C9 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	C9
Entrez Gene ID	735
Full Name	complement C9
Synonyms	ARMD15,C9D
General protein information	Preferred Names complement C9 Names complement component C9 complement component 9
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5p13.1
Summary	This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. [provided by RefSeq, Feb 2009].
Disorder MIM:	120940
Disorder Html:	C9 deficiency, 613825 (3); {Macular degeneration, age-related, 15, susceptibility to}, 615591 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001737.3	NP_001728.1	complement component C9 precursor
NM_001737.5	NP_001728.1	complement component C9 preproprotein
NM_001737.4	NP_001728.1	complement component C9 preproprotein

Pathways from BioSystems

Homologies

	C9	XP_001084671.1
Canis lupus familiaris (dog)	C9	XP_005619427.1
Homo sapiens (human)	C9	NP_001728.1
Rattus norvegicus (Norway rat)	C9	NP_476487.1
Pan troglodytes (chimpanzee)	C9	XP_003310788.1
Xenopus tropicalis (tropical clawed frog)	c9	XP_004910502.1
Bos taurus (cattle)	C9	NP_001030441.1
Mus musculus (house mouse)	C9	NP_038513.1

Gene Ontology
Bibliography

Related articles in PubMed

Rare Genetic Variants Associated With Development of Age-Related Macular Degeneration.
Saksens NT, Geerlings MJ, Bakker B, Schick T, Daha MR, Fauser S, Boon CJ, de Jong EK, Hoyng CB, den Hollander AI
JAMA ophthalmology134(3)287-93(2016 Mar)

Structure of the poly-C9 component of the complement membrane attack complex.
Dudkina NV, Spicer BA, Reboul CF, Conroy PJ, Lukoyanova N, Elmlund H, Law RH, Ekkel SM, Kondos SC, Goode RJ, Ramm G, Whisstock JC, Saibil HR, Dunstone MA
Nature communications710588(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Patients with advanced atrophic AMD carried these rare variants more frequently than patients with neovascular AMD (11 of 93 [11.8%] vs 40 of 835 [4.8%]; P = .04).
Title: Rare Genetic Variants Associated With Development of Age-Related Macular Degeneration.

Serum-expressed apolipoprotein B-100 protein, C9 Complement, and gelsolin can be used for differential diagnosis of Barrertts esophagus and adenocarcinoma of esophagus.
Title: Serum Glycoprotein Biomarker Discovery and Qualification Pipeline Reveals Novel Diagnostic Biomarker Candidates for Esophageal Adenocarcinoma.

Complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis.
Title: Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis.

Data indicate that complement C9 binds to the ATPase domain of mortalin.
Title: Mortalin/GRP75 binds to complement C9 and plays a role in resistance to complement-dependent cytotoxicity.

Borrelial CspA binds the human terminal complement components C7 and C9 and blocks assembly and membrane insertion of the terminal complement complex (TCC).
Title: CspA from Borrelia burgdorferi inhibits the terminal complement pathway.

The following C9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the C9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18785	NM_001737.5 Latest version!	Homo sapiens complement C9 (C9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu18785	NM_001737.3	Homo sapiens complement component 9 (C9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu18785	NM_001737.4	Homo sapiens complement C9 (C9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

C9 ( NM_001737.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001728.1 Homo sapiens complement component 9 (C9), mRNA.

Price & Availability↑

CloneID	OHu18785
Clone ID Related Accession (Same CDS sequence)	NM_001737.3 , NM_001737.5 , NM_001737.4
Accession Version	NM_001737.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1680bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	complement component C9 precursor
Comment

