UBC cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UBC
Entrez Gene ID	7316
Full Name	ubiquitin C
Synonyms	HMG20
General protein information	Preferred Names ubiquitin C Names polyubiquitin-C
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q24.31
Summary	This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010].
Disorder MIM:	191340

mRNA and Protein(s)

mRNA	Protein	Name
NM_021009.6	NP_066289.3	polyubiquitin-C
NM_021009.7	NP_066289.3	polyubiquitin-C

Pathways from BioSystems

Homologies

	LOC712934	XP_002798876.1
Homo sapiens (human)	UBC	NP_066289.2
Bos taurus (cattle)	UBC	NP_001193236.1
Drosophila melanogaster (fruit fly)	Ubi-p63E	NP_001261383.1
Arabidopsis thaliana (thale cress)	UBQ8	NP_566357.1
Pan troglodytes (chimpanzee)	UBC	NP_001129078.1
Mus musculus (house mouse)	Ubc	NP_062613.3
Rattus norvegicus (Norway rat)	Ubc	NP_059010.1
Canis lupus familiaris (dog)	UBC	XP_853060.1
Xenopus tropicalis (tropical clawed frog)	ubb	XP_004911738.1

Gene Ontology
Bibliography

Related articles in PubMed

Recurrent ubiquitin B silencing in gynecological cancers establishes dependence on ubiquitin C.
Kedves AT, Gleim S, Liang X, Bonal DM, Sigoillot F, Harbinski F, Sanghavi S, Benander C, George E, Gokhale PC, Nguyen QD, Kirschmeier PT, Distel RJ, Jenkins J, Goldberg MS, Forrester WC
The Journal of clinical investigation(2017 Nov)

Slow conformational exchange and overall rocking motion in ubiquitin protein crystals.
Kurauskas V, Izmailov SA, Rogacheva ON, Hessel A, Ayala I, Woodhouse J, Shilova A, Xue Y, Yuwen T, Coquelle N, Colletier JP, Skrynnikov NR, Schanda P
Nature communications8(1)145(2017 07)

Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Kumar A, Chaugule VK, Condos TEC, Barber KR, Johnson C, Toth R, Sundaramoorthy R, Knebel A, Shaw GS, Walden H
Nature structural & molecular biology24(5)475-483(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that the packing of ubiquitin can significantly alter the thermodynamics and kinetics of local conformational exchange.
Title: Slow conformational exchange and overall rocking motion in ubiquitin protein crystals.

The authors now report the crystal structure of a human Parkin-phosphoubiquitin complex, which shows that phosphoubiquitin binding induces movement in the 'in-between RING' (IBR) domain to reveal a cryptic ubiquitin-binding site.
Title: Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.

Data show that the stereospecific complex of ubiquitin and the ubiquitin-associated domain (UBA) is minimally perturbed by the crowding agent Ficoll.
Title: Identification of primary and secondary UBA footprints on the surface of ubiquitin in cell-mimicking crowded solution.

Studies suggest that ubiquitin signals for the proteasome involved more that Lys48 (K48).
Title: Ubiquitin recognition by the proteasome.

Studies indicate complex ubiquitin architectures function as important signals including post-translational modification (PTM) of ubiquitin itself, such as acetylated ubiquitin and phospho-ubiquitin..
Title: The emerging complexity of ubiquitin architecture.

The following UBC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UBC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28056	NM_021009.7 Latest version!	Homo sapiens ubiquitin C (UBC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
View Old Accession Versions >>
OHu28056	NM_021009.6	Homo sapiens ubiquitin C (UBC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UBC ( NM_021009.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_066289.3 Homo sapiens ubiquitin C (UBC), mRNA.

