCTGATCAAG ACATGAGGGA GGCAGGGGCT 
CAGCTGAAGA AGCTGGTGGA CACCCTCCCC CAAAAGCCCA GAGAAAGCAT CATTAAGCTC 
ATGGAAAAAA TAGCCCAAAG CTCACTGTGT AATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003348.1
CDS	64..339
Translation	MKLAVTLTLVTLALCCSSASAEICPSFQRVIETLLMDTPSSYEAAMELFSPDQDMREAGAQLKKLVDTLPQKPRESIIKLMEKIAQSSLCN

Target ORF information:

RefSeq Version	NM_003357.5
Organism	Homo sapiens(human)
Definition	Homo sapiens secretoglobin family 1A member 1 (SCGB1A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003357.5

ORF Insert Sequence:

ATGAAACTCG CTGTCACCCT CACCCTGGTC ACACTGGCTC TCTGCTGCAG CTCCGCTTCT 
GCAGAGATCT GCCCGAGCTT TCAGCGTGTC ATCGAAACCC TCCTCATGGA CACACCCTCC 
AGTTATGAGG CTGCCATGGA ACTTTTCAGC CCTGATCAAG ACATGAGGGA GGCAGGGGCT 
CAGCTGAAGA AGCTGGTGGA CACCCTCCCC CAAAAGCCCA GAGAAAGCAT CATTAAGCTC 
ATGGAAAAAA TAGCCCAAAG CTCACTGTGT AATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Increased Expression of CC16 in Patients with Idiopathic Pulmonary Fibrosis.
PloS one11(12)e0168552(2016)
Buend?a-Rold?n I,Ruiz V,Sierra P,Montes E,Ram?rez R,Vega A,Salgado A,Vargas MH,Mej?a M,Pardo A,Selman M

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SCGB1A1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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