ATGTCAGCCT GCCGGAGCTT TGCAGTTGCA ATCTGCATTT TAGAAATAAG CATCCTCACA 
GCACAGTACA CGACCAGTTA TGACCCAGAG CTAACAGAAA GCAGTGGCTC TGCATCACAC 
ATAGACTGCA GAATGAGCCC CTGGAGTGAA TGGTCACAAT GCGATCCTTG TCTCAGACAA 
ATGTTTCGTT CAAGAAGCAT TGAGGTCTTT GGACAATTTA ATGGGAAAAG ATGCACCGAC 
GCTGTGGGAG ACAGACGACA GTGTGTGCCC ACAGAGCCCT GTGAGGATGC TGAGGATGAC 
TGCGGAAATG ACTTTCAATG CAGTACAGGC AGATGCATAA AGATGCGACT TCGGTGTAAT 
GGTGACAATG ACTGCGGAGA CTTTTCAGAT GAGGATGATT GTGAAAGTGA GCCCCGTCCC 
CCCTGCAGAG ACAGAGTGGT AGAAGAGTCT GAGCTGGCAC GAACAGCAGG CTATGGGATC 
AACATTTTAG GGATGGATCC CCTAAGCACA CCTTTTGACA ATGAGTTCTA CAATGGACTC 
TGTAACCGGG ATCGGGATGG AAACACTCTG ACATACTACC GAAGACCTTG GAACGTGGCT 
TCTTTGATCT ATGAAACCAA AGGCGAGAAA AATTTCAGAA CCGAACATTA CGAAGAACAA 
ATTGAAGCAT TTAAAAGTAT CATCCAAGAG AAGACATCAA ATTTTAATGC AGCTATATCT 
CTAAAATTTA CACCCACTGA AACAAATAAA GCTGAACAAT GTTGTGAGGA AACAGCCTCC 
TCAATTTCTT TACATGGCAA GGGTAGTTTT CGGTTTTCAT ATTCCAAAAA TGAAACTTAC 
CAACTATTTT TGTCATATTC TTCAAAGAAG GAAAAAATGT TTCTGCATGT GAAAGGAGAA 
ATTCATCTGG GAAGATTTGT AATGAGAAAT CGCGATGTTG TGCTCACAAC AACTTTTGTG 
GATGATATAA AAGCTTTGCC AACTACCTAT GAAAAGGGAG AATATTTTGC CTTTTTGGAA 
ACCTATGGAA CTCACTACAG TAGCTCTGGG TCTCTAGGAG GACTCTATGA ACTAATATAT 
GTTTTGGATA AAGCTTCCAT GAAGCGGAAA GGTGTTGAAC TAAAAGACAT AAAGAGATGC 
CTTGGGTATC ATCTGGATGT ATCTCTGGCT TTCTCTGAAA TCTCTGTTGG AGCTGAATTT 
AATAAAGATG ATTGTGTAAA GAGGGGAGAG GGTAGAGCTG TAAACATCAC CAGTGAAAAC 
CTCATAGATG ATGTTGTTTC ACTCATAAGA GGTGGAACCA GAAAATATGC ATTTGAACTG 
AAAGAAAAGC TTCTCCGAGG AACCGTGATT GATGTGACTG ACTTTGTCAA CTGGGCCTCT 
TCCATAAATG ATGCTCCTGT TCTCATTAGT CAAAAACTGT CTCCTATATA TAATCTGGTT 
CCAGTGAAAA TGAAAAATGC ACACCTAAAG AAACAAAACT TGGAAAGAGC CATTGAAGAC 
TATATCAATG AATTTAGTGT AAGAAAATGC CACACATGCC AAAATGGAGG TACAGTGATT 
CTAATGGATG GAAAGTGTTT GTGTGCCTGC CCATTCAAAT TTGAGGGAAT TGCCTGTGAA 
ATCAGTAAAC AAAAAATTTC TGAAGGATTG CCAGCCCTAG AGTTCCCCAA TGAAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_001728.1

Translation

MSACRSFAVAICILEISILTAQYTTSYDPELTESSGSASHIDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGYGINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWNVASLIYETKGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAAISLKFTPTETNKAEQCCEETASSISLHGKGSFRFSYSKNETYQLFLSYSSKKEKMFLHVKGEIHLGRFVMRNRDVVLTTTFVDDIKALPTTYEKGEYFAFLETYGTHYSSSGSLGGLYELIYVLDKASMKRKGVELKDIKRCLGYHLDVSLAFSEISVGAEFNKDDCVKRGEGRAVNITSENLIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTDFVNWASSINDAPVLISQKLSPIYNLVPVKMKNAHLKKQNLERAIEDYINEFSVRKCHTCQNGGTVILMDGKCLCACPFKFEGIACEISKQKISEGLPALEFPNEK

