UBE2D2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UBE2D2
Entrez Gene ID	7322
Full Name	ubiquitin conjugating enzyme E2 D2
Synonyms	E2(17)KB2,PUBC1,UBC4,UBC4/5,UBCH4,UBCH5B
General protein information	Preferred Names ubiquitin conjugating enzyme E2 D2 Names ubiquitin-conjugating enzyme E2 D2 (E3-independent) E2 ubiquitin-conjugating enzyme D2 E2 ubiquitin-conjugating enzyme D2 p53-regulated ubiquitin-conjugating enzyme 1 ubiquitin carrier protein D2 ubiquitin conjugating enzyme E2D 2 ubiquitin-conjugating enzyme E2-17 kDa 2 ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5) ubiquitin-protein ligase D2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.2
Summary	Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013].
Disorder MIM:	602962

mRNA and Protein(s)

mRNA	Protein	Name
NM_181838.1	NP_862821.1	ubiquitin-conjugating enzyme E2 D2 isoform 2
NM_003339.2	NP_003330.1	ubiquitin-conjugating enzyme E2 D2 isoform 1
NM_003339.3	NP_003330.1	ubiquitin-conjugating enzyme E2 D2 isoform 1
XM_017009820.1	XP_016865309.1	ubiquitin-conjugating enzyme E2 D2 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	UBE2D2	NP_003330.1
Pan troglodytes (chimpanzee)	UBE2D2	XP_517968.1
Rattus norvegicus (Norway rat)	Ube2d2	NP_001032369.1
Kluyveromyces lactis	KLLA0E12563g	XP_454516.1
Magnaporthe oryzae (rice blast fungus)	MGG_06562	XP_003716978.1
Neurospora crassa	NCU02289	XP_959933.2
	LOC694667	XP_002804584.1
Canis lupus familiaris (dog)	UBE2D2	XP_855983.1
Bos taurus (cattle)	UBE2D2	NP_001039961.1
Mus musculus (house mouse)	Ube2d2a	NP_064296.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000145	XP_310998.2
Caenorhabditis elegans (roundworm)	let-70	NP_502065.1
Oryza sativa (rice)	Os09g0293400	NP_001062791.1
Xenopus tropicalis (tropical clawed frog)	ube2d3	NP_001016064.1
Gallus gallus (chicken)	UBE2D2	XP_414470.4
Danio rerio (zebrafish)	zgc:77149	NP_957253.1
Saccharomyces cerevisiae (baker's yeast)	UBC4	NP_009638.1
Eremothecium gossypii	AGOS_AER173C	NP_985031.1
Schizosaccharomyces pombe (fission yeast)	ubc4	NP_595283.1
Drosophila melanogaster (fruit fly)	eff	NP_001262578.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination.
DiBello A, Datta AB, Zhang X, Wolberger C
Journal of molecular biology428(23)4639-4650(2016 Nov)

Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity.
Lee JY, Tokumoto M, Fujiwara Y, Hasegawa T, Seko Y, Shimada A, Satoh M
Scientific reports621968(2016 Feb)

Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation.
Lechtenberg BC, Rajput A, Sanishvili R, Dobaczewska MK, Ware CF, Mace PD, Riedl SJ
Nature529(7587)546-50(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results point to an important role of the affinity between RNF4 and its cognate RAD6B or UBCH5B in governing the multiplicity of substrate ubiquitination.
Title: Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination.

Knockdown of UBE2D2 caused an increase in p53 protein levels, and knockdown of p53 attenuated not only cadmium-induced apoptosis, but also cadmium-induced apoptosis-related gene expression.
Title: Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity.

mutations having marked effects on function only minimally affect the intermolecular interactions between the AO7 RING and UbcH5B, establishing a high degree of complexity in activation through the RING-E2 interface.
Title: Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B.

Data show that ubiquitin E2 enzymes UBE2D1/2/3 and E3 ligase RNF138 accumulate at DNA-damage sites and act at early resection stages by promoting CtIP protein ubiquitylation and accrual.
Title: Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.

together with UBE2L3 and UBE2N, synergistically contribute to Parkin-mediated mitophagy
Title: The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy.

