SPANXA2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SPANXA2
Entrez Gene ID	728712
Full Name	SPANX family member A2
Synonyms	CT11.1,SPANX,SPANX-A,SPANXA
General protein information	Preferred Names SPANX family member A2 Names sperm protein associated with the nucleus on the X chromosome A SPANX family member A cancer/testis antigen 11.1 nuclear-associated protein SPAN-Xa sperm protein associated with the nucleus, X chromosome, family member A2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq27.2
Summary	Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A1 and appears to be a duplication of that locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008].
Disorder MIM:	300493

mRNA and Protein(s)

mRNA	Protein	Name
NM_145662.3	NP_663695.1	sperm protein associated with the nucleus on the X chromosome A
NM_145662.4	NP_663695.1	sperm protein associated with the nucleus on the X chromosome A
XM_016999968.1	XP_016855457.1	sperm protein associated with the nucleus on the X chromosome A isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	SPANXA1	NP_038481.2
Homo sapiens (human)	SPANXA2	NP_663695.1
Homo sapiens (human)	SPANXC	NP_073152.1
Homo sapiens (human)	SPANXB1	NP_115850.1
Homo sapiens (human)	SPANXD	NP_115793.1

Gene Ontology
Bibliography

Related articles in PubMed

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

SPANX gene variation in fertile and infertile males.
Hansen S, Eichler EE, Fullerton SM, Carrell D
Systems biology in reproductive medicine5518-26(2010 Feb)

Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis.
Westbrook VA, Schoppee PD, Vanage GR, Klotz KL, Diekman AB, Flickinger CJ, Coppola MA, Herr JC
Molecular human reproduction12(11)703-16(2006 Nov)

Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27.
Kouprina N, Pavlicek A, Noskov VN, Solomon G, Otstot J, Isaacs W, Carpten JD, Trent JM, Schleutker J, Barrett JC, Jurka J, Larionov V
Genome research15(11)1477-86(2005 Nov)

The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids.
Kouprina N, Mullokandov M, Rogozin IB, Collins NK, Solomon G, Otstot J, Risinger JI, Koonin EV, Barrett JC, Larionov V
Proceedings of the National Academy of Sciences of the United States of America101(9)3077-82(2004 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: SPANX gene variation in fertile and infertile males.

The following SPANXA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SPANXA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23428	NM_145662.4 Latest version!	Homo sapiens SPANX family member A2 (SPANXA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu100081	XM_016999968.1 Latest version!	Homo sapiens SPANX family member A2 (SPANXA2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu23428	NM_145662.3	Homo sapiens SPANX family member A2 (SPANXA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SPANXA2 ( NM_145662.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_663695.1 Homo sapiens SPANX family member A2 (SPANXA2), mRNA.

Price & Availability↑

CloneID	OHu23428
Clone ID Related Accession (Same CDS sequence)	NM_145662.3 , NM_145662.4
Accession Version	NM_145662.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	sperm protein associated with the nucleus on the X chromosome A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB110020.1. On Apr 9, 2014 this sequence version replaced NM_145662.2. ##Evidence-Data-START## Transcript exon combination :: CB110020.1, CB122922.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACAAAC AATCCAGTGC CGGCGGGGTG AAGAGGAGCG TCCCCTGTGA TTCCAACGAG 
GCCAACGAGA TGATGCCGGA GACCCCAACT GGGGACTCAG ACCCGCAACC TGCTCCTAAA 
AAAATGAAAA CATCTGAGTC CTCGACCATA CTAGTGGTTC GCTACAGGAG GAACTTTAAA 
AGAACATCTC CAGAGGAACT GCTGAATGAC CACGCCCGAG AGAACAGAAT CAACCCCCTC 
CAAATGGAGG AGGAGGAATT CATGGAAATA ATGGTTGAAA TACCTGCAAA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_663695.1
CDS	61..354
Translation	MDKQSSAGGVKRSVPCDSNEANEMMPETPTGDSDPQPAPKKMKTSESSTILVVRYRRNFKRTSPEELLNDHARENRINPLQMEEEEFMEIMVEIPAK

Target ORF information:

RefSeq Version	NM_145662.3
Organism	Homo sapiens(human)
Definition	Homo sapiens SPANX family member A2 (SPANXA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145662.3

ORF Insert Sequence:

ATGGACAAAC AATCCAGTGC CGGCGGGGTG AAGAGGAGCG TCCCCTGTGA TTCCAACGAG 
GCCAACGAGA TGATGCCGGA GACCCCAACT GGGGACTCAG ACCCGCAACC TGCTCCTAAA 
AAAATGAAAA CATCTGAGTC CTCGACCATA CTAGTGGTTC GCTACAGGAG GAACTTTAAA 
AGAACATCTC CAGAGGAACT GCTGAATGAC CACGCCCGAG AGAACAGAAT CAACCCCCTC 
CAAATGGAGG AGGAGGAATT CATGGAAATA ATGGTTGAAA TACCTGCAAA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPANXA2 ( NM_145662.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_663695.1 Homo sapiens SPANX family member A2 (SPANXA2), mRNA.