Target ORF information:

RefSeq Version	NM_001737.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens complement component 9 (C9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001737.3

ORF Insert Sequence:

ATGTCAGCCT GCCGGAGCTT TGCAGTTGCA ATCTGCATTT TAGAAATAAG CATCCTCACA 
GCACAGTACA CGACCAGTTA TGACCCAGAG CTAACAGAAA GCAGTGGCTC TGCATCACAC 
ATAGACTGCA GAATGAGCCC CTGGAGTGAA TGGTCACAAT GCGATCCTTG TCTCAGACAA 
ATGTTTCGTT CAAGAAGCAT TGAGGTCTTT GGACAATTTA ATGGGAAAAG ATGCACCGAC 
GCTGTGGGAG ACAGACGACA GTGTGTGCCC ACAGAGCCCT GTGAGGATGC TGAGGATGAC 
TGCGGAAATG ACTTTCAATG CAGTACAGGC AGATGCATAA AGATGCGACT TCGGTGTAAT 
GGTGACAATG ACTGCGGAGA CTTTTCAGAT GAGGATGATT GTGAAAGTGA GCCCCGTCCC 
CCCTGCAGAG ACAGAGTGGT AGAAGAGTCT GAGCTGGCAC GAACAGCAGG CTATGGGATC 
AACATTTTAG GGATGGATCC CCTAAGCACA CCTTTTGACA ATGAGTTCTA CAATGGACTC 
TGTAACCGGG ATCGGGATGG AAACACTCTG ACATACTACC GAAGACCTTG GAACGTGGCT 
TCTTTGATCT ATGAAACCAA AGGCGAGAAA AATTTCAGAA CCGAACATTA CGAAGAACAA 
ATTGAAGCAT TTAAAAGTAT CATCCAAGAG AAGACATCAA ATTTTAATGC AGCTATATCT 
CTAAAATTTA CACCCACTGA AACAAATAAA GCTGAACAAT GTTGTGAGGA AACAGCCTCC 
TCAATTTCTT TACATGGCAA GGGTAGTTTT CGGTTTTCAT ATTCCAAAAA TGAAACTTAC 
CAACTATTTT TGTCATATTC TTCAAAGAAG GAAAAAATGT TTCTGCATGT GAAAGGAGAA 
ATTCATCTGG GAAGATTTGT AATGAGAAAT CGCGATGTTG TGCTCACAAC AACTTTTGTG 
GATGATATAA AAGCTTTGCC AACTACCTAT GAAAAGGGAG AATATTTTGC CTTTTTGGAA 
ACCTATGGAA CTCACTACAG TAGCTCTGGG TCTCTAGGAG GACTCTATGA ACTAATATAT 
GTTTTGGATA AAGCTTCCAT GAAGCGGAAA GGTGTTGAAC TAAAAGACAT AAAGAGATGC 
CTTGGGTATC ATCTGGATGT ATCTCTGGCT TTCTCTGAAA TCTCTGTTGG AGCTGAATTT 
AATAAAGATG ATTGTGTAAA GAGGGGAGAG GGTAGAGCTG TAAACATCAC CAGTGAAAAC 
CTCATAGATG ATGTTGTTTC ACTCATAAGA GGTGGAACCA GAAAATATGC ATTTGAACTG 
AAAGAAAAGC TTCTCCGAGG AACCGTGATT GATGTGACTG ACTTTGTCAA CTGGGCCTCT 
TCCATAAATG ATGCTCCTGT TCTCATTAGT CAAAAACTGT CTCCTATATA TAATCTGGTT 
CCAGTGAAAA TGAAAAATGC ACACCTAAAG AAACAAAACT TGGAAAGAGC CATTGAAGAC 
TATATCAATG AATTTAGTGT AAGAAAATGC CACACATGCC AAAATGGAGG TACAGTGATT 
CTAATGGATG GAAAGTGTTT GTGTGCCTGC CCATTCAAAT TTGAGGGAAT TGCCTGTGAA 
ATCAGTAAAC AAAAAATTTC TGAAGGATTG CCAGCCCTAG AGTTCCCCAA TGAAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C9 ( NM_001737.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001728.1 Homo sapiens complement C9 (C9), mRNA.