The following UBE2D2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UBE2D2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24629	NM_181838.1 Latest version!	Homo sapiens ubiquitin conjugating enzyme E2 D2 (UBE2D2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu24641	NM_003339.3 Latest version!	Homo sapiens ubiquitin conjugating enzyme E2 D2 (UBE2D2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu61207	XM_017009820.1 Latest version!	Homo sapiens ubiquitin conjugating enzyme E2 D2 (UBE2D2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu24641	NM_003339.2	Homo sapiens ubiquitin conjugating enzyme E2 D2 (UBE2D2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UBE2D2 ( NM_181838.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_862821.1 Homo sapiens ubiquitin conjugating enzyme E2 D2 (UBE2D2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu24629
Clone ID Related Accession (Same CDS sequence)	NM_181838.1
Accession Version	NM_181838.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	ubiquitin-conjugating enzyme E2 D2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC033349.1, BC048426.1, BQ186099.1, AK001311.1, AK001428.1 and AF317220.1. Transcript Variant: This variant (2) contains an alternate exon in the 5' region, differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2 which is shorter at the N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.977330.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTCCATT GGCAAGCTAC AATAATGGGG CCAAATGACA GTCCCTATCA GGGTGGAGTA 
TTTTTCTTGA CAATTCATTT CCCAACAGAT TACCCCTTCA AACCACCTAA GGTTGCATTT 
ACAACAAGAA TTTATCATCC AAATATTAAC AGTAATGGCA GCATTTGTCT TGATATTCTA 
CGATCACAGT GGTCTCCAGC ACTAACTATT TCAAAAGTAC TCTTGTCCAT CTGTTCTCTG 
TTGTGTGATC CCAATCCAGA TGATCCTTTA GTGCCTGAGA TTGCTCGGAT CTACAAAACA 
GATAGAGAAA AGTACAACAG AATAGCTCGG GAATGGACTC AGAAGTATGC GATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_862821.1
CDS	878..1234
Translation	MFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAREWTQKYAM

Target ORF information:

RefSeq Version	NM_181838.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquitin conjugating enzyme E2 D2 (UBE2D2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181838.1

ORF Insert Sequence:

ATGTTCCATT GGCAAGCTAC AATAATGGGG CCAAATGACA GTCCCTATCA GGGTGGAGTA 
TTTTTCTTGA CAATTCATTT CCCAACAGAT TACCCCTTCA AACCACCTAA GGTTGCATTT 
ACAACAAGAA TTTATCATCC AAATATTAAC AGTAATGGCA GCATTTGTCT TGATATTCTA 
CGATCACAGT GGTCTCCAGC ACTAACTATT TCAAAAGTAC TCTTGTCCAT CTGTTCTCTG 
TTGTGTGATC CCAATCCAGA TGATCCTTTA GTGCCTGAGA TTGCTCGGAT CTACAAAACA 
GATAGAGAAA AGTACAACAG AATAGCTCGG GAATGGACTC AGAAGTATGC GATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UBE2D2 ( NM_003339.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003330.1 Homo sapiens ubiquitin conjugating enzyme E2 D2 (UBE2D2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24641
Clone ID Related Accession (Same CDS sequence)	NM_003339.2 , NM_003339.3
Accession Version	NM_003339.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 444bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	ubiquitin-conjugating enzyme E2 D2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC033349.1, AK001311.1, AK001428.1 and AF317220.1. On Jul 24, 2003 this sequence version replaced NM_003339.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCTGA AGAGAATCCA CAAGGAATTG AATGATCTGG CACGGGACCC TCCAGCACAG 
TGTTCAGCAG GTCCTGTTGG AGATGATATG TTCCATTGGC AAGCTACAAT AATGGGGCCA 
AATGACAGTC CCTATCAGGG TGGAGTATTT TTCTTGACAA TTCATTTCCC AACAGATTAC 
CCCTTCAAAC CACCTAAGGT TGCATTTACA ACAAGAATTT ATCATCCAAA TATTAACAGT 
AATGGCAGCA TTTGTCTTGA TATTCTACGA TCACAGTGGT CTCCAGCACT AACTATTTCA 
AAAGTACTCT TGTCCATCTG TTCTCTGTTG TGTGATCCCA ATCCAGATGA TCCTTTAGTG 
CCTGAGATTG CTCGGATCTA CAAAACAGAT AGAGAAAAGT ACAACAGAAT AGCTCGGGAA 
TGGACTCAGA AGTATGCGAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003330.1
CDS	627..1070
Translation	MALKRIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAREWTQKYAM

Target ORF information:

RefSeq Version	NM_003339.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquitin conjugating enzyme E2 D2 (UBE2D2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003339.2

ORF Insert Sequence:

ATGGCTCTGA AGAGAATCCA CAAGGAATTG AATGATCTGG CACGGGACCC TCCAGCACAG 
TGTTCAGCAG GTCCTGTTGG AGATGATATG TTCCATTGGC AAGCTACAAT AATGGGGCCA 
AATGACAGTC CCTATCAGGG TGGAGTATTT TTCTTGACAA TTCATTTCCC AACAGATTAC 
CCCTTCAAAC CACCTAAGGT TGCATTTACA ACAAGAATTT ATCATCCAAA TATTAACAGT 
AATGGCAGCA TTTGTCTTGA TATTCTACGA TCACAGTGGT CTCCAGCACT AACTATTTCA 
AAAGTACTCT TGTCCATCTG TTCTCTGTTG TGTGATCCCA ATCCAGATGA TCCTTTAGTG 
CCTGAGATTG CTCGGATCTA CAAAACAGAT AGAGAAAAGT ACAACAGAAT AGCTCGGGAA 
TGGACTCAGA AGTATGCGAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UBE2D2 ( NM_003339.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003330.1 Homo sapiens ubiquitin conjugating enzyme E2 D2 (UBE2D2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24641
Clone ID Related Accession (Same CDS sequence)	NM_003339.2 , NM_003339.3
Accession Version	NM_003339.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 444bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	ubiquitin-conjugating enzyme E2 D2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC033349.1, AK001311.1, AK001428.1 and AF317220.1. On Nov 23, 2018 this sequence version replaced NM_003339.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK001428.1, SRR3476690.977885.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000398733.8/ ENSP00000381717.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCTGA AGAGAATCCA CAAGGAATTG AATGATCTGG CACGGGACCC TCCAGCACAG 
TGTTCAGCAG GTCCTGTTGG AGATGATATG TTCCATTGGC AAGCTACAAT AATGGGGCCA 
AATGACAGTC CCTATCAGGG TGGAGTATTT TTCTTGACAA TTCATTTCCC AACAGATTAC 
CCCTTCAAAC CACCTAAGGT TGCATTTACA ACAAGAATTT ATCATCCAAA TATTAACAGT 
AATGGCAGCA TTTGTCTTGA TATTCTACGA TCACAGTGGT CTCCAGCACT AACTATTTCA 
AAAGTACTCT TGTCCATCTG TTCTCTGTTG TGTGATCCCA ATCCAGATGA TCCTTTAGTG 
CCTGAGATTG CTCGGATCTA CAAAACAGAT AGAGAAAAGT ACAACAGAAT AGCTCGGGAA 
TGGACTCAGA AGTATGCGAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003330.1
CDS	454..897
Translation	MALKRIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAREWTQKYAM

Target ORF information:

RefSeq Version	NM_003339.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquitin conjugating enzyme E2 D2 (UBE2D2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003339.3

ORF Insert Sequence:

ATGGCTCTGA AGAGAATCCA CAAGGAATTG AATGATCTGG CACGGGACCC TCCAGCACAG 
TGTTCAGCAG GTCCTGTTGG AGATGATATG TTCCATTGGC AAGCTACAAT AATGGGGCCA 
AATGACAGTC CCTATCAGGG TGGAGTATTT TTCTTGACAA TTCATTTCCC AACAGATTAC 
CCCTTCAAAC CACCTAAGGT TGCATTTACA ACAAGAATTT ATCATCCAAA TATTAACAGT 
AATGGCAGCA TTTGTCTTGA TATTCTACGA TCACAGTGGT CTCCAGCACT AACTATTTCA 
AAAGTACTCT TGTCCATCTG TTCTCTGTTG TGTGATCCCA ATCCAGATGA TCCTTTAGTG 
CCTGAGATTG CTCGGATCTA CAAAACAGAT AGAGAAAAGT ACAACAGAAT AGCTCGGGAA 
TGGACTCAGA AGTATGCGAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UBE2D2 ( XM_017009820.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016865309.1 Homo sapiens ubiquitin conjugating enzyme E2 D2 (UBE2D2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu61207
Clone ID Related Accession (Same CDS sequence)	XM_017009820.1
Accession Version	XM_017009820.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 522bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	ubiquitin-conjugating enzyme E2 D2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTCCCT GTGCCTGGCC TATAGACTTT CTGTTTCCTG CCGCTATTGG TGATTGGGCT 
GAATGGACTA GACTTCCTTT TGGAAATTTT TTATGTGCCT TTGAATTGAA TGATCTGGCA 
CGGGACCCTC CAGCACAGTG TTCAGCAGGT CCTGTTGGAG ATGATATGTT CCATTGGCAA 
GCTACAATAA TGGGGCCAAA TGACAGTCCC TATCAGGGTG GAGTATTTTT CTTGACAATT 
CATTTCCCAA CAGATTACCC CTTCAAACCA CCTAAGGTTG CATTTACAAC AAGAATTTAT 
CATCCAAATA TTAACAGTAA TGGCAGCATT TGTCTTGATA TTCTACGATC ACAGTGGTCT 
CCAGCACTAA CTATTTCAAA AGTACTCTTG TCCATCTGTT CTCTGTTGTG TGATCCCAAT 
CCAGATGATC CTTTAGTGCC TGAGATTGCT CGGATCTACA AAACAGATAG AGAAAAGTAC 
AACAGAATAG CTCGGGAATG GACTCAGAAG TATGCGATGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016865309.1
CDS	920..1441
Translation	MSPCAWPIDFLFPAAIGDWAEWTRLPFGNFLCAFELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAREWTQKYAM

Target ORF information:

RefSeq Version	XM_017009820.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquitin conjugating enzyme E2 D2 (UBE2D2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017009820.1

ORF Insert Sequence:

ATGAGTCCCT GTGCCTGGCC TATAGACTTT CTGTTTCCTG CCGCTATTGG TGATTGGGCT 
GAATGGACTA GACTTCCTTT TGGAAATTTT TTATGTGCCT TTGAATTGAA TGATCTGGCA 
CGGGACCCTC CAGCACAGTG TTCAGCAGGT CCTGTTGGAG ATGATATGTT CCATTGGCAA 
GCTACAATAA TGGGGCCAAA TGACAGTCCC TATCAGGGTG GAGTATTTTT CTTGACAATT 
CATTTCCCAA CAGATTACCC CTTCAAACCA CCTAAGGTTG CATTTACAAC AAGAATTTAT 
CATCCAAATA TTAACAGTAA TGGCAGCATT TGTCTTGATA TTCTACGATC ACAGTGGTCT 
CCAGCACTAA CTATTTCAAA AGTACTCTTG TCCATCTGTT CTCTGTTGTG TGATCCCAAT 
CCAGATGATC CTTTAGTGCC TGAGATTGCT CGGATCTACA AAACAGATAG AGAAAAGTAC 
AACAGAATAG CTCGGGAATG GACTCAGAAG TATGCGATGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination.
Journal of molecular biology428(23)4639-4650(2016 Nov)
DiBello A,Datta AB,Zhang X,Wolberger C

Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity.
Scientific reports621968(2016 Feb)
Lee JY,Tokumoto M,Fujiwara Y,Hasegawa T,Seko Y,Shimada A,Satoh M

Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation.
Nature529(7587)546-50(2016 Jan)
Lechtenberg BC,Rajput A,Sanishvili R,Dobaczewska MK,Ware CF,Mace PD,Riedl SJ

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UBE2D2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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