UPK1B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UPK1B
Entrez Gene ID	7348
Full Name	uroplakin 1B
Synonyms	TSPAN20,UPIB,UPK1
General protein information	Preferred Names uroplakin 1B Names uroplakin-1b UP1b tetraspan tetraspanin-20 tspan-20 uroplakin Ib
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q13.32
Summary	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	602380

mRNA and Protein(s)

mRNA	Protein	Name
NM_006952.3	NP_008883.2	uroplakin-1b
NM_006952.4	NP_008883.2	uroplakin-1b

Pathways from BioSystems

Homologies

	UPK1B	XP_001108219.1
Bos taurus (cattle)	UPK1B	NP_776907.2
Rattus norvegicus (Norway rat)	Upk1b	NP_001019424.1
Homo sapiens (human)	UPK1B	NP_008883.2
Mus musculus (house mouse)	Upk1b	NP_849255.2
Xenopus tropicalis (tropical clawed frog)	upk1b	NP_001037968.1
Gallus gallus (chicken)	UPK1B	XP_416567.3
Pan troglodytes (chimpanzee)	UPK1B	XP_526274.3
Canis lupus familiaris (dog)	UPK1B	XP_850140.2

Gene Ontology
Bibliography

Related articles in PubMed

The predictive value of urinary UPIb mRNA levels in VUR and recurrent urinary tract infections.
Bulut IK, Mir S, Berdeli A, Sozeri B
Clinical nephrology81(3)152-8(2014 Mar)

Endometrial biopsy-induced gene modulation: first evidence for the expression of bladder-transmembranal uroplakin Ib in human endometrium.
Kalma Y, Granot I, Gnainsky Y, Or Y, Czernobilsky B, Dekel N, Barash A
Fertility and sterility91(4)1042-9, 1049.e1-9(2009 Apr)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

Uroplakin Ib gene transcription in urothelial tumor cells is regulated by CpG methylation.
Cowled P, Kanter I, Leonardos L, Jackson P
Neoplasia (New York, N.Y.)7(12)1091-103(2005 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Urine UPIb levels may be useful for predicting the risk of recurrent urinary tract infections in patients diagnosed with their first UTI and may also be considered as a noninvasive screening test for vesicoureteral reflux.
Title: The predictive value of urinary UPIb mRNA levels in VUR and recurrent urinary tract infections.

The biopsy-induced increase in the expression of UPIb and other genes encoding membrane proteins supports the possible importance of the membrane structure and stability during implantation.
Title: Endometrial biopsy-induced gene modulation: first evidence for the expression of bladder-transmembranal uroplakin Ib in human endometrium.

Loss of uroplakin Ib expression by CpG methylation of Sp1/NFkappaB-binding motifs within the proximal promoter is associated with urothelial tumors
Title: Uroplakin Ib gene transcription in urothelial tumor cells is regulated by CpG methylation.

Loss of uroplakin Ib expression is associated with bladder carcinomas
Title: Methylation of a CpG island within the uroplakin Ib promoter: a possible mechanism for loss of uroplakin Ib expression in bladder carcinoma.

established the genomic organization of the UPIb gene
Title: Human uroplakin lb gene structure and promoter analysis.

The following UPK1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UPK1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15830	NM_006952.4 Latest version!	Homo sapiens uroplakin 1B (UPK1B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu15830	NM_006952.3	Homo sapiens uroplakin 1B (UPK1B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UPK1B ( NM_006952.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_008883.2 Homo sapiens uroplakin 1B (UPK1B), mRNA.