Price & Availability↑

CloneID	OHu23428
Clone ID Related Accession (Same CDS sequence)	NM_145662.3 , NM_145662.4
Accession Version	NM_145662.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	sperm protein associated with the nucleus on the X chromosome A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB110020.1. On Nov 22, 2018 this sequence version replaced NM_145662.3. ##Evidence-Data-START## Transcript exon combination :: CB113891.1, CB122914.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370518.4/ ENSP00000359549.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACAAAC AATCCAGTGC CGGCGGGGTG AAGAGGAGCG TCCCCTGTGA TTCCAACGAG 
GCCAACGAGA TGATGCCGGA GACCCCAACT GGGGACTCAG ACCCGCAACC TGCTCCTAAA 
AAAATGAAAA CATCTGAGTC CTCGACCATA CTAGTGGTTC GCTACAGGAG GAACTTTAAA 
AGAACATCTC CAGAGGAACT GCTGAATGAC CACGCCCGAG AGAACAGAAT CAACCCCCTC 
CAAATGGAGG AGGAGGAATT CATGGAAATA ATGGTTGAAA TACCTGCAAA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_663695.1
CDS	61..354
Translation	MDKQSSAGGVKRSVPCDSNEANEMMPETPTGDSDPQPAPKKMKTSESSTILVVRYRRNFKRTSPEELLNDHARENRINPLQMEEEEFMEIMVEIPAK

Target ORF information:

RefSeq Version	NM_145662.4
Organism	Homo sapiens(human)
Definition	Homo sapiens SPANX family member A2 (SPANXA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145662.4

ORF Insert Sequence:

ATGGACAAAC AATCCAGTGC CGGCGGGGTG AAGAGGAGCG TCCCCTGTGA TTCCAACGAG 
GCCAACGAGA TGATGCCGGA GACCCCAACT GGGGACTCAG ACCCGCAACC TGCTCCTAAA 
AAAATGAAAA CATCTGAGTC CTCGACCATA CTAGTGGTTC GCTACAGGAG GAACTTTAAA 
AGAACATCTC CAGAGGAACT GCTGAATGAC CACGCCCGAG AGAACAGAAT CAACCCCCTC 
CAAATGGAGG AGGAGGAATT CATGGAAATA ATGGTTGAAA TACCTGCAAA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPANXA2 ( XM_016999968.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016855457.1 Homo sapiens SPANX family member A2 (SPANXA2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu100081
Clone ID Related Accession (Same CDS sequence)	XM_016999968.1
Accession Version	XM_016999968.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	sperm protein associated with the nucleus on the X chromosome A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_018934.2) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACAAAC AATCCAGTGC CGGCGGGGTG AAGAGGAGCG TCCCCTGTGA ATCCAACGAG 
GTGAATGAGA CGATGCCGGA GACCCCAACT GGGGACTCAG ACCCGCAACC TGCTCCTAAA 
AAAATGAAAA CATCTGAGTC CTCGACCATA CTAGTGGTTC GCTACAGGAG GAACTTTAAA 
AGAACATCTC CAGAGGAACT GCTGAATGAC CACGCCCGAG AGAACAGAAT CAACCCCCTC 
CAAATGGAGG AGGAGGAATT CATGGAAATA ATGGTTGAAA TACCTGCAAA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016855457.1
CDS	34..327
Translation	MDKQSSAGGVKRSVPCESNEVNETMPETPTGDSDPQPAPKKMKTSESSTILVVRYRRNFKRTSPEELLNDHARENRINPLQMEEEEFMEIMVEIPAK

Target ORF information:

RefSeq Version	XM_016999968.1
Organism	Homo sapiens(human)
Definition	Homo sapiens SPANX family member A2 (SPANXA2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_016999968.1

ORF Insert Sequence:

ATGGACAAAC AATCCAGTGC CGGCGGGGTG AAGAGGAGCG TCCCCTGTGA ATCCAACGAG 
GTGAATGAGA CGATGCCGGA GACCCCAACT GGGGACTCAG ACCCGCAACC TGCTCCTAAA 
AAAATGAAAA CATCTGAGTC CTCGACCATA CTAGTGGTTC GCTACAGGAG GAACTTTAAA 
AGAACATCTC CAGAGGAACT GCTGAATGAC CACGCCCGAG AGAACAGAAT CAACCCCCTC 
CAAATGGAGG AGGAGGAATT CATGGAAATA ATGGTTGAAA TACCTGCAAA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

SPANX gene variation in fertile and infertile males.
Systems biology in reproductive medicine5518-26(2010 Feb)
Hansen S,Eichler EE,Fullerton SM,Carrell D

Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis.
Molecular human reproduction12(11)703-16(2006 Nov)
Westbrook VA,Schoppee PD,Vanage GR,Klotz KL,Diekman AB,Flickinger CJ,Coppola MA,Herr JC

Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27.
Genome research15(11)1477-86(2005 Nov)
Kouprina N,Pavlicek A,Noskov VN,Solomon G,Otstot J,Isaacs W,Carpten JD,Trent JM,Schleutker J,Barrett JC,Jurka J,Larionov V

The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids.
Proceedings of the National Academy of Sciences of the United States of America101(9)3077-82(2004 Mar)
Kouprina N,Mullokandov M,Rogozin IB,Collins NK,Solomon G,Otstot J,Risinger JI,Koonin EV,Barrett JC,Larionov V

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SPANXA2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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