Price & Availability↑

CloneID	OHu28056
Clone ID Related Accession (Same CDS sequence)	NM_021009.6 , NM_021009.7
Accession Version	NM_021009.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2058bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	polyubiquitin-C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC126309.8, DB077241.1, AK129749.1, BC093445.1 and BF793240.1. This sequence is a reference standard in the RefSeqGene project. On Mar 29, 2014 this sequence version replaced NM_021009.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC039193.1, AB009010.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGATCT TCGTGAAGAC TCTGACTGGT AAGACCATCA CCCTCGAGGT TGAGCCCAGT 
GACACCATCG AGAATGTCAA GGCAAAGATC CAAGATAAGG AAGGCATCCC TCCTGACCAG 
CAGAGGCTGA TCTTTGCTGG AAAACAGCTG GAAGATGGGC GCACCCTGTC TGACTACAAC 
ATCCAGAAAG AGTCCACCCT GCACCTGGTG CTCCGTCTCA GAGGTGGGAT GCAAATCTTC 
GTGAAGACAC TCACTGGCAA GACCATCACC CTTGAGGTCG AGCCCAGTGA CACCATCGAG 
AACGTCAAAG CAAAGATCCA GGACAAGGAA GGCATTCCTC CTGACCAGCA GAGGTTGATC 
TTTGCCGGAA AGCAGCTGGA AGATGGGCGC ACCCTGTCTG ACTACAACAT CCAGAAAGAG 
TCTACCCTGC ACCTGGTGCT CCGTCTCAGA GGTGGGATGC AGATCTTCGT GAAGACCCTG 
ACTGGTAAGA CCATCACCCT CGAGGTGGAG CCCAGTGACA CCATCGAGAA TGTCAAGGCA 
AAGATCCAAG ATAAGGAAGG CATTCCTCCT GATCAGCAGA GGTTGATCTT TGCCGGAAAA 
CAGCTGGAAG ATGGTCGTAC CCTGTCTGAC TACAACATCC AGAAAGAGTC CACCTTGCAC 
CTGGTACTCC GTCTCAGAGG TGGGATGCAA ATCTTCGTGA AGACACTCAC TGGCAAGACC 
ATCACCCTTG AGGTCGAGCC CAGTGACACT ATCGAGAACG TCAAAGCAAA GATCCAAGAC 
AAGGAAGGCA TTCCTCCTGA CCAGCAGAGG TTGATCTTTG CCGGAAAGCA GCTGGAAGAT 
GGGCGCACCC TGTCTGACTA CAACATCCAG AAAGAGTCTA CCCTGCACCT GGTGCTCCGT 
CTCAGAGGTG GGATGCAGAT CTTCGTGAAG ACCCTGACTG GTAAGACCAT CACTCTCGAA 
GTGGAGCCGA GTGACACCAT TGAGAATGTC AAGGCAAAGA TCCAAGACAA GGAAGGCATC 
CCTCCTGACC AGCAGAGGTT GATCTTTGCC GGAAAACAGC TGGAAGATGG TCGTACCCTG 
TCTGACTACA ACATCCAGAA AGAGTCCACC TTGCACCTGG TGCTCCGTCT CAGAGGTGGG 
ATGCAGATCT TCGTGAAGAC CCTGACTGGT AAGACCATCA CTCTCGAGGT GGAGCCGAGT 
GACACCATTG AGAATGTCAA GGCAAAGATC CAAGACAAGG AAGGCATCCC TCCTGACCAG 
CAGAGGTTGA TCTTTGCTGG GAAACAGCTG GAAGATGGAC GCACCCTGTC TGACTACAAC 
ATCCAGAAAG AGTCCACCCT GCACCTGGTG CTCCGTCTTA GAGGTGGGAT GCAGATCTTC 
GTGAAGACCC TGACTGGTAA GACCATCACT CTCGAAGTGG AGCCGAGTGA CACCATTGAG 
AATGTCAAGG CAAAGATCCA AGACAAGGAA GGCATCCCTC CTGACCAGCA GAGGTTGATC 
TTTGCTGGGA AACAGCTGGA AGATGGACGC ACCCTGTCTG ACTACAACAT CCAGAAAGAG 
TCCACCCTGC ACCTGGTGCT CCGTCTTAGA GGTGGGATGC AGATCTTCGT GAAGACCCTG 
ACTGGTAAGA CCATCACTCT CGAAGTGGAG CCGAGTGACA CCATTGAGAA TGTCAAGGCA 
AAGATCCAAG ACAAGGAAGG CATCCCTCCT GACCAGCAGA GGTTGATCTT TGCTGGGAAA 
CAGCTGGAAG ATGGACGCAC CCTGTCTGAC TACAACATCC AGAAAGAGTC CACCCTGCAC 
CTGGTGCTCC GTCTCAGAGG TGGGATGCAA ATCTTCGTGA AGACCCTGAC TGGTAAGACC 
ATCACCCTCG AGGTGGAGCC CAGTGACACC ATCGAGAATG TCAAGGCAAA GATCCAAGAT 
AAGGAAGGCA TCCCTCCTGA TCAGCAGAGG TTGATCTTTG CTGGGAAACA GCTGGAAGAT 
GGACGCACCC TGTCTGACTA CAACATCCAG AAAGAGTCCA CTCTGCACTT GGTCCTGCGC 
TTGAGGGGGG GTGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066289.3
CDS	459..2516
Translation	MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGV

Target ORF information:

RefSeq Version	NM_021009.6
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquitin C (UBC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021009.6

ORF Insert Sequence:

ATGCAGATCT TCGTGAAGAC TCTGACTGGT AAGACCATCA CCCTCGAGGT TGAGCCCAGT 
GACACCATCG AGAATGTCAA GGCAAAGATC CAAGATAAGG AAGGCATCCC TCCTGACCAG 
CAGAGGCTGA TCTTTGCTGG AAAACAGCTG GAAGATGGGC GCACCCTGTC TGACTACAAC 
ATCCAGAAAG AGTCCACCCT GCACCTGGTG CTCCGTCTCA GAGGTGGGAT GCAAATCTTC 
GTGAAGACAC TCACTGGCAA GACCATCACC CTTGAGGTCG AGCCCAGTGA CACCATCGAG 
AACGTCAAAG CAAAGATCCA GGACAAGGAA GGCATTCCTC CTGACCAGCA GAGGTTGATC 
TTTGCCGGAA AGCAGCTGGA AGATGGGCGC ACCCTGTCTG ACTACAACAT CCAGAAAGAG 
TCTACCCTGC ACCTGGTGCT CCGTCTCAGA GGTGGGATGC AGATCTTCGT GAAGACCCTG 
ACTGGTAAGA CCATCACCCT CGAGGTGGAG CCCAGTGACA CCATCGAGAA TGTCAAGGCA 
AAGATCCAAG ATAAGGAAGG CATTCCTCCT GATCAGCAGA GGTTGATCTT TGCCGGAAAA 
CAGCTGGAAG ATGGTCGTAC CCTGTCTGAC TACAACATCC AGAAAGAGTC CACCTTGCAC 
CTGGTACTCC GTCTCAGAGG TGGGATGCAA ATCTTCGTGA AGACACTCAC TGGCAAGACC 
ATCACCCTTG AGGTCGAGCC CAGTGACACT ATCGAGAACG TCAAAGCAAA GATCCAAGAC 
AAGGAAGGCA TTCCTCCTGA CCAGCAGAGG TTGATCTTTG CCGGAAAGCA GCTGGAAGAT 
GGGCGCACCC TGTCTGACTA CAACATCCAG AAAGAGTCTA CCCTGCACCT GGTGCTCCGT 
CTCAGAGGTG GGATGCAGAT CTTCGTGAAG ACCCTGACTG GTAAGACCAT CACTCTCGAA 
GTGGAGCCGA GTGACACCAT TGAGAATGTC AAGGCAAAGA TCCAAGACAA GGAAGGCATC 
CCTCCTGACC AGCAGAGGTT GATCTTTGCC GGAAAACAGC TGGAAGATGG TCGTACCCTG 
TCTGACTACA ACATCCAGAA AGAGTCCACC TTGCACCTGG TGCTCCGTCT CAGAGGTGGG 
ATGCAGATCT TCGTGAAGAC CCTGACTGGT AAGACCATCA CTCTCGAGGT GGAGCCGAGT 
GACACCATTG AGAATGTCAA GGCAAAGATC CAAGACAAGG AAGGCATCCC TCCTGACCAG 
CAGAGGTTGA TCTTTGCTGG GAAACAGCTG GAAGATGGAC GCACCCTGTC TGACTACAAC 
ATCCAGAAAG AGTCCACCCT GCACCTGGTG CTCCGTCTTA GAGGTGGGAT GCAGATCTTC 
GTGAAGACCC TGACTGGTAA GACCATCACT CTCGAAGTGG AGCCGAGTGA CACCATTGAG 
AATGTCAAGG CAAAGATCCA AGACAAGGAA GGCATCCCTC CTGACCAGCA GAGGTTGATC 
TTTGCTGGGA AACAGCTGGA AGATGGACGC ACCCTGTCTG ACTACAACAT CCAGAAAGAG 
TCCACCCTGC ACCTGGTGCT CCGTCTTAGA GGTGGGATGC AGATCTTCGT GAAGACCCTG 
ACTGGTAAGA CCATCACTCT CGAAGTGGAG CCGAGTGACA CCATTGAGAA TGTCAAGGCA 
AAGATCCAAG ACAAGGAAGG CATCCCTCCT GACCAGCAGA GGTTGATCTT TGCTGGGAAA 
CAGCTGGAAG ATGGACGCAC CCTGTCTGAC TACAACATCC AGAAAGAGTC CACCCTGCAC 
CTGGTGCTCC GTCTCAGAGG TGGGATGCAA ATCTTCGTGA AGACCCTGAC TGGTAAGACC 
ATCACCCTCG AGGTGGAGCC CAGTGACACC ATCGAGAATG TCAAGGCAAA GATCCAAGAT 
AAGGAAGGCA TCCCTCCTGA TCAGCAGAGG TTGATCTTTG CTGGGAAACA GCTGGAAGAT 
GGACGCACCC TGTCTGACTA CAACATCCAG AAAGAGTCCA CTCTGCACTT GGTCCTGCGC 
TTGAGGGGGG GTGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UBC ( NM_021009.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_066289.3 Homo sapiens ubiquitin C (UBC), mRNA.