Price & Availability↑

CloneID	OHu15830
Clone ID Related Accession (Same CDS sequence)	NM_006952.3 , NM_006952.4
Accession Version	NM_006952.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	uroplakin-1b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL709739.1 and AB002155.1. On Jul 2, 2004 this sequence version replaced NM_006952.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB002155.1, SRR1803617.120844.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCAAAG ACAACTCAAC TGTTCGTTGC TTCCAGGGCC TGCTGATTTT TGGAAATGTG 
ATTATTGGTT GTTGCGGCAT TGCCCTGACT GCGGAGTGCA TCTTCTTTGT ATCTGACCAA 
CACAGCCTCT ACCCACTGCT TGAAGCCACC GACAACGATG ACATCTATGG GGCTGCCTGG 
ATCGGCATAT TTGTGGGCAT CTGCCTCTTC TGCCTGTCTG TTCTAGGCAT TGTAGGCATC 
ATGAAGTCCA GCAGGAAAAT TCTTCTGGCG TATTTCATTC TGATGTTTAT AGTATATGCC 
TTTGAAGTGG CATCTTGTAT CACAGCAGCA ACACAACAAG ACTTTTTCAC ACCCAACCTC 
TTCCTGAAGC AGATGCTAGA GAGGTACCAA AACAACAGCC CTCCAAACAA TGATGACCAG 
TGGAAAAACA ATGGAGTCAC CAAAACCTGG GACAGGCTCA TGCTCCAGGA CAATTGCTGT 
GGCGTAAATG GTCCATCAGA CTGGCAAAAA TACACATCTG CCTTCCGGAC TGAGAATAAT 
GATGCTGACT ATCCCTGGCC TCGTCAATGC TGTGTTATGA ACAATCTTAA AGAACCTCTC 
AACCTGGAGG CTTGTAAACT AGGCGTGCCT GGTTTTTATC ACAATCAGGG CTGCTATGAA 
CTGATCTCTG GTCCAATGAA CCGACACGCC TGGGGGGTTG CCTGGTTTGG ATTTGCCATT 
CTCTGCTGGA CTTTTTGGGT TCTCCTGGGT ACCATGTTCT ACTGGAGCAG AATTGAATAT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008883.2
CDS	90..872
Translation	MAKDNSTVRCFQGLLIFGNVIIGCCGIALTAECIFFVSDQHSLYPLLEATDNDDIYGAAWIGIFVGICLFCLSVLGIVGIMKSSRKILLAYFILMFIVYAFEVASCITAATQQDFFTPNLFLKQMLERYQNNSPPNNDDQWKNNGVTKTWDRLMLQDNCCGVNGPSDWQKYTSAFRTENNDADYPWPRQCCVMNNLKEPLNLEACKLGVPGFYHNQGCYELISGPMNRHAWGVAWFGFAILCWTFWVLLGTMFYWSRIEY

Target ORF information:

RefSeq Version	NM_006952.3
Organism	Homo sapiens(human)
Definition	Homo sapiens uroplakin 1B (UPK1B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006952.3

ORF Insert Sequence:

ATGGCCAAAG ACAACTCAAC TGTTCGTTGC TTCCAGGGCC TGCTGATTTT TGGAAATGTG 
ATTATTGGTT GTTGCGGCAT TGCCCTGACT GCGGAGTGCA TCTTCTTTGT ATCTGACCAA 
CACAGCCTCT ACCCACTGCT TGAAGCCACC GACAACGATG ACATCTATGG GGCTGCCTGG 
ATCGGCATAT TTGTGGGCAT CTGCCTCTTC TGCCTGTCTG TTCTAGGCAT TGTAGGCATC 
ATGAAGTCCA GCAGGAAAAT TCTTCTGGCG TATTTCATTC TGATGTTTAT AGTATATGCC 
TTTGAAGTGG CATCTTGTAT CACAGCAGCA ACACAACAAG ACTTTTTCAC ACCCAACCTC 
TTCCTGAAGC AGATGCTAGA GAGGTACCAA AACAACAGCC CTCCAAACAA TGATGACCAG 
TGGAAAAACA ATGGAGTCAC CAAAACCTGG GACAGGCTCA TGCTCCAGGA CAATTGCTGT 
GGCGTAAATG GTCCATCAGA CTGGCAAAAA TACACATCTG CCTTCCGGAC TGAGAATAAT 
GATGCTGACT ATCCCTGGCC TCGTCAATGC TGTGTTATGA ACAATCTTAA AGAACCTCTC 
AACCTGGAGG CTTGTAAACT AGGCGTGCCT GGTTTTTATC ACAATCAGGG CTGCTATGAA 
CTGATCTCTG GTCCAATGAA CCGACACGCC TGGGGGGTTG CCTGGTTTGG ATTTGCCATT 
CTCTGCTGGA CTTTTTGGGT TCTCCTGGGT ACCATGTTCT ACTGGAGCAG AATTGAATAT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UPK1B ( NM_006952.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_008883.2 Homo sapiens uroplakin 1B (UPK1B), mRNA.