Price & Availability↑

CloneID	OHu18785
Clone ID Related Accession (Same CDS sequence)	NM_001737.3 , NM_001737.5 , NM_001737.4
Accession Version	NM_001737.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1680bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	complement component C9 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC020721.1, CB157001.1, AW662752.1 and AC025471.6. On Nov 23, 2018 this sequence version replaced NM_001737.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189664.166764.1, K02766.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04284274 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000263408.5/ ENSP00000263408.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCAGCCT GCCGGAGCTT TGCAGTTGCA ATCTGCATTT TAGAAATAAG CATCCTCACA 
GCACAGTACA CGACCAGTTA TGACCCAGAG CTAACAGAAA GCAGTGGCTC TGCATCACAC 
ATAGACTGCA GAATGAGCCC CTGGAGTGAA TGGTCACAAT GCGATCCTTG TCTCAGACAA 
ATGTTTCGTT CAAGAAGCAT TGAGGTCTTT GGACAATTTA ATGGGAAAAG ATGCACCGAC 
GCTGTGGGAG ACAGACGACA GTGTGTGCCC ACAGAGCCCT GTGAGGATGC TGAGGATGAC 
TGCGGAAATG ACTTTCAATG CAGTACAGGC AGATGCATAA AGATGCGACT TCGGTGTAAT 
GGTGACAATG ACTGCGGAGA CTTTTCAGAT GAGGATGATT GTGAAAGTGA GCCCCGTCCC 
CCCTGCAGAG ACAGAGTGGT AGAAGAGTCT GAGCTGGCAC GAACAGCAGG CTATGGGATC 
AACATTTTAG GGATGGATCC CCTAAGCACA CCTTTTGACA ATGAGTTCTA CAATGGACTC 
TGTAACCGGG ATCGGGATGG AAACACTCTG ACATACTACC GAAGACCTTG GAACGTGGCT 
TCTTTGATCT ATGAAACCAA AGGCGAGAAA AATTTCAGAA CCGAACATTA CGAAGAACAA 
ATTGAAGCAT TTAAAAGTAT CATCCAAGAG AAGACATCAA ATTTTAATGC AGCTATATCT 
CTAAAATTTA CACCCACTGA AACAAATAAA GCTGAACAAT GTTGTGAGGA AACAGCCTCC 
TCAATTTCTT TACATGGCAA GGGTAGTTTT CGGTTTTCAT ATTCCAAAAA TGAAACTTAC 
CAACTATTTT TGTCATATTC TTCAAAGAAG GAAAAAATGT TTCTGCATGT GAAAGGAGAA 
ATTCATCTGG GAAGATTTGT AATGAGAAAT CGCGATGTTG TGCTCACAAC AACTTTTGTG 
GATGATATAA AAGCTTTGCC AACTACCTAT GAAAAGGGAG AATATTTTGC CTTTTTGGAA 
ACCTATGGAA CTCACTACAG TAGCTCTGGG TCTCTAGGAG GACTCTATGA ACTAATATAT 
GTTTTGGATA AAGCTTCCAT GAAGCGGAAA GGTGTTGAAC TAAAAGACAT AAAGAGATGC 
CTTGGGTATC ATCTGGATGT ATCTCTGGCT TTCTCTGAAA TCTCTGTTGG AGCTGAATTT 
AATAAAGATG ATTGTGTAAA GAGGGGAGAG GGTAGAGCTG TAAACATCAC CAGTGAAAAC 
CTCATAGATG ATGTTGTTTC ACTCATAAGA GGTGGAACCA GAAAATATGC ATTTGAACTG 
AAAGAAAAGC TTCTCCGAGG AACCGTGATT GATGTGACTG ACTTTGTCAA CTGGGCCTCT 
TCCATAAATG ATGCTCCTGT TCTCATTAGT CAAAAACTGT CTCCTATATA TAATCTGGTT 
CCAGTGAAAA TGAAAAATGC ACACCTAAAG AAACAAAACT TGGAAAGAGC CATTGAAGAC 
TATATCAATG AATTTAGTGT AAGAAAATGC CACACATGCC AAAATGGAGG TACAGTGATT 
CTAATGGATG GAAAGTGTTT GTGTGCCTGC CCATTCAAAT TTGAGGGAAT TGCCTGTGAA 
ATCAGTAAAC AAAAAATTTC TGAAGGATTG CCAGCCCTAG AGTTCCCCAA TGAAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001728.1
CDS	32..1711
Translation	MSACRSFAVAICILEISILTAQYTTSYDPELTESSGSASHIDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGYGINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWNVASLIYETKGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAAISLKFTPTETNKAEQCCEETASSISLHGKGSFRFSYSKNETYQLFLSYSSKKEKMFLHVKGEIHLGRFVMRNRDVVLTTTFVDDIKALPTTYEKGEYFAFLETYGTHYSSSGSLGGLYELIYVLDKASMKRKGVELKDIKRCLGYHLDVSLAFSEISVGAEFNKDDCVKRGEGRAVNITSENLIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTDFVNWASSINDAPVLISQKLSPIYNLVPVKMKNAHLKKQNLERAIEDYINEFSVRKCHTCQNGGTVILMDGKCLCACPFKFEGIACEISKQKISEGLPALEFPNEK