Price & Availability↑

CloneID	OHu28056
Clone ID Related Accession (Same CDS sequence)	NM_021009.6 , NM_021009.7
Accession Version	NM_021009.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2058bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	polyubiquitin-C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK129749.1 and BC093445.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_021009.6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC093445.1, BC039193.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000339647.6/ ENSP00000344818.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGATCT TCGTGAAGAC TCTGACTGGT AAGACCATCA CCCTCGAGGT TGAGCCCAGT 
GACACCATCG AGAATGTCAA GGCAAAGATC CAAGATAAGG AAGGCATCCC TCCTGACCAG 
CAGAGGCTGA TCTTTGCTGG AAAACAGCTG GAAGATGGGC GCACCCTGTC TGACTACAAC 
ATCCAGAAAG AGTCCACCCT GCACCTGGTG CTCCGTCTCA GAGGTGGGAT GCAAATCTTC 
GTGAAGACAC TCACTGGCAA GACCATCACC CTTGAGGTCG AGCCCAGTGA CACCATCGAG 
AACGTCAAAG CAAAGATCCA GGACAAGGAA GGCATTCCTC CTGACCAGCA GAGGTTGATC 
TTTGCCGGAA AGCAGCTGGA AGATGGGCGC ACCCTGTCTG ACTACAACAT CCAGAAAGAG 
TCTACCCTGC ACCTGGTGCT CCGTCTCAGA GGTGGGATGC AGATCTTCGT GAAGACCCTG 
ACTGGTAAGA CCATCACCCT CGAGGTGGAG CCCAGTGACA CCATCGAGAA TGTCAAGGCA 
AAGATCCAAG ATAAGGAAGG CATTCCTCCT GATCAGCAGA GGTTGATCTT TGCCGGAAAA 
CAGCTGGAAG ATGGTCGTAC CCTGTCTGAC TACAACATCC AGAAAGAGTC CACCTTGCAC 
CTGGTACTCC GTCTCAGAGG TGGGATGCAA ATCTTCGTGA AGACACTCAC TGGCAAGACC 
ATCACCCTTG AGGTCGAGCC CAGTGACACT ATCGAGAACG TCAAAGCAAA GATCCAAGAC 
AAGGAAGGCA TTCCTCCTGA CCAGCAGAGG TTGATCTTTG CCGGAAAGCA GCTGGAAGAT 
GGGCGCACCC TGTCTGACTA CAACATCCAG AAAGAGTCTA CCCTGCACCT GGTGCTCCGT 
CTCAGAGGTG GGATGCAGAT CTTCGTGAAG ACCCTGACTG GTAAGACCAT CACTCTCGAA 
GTGGAGCCGA GTGACACCAT TGAGAATGTC AAGGCAAAGA TCCAAGACAA GGAAGGCATC 
CCTCCTGACC AGCAGAGGTT GATCTTTGCC GGAAAACAGC TGGAAGATGG TCGTACCCTG 
TCTGACTACA ACATCCAGAA AGAGTCCACC TTGCACCTGG TGCTCCGTCT CAGAGGTGGG 
ATGCAGATCT TCGTGAAGAC CCTGACTGGT AAGACCATCA CTCTCGAGGT GGAGCCGAGT 
GACACCATTG AGAATGTCAA GGCAAAGATC CAAGACAAGG AAGGCATCCC TCCTGACCAG 
CAGAGGTTGA TCTTTGCTGG GAAACAGCTG GAAGATGGAC GCACCCTGTC TGACTACAAC 
ATCCAGAAAG AGTCCACCCT GCACCTGGTG CTCCGTCTTA GAGGTGGGAT GCAGATCTTC 
GTGAAGACCC TGACTGGTAA GACCATCACT CTCGAAGTGG AGCCGAGTGA CACCATTGAG 
AATGTCAAGG CAAAGATCCA AGACAAGGAA GGCATCCCTC CTGACCAGCA GAGGTTGATC 
TTTGCTGGGA AACAGCTGGA AGATGGACGC ACCCTGTCTG ACTACAACAT CCAGAAAGAG 
TCCACCCTGC ACCTGGTGCT CCGTCTTAGA GGTGGGATGC AGATCTTCGT GAAGACCCTG 
ACTGGTAAGA CCATCACTCT CGAAGTGGAG CCGAGTGACA CCATTGAGAA TGTCAAGGCA 
AAGATCCAAG ACAAGGAAGG CATCCCTCCT GACCAGCAGA GGTTGATCTT TGCTGGGAAA 
CAGCTGGAAG ATGGACGCAC CCTGTCTGAC TACAACATCC AGAAAGAGTC CACCCTGCAC 
CTGGTGCTCC GTCTCAGAGG TGGGATGCAA ATCTTCGTGA AGACCCTGAC TGGTAAGACC 
ATCACCCTCG AGGTGGAGCC CAGTGACACC ATCGAGAATG TCAAGGCAAA GATCCAAGAT 
AAGGAAGGCA TCCCTCCTGA TCAGCAGAGG TTGATCTTTG CTGGGAAACA GCTGGAAGAT 
GGACGCACCC TGTCTGACTA CAACATCCAG AAAGAGTCCA CTCTGCACTT GGTCCTGCGC 
TTGAGGGGGG GTGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066289.3
CDS	68..2125
Translation	MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGV

Target ORF information:

RefSeq Version	NM_021009.7
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquitin C (UBC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021009.7

ORF Insert Sequence:

ATGCAGATCT TCGTGAAGAC TCTGACTGGT AAGACCATCA CCCTCGAGGT TGAGCCCAGT 
GACACCATCG AGAATGTCAA GGCAAAGATC CAAGATAAGG AAGGCATCCC TCCTGACCAG 
CAGAGGCTGA TCTTTGCTGG AAAACAGCTG GAAGATGGGC GCACCCTGTC TGACTACAAC 
ATCCAGAAAG AGTCCACCCT GCACCTGGTG CTCCGTCTCA GAGGTGGGAT GCAAATCTTC 
GTGAAGACAC TCACTGGCAA GACCATCACC CTTGAGGTCG AGCCCAGTGA CACCATCGAG 
AACGTCAAAG CAAAGATCCA GGACAAGGAA GGCATTCCTC CTGACCAGCA GAGGTTGATC 
TTTGCCGGAA AGCAGCTGGA AGATGGGCGC ACCCTGTCTG ACTACAACAT CCAGAAAGAG 
TCTACCCTGC ACCTGGTGCT CCGTCTCAGA GGTGGGATGC AGATCTTCGT GAAGACCCTG 
ACTGGTAAGA CCATCACCCT CGAGGTGGAG CCCAGTGACA CCATCGAGAA TGTCAAGGCA 
AAGATCCAAG ATAAGGAAGG CATTCCTCCT GATCAGCAGA GGTTGATCTT TGCCGGAAAA 
CAGCTGGAAG ATGGTCGTAC CCTGTCTGAC TACAACATCC AGAAAGAGTC CACCTTGCAC 
CTGGTACTCC GTCTCAGAGG TGGGATGCAA ATCTTCGTGA AGACACTCAC TGGCAAGACC 
ATCACCCTTG AGGTCGAGCC CAGTGACACT ATCGAGAACG TCAAAGCAAA GATCCAAGAC 
AAGGAAGGCA TTCCTCCTGA CCAGCAGAGG TTGATCTTTG CCGGAAAGCA GCTGGAAGAT 
GGGCGCACCC TGTCTGACTA CAACATCCAG AAAGAGTCTA CCCTGCACCT GGTGCTCCGT 
CTCAGAGGTG GGATGCAGAT CTTCGTGAAG ACCCTGACTG GTAAGACCAT CACTCTCGAA 
GTGGAGCCGA GTGACACCAT TGAGAATGTC AAGGCAAAGA TCCAAGACAA GGAAGGCATC 
CCTCCTGACC AGCAGAGGTT GATCTTTGCC GGAAAACAGC TGGAAGATGG TCGTACCCTG 
TCTGACTACA ACATCCAGAA AGAGTCCACC TTGCACCTGG TGCTCCGTCT CAGAGGTGGG 
ATGCAGATCT TCGTGAAGAC CCTGACTGGT AAGACCATCA CTCTCGAGGT GGAGCCGAGT 
GACACCATTG AGAATGTCAA GGCAAAGATC CAAGACAAGG AAGGCATCCC TCCTGACCAG 
CAGAGGTTGA TCTTTGCTGG GAAACAGCTG GAAGATGGAC GCACCCTGTC TGACTACAAC 
ATCCAGAAAG AGTCCACCCT GCACCTGGTG CTCCGTCTTA GAGGTGGGAT GCAGATCTTC 
