TBC1D3 cDNA ORF clone, Homo sapiens(human)

Up-regulation of OLR1 expression by TBC1D3 through activation of TNF?/NF-?B pathway promotes the migration of human breast cancer cells.
Wang B, Zhao H, Zhao L, Zhang Y, Wan Q, Shen Y, Bu X, Wan M, Shen C
Cancer letters40860-70(2017 Nov)

Calmodulin promotes matrix metalloproteinase 9 production and cell migration by inhibiting the ubiquitination and degradation of TBC1D3 oncoprotein in human breast cancer cells.
Zhao H, Zhang L, Zhang Y, Zhao L, Wan Q, Wang B, Bu X, Wan M, Shen C
Oncotarget8(22)36383-36398(2017 May)

The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice.
Ju XC, Hou QQ, Sheng AL, Wu KY, Zhou Y, Jin Y, Wen T, Yang Z, Wang X, Luo ZG
eLife5(2016 08)

Cytoplasmic retention of a nucleocytoplasmic protein TBC1D3 by microtubule network is required for enhanced EGFR signaling.
He Z, Tian T, Guo D, Wu H, Chen Y, Zhang Y, Wan Q, Zhao H, Wang C, Shen H, Zhao L, Bu X, Wan M, Shen C
PloS one9(4)e94134(2014)

Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is regulated by protein palmitoylation.
Kong C, Lange JJ, Samovski D, Su X, Liu J, Sundaresan S, Stahl PD
Biochemical and biophysical research communications434(2)388-93(2013 May)

High TBC1B3 expression is associated with breast cancer.
Title: Up-regulation of OLR1 expression by TBC1D3 through activation of TNF?/NF-?B pathway promotes the migration of human breast cancer cells.

Here, the found that expression of TBC1D3 in ventricular cortical progenitors of mice via in utero electroporation caused delamination of ventricular radial glia cells (vRGs) and promoted generation of self-renewing basal progenitors with typical morphology of outer radial glia (oRG), which are most abundant in primates. Expression of TBC1D3, was often found to underlie cortical regions exhibiting folding.
Title: The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice.

these studies indicate a novel model by which the microtubule network regulates EGFR stability and signaling through tubulin dimer/oligomer interaction with the nucleocytoplasmic protein TBC1D3.
Title: Cytoplasmic retention of a nucleocytoplasmic protein TBC1D3 by microtubule network is required for enhanced EGFR signaling.

TBC1D3 is targeted to the plasma membrane by protein palmitoylation.
Title: Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is regulated by protein palmitoylation.

Growth factor-stimulated TBC1D3 ubiquitination and degradation are regulated by its interaction with CUL7-Fbw8.
Title: Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is mediated by CUL7 E3 ligase.