Target ORF information:

RefSeq Version	NM_001737.5
Organism	Homo sapiens(human)
Definition	Homo sapiens complement C9 (C9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001737.5

ORF Insert Sequence:

ATGTCAGCCT GCCGGAGCTT TGCAGTTGCA ATCTGCATTT TAGAAATAAG CATCCTCACA 
GCACAGTACA CGACCAGTTA TGACCCAGAG CTAACAGAAA GCAGTGGCTC TGCATCACAC 
ATAGACTGCA GAATGAGCCC CTGGAGTGAA TGGTCACAAT GCGATCCTTG TCTCAGACAA 
ATGTTTCGTT CAAGAAGCAT TGAGGTCTTT GGACAATTTA ATGGGAAAAG ATGCACCGAC 
GCTGTGGGAG ACAGACGACA GTGTGTGCCC ACAGAGCCCT GTGAGGATGC TGAGGATGAC 
TGCGGAAATG ACTTTCAATG CAGTACAGGC AGATGCATAA AGATGCGACT TCGGTGTAAT 
GGTGACAATG ACTGCGGAGA CTTTTCAGAT GAGGATGATT GTGAAAGTGA GCCCCGTCCC 
CCCTGCAGAG ACAGAGTGGT AGAAGAGTCT GAGCTGGCAC GAACAGCAGG CTATGGGATC 
AACATTTTAG GGATGGATCC CCTAAGCACA CCTTTTGACA ATGAGTTCTA CAATGGACTC 
TGTAACCGGG ATCGGGATGG AAACACTCTG ACATACTACC GAAGACCTTG GAACGTGGCT 
TCTTTGATCT ATGAAACCAA AGGCGAGAAA AATTTCAGAA CCGAACATTA CGAAGAACAA 
ATTGAAGCAT TTAAAAGTAT CATCCAAGAG AAGACATCAA ATTTTAATGC AGCTATATCT 
CTAAAATTTA CACCCACTGA AACAAATAAA GCTGAACAAT GTTGTGAGGA AACAGCCTCC 
TCAATTTCTT TACATGGCAA GGGTAGTTTT CGGTTTTCAT ATTCCAAAAA TGAAACTTAC 
CAACTATTTT TGTCATATTC TTCAAAGAAG GAAAAAATGT TTCTGCATGT GAAAGGAGAA 
ATTCATCTGG GAAGATTTGT AATGAGAAAT CGCGATGTTG TGCTCACAAC AACTTTTGTG 
GATGATATAA AAGCTTTGCC AACTACCTAT GAAAAGGGAG AATATTTTGC CTTTTTGGAA 
ACCTATGGAA CTCACTACAG TAGCTCTGGG TCTCTAGGAG GACTCTATGA ACTAATATAT 
GTTTTGGATA AAGCTTCCAT GAAGCGGAAA GGTGTTGAAC TAAAAGACAT AAAGAGATGC 
CTTGGGTATC ATCTGGATGT ATCTCTGGCT TTCTCTGAAA TCTCTGTTGG AGCTGAATTT 
AATAAAGATG ATTGTGTAAA GAGGGGAGAG GGTAGAGCTG TAAACATCAC CAGTGAAAAC 
CTCATAGATG ATGTTGTTTC ACTCATAAGA GGTGGAACCA GAAAATATGC ATTTGAACTG 
AAAGAAAAGC TTCTCCGAGG AACCGTGATT GATGTGACTG ACTTTGTCAA CTGGGCCTCT 
TCCATAAATG ATGCTCCTGT TCTCATTAGT CAAAAACTGT CTCCTATATA TAATCTGGTT 
CCAGTGAAAA TGAAAAATGC ACACCTAAAG AAACAAAACT TGGAAAGAGC CATTGAAGAC 
TATATCAATG AATTTAGTGT AAGAAAATGC CACACATGCC AAAATGGAGG TACAGTGATT 
CTAATGGATG GAAAGTGTTT GTGTGCCTGC CCATTCAAAT TTGAGGGAAT TGCCTGTGAA 
ATCAGTAAAC AAAAAATTTC TGAAGGATTG CCAGCCCTAG AGTTCCCCAA TGAAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C9 ( NM_001737.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001728.1 Homo sapiens complement C9 (C9), mRNA.

