UCN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UCN
Entrez Gene ID	7349
Full Name	urocortin
Synonyms	UI,UROC
General protein information	Preferred Names urocortin Names urocortin prepro-urocortin urocortin, preproprotein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p23.3
Summary	This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family. The encoded preproprotein is proteolytically processed to generate the mature peptide, an endogenous ligand for both corticotropin-releasing factor receptor 1 and corticotropin-releasing factor receptor 2. In the brain this peptide may be responsible for the effects of stress on appetite. This peptide may also play a role in mood disorders, neurodegeneration, and skeletal system disorders. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin-2. [provided by RefSeq, Feb 2016].
Disorder MIM:	600945

mRNA and Protein(s)

mRNA	Protein	Name
NM_003353.2	NP_003344.1	urocortin preproprotein
NM_003353.4	NP_003344.1	urocortin preproprotein
NM_003353.3	NP_003344.1	urocortin preproprotein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	UCN	NP_001027472.1
Mus musculus (house mouse)	Ucn	NP_067265.1
Pan troglodytes (chimpanzee)	UCN	XP_001156027.1
Rattus norvegicus (Norway rat)	Ucn	NP_062023.1
Canis lupus familiaris (dog)	UCN	XP_853760.1
Homo sapiens (human)	UCN	NP_003344.1
	UCN	XP_001092536.1

Gene Ontology
Bibliography

Related articles in PubMed

Plasma urocortin-1 as a preoperative marker of endometriosis in symptomatic women.
Maia LM, Rocha AL, Del Puerto HL, Petraglia F, Reis FM
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology1-4(2017 Sep)

Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1.
Lawrence KM, Jones RC, Jackson TR, Baylie RL, Abbott B, Bruhn-Olszewska B, Board TN, Locke IC, Richardson SM, Townsend PA
Scientific reports7(1)5147(2017 Jul)

Cardioprotective Utility of Urocortin in Myocardial Ischemia-Reperfusion Injury: Where do we stand?
Basman C, Agrawal P, Knight R, Saravolatz L, McRee C, Chen-Scarabelli C, Narula J, Scarabelli T
Current molecular pharmacology(2017 Feb)

Urocortin and corticotrophin-releasing hormone receptor type 2 mRNA are highly expressed in deep infiltrating endometriotic lesions.
Carrarelli P, Luddi A, Funghi L, Arcuri F, Batteux F, Dela Cruz C, Tosti C, Reis FM, Chapron C, Petraglia F
Reproductive biomedicine online33(4)476-483(2016 Oct)

Urocortin--from Parkinson's disease to the skeleton.
Lawrence KM, Jackson TR, Jamieson D, Stevens A, Owens G, Sayan BS, Locke IC, Townsend PA
The international journal of biochemistry & cell biology60130-8(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In deep infiltrating endometriotic lesions, CRH, Ucn and CRH-R2 mRNA levels were significantly higher than in ovarian endometrioma.
Title: Urocortin and corticotrophin-releasing hormone receptor type 2 mRNA are highly expressed in deep infiltrating endometriotic lesions.

Study found reduced miR-326 levels concomitant with elevated Ucn1 levels in Edinger-Westphal nucleus (EWcp) of depressed suicide completers and in the EWcp of depressed rats. In fully recovered rats, both serum and EWcp miR-326 levels rebounded to nonstressed levels. While downregulation of miR-326 levels in primary midbrain neurons enhanced Ucn1 expression levels, miR-326 overexpression selectively reduced its levels.
Title: MicroRNA-326 acts as a molecular switch in the regulation of midbrain urocortin 1 expression.

Findings identify Ucn as a potential mediator that inhibits TGFbeta1 oncogenic signaling in breast neoplasm.
Title: Urocortin attenuates TGF?1-induced Snail1 and slug expressions: inhibitory role of Smad7 in Smad2/3 signaling in breast cancer cells.

In women with adnexal endometrioma versus teratoma, the medians were 105.31 pg/mL versus 120.84 pg/mL for urocortin, 7.16 pg/mL versus 9.13 pg/mL for leptin and 584.33 pg/mL versus 657.82 pg/mL for ghrelin (p > 0.05), respectively.
Title: Novel markers in the diagnostics of endometriomas: Urocortin, ghrelin, and leptin or leukocytes, fibrinogen, and CA-125?

Ucn1 prevents the development of atherosclerosis by suppressing EC inflammatory response and proliferation, macrophage foam cell formation, and VSMC migration and proliferation
Title: Vasoprotective effects of urocortin 1 against atherosclerosis in vitro and in vivo.

The following UCN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UCN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25320	NM_003353.4 Latest version!	Homo sapiens urocortin (UCN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu25320	NM_003353.2	Homo sapiens urocortin (UCN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu25320	NM_003353.3	Homo sapiens urocortin (UCN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UCN ( NM_003353.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003344.1 Homo sapiens urocortin (UCN), mRNA.