GTGAAGACCC TGACTGGTAA GACCATCACT CTCGAAGTGG AGCCGAGTGA CACCATTGAG 
AATGTCAAGG CAAAGATCCA AGACAAGGAA GGCATCCCTC CTGACCAGCA GAGGTTGATC 
TTTGCTGGGA AACAGCTGGA AGATGGACGC ACCCTGTCTG ACTACAACAT CCAGAAAGAG 
TCCACCCTGC ACCTGGTGCT CCGTCTTAGA GGTGGGATGC AGATCTTCGT GAAGACCCTG 
ACTGGTAAGA CCATCACTCT CGAAGTGGAG CCGAGTGACA CCATTGAGAA TGTCAAGGCA 
AAGATCCAAG ACAAGGAAGG CATCCCTCCT GACCAGCAGA GGTTGATCTT TGCTGGGAAA 
CAGCTGGAAG ATGGACGCAC CCTGTCTGAC TACAACATCC AGAAAGAGTC CACCCTGCAC 
CTGGTGCTCC GTCTCAGAGG TGGGATGCAA ATCTTCGTGA AGACCCTGAC TGGTAAGACC 
ATCACCCTCG AGGTGGAGCC CAGTGACACC ATCGAGAATG TCAAGGCAAA GATCCAAGAT 
AAGGAAGGCA TCCCTCCTGA TCAGCAGAGG TTGATCTTTG CTGGGAAACA GCTGGAAGAT 
GGACGCACCC TGTCTGACTA CAACATCCAG AAAGAGTCCA CTCTGCACTT GGTCCTGCGC 
TTGAGGGGGG GTGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Recurrent ubiquitin B silencing in gynecological cancers establishes dependence on ubiquitin C.
The Journal of clinical investigation(2017 Nov)
Kedves AT,Gleim S,Liang X,Bonal DM,Sigoillot F,Harbinski F,Sanghavi S,Benander C,George E,Gokhale PC,Nguyen QD,Kirschmeier PT,Distel RJ,Jenkins J,Goldberg MS,Forrester WC

Slow conformational exchange and overall rocking motion in ubiquitin protein crystals.
Nature communications8(1)145(2017 07)
Kurauskas V,Izmailov SA,Rogacheva ON,Hessel A,Ayala I,Woodhouse J,Shilova A,Xue Y,Yuwen T,Coquelle N,Colletier JP,Skrynnikov NR,Schanda P

Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nature structural & molecular biology24(5)475-483(2017 May)
Kumar A,Chaugule VK,Condos TEC,Barber KR,Johnson C,Toth R,Sundaramoorthy R,Knebel A,Shaw GS,Walden H

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UBC cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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