Price & Availability↑

CloneID	OHu18785
Clone ID Related Accession (Same CDS sequence)	NM_001737.3 , NM_001737.5 , NM_001737.4
Accession Version	NM_001737.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1680bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	complement component C9 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB184596.1, BC020721.1, CB157001.1 and AW662752.1. On Jun 28, 2016 this sequence version replaced NM_001737.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: K02766.1, AK308045.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04284274 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCAGCCT GCCGGAGCTT TGCAGTTGCA ATCTGCATTT TAGAAATAAG CATCCTCACA 
GCACAGTACA CGACCAGTTA TGACCCAGAG CTAACAGAAA GCAGTGGCTC TGCATCACAC 
ATAGACTGCA GAATGAGCCC CTGGAGTGAA TGGTCACAAT GCGATCCTTG TCTCAGACAA 
ATGTTTCGTT CAAGAAGCAT TGAGGTCTTT GGACAATTTA ATGGGAAAAG ATGCACCGAC 
GCTGTGGGAG ACAGACGACA GTGTGTGCCC ACAGAGCCCT GTGAGGATGC TGAGGATGAC 
TGCGGAAATG ACTTTCAATG CAGTACAGGC AGATGCATAA AGATGCGACT TCGGTGTAAT 
GGTGACAATG ACTGCGGAGA CTTTTCAGAT GAGGATGATT GTGAAAGTGA GCCCCGTCCC 
CCCTGCAGAG ACAGAGTGGT AGAAGAGTCT GAGCTGGCAC GAACAGCAGG CTATGGGATC 
AACATTTTAG GGATGGATCC CCTAAGCACA CCTTTTGACA ATGAGTTCTA CAATGGACTC 
TGTAACCGGG ATCGGGATGG AAACACTCTG ACATACTACC GAAGACCTTG GAACGTGGCT 
TCTTTGATCT ATGAAACCAA AGGCGAGAAA AATTTCAGAA CCGAACATTA CGAAGAACAA 
ATTGAAGCAT TTAAAAGTAT CATCCAAGAG AAGACATCAA ATTTTAATGC AGCTATATCT 
CTAAAATTTA CACCCACTGA AACAAATAAA GCTGAACAAT GTTGTGAGGA AACAGCCTCC 
TCAATTTCTT TACATGGCAA GGGTAGTTTT CGGTTTTCAT ATTCCAAAAA TGAAACTTAC 
CAACTATTTT TGTCATATTC TTCAAAGAAG GAAAAAATGT TTCTGCATGT GAAAGGAGAA 
ATTCATCTGG GAAGATTTGT AATGAGAAAT CGCGATGTTG TGCTCACAAC AACTTTTGTG 