Price & Availability↑

CloneID	OHu25320
Clone ID Related Accession (Same CDS sequence)	NM_003353.2 , NM_003353.4 , NM_003353.3
Accession Version	NM_003353.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	urocortin preproprotein
Comment

ATGAGGCAGG CGGGACGCGC AGCGCTGCTG GCCGCGCTGC TGCTCCTGGT ACAGCTGTGC 
CCTGGGAGCA GCCAGAGGAG CCCCGAGGCG GCCGGGGTCC AGGACCCGAG TCTGCGCTGG 
AGCCCCGGGG CACGGAACCA GGGTGGCGGG GCCCGCGCGC TCCTCTTGCT GCTGGCGGAG 
CGCTTCCCGC GCCGCGCGGG GCCCGGCCGA TTGGGACTCG GGACGGCAGG CGAGCGGCCG 
CGGCGGGACA ACCCTTCTCT GTCCATTGAC CTCACCTTTC ACCTGCTGCG GACCCTGCTG 
GAGCTGGCGC GGACGCAGAG CCAGCGGGAG CGCGCCGAGC AGAACCGCAT CATATTCGAC 
TCGGTGGGCA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003344.1
Translation	MRQAGRAALLAALLLLVQLCPGSSQRSPEAAGVQDPSLRWSPGARNQGGGARALLLLLAERFPRRAGPGRLGLGTAGERPRRDNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSVGK

Target ORF information:

RefSeq Version	NM_003353.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens urocortin (UCN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003353.2

ORF Insert Sequence:

ATGAGGCAGG CGGGACGCGC AGCGCTGCTG GCCGCGCTGC TGCTCCTGGT ACAGCTGTGC 
CCTGGGAGCA GCCAGAGGAG CCCCGAGGCG GCCGGGGTCC AGGACCCGAG TCTGCGCTGG 
AGCCCCGGGG CACGGAACCA GGGTGGCGGG GCCCGCGCGC TCCTCTTGCT GCTGGCGGAG 
CGCTTCCCGC GCCGCGCGGG GCCCGGCCGA TTGGGACTCG GGACGGCAGG CGAGCGGCCG 
CGGCGGGACA ACCCTTCTCT GTCCATTGAC CTCACCTTTC ACCTGCTGCG GACCCTGCTG 
GAGCTGGCGC GGACGCAGAG CCAGCGGGAG CGCGCCGAGC AGAACCGCAT CATATTCGAC 
TCGGTGGGCA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UCN ( NM_003353.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003344.1 Homo sapiens urocortin (UCN), mRNA.

Price & Availability↑

CloneID	OHu25320
Clone ID Related Accession (Same CDS sequence)	NM_003353.2 , NM_003353.4 , NM_003353.3
Accession Version	NM_003353.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	urocortin preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI857458.1, BC104470.1 and BU619919.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_003353.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CA430333.1, BU619919.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000296099.2/ ENSP00000296099.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGGCAGG CGGGACGCGC AGCGCTGCTG GCCGCGCTGC TGCTCCTGGT ACAGCTGTGC 
CCTGGGAGCA GCCAGAGGAG CCCCGAGGCG GCCGGGGTCC AGGACCCGAG TCTGCGCTGG 
AGCCCCGGGG CACGGAACCA GGGTGGCGGG GCCCGCGCGC TCCTCTTGCT GCTGGCGGAG 
CGCTTCCCGC GCCGCGCGGG GCCCGGCCGA TTGGGACTCG GGACGGCAGG CGAGCGGCCG 
CGGCGGGACA ACCCTTCTCT GTCCATTGAC CTCACCTTTC ACCTGCTGCG GACCCTGCTG 
GAGCTGGCGC GGACGCAGAG CCAGCGGGAG CGCGCCGAGC AGAACCGCAT CATATTCGAC 
TCGGTGGGCA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003344.1
CDS	300..674
Translation	MRQAGRAALLAALLLLVQLCPGSSQRSPEAAGVQDPSLRWSPGARNQGGGARALLLLLAERFPRRAGPGRLGLGTAGERPRRDNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSVGK

Target ORF information:

RefSeq Version	NM_003353.4
Organism	Homo sapiens(human)
Definition	Homo sapiens urocortin (UCN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003353.4

ORF Insert Sequence:

ATGAGGCAGG CGGGACGCGC AGCGCTGCTG GCCGCGCTGC TGCTCCTGGT ACAGCTGTGC 
CCTGGGAGCA GCCAGAGGAG CCCCGAGGCG GCCGGGGTCC AGGACCCGAG TCTGCGCTGG 
AGCCCCGGGG CACGGAACCA GGGTGGCGGG GCCCGCGCGC TCCTCTTGCT GCTGGCGGAG 
CGCTTCCCGC GCCGCGCGGG GCCCGGCCGA TTGGGACTCG GGACGGCAGG CGAGCGGCCG 
CGGCGGGACA ACCCTTCTCT GTCCATTGAC CTCACCTTTC ACCTGCTGCG GACCCTGCTG 
GAGCTGGCGC GGACGCAGAG CCAGCGGGAG CGCGCCGAGC AGAACCGCAT CATATTCGAC 
TCGGTGGGCA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UCN ( NM_003353.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003344.1 Homo sapiens urocortin (UCN), mRNA.