Price & Availability↑

CloneID	OHu15830
Clone ID Related Accession (Same CDS sequence)	NM_006952.3 , NM_006952.4
Accession Version	NM_006952.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Homo sapiens(human)
Product	uroplakin-1b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL709739.1 and AB002155.1. On Nov 23, 2018 this sequence version replaced NM_006952.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB002155.1, SRR1803612.7527.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000264234.8/ ENSP00000264234.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCAAAG ACAACTCAAC TGTTCGTTGC TTCCAGGGCC TGCTGATTTT TGGAAATGTG 
ATTATTGGTT GTTGCGGCAT TGCCCTGACT GCGGAGTGCA TCTTCTTTGT ATCTGACCAA 
CACAGCCTCT ACCCACTGCT TGAAGCCACC GACAACGATG ACATCTATGG GGCTGCCTGG 
ATCGGCATAT TTGTGGGCAT CTGCCTCTTC TGCCTGTCTG TTCTAGGCAT TGTAGGCATC 
ATGAAGTCCA GCAGGAAAAT TCTTCTGGCG TATTTCATTC TGATGTTTAT AGTATATGCC 
TTTGAAGTGG CATCTTGTAT CACAGCAGCA ACACAACAAG ACTTTTTCAC ACCCAACCTC 
TTCCTGAAGC AGATGCTAGA GAGGTACCAA AACAACAGCC CTCCAAACAA TGATGACCAG 
TGGAAAAACA ATGGAGTCAC CAAAACCTGG GACAGGCTCA TGCTCCAGGA CAATTGCTGT 
GGCGTAAATG GTCCATCAGA CTGGCAAAAA TACACATCTG CCTTCCGGAC TGAGAATAAT 
GATGCTGACT ATCCCTGGCC TCGTCAATGC TGTGTTATGA ACAATCTTAA AGAACCTCTC 
AACCTGGAGG CTTGTAAACT AGGCGTGCCT GGTTTTTATC ACAATCAGGG CTGCTATGAA 
CTGATCTCTG GTCCAATGAA CCGACACGCC TGGGGGGTTG CCTGGTTTGG ATTTGCCATT 
CTCTGCTGGA CTTTTTGGGT TCTCCTGGGT ACCATGTTCT ACTGGAGCAG AATTGAATAT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008883.2
CDS	70..852
Translation	MAKDNSTVRCFQGLLIFGNVIIGCCGIALTAECIFFVSDQHSLYPLLEATDNDDIYGAAWIGIFVGICLFCLSVLGIVGIMKSSRKILLAYFILMFIVYAFEVASCITAATQQDFFTPNLFLKQMLERYQNNSPPNNDDQWKNNGVTKTWDRLMLQDNCCGVNGPSDWQKYTSAFRTENNDADYPWPRQCCVMNNLKEPLNLEACKLGVPGFYHNQGCYELISGPMNRHAWGVAWFGFAILCWTFWVLLGTMFYWSRIEY

Target ORF information:

RefSeq Version	NM_006952.4
Organism	Homo sapiens(human)
Definition	Homo sapiens uroplakin 1B (UPK1B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006952.4

ORF Insert Sequence:

ATGGCCAAAG ACAACTCAAC TGTTCGTTGC TTCCAGGGCC TGCTGATTTT TGGAAATGTG 
ATTATTGGTT GTTGCGGCAT TGCCCTGACT GCGGAGTGCA TCTTCTTTGT ATCTGACCAA 
CACAGCCTCT ACCCACTGCT TGAAGCCACC GACAACGATG ACATCTATGG GGCTGCCTGG 
ATCGGCATAT TTGTGGGCAT CTGCCTCTTC TGCCTGTCTG TTCTAGGCAT TGTAGGCATC 
ATGAAGTCCA GCAGGAAAAT TCTTCTGGCG TATTTCATTC TGATGTTTAT AGTATATGCC 
TTTGAAGTGG CATCTTGTAT CACAGCAGCA ACACAACAAG ACTTTTTCAC ACCCAACCTC 
TTCCTGAAGC AGATGCTAGA GAGGTACCAA AACAACAGCC CTCCAAACAA TGATGACCAG 
TGGAAAAACA ATGGAGTCAC CAAAACCTGG GACAGGCTCA TGCTCCAGGA CAATTGCTGT 
GGCGTAAATG GTCCATCAGA CTGGCAAAAA TACACATCTG CCTTCCGGAC TGAGAATAAT 
GATGCTGACT ATCCCTGGCC TCGTCAATGC TGTGTTATGA ACAATCTTAA AGAACCTCTC 
AACCTGGAGG CTTGTAAACT AGGCGTGCCT GGTTTTTATC ACAATCAGGG CTGCTATGAA 
CTGATCTCTG GTCCAATGAA CCGACACGCC TGGGGGGTTG CCTGGTTTGG ATTTGCCATT 
CTCTGCTGGA CTTTTTGGGT TCTCCTGGGT ACCATGTTCT ACTGGAGCAG AATTGAATAT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The predictive value of urinary UPIb mRNA levels in VUR and recurrent urinary tract infections.
Clinical nephrology81(3)152-8(2014 Mar)
Bulut IK,Mir S,Berdeli A,Sozeri B

Endometrial biopsy-induced gene modulation: first evidence for the expression of bladder-transmembranal uroplakin Ib in human endometrium.
Fertility and sterility91(4)1042-9, 1049.e1-9(2009 Apr)
Kalma Y,Granot I,Gnainsky Y,Or Y,Czernobilsky B,Dekel N,Barash A

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

Uroplakin Ib gene transcription in urothelial tumor cells is regulated by CpG methylation.
Neoplasia (New York, N.Y.)7(12)1091-103(2005 Dec)
Cowled P,Kanter I,Leonardos L,Jackson P

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UPK1B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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