GATGATATAA AAGCTTTGCC AACTACCTAT GAAAAGGGAG AATATTTTGC CTTTTTGGAA 
ACCTATGGAA CTCACTACAG TAGCTCTGGG TCTCTAGGAG GACTCTATGA ACTAATATAT 
GTTTTGGATA AAGCTTCCAT GAAGCGGAAA GGTGTTGAAC TAAAAGACAT AAAGAGATGC 
CTTGGGTATC ATCTGGATGT ATCTCTGGCT TTCTCTGAAA TCTCTGTTGG AGCTGAATTT 
AATAAAGATG ATTGTGTAAA GAGGGGAGAG GGTAGAGCTG TAAACATCAC CAGTGAAAAC 
CTCATAGATG ATGTTGTTTC ACTCATAAGA GGTGGAACCA GAAAATATGC ATTTGAACTG 
AAAGAAAAGC TTCTCCGAGG AACCGTGATT GATGTGACTG ACTTTGTCAA CTGGGCCTCT 
TCCATAAATG ATGCTCCTGT TCTCATTAGT CAAAAACTGT CTCCTATATA TAATCTGGTT 
CCAGTGAAAA TGAAAAATGC ACACCTAAAG AAACAAAACT TGGAAAGAGC CATTGAAGAC 
TATATCAATG AATTTAGTGT AAGAAAATGC CACACATGCC AAAATGGAGG TACAGTGATT 
CTAATGGATG GAAAGTGTTT GTGTGCCTGC CCATTCAAAT TTGAGGGAAT TGCCTGTGAA 
ATCAGTAAAC AAAAAATTTC TGAAGGATTG CCAGCCCTAG AGTTCCCCAA TGAAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001728.1
CDS	97..1776
Translation	MSACRSFAVAICILEISILTAQYTTSYDPELTESSGSASHIDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGYGINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWNVASLIYETKGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAAISLKFTPTETNKAEQCCEETASSISLHGKGSFRFSYSKNETYQLFLSYSSKKEKMFLHVKGEIHLGRFVMRNRDVVLTTTFVDDIKALPTTYEKGEYFAFLETYGTHYSSSGSLGGLYELIYVLDKASMKRKGVELKDIKRCLGYHLDVSLAFSEISVGAEFNKDDCVKRGEGRAVNITSENLIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTDFVNWASSINDAPVLISQKLSPIYNLVPVKMKNAHLKKQNLERAIEDYINEFSVRKCHTCQNGGTVILMDGKCLCACPFKFEGIACEISKQKISEGLPALEFPNEK

Target ORF information:

RefSeq Version	NM_001737.4
Organism	Homo sapiens(human)
Definition	Homo sapiens complement C9 (C9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001737.4

ORF Insert Sequence:

ATGTCAGCCT GCCGGAGCTT TGCAGTTGCA ATCTGCATTT TAGAAATAAG CATCCTCACA 
GCACAGTACA CGACCAGTTA TGACCCAGAG CTAACAGAAA GCAGTGGCTC TGCATCACAC 
ATAGACTGCA GAATGAGCCC CTGGAGTGAA TGGTCACAAT GCGATCCTTG TCTCAGACAA 
ATGTTTCGTT CAAGAAGCAT TGAGGTCTTT GGACAATTTA ATGGGAAAAG ATGCACCGAC 
GCTGTGGGAG ACAGACGACA GTGTGTGCCC ACAGAGCCCT GTGAGGATGC TGAGGATGAC 
TGCGGAAATG ACTTTCAATG CAGTACAGGC AGATGCATAA AGATGCGACT TCGGTGTAAT 
GGTGACAATG ACTGCGGAGA CTTTTCAGAT GAGGATGATT GTGAAAGTGA GCCCCGTCCC 
CCCTGCAGAG ACAGAGTGGT AGAAGAGTCT GAGCTGGCAC GAACAGCAGG CTATGGGATC 
AACATTTTAG GGATGGATCC CCTAAGCACA CCTTTTGACA ATGAGTTCTA CAATGGACTC 
TGTAACCGGG ATCGGGATGG AAACACTCTG ACATACTACC GAAGACCTTG GAACGTGGCT 
TCTTTGATCT ATGAAACCAA AGGCGAGAAA AATTTCAGAA CCGAACATTA CGAAGAACAA 
ATTGAAGCAT TTAAAAGTAT CATCCAAGAG AAGACATCAA ATTTTAATGC AGCTATATCT 
CTAAAATTTA CACCCACTGA AACAAATAAA GCTGAACAAT GTTGTGAGGA AACAGCCTCC 
TCAATTTCTT TACATGGCAA GGGTAGTTTT CGGTTTTCAT ATTCCAAAAA TGAAACTTAC 
CAACTATTTT TGTCATATTC TTCAAAGAAG GAAAAAATGT TTCTGCATGT GAAAGGAGAA 
ATTCATCTGG GAAGATTTGT AATGAGAAAT CGCGATGTTG TGCTCACAAC AACTTTTGTG 
GATGATATAA AAGCTTTGCC AACTACCTAT GAAAAGGGAG AATATTTTGC CTTTTTGGAA 
ACCTATGGAA CTCACTACAG TAGCTCTGGG TCTCTAGGAG GACTCTATGA ACTAATATAT 
GTTTTGGATA AAGCTTCCAT GAAGCGGAAA GGTGTTGAAC TAAAAGACAT AAAGAGATGC 
CTTGGGTATC ATCTGGATGT ATCTCTGGCT TTCTCTGAAA TCTCTGTTGG AGCTGAATTT 
AATAAAGATG ATTGTGTAAA GAGGGGAGAG GGTAGAGCTG TAAACATCAC CAGTGAAAAC 
CTCATAGATG ATGTTGTTTC ACTCATAAGA GGTGGAACCA GAAAATATGC ATTTGAACTG 
AAAGAAAAGC TTCTCCGAGG AACCGTGATT GATGTGACTG ACTTTGTCAA CTGGGCCTCT 
TCCATAAATG ATGCTCCTGT TCTCATTAGT CAAAAACTGT CTCCTATATA TAATCTGGTT 
CCAGTGAAAA TGAAAAATGC ACACCTAAAG AAACAAAACT TGGAAAGAGC CATTGAAGAC 
TATATCAATG AATTTAGTGT AAGAAAATGC CACACATGCC AAAATGGAGG TACAGTGATT 
CTAATGGATG GAAAGTGTTT GTGTGCCTGC CCATTCAAAT TTGAGGGAAT TGCCTGTGAA 
ATCAGTAAAC AAAAAATTTC TGAAGGATTG CCAGCCCTAG AGTTCCCCAA TGAAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rare Genetic Variants Associated With Development of Age-Related Macular Degeneration.
JAMA ophthalmology134(3)287-93(2016 Mar)
Saksens NT,Geerlings MJ,Bakker B,Schick T,Daha MR,Fauser S,Boon CJ,de Jong EK,Hoyng CB,den Hollander AI

Structure of the poly-C9 component of the complement membrane attack complex.
Nature communications710588(2016 Feb)
Dudkina NV,Spicer BA,Reboul CF,Conroy PJ,Lukoyanova N,Elmlund H,Law RH,Ekkel SM,Kondos SC,Goode RJ,Ramm G,Whisstock JC,Saibil HR,Dunstone MA

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C9 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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