Price & Availability↑

CloneID	OHu25320
Clone ID Related Accession (Same CDS sequence)	NM_003353.2 , NM_003353.4 , NM_003353.3
Accession Version	NM_003353.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	urocortin preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI857458.1, BC104470.1 and BU619919.1. This sequence is a reference standard in the RefSeqGene project. On Feb 18, 2016 this sequence version replaced NM_003353.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU619919.1, SRR1660809.240955.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAGGCAGG CGGGACGCGC AGCGCTGCTG GCCGCGCTGC TGCTCCTGGT ACAGCTGTGC 
CCTGGGAGCA GCCAGAGGAG CCCCGAGGCG GCCGGGGTCC AGGACCCGAG TCTGCGCTGG 
AGCCCCGGGG CACGGAACCA GGGTGGCGGG GCCCGCGCGC TCCTCTTGCT GCTGGCGGAG 
CGCTTCCCGC GCCGCGCGGG GCCCGGCCGA TTGGGACTCG GGACGGCAGG CGAGCGGCCG 
CGGCGGGACA ACCCTTCTCT GTCCATTGAC CTCACCTTTC ACCTGCTGCG GACCCTGCTG 
GAGCTGGCGC GGACGCAGAG CCAGCGGGAG CGCGCCGAGC AGAACCGCAT CATATTCGAC 
TCGGTGGGCA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003344.1
CDS	300..674
Translation	MRQAGRAALLAALLLLVQLCPGSSQRSPEAAGVQDPSLRWSPGARNQGGGARALLLLLAERFPRRAGPGRLGLGTAGERPRRDNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSVGK

Target ORF information:

RefSeq Version	NM_003353.3
Organism	Homo sapiens(human)
Definition	Homo sapiens urocortin (UCN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003353.3

ORF Insert Sequence:

ATGAGGCAGG CGGGACGCGC AGCGCTGCTG GCCGCGCTGC TGCTCCTGGT ACAGCTGTGC 
CCTGGGAGCA GCCAGAGGAG CCCCGAGGCG GCCGGGGTCC AGGACCCGAG TCTGCGCTGG 
AGCCCCGGGG CACGGAACCA GGGTGGCGGG GCCCGCGCGC TCCTCTTGCT GCTGGCGGAG 
CGCTTCCCGC GCCGCGCGGG GCCCGGCCGA TTGGGACTCG GGACGGCAGG CGAGCGGCCG 
CGGCGGGACA ACCCTTCTCT GTCCATTGAC CTCACCTTTC ACCTGCTGCG GACCCTGCTG 
GAGCTGGCGC GGACGCAGAG CCAGCGGGAG CGCGCCGAGC AGAACCGCAT CATATTCGAC 
TCGGTGGGCA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Plasma urocortin-1 as a preoperative marker of endometriosis in symptomatic women.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology1-4(2017 Sep)
Maia LM,Rocha AL,Del Puerto HL,Petraglia F,Reis FM

Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1.
Scientific reports7(1)5147(2017 Jul)
Lawrence KM,Jones RC,Jackson TR,Baylie RL,Abbott B,Bruhn-Olszewska B,Board TN,Locke IC,Richardson SM,Townsend PA

Cardioprotective Utility of Urocortin in Myocardial Ischemia-Reperfusion Injury: Where do we stand?
Current molecular pharmacology(2017 Feb)
Basman C,Agrawal P,Knight R,Saravolatz L,McRee C,Chen-Scarabelli C,Narula J,Scarabelli T

Urocortin and corticotrophin-releasing hormone receptor type 2 mRNA are highly expressed in deep infiltrating endometriotic lesions.
Reproductive biomedicine online33(4)476-483(2016 Oct)
Carrarelli P,Luddi A,Funghi L,Arcuri F,Batteux F,Dela Cruz C,Tosti C,Reis FM,Chapron C,Petraglia F

Urocortin--from Parkinson's disease to the skeleton.
The international journal of biochemistry & cell biology60130-8(2015 Mar)
Lawrence KM,Jackson TR,Jamieson D,Stevens A,Owens G,Sayan BS,Locke IC,Townsend PA

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UCN cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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